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Q8BGB8

- COQ4_MOUSE

UniProt

Q8BGB8 - COQ4_MOUSE

Protein

Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

Gene

Coq4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.UniRule annotation

    Pathwayi

    GO - Biological processi

    1. ubiquinone biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Ubiquinone biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialUniRule annotation
    Alternative name(s):
    Coenzyme Q biosynthesis protein 4 homologUniRule annotation
    Gene namesi
    Name:Coq4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1098826. Coq4.

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

    GO - Cellular componenti

    1. extrinsic component of mitochondrial inner membrane Source: UniProtKB-HAMAP
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionUniRule annotationAdd
    BLAST
    Chaini31 – 266236Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialPRO_0000320291Add
    BLAST

    Proteomic databases

    MaxQBiQ8BGB8.
    PaxDbiQ8BGB8.
    PRIDEiQ8BGB8.

    PTM databases

    PhosphoSiteiQ8BGB8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BGB8.
    BgeeiQ8BGB8.
    CleanExiMM_COQ4.
    GenevestigatoriQ8BGB8.

    Interactioni

    Subunit structurei

    Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

    Protein-protein interaction databases

    BioGridi230662. 1 interaction.
    STRINGi10090.ENSMUSP00000028137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGB8.
    SMRiQ8BGB8. Positions 94-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COQ4 family.UniRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG5031.
    GeneTreeiENSGT00390000003828.
    HOGENOMiHOG000194110.
    HOVERGENiHBG027006.
    InParanoidiQ8BGB8.
    OMAiYEQRWEQ.
    OrthoDBiEOG7S7SGB.
    PhylomeDBiQ8BGB8.
    TreeFamiTF314625.

    Family and domain databases

    HAMAPiMF_03111. Coq4.
    InterProiIPR007715. Coq4.
    IPR027540. Coq4_euk.
    [Graphical view]
    PfamiPF05019. Coq4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BGB8-1 [UniParc]FASTAAdd to Basket

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    MATLLLLRSL RLHRSLRPRT RPAVDVPLRA GSHGARLLYP DHIPTTPLQK    50
    MLLAAGAAGM ALYNPYRHDM VAVLGETTGC HTLKFLRDQM KKDPEGAQIL 100
    QERPRISLST LDLSKLQSLP EGSLGREYLR FLDVNKVSPD TRAPTRFVDD 150
    EELAYVIQRY REVHDMLHTL LGMPTNMLGE VVVKWFEAVQ TGLPMCILGA 200
    LFGPIRLRTQ SLQVLFSELI PWAIQNGRRA PCVLNIYYEQ RWEQPLTALR 250
    EELGISPPPK HIQGLA 266
    Length:266
    Mass (Da):30,084
    Last modified:March 1, 2003 - v1
    Checksum:iAD4CB7CAD1690A73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039422 mRNA. Translation: BAC30344.1.
    AK039676 mRNA. Translation: BAC30416.1.
    AK050459 mRNA. Translation: BAC34269.1.
    AL845323 Genomic DNA. Translation: CAM20267.1.
    CCDSiCCDS15857.1.
    RefSeqiNP_848808.1. NM_178693.4.
    UniGeneiMm.245948.

    Genome annotation databases

    EnsembliENSMUST00000028137; ENSMUSP00000028137; ENSMUSG00000026798.
    GeneIDi227683.
    KEGGimmu:227683.
    UCSCiuc008jac.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039422 mRNA. Translation: BAC30344.1 .
    AK039676 mRNA. Translation: BAC30416.1 .
    AK050459 mRNA. Translation: BAC34269.1 .
    AL845323 Genomic DNA. Translation: CAM20267.1 .
    CCDSi CCDS15857.1.
    RefSeqi NP_848808.1. NM_178693.4.
    UniGenei Mm.245948.

    3D structure databases

    ProteinModelPortali Q8BGB8.
    SMRi Q8BGB8. Positions 94-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230662. 1 interaction.
    STRINGi 10090.ENSMUSP00000028137.

    PTM databases

    PhosphoSitei Q8BGB8.

    Proteomic databases

    MaxQBi Q8BGB8.
    PaxDbi Q8BGB8.
    PRIDEi Q8BGB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028137 ; ENSMUSP00000028137 ; ENSMUSG00000026798 .
    GeneIDi 227683.
    KEGGi mmu:227683.
    UCSCi uc008jac.1. mouse.

    Organism-specific databases

    CTDi 51117.
    MGIi MGI:1098826. Coq4.

    Phylogenomic databases

    eggNOGi COG5031.
    GeneTreei ENSGT00390000003828.
    HOGENOMi HOG000194110.
    HOVERGENi HBG027006.
    InParanoidi Q8BGB8.
    OMAi YEQRWEQ.
    OrthoDBi EOG7S7SGB.
    PhylomeDBi Q8BGB8.
    TreeFami TF314625.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .

    Miscellaneous databases

    ChiTaRSi COQ4. mouse.
    NextBioi 378744.
    PROi Q8BGB8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BGB8.
    Bgeei Q8BGB8.
    CleanExi MM_COQ4.
    Genevestigatori Q8BGB8.

    Family and domain databases

    HAMAPi MF_03111. Coq4.
    InterProi IPR007715. Coq4.
    IPR027540. Coq4_euk.
    [Graphical view ]
    Pfami PF05019. Coq4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver and Spinal cord.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCOQ4_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3