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Protein

Solute carrier organic anion transporter family member 4C1

Gene

Slco4c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Ion transport, Spermatogenesis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 4C1
Alternative name(s):
Oatp-R
Solute carrier family 21 member 20
Gene namesi
Name:Slco4c1Imported
Synonyms:Oatp4c1By similarity, Slc21a20By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2442784. Slco4c1.

Subcellular locationi

  • Basolateral cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Detected at the basolateral membrane of the proximal tubule cell in the kidney.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 101101CytoplasmicSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini123 – 14119ExtracellularSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini163 – 1686CytoplasmicSequence analysis
Transmembranei169 – 19325Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini194 – 21825ExtracellularSequence analysisAdd
BLAST
Transmembranei219 – 24931Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini250 – 26920CytoplasmicSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini291 – 30616ExtracellularSequence analysisAdd
BLAST
Transmembranei307 – 33125Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini332 – 37645CytoplasmicSequence analysisAdd
BLAST
Transmembranei377 – 39822Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini399 – 41820ExtracellularSequence analysisAdd
BLAST
Transmembranei419 – 44224Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini443 – 4464CytoplasmicSequence analysis
Transmembranei447 – 47024Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini471 – 578108ExtracellularSequence analysisAdd
BLAST
Transmembranei579 – 60123Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini602 – 6109CytoplasmicSequence analysis
Transmembranei611 – 63626Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini637 – 67034ExtracellularSequence analysisAdd
BLAST
Transmembranei671 – 68818Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini689 – 72234CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Solute carrier organic anion transporter family member 4C1PRO_0000337152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei16 – 161PhosphoserineCombined sources
Modified residuei19 – 191PhosphothreonineCombined sources
Modified residuei24 – 241PhosphoserineCombined sources
Modified residuei26 – 261PhosphoserineCombined sources
Modified residuei28 – 281PhosphoserineCombined sources
Disulfide bondi500 ↔ 526PROSITE-ProRule annotation
Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
Disulfide bondi506 ↔ 530PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ8BGD4.
PaxDbiQ8BGD4.
PRIDEiQ8BGD4.

PTM databases

iPTMnetiQ8BGD4.
PhosphoSiteiQ8BGD4.

Expressioni

Tissue specificityi

Strongly expressed in initial segment of epididymis and seminal vesicles.1 Publication

Inductioni

Dramatically down-regulated 1 day after gonadectomy.1 Publication

Gene expression databases

BgeeiQ8BGD4.
GenevisibleiQ8BGD4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071875.

Structurei

3D structure databases

ProteinModelPortaliQ8BGD4.
SMRiQ8BGD4. Positions 497-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini494 – 54956Kazal-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi690 – 6934Poly-ProSequence analysis

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ8BGD4.
KOiK14355.
OMAiVFTFMAG.
OrthoDBiEOG75TMBK.
PhylomeDBiQ8BGD4.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGSKGIENP AFVPSSPGTP RRASASPSQV EVSAVASRNQ NGGSQPRESE
60 70 80 90 100
EPQKSTEPSP PSSNPPASDE PPGSQLSELE EGPCGWRGFH PQCLQRCNTP
110 120 130 140 150
QGFLLHYCLL ALTQGIVVNG LVNISISTIE KRYEMKSSLT GLISSSYDIS
160 170 180 190 200
FCVLSLFVSF FGERGHKPRW LAFASFMIGL GALVFSLPHF FSGRYELGSI
210 220 230 240 250
FEDTCLTRNS TRCSSSTSLL SNYFYVFVLG QLLLGTGGTP LYTLGTAFID
260 270 280 290 300
DSVPTHKSSL YIGIGYSMSI LGPAIGYVLG GQLLTMYIDI AMGQSSDLTE
310 320 330 340 350
DDPRWLGAWW IGFLLAWLFA WSLIMPFSCF PKHLPGTAKI QAGKTSQTHQ
360 370 380 390 400
NNSTSFQHTD ENFGKSIKDF PTAVKNLMRN TVFICLVLST TSEALITTGF
410 420 430 440 450
ATFLPKFIEN QFGLTSSFAA TLGGAVLIPG AALGQILGGV LVSKFKMKCK
460 470 480 490 500
NTMKFALCTS GVALVLSFVF IYAKCENEPF AGVSESYNGT GEMGNLTAPC
510 520 530 540 550
NANCNCLRSY YYPLCGSDGI QYFSPCFAGC LNSVSNRKPK VYYNCSCIER
560 570 580 590 600
KITSTAESTD FEAKAGKCRT RCSNLPIFLG IFFITVIFTF MAGTPITVSI
610 620 630 640 650
LRCVNHRHRS LALGVQFMLL RLLGTIPGPI IFGVIIDSTC VLWDVNECGI
660 670 680 690 700
KGACWIYDNI KMAHMLVAIS VTCKVITIFF NGLAIVLYKP PPPGTEVSFQ
710 720
SQNVIVSTIS VEEDLDKAEN EG
Length:722
Mass (Da):78,412
Last modified:March 1, 2003 - v1
Checksum:iA48F2F5853DBAE7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY654588 mRNA. Translation: AAT73731.1.
AK049253 mRNA. Translation: BAC33637.1.
AK049944 mRNA. Translation: BAC33997.1.
BC119022 mRNA. Translation: AAI19023.1.
CCDSiCCDS35675.1.
RefSeqiNP_766246.1. NM_172658.3.
UniGeneiMm.11662.

Genome annotation databases

EnsembliENSMUST00000071985; ENSMUSP00000071875; ENSMUSG00000040693.
GeneIDi227394.
KEGGimmu:227394.
UCSCiuc007cfc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY654588 mRNA. Translation: AAT73731.1.
AK049253 mRNA. Translation: BAC33637.1.
AK049944 mRNA. Translation: BAC33997.1.
BC119022 mRNA. Translation: AAI19023.1.
CCDSiCCDS35675.1.
RefSeqiNP_766246.1. NM_172658.3.
UniGeneiMm.11662.

3D structure databases

ProteinModelPortaliQ8BGD4.
SMRiQ8BGD4. Positions 497-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071875.

PTM databases

iPTMnetiQ8BGD4.
PhosphoSiteiQ8BGD4.

Proteomic databases

MaxQBiQ8BGD4.
PaxDbiQ8BGD4.
PRIDEiQ8BGD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071985; ENSMUSP00000071875; ENSMUSG00000040693.
GeneIDi227394.
KEGGimmu:227394.
UCSCiuc007cfc.1. mouse.

Organism-specific databases

CTDi353189.
MGIiMGI:2442784. Slco4c1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231270.
HOVERGENiHBG100565.
InParanoidiQ8BGD4.
KOiK14355.
OMAiVFTFMAG.
OrthoDBiEOG75TMBK.
PhylomeDBiQ8BGD4.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSlco4c1. mouse.
PROiQ8BGD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGD4.
GenevisibleiQ8BGD4. MM.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse organic anion transporter oatp-R."
    Ishiyama K., Suzuki T., Mikkaichi T., Tanemoto M., Abe T.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Embryonic stem cell1 Publication and HippocampusImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  4. "Differential endocrine regulation of genes enriched in initial segment and distal caput of the mouse epididymis as revealed by genome-wide expression profiling."
    Sipila P., Pujianto D.A., Shariatmadari R., Nikkila J., Lehtoranta M., Huhtaniemi I.T., Poutanen M.
    Biol. Reprod. 75:240-251(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; THR-19; SER-24; SER-26 AND SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung and Spleen.

Entry informationi

Entry nameiSO4C1_MOUSE
AccessioniPrimary (citable) accession number: Q8BGD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.