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Q8BGA9

- OXA1L_MOUSE

UniProt

Q8BGA9 - OXA1L_MOUSE

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Protein
Mitochondrial inner membrane protein OXA1L
Gene
Oxa1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria By similarity.

GO - Molecular functioni

  1. mitochondrial ribosome binding Source: UniProtKB
  2. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. mitochondrial respiratory chain complex I biogenesis Source: UniProtKB
  2. protein insertion into membrane Source: InterPro
  3. protein tetramerization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protein OXA1L
Alternative name(s):
Oxidase assembly 1-like protein
Short name:
OXA1-like protein
Gene namesi
Name:Oxa1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1916339. Oxa1l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Topological domaini130 – 1345Mitochondrial matrix Reviewed prediction
Transmembranei135 – 15521Helical; Reviewed prediction
Add
BLAST
Topological domaini156 – 20752Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei208 – 22821Helical; Reviewed prediction
Add
BLAST
Topological domaini229 – 25527Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei256 – 27621Helical; Reviewed prediction
Add
BLAST
Topological domaini277 – 29317Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei294 – 31421Helical; Reviewed prediction
Add
BLAST
Topological domaini315 – 433119Mitochondrial matrix Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial membrane Source: UniProtKB
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 433Mitochondrial inner membrane protein OXA1LPRO_0000020353
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiQ8BGA9.
PaxDbiQ8BGA9.
PRIDEiQ8BGA9.

PTM databases

PhosphoSiteiQ8BGA9.

Expressioni

Gene expression databases

BgeeiQ8BGA9.
CleanExiMM_OXA1L.
GenevestigatoriQ8BGA9.

Interactioni

Subunit structurei

Monomer; predominantly monomeric at low salt concentrations. Homooligomer; predominantly homooligomeric at high salt concentrations. Homodimer. Homotetramer. Interacts with MRPL13, MRPL20, MRPL28, MRPL48, MRPL49 and MRPL51. Associates preferentially as a dimer with the large ribosomal subunit 39S of the mitochondrial ribosome By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family.

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0706.
GeneTreeiENSGT00530000063506.
HOGENOMiHOG000046915.
HOVERGENiHBG053388.
InParanoidiQ8BGA9.
KOiK03217.
OMAiMQNHLEL.
OrthoDBiEOG7S4X6H.
PhylomeDBiQ8BGA9.
TreeFamiTF354324.

Family and domain databases

InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGA9-1 [UniParc]FASTAAdd to Basket

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MARNLVCGRW QLLRLLRPQR SYHSVAVSLR PLAAELLAAR RGNGRPPCAL    50
LAVFTPRCIS TSATLFAEAQ VQAPPVIPAT SIPAAVPEVA SGGAADVVQC 100
ATEPSFTELG LGSYTPVGLI QNLLEYIHVD LGLPWWGAIA TCTVLARCLV 150
FPLIVKGQRE AAKIHNHMPE MQKFSARIRE AKLAGDQAEF YKATIEMTRY 200
QKKHDIKLLR PLILPLTQAP VFISFFIALR EMANLPVPSL QTGGLWWFQD 250
LTVSDPIYVL PLVVTATMWC VLELGAETGV QSNDLQFMRN IIRVMPLVVL 300
PVTIHFPSAV FMYWLSSNVF SLCQVACLRI PAVRTVLKIP QRVVHDPDKL 350
PPREGFLKSF KKGWKNAEIA QQLREREQRM QKHLDLAARG PLRQTFTHNP 400
LLQHDPSHPP KAPNSNNSSI KANAKKPWQD TLG 433
Length:433
Mass (Da):48,220
Last modified:March 1, 2003 - v1
Checksum:iAF57459B86D2D627
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181P → L in AAH27191. 1 Publication
Sequence conflicti42 – 421G → S in AAH27191. 1 Publication
Sequence conflicti48 – 481C → Y in AAH27191. 1 Publication
Sequence conflicti77 – 771I → V in AAH27191. 1 Publication
Sequence conflicti104 – 1041P → L in AAH27191. 1 Publication
Sequence conflicti109 – 13022Missing in AAH27191. 1 Publication
Add
BLAST
Sequence conflicti218 – 2181Q → H in BAB25113. 1 Publication
Sequence conflicti275 – 2751G → D in BAC36908. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007567 mRNA. Translation: BAB25113.1.
AK044817 mRNA. Translation: BAC32104.1.
AK052432 mRNA. Translation: BAC34985.1.
AK077624 mRNA. Translation: BAC36908.1.
BC027191 mRNA. Translation: AAH27191.1.
CCDSiCCDS27086.1.
RefSeqiNP_081212.1. NM_026936.3.
UniGeneiMm.182340.

Genome annotation databases

EnsembliENSMUST00000000985; ENSMUSP00000000985; ENSMUSG00000000959.
GeneIDi69089.
KEGGimmu:69089.
UCSCiuc007tvu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007567 mRNA. Translation: BAB25113.1 .
AK044817 mRNA. Translation: BAC32104.1 .
AK052432 mRNA. Translation: BAC34985.1 .
AK077624 mRNA. Translation: BAC36908.1 .
BC027191 mRNA. Translation: AAH27191.1 .
CCDSi CCDS27086.1.
RefSeqi NP_081212.1. NM_026936.3.
UniGenei Mm.182340.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BGA9.

Proteomic databases

MaxQBi Q8BGA9.
PaxDbi Q8BGA9.
PRIDEi Q8BGA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000985 ; ENSMUSP00000000985 ; ENSMUSG00000000959 .
GeneIDi 69089.
KEGGi mmu:69089.
UCSCi uc007tvu.1. mouse.

Organism-specific databases

CTDi 5018.
MGIi MGI:1916339. Oxa1l.

Phylogenomic databases

eggNOGi COG0706.
GeneTreei ENSGT00530000063506.
HOGENOMi HOG000046915.
HOVERGENi HBG053388.
InParanoidi Q8BGA9.
KOi K03217.
OMAi MQNHLEL.
OrthoDBi EOG7S4X6H.
PhylomeDBi Q8BGA9.
TreeFami TF354324.

Miscellaneous databases

ChiTaRSi OXA1L. mouse.
NextBioi 328576.
PROi Q8BGA9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGA9.
CleanExi MM_OXA1L.
Genevestigatori Q8BGA9.

Family and domain databases

InterProi IPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view ]
PANTHERi PTHR12428. PTHR12428. 1 hit.
Pfami PF02096. 60KD_IMP. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Lung and Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiOXA1L_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA9
Secondary accession number(s): Q8BK01, Q8R091, Q9D8X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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