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Protein

Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

Gene

Coq4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.UniRule annotation

Pathway: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubiquinone biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialUniRule annotation
Alternative name(s):
Coenzyme Q biosynthesis protein 4 homologUniRule annotation
Gene namesi
Name:Coq4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1098826. Coq4.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: UniProtKB-HAMAP
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionUniRule annotationAdd
BLAST
Chaini31 – 266236Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialPRO_0000320291Add
BLAST

Proteomic databases

MaxQBiQ8BGB8.
PaxDbiQ8BGB8.
PRIDEiQ8BGB8.

PTM databases

PhosphoSiteiQ8BGB8.

Expressioni

Gene expression databases

BgeeiQ8BGB8.
CleanExiMM_COQ4.
ExpressionAtlasiQ8BGB8. baseline and differential.
GenevisibleiQ8BGB8. MM.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

BioGridi230662. 1 interaction.
STRINGi10090.ENSMUSP00000028137.

Structurei

3D structure databases

ProteinModelPortaliQ8BGB8.
SMRiQ8BGB8. Positions 94-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ4 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5031.
GeneTreeiENSGT00390000003828.
HOGENOMiHOG000194110.
HOVERGENiHBG027006.
InParanoidiQ8BGB8.
KOiK18586.
OMAiYEQRWEQ.
OrthoDBiEOG7S7SGB.
PhylomeDBiQ8BGB8.
TreeFamiTF314625.

Family and domain databases

HAMAPiMF_03111. Coq4.
InterProiIPR007715. Coq4.
IPR027540. Coq4_euk.
[Graphical view]
PfamiPF05019. Coq4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLLLLRSL RLHRSLRPRT RPAVDVPLRA GSHGARLLYP DHIPTTPLQK
60 70 80 90 100
MLLAAGAAGM ALYNPYRHDM VAVLGETTGC HTLKFLRDQM KKDPEGAQIL
110 120 130 140 150
QERPRISLST LDLSKLQSLP EGSLGREYLR FLDVNKVSPD TRAPTRFVDD
160 170 180 190 200
EELAYVIQRY REVHDMLHTL LGMPTNMLGE VVVKWFEAVQ TGLPMCILGA
210 220 230 240 250
LFGPIRLRTQ SLQVLFSELI PWAIQNGRRA PCVLNIYYEQ RWEQPLTALR
260
EELGISPPPK HIQGLA
Length:266
Mass (Da):30,084
Last modified:March 1, 2003 - v1
Checksum:iAD4CB7CAD1690A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039422 mRNA. Translation: BAC30344.1.
AK039676 mRNA. Translation: BAC30416.1.
AK050459 mRNA. Translation: BAC34269.1.
AL845323 Genomic DNA. Translation: CAM20267.1.
CCDSiCCDS15857.1.
RefSeqiNP_848808.1. NM_178693.4.
UniGeneiMm.245948.

Genome annotation databases

EnsembliENSMUST00000028137; ENSMUSP00000028137; ENSMUSG00000026798.
GeneIDi227683.
KEGGimmu:227683.
UCSCiuc008jac.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039422 mRNA. Translation: BAC30344.1.
AK039676 mRNA. Translation: BAC30416.1.
AK050459 mRNA. Translation: BAC34269.1.
AL845323 Genomic DNA. Translation: CAM20267.1.
CCDSiCCDS15857.1.
RefSeqiNP_848808.1. NM_178693.4.
UniGeneiMm.245948.

3D structure databases

ProteinModelPortaliQ8BGB8.
SMRiQ8BGB8. Positions 94-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230662. 1 interaction.
STRINGi10090.ENSMUSP00000028137.

PTM databases

PhosphoSiteiQ8BGB8.

Proteomic databases

MaxQBiQ8BGB8.
PaxDbiQ8BGB8.
PRIDEiQ8BGB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028137; ENSMUSP00000028137; ENSMUSG00000026798.
GeneIDi227683.
KEGGimmu:227683.
UCSCiuc008jac.1. mouse.

Organism-specific databases

CTDi51117.
MGIiMGI:1098826. Coq4.

Phylogenomic databases

eggNOGiCOG5031.
GeneTreeiENSGT00390000003828.
HOGENOMiHOG000194110.
HOVERGENiHBG027006.
InParanoidiQ8BGB8.
KOiK18586.
OMAiYEQRWEQ.
OrthoDBiEOG7S7SGB.
PhylomeDBiQ8BGB8.
TreeFamiTF314625.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

ChiTaRSiCoq4. mouse.
NextBioi378744.
PROiQ8BGB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BGB8.
CleanExiMM_COQ4.
ExpressionAtlasiQ8BGB8. baseline and differential.
GenevisibleiQ8BGB8. MM.

Family and domain databases

HAMAPiMF_03111. Coq4.
InterProiIPR007715. Coq4.
IPR027540. Coq4_euk.
[Graphical view]
PfamiPF05019. Coq4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Spinal cord.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCOQ4_MOUSE
AccessioniPrimary (citable) accession number: Q8BGB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.