Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Monocarboxylate transporter 12

Gene

Slc16a12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 12
Short name:
MCT 12
Alternative name(s):
Solute carrier family 16 member 12
Gene namesi
Name:Slc16a12
Synonyms:Mct12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147716. Slc16a12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 486CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866761 – 486Monocarboxylate transporter 12Add BLAST486

Proteomic databases

PaxDbiQ8BGC3.
PeptideAtlasiQ8BGC3.
PRIDEiQ8BGC3.

PTM databases

iPTMnetiQ8BGC3.
PhosphoSitePlusiQ8BGC3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009378.
GenevisibleiQ8BGC3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009522.

Structurei

3D structure databases

ProteinModelPortaliQ8BGC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG097674.
InParanoidiQ8BGC3.
KOiK11810.
OMAiYQYVCYL.
OrthoDBiEOG091G05H1.
PhylomeDBiQ8BGC3.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BGC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKITRVSLA SPPDGGWGWM IVAGCFLVTI CTRAVTRCIS IFFVEFQTYF
60 70 80 90 100
AQDYSQTAWI HSIVDCMTML CAPLGSVVSN QLSCQAGIML GGLLASTGFI
110 120 130 140 150
LGSFATSLKH LYLSLGVLTG LGFALCYSPA IAMVGKYFSR RKALAYGIAM
160 170 180 190 200
SGSGIGTFIL APVVQLLIEQ FSWRGALLIL GGFVLNLCVC GALMRPITLK
210 220 230 240 250
EDRSVPEKNH NRESQREDCK QASPYSPLTK ECTETRLCCS LQQEYGFLLM
260 270 280 290 300
SDFVVLAVSV LFMAYGCSPL FVYLVPYALS VGVSHHQAAF LMSILGVIDI
310 320 330 340 350
VGNITFGWLT DRRCLKNYRY VCYLFAVALD GLCYLCLPML QTFPLLVPFS
360 370 380 390 400
CTFGYFDGAY VTLIPVVTAE IVGTTSLSSA LGVVYFLHAV PYLVSPPIAG
410 420 430 440 450
WLVDTTGSYT AAFLLCGFAM IFSSILLGFV RIVKRMKRTQ VPFPVKDSDP
460 470 480
KLQLWTNGSV AYSVARELDQ KDEEPLPKAR SGCNLT
Length:486
Mass (Da):53,152
Last modified:March 1, 2003 - v1
Checksum:iAA3CC9951FB28247
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234E → K in AAI13804 (PubMed:15489334).Curated1
Sequence conflicti234E → K in AAI11903 (PubMed:15489334).Curated1
Sequence conflicti293S → C in AAI13804 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028284 mRNA. Translation: BAC25857.1.
AK029076 mRNA. Translation: BAC26279.1.
BC111902 mRNA. Translation: AAI11903.1.
BC113803 mRNA. Translation: AAI13804.1.
CCDSiCCDS29767.1.
RefSeqiNP_766426.1. NM_172838.3.
XP_006527141.1. XM_006527078.3.
XP_011245548.1. XM_011247246.2.
UniGeneiMm.74636.

Genome annotation databases

EnsembliENSMUST00000009522; ENSMUSP00000009522; ENSMUSG00000009378.
GeneIDi240638.
KEGGimmu:240638.
UCSCiuc008hgu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028284 mRNA. Translation: BAC25857.1.
AK029076 mRNA. Translation: BAC26279.1.
BC111902 mRNA. Translation: AAI11903.1.
BC113803 mRNA. Translation: AAI13804.1.
CCDSiCCDS29767.1.
RefSeqiNP_766426.1. NM_172838.3.
XP_006527141.1. XM_006527078.3.
XP_011245548.1. XM_011247246.2.
UniGeneiMm.74636.

3D structure databases

ProteinModelPortaliQ8BGC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009522.

PTM databases

iPTMnetiQ8BGC3.
PhosphoSitePlusiQ8BGC3.

Proteomic databases

PaxDbiQ8BGC3.
PeptideAtlasiQ8BGC3.
PRIDEiQ8BGC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009522; ENSMUSP00000009522; ENSMUSG00000009378.
GeneIDi240638.
KEGGimmu:240638.
UCSCiuc008hgu.1. mouse.

Organism-specific databases

CTDi387700.
MGIiMGI:2147716. Slc16a12.

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG097674.
InParanoidiQ8BGC3.
KOiK11810.
OMAiYQYVCYL.
OrthoDBiEOG091G05H1.
PhylomeDBiQ8BGC3.
TreeFamiTF313792.

Miscellaneous databases

PROiQ8BGC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009378.
GenevisibleiQ8BGC3. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT12_MOUSE
AccessioniPrimary (citable) accession number: Q8BGC3
Secondary accession number(s): Q14CF9, Q14DR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.