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Q8BGA9

- OXA1L_MOUSE

UniProt

Q8BGA9 - OXA1L_MOUSE

Protein

Mitochondrial inner membrane protein OXA1L

Gene

Oxa1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria By similarity.By similarity

    GO - Molecular functioni

    1. mitochondrial ribosome binding Source: UniProtKB
    2. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. mitochondrial respiratory chain complex I biogenesis Source: UniProtKB
    2. protein insertion into membrane Source: InterPro
    3. protein tetramerization Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial inner membrane protein OXA1L
    Alternative name(s):
    Oxidase assembly 1-like protein
    Short name:
    OXA1-like protein
    Gene namesi
    Name:Oxa1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1916339. Oxa1l.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrial membrane Source: UniProtKB
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 433Mitochondrial inner membrane protein OXA1LPRO_0000020353
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ8BGA9.
    PaxDbiQ8BGA9.
    PRIDEiQ8BGA9.

    PTM databases

    PhosphoSiteiQ8BGA9.

    Expressioni

    Gene expression databases

    BgeeiQ8BGA9.
    CleanExiMM_OXA1L.
    GenevestigatoriQ8BGA9.

    Interactioni

    Subunit structurei

    Monomer; predominantly monomeric at low salt concentrations. Homooligomer; predominantly homooligomeric at high salt concentrations. Homodimer. Homotetramer. Interacts with MRPL13, MRPL20, MRPL28, MRPL48, MRPL49 and MRPL51. Associates preferentially as a dimer with the large ribosomal subunit 39S of the mitochondrial ribosome By similarity.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 108108Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini130 – 1345Mitochondrial matrixSequence Analysis
    Topological domaini156 – 20752Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini229 – 25527Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini277 – 29317Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini315 – 433119Mitochondrial matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OXA1/ALB3/YidC family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0706.
    GeneTreeiENSGT00530000063506.
    HOGENOMiHOG000046915.
    HOVERGENiHBG053388.
    InParanoidiQ8BGA9.
    KOiK03217.
    OMAiMQNHLEL.
    OrthoDBiEOG7S4X6H.
    PhylomeDBiQ8BGA9.
    TreeFamiTF354324.

    Family and domain databases

    InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
    IPR001708. Membrane_insert_OXA1/ALB3/YidC.
    [Graphical view]
    PANTHERiPTHR12428. PTHR12428. 1 hit.
    PfamiPF02096. 60KD_IMP. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BGA9-1 [UniParc]FASTAAdd to Basket

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    MARNLVCGRW QLLRLLRPQR SYHSVAVSLR PLAAELLAAR RGNGRPPCAL    50
    LAVFTPRCIS TSATLFAEAQ VQAPPVIPAT SIPAAVPEVA SGGAADVVQC 100
    ATEPSFTELG LGSYTPVGLI QNLLEYIHVD LGLPWWGAIA TCTVLARCLV 150
    FPLIVKGQRE AAKIHNHMPE MQKFSARIRE AKLAGDQAEF YKATIEMTRY 200
    QKKHDIKLLR PLILPLTQAP VFISFFIALR EMANLPVPSL QTGGLWWFQD 250
    LTVSDPIYVL PLVVTATMWC VLELGAETGV QSNDLQFMRN IIRVMPLVVL 300
    PVTIHFPSAV FMYWLSSNVF SLCQVACLRI PAVRTVLKIP QRVVHDPDKL 350
    PPREGFLKSF KKGWKNAEIA QQLREREQRM QKHLDLAARG PLRQTFTHNP 400
    LLQHDPSHPP KAPNSNNSSI KANAKKPWQD TLG 433
    Length:433
    Mass (Da):48,220
    Last modified:March 1, 2003 - v1
    Checksum:iAF57459B86D2D627
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181P → L in AAH27191. (PubMed:15489334)Curated
    Sequence conflicti42 – 421G → S in AAH27191. (PubMed:15489334)Curated
    Sequence conflicti48 – 481C → Y in AAH27191. (PubMed:15489334)Curated
    Sequence conflicti77 – 771I → V in AAH27191. (PubMed:15489334)Curated
    Sequence conflicti104 – 1041P → L in AAH27191. (PubMed:15489334)Curated
    Sequence conflicti109 – 13022Missing in AAH27191. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti218 – 2181Q → H in BAB25113. (PubMed:16141072)Curated
    Sequence conflicti275 – 2751G → D in BAC36908. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007567 mRNA. Translation: BAB25113.1.
    AK044817 mRNA. Translation: BAC32104.1.
    AK052432 mRNA. Translation: BAC34985.1.
    AK077624 mRNA. Translation: BAC36908.1.
    BC027191 mRNA. Translation: AAH27191.1.
    CCDSiCCDS27086.1.
    RefSeqiNP_081212.1. NM_026936.3.
    UniGeneiMm.182340.

    Genome annotation databases

    EnsembliENSMUST00000000985; ENSMUSP00000000985; ENSMUSG00000000959.
    GeneIDi69089.
    KEGGimmu:69089.
    UCSCiuc007tvu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007567 mRNA. Translation: BAB25113.1 .
    AK044817 mRNA. Translation: BAC32104.1 .
    AK052432 mRNA. Translation: BAC34985.1 .
    AK077624 mRNA. Translation: BAC36908.1 .
    BC027191 mRNA. Translation: AAH27191.1 .
    CCDSi CCDS27086.1.
    RefSeqi NP_081212.1. NM_026936.3.
    UniGenei Mm.182340.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BGA9.

    Proteomic databases

    MaxQBi Q8BGA9.
    PaxDbi Q8BGA9.
    PRIDEi Q8BGA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000985 ; ENSMUSP00000000985 ; ENSMUSG00000000959 .
    GeneIDi 69089.
    KEGGi mmu:69089.
    UCSCi uc007tvu.1. mouse.

    Organism-specific databases

    CTDi 5018.
    MGIi MGI:1916339. Oxa1l.

    Phylogenomic databases

    eggNOGi COG0706.
    GeneTreei ENSGT00530000063506.
    HOGENOMi HOG000046915.
    HOVERGENi HBG053388.
    InParanoidi Q8BGA9.
    KOi K03217.
    OMAi MQNHLEL.
    OrthoDBi EOG7S4X6H.
    PhylomeDBi Q8BGA9.
    TreeFami TF354324.

    Miscellaneous databases

    ChiTaRSi OXA1L. mouse.
    NextBioi 328576.
    PROi Q8BGA9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BGA9.
    CleanExi MM_OXA1L.
    Genevestigatori Q8BGA9.

    Family and domain databases

    InterProi IPR028055. Membr_insert_YidC/Oxa1_C.
    IPR001708. Membrane_insert_OXA1/ALB3/YidC.
    [Graphical view ]
    PANTHERi PTHR12428. PTHR12428. 1 hit.
    Pfami PF02096. 60KD_IMP. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03592. yidC_oxa1_cterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Lung and Pancreas.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiOXA1L_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGA9
    Secondary accession number(s): Q8BK01, Q8R091, Q9D8X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3