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Q8BGB8

- COQ4_MOUSE

UniProt

Q8BGB8 - COQ4_MOUSE

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Protein

Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

Gene

Coq4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.UniRule annotation

Pathwayi

GO - Biological processi

  1. ubiquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Ubiquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialUniRule annotation
Alternative name(s):
Coenzyme Q biosynthesis protein 4 homologUniRule annotation
Gene namesi
Name:Coq4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1098826. Coq4.

Subcellular locationi

Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  1. extrinsic component of mitochondrial inner membrane Source: UniProtKB-HAMAP
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionUniRule annotationAdd
BLAST
Chaini31 – 266236Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialPRO_0000320291Add
BLAST

Proteomic databases

MaxQBiQ8BGB8.
PaxDbiQ8BGB8.
PRIDEiQ8BGB8.

PTM databases

PhosphoSiteiQ8BGB8.

Expressioni

Gene expression databases

BgeeiQ8BGB8.
CleanExiMM_COQ4.
ExpressionAtlasiQ8BGB8. baseline and differential.
GenevestigatoriQ8BGB8.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

BioGridi230662. 1 interaction.
STRINGi10090.ENSMUSP00000028137.

Structurei

3D structure databases

ProteinModelPortaliQ8BGB8.
SMRiQ8BGB8. Positions 94-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ4 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5031.
GeneTreeiENSGT00390000003828.
HOGENOMiHOG000194110.
HOVERGENiHBG027006.
InParanoidiQ8BGB8.
OMAiYEQRWEQ.
OrthoDBiEOG7S7SGB.
PhylomeDBiQ8BGB8.
TreeFamiTF314625.

Family and domain databases

HAMAPiMF_03111. Coq4.
InterProiIPR007715. Coq4.
IPR027540. Coq4_euk.
[Graphical view]
PfamiPF05019. Coq4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLLLLRSL RLHRSLRPRT RPAVDVPLRA GSHGARLLYP DHIPTTPLQK
60 70 80 90 100
MLLAAGAAGM ALYNPYRHDM VAVLGETTGC HTLKFLRDQM KKDPEGAQIL
110 120 130 140 150
QERPRISLST LDLSKLQSLP EGSLGREYLR FLDVNKVSPD TRAPTRFVDD
160 170 180 190 200
EELAYVIQRY REVHDMLHTL LGMPTNMLGE VVVKWFEAVQ TGLPMCILGA
210 220 230 240 250
LFGPIRLRTQ SLQVLFSELI PWAIQNGRRA PCVLNIYYEQ RWEQPLTALR
260
EELGISPPPK HIQGLA
Length:266
Mass (Da):30,084
Last modified:March 1, 2003 - v1
Checksum:iAD4CB7CAD1690A73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK039422 mRNA. Translation: BAC30344.1.
AK039676 mRNA. Translation: BAC30416.1.
AK050459 mRNA. Translation: BAC34269.1.
AL845323 Genomic DNA. Translation: CAM20267.1.
CCDSiCCDS15857.1.
RefSeqiNP_848808.1. NM_178693.4.
UniGeneiMm.245948.

Genome annotation databases

EnsembliENSMUST00000028137; ENSMUSP00000028137; ENSMUSG00000026798.
GeneIDi227683.
KEGGimmu:227683.
UCSCiuc008jac.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK039422 mRNA. Translation: BAC30344.1 .
AK039676 mRNA. Translation: BAC30416.1 .
AK050459 mRNA. Translation: BAC34269.1 .
AL845323 Genomic DNA. Translation: CAM20267.1 .
CCDSi CCDS15857.1.
RefSeqi NP_848808.1. NM_178693.4.
UniGenei Mm.245948.

3D structure databases

ProteinModelPortali Q8BGB8.
SMRi Q8BGB8. Positions 94-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230662. 1 interaction.
STRINGi 10090.ENSMUSP00000028137.

PTM databases

PhosphoSitei Q8BGB8.

Proteomic databases

MaxQBi Q8BGB8.
PaxDbi Q8BGB8.
PRIDEi Q8BGB8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028137 ; ENSMUSP00000028137 ; ENSMUSG00000026798 .
GeneIDi 227683.
KEGGi mmu:227683.
UCSCi uc008jac.1. mouse.

Organism-specific databases

CTDi 51117.
MGIi MGI:1098826. Coq4.

Phylogenomic databases

eggNOGi COG5031.
GeneTreei ENSGT00390000003828.
HOGENOMi HOG000194110.
HOVERGENi HBG027006.
InParanoidi Q8BGB8.
OMAi YEQRWEQ.
OrthoDBi EOG7S7SGB.
PhylomeDBi Q8BGB8.
TreeFami TF314625.

Enzyme and pathway databases

UniPathwayi UPA00232 .

Miscellaneous databases

ChiTaRSi COQ4. mouse.
NextBioi 378744.
PROi Q8BGB8.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGB8.
CleanExi MM_COQ4.
ExpressionAtlasi Q8BGB8. baseline and differential.
Genevestigatori Q8BGB8.

Family and domain databases

HAMAPi MF_03111. Coq4.
InterProi IPR007715. Coq4.
IPR027540. Coq4_euk.
[Graphical view ]
Pfami PF05019. Coq4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Spinal cord.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCOQ4_MOUSE
AccessioniPrimary (citable) accession number: Q8BGB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3