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Protein

LIM domain-containing protein 2

Gene

Limd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an activator of the protein-kinase ILK, thereby regulating cell motility.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Zinc 1By similarity1
Metal bindingi44Zinc 1By similarity1
Metal bindingi62Zinc 1; via pros nitrogenBy similarity1
Metal bindingi65Zinc 1By similarity1
Metal bindingi68Zinc 2By similarity1
Metal bindingi71Zinc 2By similarity1
Metal bindingi89Zinc 2By similarity1
Metal bindingi92Zinc 2; via pros nitrogenBy similarity1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain-containing protein 2Curated
Gene namesi
Name:Limd2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915053. Limd2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512081 – 128LIM domain-containing protein 2Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BGB5.
MaxQBiQ8BGB5.
PaxDbiQ8BGB5.
PeptideAtlasiQ8BGB5.
PRIDEiQ8BGB5.

PTM databases

iPTMnetiQ8BGB5.
PhosphoSitePlusiQ8BGB5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040699.
CleanExiMM_LIMD2.
GenevisibleiQ8BGB5. MM.

Interactioni

Subunit structurei

Interacts with ILK.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045357.

Structurei

3D structure databases

ProteinModelPortaliQ8BGB5.
SMRiQ8BGB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 99LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiENOG410ITI3. Eukaryota.
ENOG4111S7F. LUCA.
GeneTreeiENSGT00510000046839.
HOGENOMiHOG000111235.
HOVERGENiHBG056520.
InParanoidiQ8BGB5.
OMAiQATPSHE.
OrthoDBiEOG091G0043.
PhylomeDBiQ8BGB5.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 1 hit.
SMARTiView protein in SMART
SM00132. LIM. 1 hit.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQAAGAAQA TPSHEAKGSS GSSTVQRSKS FSLRAQVKET CAACQKTVYP
60 70 80 90 100
MERLVADKLI FHNSCFCCKH CHTKLSLGSY AAMHGEFYCR PHFQQLFKSK
110 120
GNYDEGFGRK QHKELWAHKE VDSGTKTA
Length:128
Mass (Da):14,237
Last modified:March 1, 2003 - v1
Checksum:iADF9161771331D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012581 mRNA. Translation: BAC25371.1.
AK032430 mRNA. Translation: BAC27866.1.
AK049809 mRNA. Translation: BAC33928.1.
AK167349 mRNA. Translation: BAE39448.1.
AK169829 mRNA. Translation: BAE41396.1.
AK171794 mRNA. Translation: BAE42667.1.
BC068130 mRNA. Translation: AAH68130.1.
CCDSiCCDS25549.1.
RefSeqiNP_765985.1. NM_172397.3.
XP_006534082.1. XM_006534019.3.
XP_006534083.1. XM_006534020.3.
UniGeneiMm.21687.

Genome annotation databases

EnsembliENSMUST00000045923; ENSMUSP00000045357; ENSMUSG00000040699.
ENSMUST00000064545; ENSMUSP00000067070; ENSMUSG00000040699.
ENSMUST00000106875; ENSMUSP00000102488; ENSMUSG00000040699.
GeneIDi67803.
KEGGimmu:67803.
UCSCiuc007lyd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLIMD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: July 5, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot