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Q8BGA9 (OXA1L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial inner membrane protein OXA1L
Alternative name(s):
Oxidase assembly 1-like protein
Short name=OXA1-like protein
Gene names
Name:Oxa1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria By similarity.

Subunit structure

Monomer; predominantly monomeric at low salt concentrations. Homooligomer; predominantly homooligomeric at high salt concentrations. Homodimer. Homotetramer. Interacts with MRPL13, MRPL20, MRPL28, MRPL48, MRPL49 and MRPL51. Associates preferentially as a dimer with the large ribosomal subunit 39S of the mitochondrial ribosome By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the OXA1/ALB3/YidC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 433Mitochondrial inner membrane protein OXA1LPRO_0000020353

Regions

Topological domain1 – 108108Mitochondrial intermembrane Potential
Transmembrane109 – 12921Helical; Potential
Topological domain130 – 1345Mitochondrial matrix Potential
Transmembrane135 – 15521Helical; Potential
Topological domain156 – 20752Mitochondrial intermembrane Potential
Transmembrane208 – 22821Helical; Potential
Topological domain229 – 25527Mitochondrial matrix Potential
Transmembrane256 – 27621Helical; Potential
Topological domain277 – 29317Mitochondrial intermembrane Potential
Transmembrane294 – 31421Helical; Potential
Topological domain315 – 433119Mitochondrial matrix Potential

Experimental info

Sequence conflict181P → L in AAH27191. Ref.2
Sequence conflict421G → S in AAH27191. Ref.2
Sequence conflict481C → Y in AAH27191. Ref.2
Sequence conflict771I → V in AAH27191. Ref.2
Sequence conflict1041P → L in AAH27191. Ref.2
Sequence conflict109 – 13022Missing in AAH27191. Ref.2
Sequence conflict2181Q → H in BAB25113. Ref.1
Sequence conflict2751G → D in BAC36908. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BGA9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: AF57459B86D2D627

FASTA43348,220
        10         20         30         40         50         60 
MARNLVCGRW QLLRLLRPQR SYHSVAVSLR PLAAELLAAR RGNGRPPCAL LAVFTPRCIS 

        70         80         90        100        110        120 
TSATLFAEAQ VQAPPVIPAT SIPAAVPEVA SGGAADVVQC ATEPSFTELG LGSYTPVGLI 

       130        140        150        160        170        180 
QNLLEYIHVD LGLPWWGAIA TCTVLARCLV FPLIVKGQRE AAKIHNHMPE MQKFSARIRE 

       190        200        210        220        230        240 
AKLAGDQAEF YKATIEMTRY QKKHDIKLLR PLILPLTQAP VFISFFIALR EMANLPVPSL 

       250        260        270        280        290        300 
QTGGLWWFQD LTVSDPIYVL PLVVTATMWC VLELGAETGV QSNDLQFMRN IIRVMPLVVL 

       310        320        330        340        350        360 
PVTIHFPSAV FMYWLSSNVF SLCQVACLRI PAVRTVLKIP QRVVHDPDKL PPREGFLKSF 

       370        380        390        400        410        420 
KKGWKNAEIA QQLREREQRM QKHLDLAARG PLRQTFTHNP LLQHDPSHPP KAPNSNNSSI 

       430 
KANAKKPWQD TLG

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Lung and Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK007567 mRNA. Translation: BAB25113.1.
AK044817 mRNA. Translation: BAC32104.1.
AK052432 mRNA. Translation: BAC34985.1.
AK077624 mRNA. Translation: BAC36908.1.
BC027191 mRNA. Translation: AAH27191.1.
IPIIPI00308001.
RefSeqNP_081212.1. NM_026936.3.
UniGeneMm.182340.

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ8BGA9.

Proteomic databases

PaxDbQ8BGA9.
PRIDEQ8BGA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000985; ENSMUSP00000000985; ENSMUSG00000000959.
GeneID69089.
KEGGmmu:69089.
UCSCuc007tvu.1. mouse.

Organism-specific databases

CTD5018.
MGIMGI:1916339. Oxa1l.

Phylogenomic databases

eggNOGCOG0706.
GeneTreeENSGT00530000063506.
HOGENOMHOG000046915.
HOVERGENHBG053388.
InParanoidQ8BGA9.
KOK03217.
OMANPLLQHG.
OrthoDBEOG4QRH4J.

Gene expression databases

BgeeQ8BGA9.
CleanExMM_OXA1L.
GenevestigatorQ8BGA9.
GermOnlineENSMUSG00000000959. Mus musculus.

Family and domain databases

InterProIPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERPTHR12428. PTHR12428. 1 hit.
PfamPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsTIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetSearch...

Other

ChiTaRSOXA1L. mouse.
NextBio328576.
SOURCESearch...

Entry information

Entry nameOXA1L_MOUSE
AccessionPrimary (citable) accession number: Q8BGA9
Secondary accession number(s): Q8BK01, Q8R091, Q9D8X7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents