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Q8BGA9

- OXA1L_MOUSE

UniProt

Q8BGA9 - OXA1L_MOUSE

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Protein

Mitochondrial inner membrane protein OXA1L

Gene

Oxa1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (By similarity).By similarity

GO - Molecular functioni

  1. mitochondrial ribosome binding Source: UniProtKB
  2. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. mitochondrial respiratory chain complex I biogenesis Source: UniProtKB
  2. protein insertion into membrane Source: InterPro
  3. protein tetramerization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protein OXA1L
Alternative name(s):
Oxidase assembly 1-like protein
Short name:
OXA1-like protein
Gene namesi
Name:Oxa1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1916339. Oxa1l.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrial membrane Source: UniProtKB
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 433Mitochondrial inner membrane protein OXA1LPRO_0000020353
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ8BGA9.
PaxDbiQ8BGA9.
PRIDEiQ8BGA9.

PTM databases

PhosphoSiteiQ8BGA9.

Expressioni

Gene expression databases

BgeeiQ8BGA9.
CleanExiMM_OXA1L.
GenevestigatoriQ8BGA9.

Interactioni

Subunit structurei

Monomer; predominantly monomeric at low salt concentrations. Homooligomer; predominantly homooligomeric at high salt concentrations. Homodimer. Homotetramer. Interacts with MRPL13, MRPL20, MRPL28, MRPL48, MRPL49 and MRPL51. Associates preferentially as a dimer with the large ribosomal subunit 39S of the mitochondrial ribosome (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BGA9.
SMRiQ8BGA9. Positions 138-324.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini130 – 1345Mitochondrial matrixSequence Analysis
Topological domaini156 – 20752Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini229 – 25527Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini277 – 29317Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini315 – 433119Mitochondrial matrixSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence AnalysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence AnalysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0706.
GeneTreeiENSGT00530000063506.
HOGENOMiHOG000046915.
HOVERGENiHBG053388.
InParanoidiQ8BGA9.
KOiK03217.
OMAiMQNHLEL.
OrthoDBiEOG7S4X6H.
PhylomeDBiQ8BGA9.
TreeFamiTF354324.

Family and domain databases

InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGA9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARNLVCGRW QLLRLLRPQR SYHSVAVSLR PLAAELLAAR RGNGRPPCAL
60 70 80 90 100
LAVFTPRCIS TSATLFAEAQ VQAPPVIPAT SIPAAVPEVA SGGAADVVQC
110 120 130 140 150
ATEPSFTELG LGSYTPVGLI QNLLEYIHVD LGLPWWGAIA TCTVLARCLV
160 170 180 190 200
FPLIVKGQRE AAKIHNHMPE MQKFSARIRE AKLAGDQAEF YKATIEMTRY
210 220 230 240 250
QKKHDIKLLR PLILPLTQAP VFISFFIALR EMANLPVPSL QTGGLWWFQD
260 270 280 290 300
LTVSDPIYVL PLVVTATMWC VLELGAETGV QSNDLQFMRN IIRVMPLVVL
310 320 330 340 350
PVTIHFPSAV FMYWLSSNVF SLCQVACLRI PAVRTVLKIP QRVVHDPDKL
360 370 380 390 400
PPREGFLKSF KKGWKNAEIA QQLREREQRM QKHLDLAARG PLRQTFTHNP
410 420 430
LLQHDPSHPP KAPNSNNSSI KANAKKPWQD TLG
Length:433
Mass (Da):48,220
Last modified:March 1, 2003 - v1
Checksum:iAF57459B86D2D627
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181P → L in AAH27191. (PubMed:15489334)Curated
Sequence conflicti42 – 421G → S in AAH27191. (PubMed:15489334)Curated
Sequence conflicti48 – 481C → Y in AAH27191. (PubMed:15489334)Curated
Sequence conflicti77 – 771I → V in AAH27191. (PubMed:15489334)Curated
Sequence conflicti104 – 1041P → L in AAH27191. (PubMed:15489334)Curated
Sequence conflicti109 – 13022Missing in AAH27191. (PubMed:15489334)CuratedAdd
BLAST
Sequence conflicti218 – 2181Q → H in BAB25113. (PubMed:16141072)Curated
Sequence conflicti275 – 2751G → D in BAC36908. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007567 mRNA. Translation: BAB25113.1.
AK044817 mRNA. Translation: BAC32104.1.
AK052432 mRNA. Translation: BAC34985.1.
AK077624 mRNA. Translation: BAC36908.1.
BC027191 mRNA. Translation: AAH27191.1.
CCDSiCCDS27086.1.
RefSeqiNP_081212.1. NM_026936.3.
UniGeneiMm.182340.

Genome annotation databases

EnsembliENSMUST00000000985; ENSMUSP00000000985; ENSMUSG00000000959.
GeneIDi69089.
KEGGimmu:69089.
UCSCiuc007tvu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007567 mRNA. Translation: BAB25113.1 .
AK044817 mRNA. Translation: BAC32104.1 .
AK052432 mRNA. Translation: BAC34985.1 .
AK077624 mRNA. Translation: BAC36908.1 .
BC027191 mRNA. Translation: AAH27191.1 .
CCDSi CCDS27086.1.
RefSeqi NP_081212.1. NM_026936.3.
UniGenei Mm.182340.

3D structure databases

ProteinModelPortali Q8BGA9.
SMRi Q8BGA9. Positions 138-324.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BGA9.

Proteomic databases

MaxQBi Q8BGA9.
PaxDbi Q8BGA9.
PRIDEi Q8BGA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000985 ; ENSMUSP00000000985 ; ENSMUSG00000000959 .
GeneIDi 69089.
KEGGi mmu:69089.
UCSCi uc007tvu.1. mouse.

Organism-specific databases

CTDi 5018.
MGIi MGI:1916339. Oxa1l.

Phylogenomic databases

eggNOGi COG0706.
GeneTreei ENSGT00530000063506.
HOGENOMi HOG000046915.
HOVERGENi HBG053388.
InParanoidi Q8BGA9.
KOi K03217.
OMAi MQNHLEL.
OrthoDBi EOG7S4X6H.
PhylomeDBi Q8BGA9.
TreeFami TF354324.

Miscellaneous databases

ChiTaRSi OXA1L. mouse.
NextBioi 328576.
PROi Q8BGA9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGA9.
CleanExi MM_OXA1L.
Genevestigatori Q8BGA9.

Family and domain databases

InterProi IPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view ]
PANTHERi PTHR12428. PTHR12428. 1 hit.
Pfami PF02096. 60KD_IMP. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Lung and Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiOXA1L_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA9
Secondary accession number(s): Q8BK01, Q8R091, Q9D8X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3