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Protein

Solute carrier organic anion transporter family member 4C1

Gene

Slco4c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Ion transport, Spermatogenesis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 4C1
Alternative name(s):
Oatp-R
Solute carrier family 21 member 20
Gene namesi
Name:Slco4c1Imported
Synonyms:Oatp4c1By similarity, Slc21a20By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2442784. Slco4c1.

Subcellular locationi

  • Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Detected at the basolateral membrane of the proximal tubule cell in the kidney.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 101CytoplasmicSequence analysisAdd BLAST101
Transmembranei102 – 122Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini123 – 141ExtracellularSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini163 – 168CytoplasmicSequence analysis6
Transmembranei169 – 193Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini194 – 218ExtracellularSequence analysisAdd BLAST25
Transmembranei219 – 249Helical; Name=4Sequence analysisAdd BLAST31
Topological domaini250 – 269CytoplasmicSequence analysisAdd BLAST20
Transmembranei270 – 290Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini291 – 306ExtracellularSequence analysisAdd BLAST16
Transmembranei307 – 331Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini332 – 376CytoplasmicSequence analysisAdd BLAST45
Transmembranei377 – 398Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini399 – 418ExtracellularSequence analysisAdd BLAST20
Transmembranei419 – 442Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini443 – 446CytoplasmicSequence analysis4
Transmembranei447 – 470Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini471 – 578ExtracellularSequence analysisAdd BLAST108
Transmembranei579 – 601Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini602 – 610CytoplasmicSequence analysis9
Transmembranei611 – 636Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini637 – 670ExtracellularSequence analysisAdd BLAST34
Transmembranei671 – 688Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini689 – 722CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371521 – 722Solute carrier organic anion transporter family member 4C1Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei16PhosphoserineCombined sources1
Modified residuei19PhosphothreonineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Disulfide bondi500 ↔ 526PROSITE-ProRule annotation
Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
Disulfide bondi506 ↔ 530PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ8BGD4.
PaxDbiQ8BGD4.
PRIDEiQ8BGD4.

PTM databases

iPTMnetiQ8BGD4.
PhosphoSitePlusiQ8BGD4.

Expressioni

Tissue specificityi

Strongly expressed in initial segment of epididymis and seminal vesicles.1 Publication

Inductioni

Dramatically down-regulated 1 day after gonadectomy.1 Publication

Gene expression databases

BgeeiENSMUSG00000040693.
GenevisibleiQ8BGD4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071875.

Structurei

3D structure databases

ProteinModelPortaliQ8BGD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini494 – 549Kazal-likePROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi690 – 693Poly-ProSequence analysis4

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ8BGD4.
KOiK14355.
OMAiVFTFMAG.
OrthoDBiEOG091G02FX.
PhylomeDBiQ8BGD4.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGSKGIENP AFVPSSPGTP RRASASPSQV EVSAVASRNQ NGGSQPRESE
60 70 80 90 100
EPQKSTEPSP PSSNPPASDE PPGSQLSELE EGPCGWRGFH PQCLQRCNTP
110 120 130 140 150
QGFLLHYCLL ALTQGIVVNG LVNISISTIE KRYEMKSSLT GLISSSYDIS
160 170 180 190 200
FCVLSLFVSF FGERGHKPRW LAFASFMIGL GALVFSLPHF FSGRYELGSI
210 220 230 240 250
FEDTCLTRNS TRCSSSTSLL SNYFYVFVLG QLLLGTGGTP LYTLGTAFID
260 270 280 290 300
DSVPTHKSSL YIGIGYSMSI LGPAIGYVLG GQLLTMYIDI AMGQSSDLTE
310 320 330 340 350
DDPRWLGAWW IGFLLAWLFA WSLIMPFSCF PKHLPGTAKI QAGKTSQTHQ
360 370 380 390 400
NNSTSFQHTD ENFGKSIKDF PTAVKNLMRN TVFICLVLST TSEALITTGF
410 420 430 440 450
ATFLPKFIEN QFGLTSSFAA TLGGAVLIPG AALGQILGGV LVSKFKMKCK
460 470 480 490 500
NTMKFALCTS GVALVLSFVF IYAKCENEPF AGVSESYNGT GEMGNLTAPC
510 520 530 540 550
NANCNCLRSY YYPLCGSDGI QYFSPCFAGC LNSVSNRKPK VYYNCSCIER
560 570 580 590 600
KITSTAESTD FEAKAGKCRT RCSNLPIFLG IFFITVIFTF MAGTPITVSI
610 620 630 640 650
LRCVNHRHRS LALGVQFMLL RLLGTIPGPI IFGVIIDSTC VLWDVNECGI
660 670 680 690 700
KGACWIYDNI KMAHMLVAIS VTCKVITIFF NGLAIVLYKP PPPGTEVSFQ
710 720
SQNVIVSTIS VEEDLDKAEN EG
Length:722
Mass (Da):78,412
Last modified:March 1, 2003 - v1
Checksum:iA48F2F5853DBAE7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY654588 mRNA. Translation: AAT73731.1.
AK049253 mRNA. Translation: BAC33637.1.
AK049944 mRNA. Translation: BAC33997.1.
BC119022 mRNA. Translation: AAI19023.1.
CCDSiCCDS35675.1.
RefSeqiNP_766246.1. NM_172658.3.
UniGeneiMm.11662.

Genome annotation databases

EnsembliENSMUST00000071985; ENSMUSP00000071875; ENSMUSG00000040693.
GeneIDi227394.
KEGGimmu:227394.
UCSCiuc007cfc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY654588 mRNA. Translation: AAT73731.1.
AK049253 mRNA. Translation: BAC33637.1.
AK049944 mRNA. Translation: BAC33997.1.
BC119022 mRNA. Translation: AAI19023.1.
CCDSiCCDS35675.1.
RefSeqiNP_766246.1. NM_172658.3.
UniGeneiMm.11662.

3D structure databases

ProteinModelPortaliQ8BGD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071875.

PTM databases

iPTMnetiQ8BGD4.
PhosphoSitePlusiQ8BGD4.

Proteomic databases

MaxQBiQ8BGD4.
PaxDbiQ8BGD4.
PRIDEiQ8BGD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071985; ENSMUSP00000071875; ENSMUSG00000040693.
GeneIDi227394.
KEGGimmu:227394.
UCSCiuc007cfc.1. mouse.

Organism-specific databases

CTDi353189.
MGIiMGI:2442784. Slco4c1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ8BGD4.
KOiK14355.
OMAiVFTFMAG.
OrthoDBiEOG091G02FX.
PhylomeDBiQ8BGD4.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSlco4c1. mouse.
PROiQ8BGD4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040693.
GenevisibleiQ8BGD4. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO4C1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.