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Protein

Monocarboxylate transporter 12

Gene

Slc16a12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 12
Short name:
MCT 12
Alternative name(s):
Solute carrier family 16 member 12
Gene namesi
Name:Slc16a12
Synonyms:Mct12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147716 Slc16a12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 486CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866761 – 486Monocarboxylate transporter 12Add BLAST486

Proteomic databases

PaxDbiQ8BGC3
PeptideAtlasiQ8BGC3
PRIDEiQ8BGC3

PTM databases

iPTMnetiQ8BGC3
PhosphoSitePlusiQ8BGC3

Expressioni

Gene expression databases

BgeeiENSMUSG00000009378
GenevisibleiQ8BGC3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009522

Structurei

3D structure databases

ProteinModelPortaliQ8BGC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118926
HOGENOMiHOG000280688
HOVERGENiHBG097674
InParanoidiQ8BGC3
KOiK11810
OMAiRRCLKNY
OrthoDBiEOG091G05H1
PhylomeDBiQ8BGC3
TreeFamiTF313792

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 2 hits
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BGC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKITRVSLA SPPDGGWGWM IVAGCFLVTI CTRAVTRCIS IFFVEFQTYF
60 70 80 90 100
AQDYSQTAWI HSIVDCMTML CAPLGSVVSN QLSCQAGIML GGLLASTGFI
110 120 130 140 150
LGSFATSLKH LYLSLGVLTG LGFALCYSPA IAMVGKYFSR RKALAYGIAM
160 170 180 190 200
SGSGIGTFIL APVVQLLIEQ FSWRGALLIL GGFVLNLCVC GALMRPITLK
210 220 230 240 250
EDRSVPEKNH NRESQREDCK QASPYSPLTK ECTETRLCCS LQQEYGFLLM
260 270 280 290 300
SDFVVLAVSV LFMAYGCSPL FVYLVPYALS VGVSHHQAAF LMSILGVIDI
310 320 330 340 350
VGNITFGWLT DRRCLKNYRY VCYLFAVALD GLCYLCLPML QTFPLLVPFS
360 370 380 390 400
CTFGYFDGAY VTLIPVVTAE IVGTTSLSSA LGVVYFLHAV PYLVSPPIAG
410 420 430 440 450
WLVDTTGSYT AAFLLCGFAM IFSSILLGFV RIVKRMKRTQ VPFPVKDSDP
460 470 480
KLQLWTNGSV AYSVARELDQ KDEEPLPKAR SGCNLT
Length:486
Mass (Da):53,152
Last modified:March 1, 2003 - v1
Checksum:iAA3CC9951FB28247
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234E → K in AAI13804 (PubMed:15489334).Curated1
Sequence conflicti234E → K in AAI11903 (PubMed:15489334).Curated1
Sequence conflicti293S → C in AAI13804 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028284 mRNA Translation: BAC25857.1
AK029076 mRNA Translation: BAC26279.1
BC111902 mRNA Translation: AAI11903.1
BC113803 mRNA Translation: AAI13804.1
CCDSiCCDS29767.1
RefSeqiNP_766426.1, NM_172838.3
XP_006527141.1, XM_006527078.3
XP_011245548.1, XM_011247246.2
UniGeneiMm.74636

Genome annotation databases

EnsembliENSMUST00000009522; ENSMUSP00000009522; ENSMUSG00000009378
GeneIDi240638
KEGGimmu:240638
UCSCiuc008hgu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMOT12_MOUSE
AccessioniPrimary (citable) accession number: Q8BGC3
Secondary accession number(s): Q14CF9, Q14DR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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