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Protein

Leucine-rich repeat transmembrane neuronal protein 2

Gene

Lrrtm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).By similarity

GO - Biological processi

  • long-term synaptic potentiation Source: MGI
  • negative regulation of receptor internalization Source: MGI
  • positive regulation of synapse assembly Source: MGI
  • synapse organization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 2
Gene namesi
Name:Lrrtm2
Synonyms:Kiaa0416
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2389174. Lrrtm2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 421ExtracellularSequence analysisAdd BLAST388
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 515CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • excitatory synapse Source: MGI
  • integral component of membrane Source: MGI
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001835434 – 515Leucine-rich repeat transmembrane neuronal protein 2Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BGA3.
PeptideAtlasiQ8BGA3.
PRIDEiQ8BGA3.

PTM databases

iPTMnetiQ8BGA3.
PhosphoSitePlusiQ8BGA3.

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000071862.
CleanExiMM_LRRTM2.
GenevisibleiQ8BGA3. MM.

Interactioni

Subunit structurei

Interacts with DLG4 and NRXN1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089225.

Structurei

3D structure databases

ProteinModelPortaliQ8BGA3.
SMRiQ8BGA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 61LRRNTAdd BLAST28
Repeati63 – 83LRR 1Add BLAST21
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Repeati206 – 227LRR 7Add BLAST22
Repeati230 – 251LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati278 – 299LRR 10Add BLAST22
Domaini311 – 362LRRCTAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi512 – 515Involved in DLG4-bindingBy similarity4

Domaini

Synaptogenic effects are mediated by the extracellular LRR region.By similarity

Sequence similaritiesi

Belongs to the LRRTM family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8BGA3.
KOiK16665.
OMAiAMATTYR.
OrthoDBiEOG091G03BI.
PhylomeDBiQ8BGA3.
TreeFamiTF332659.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLHFKWPLG APMLAAIYAM SVVLKMLPAL GMACPPKCRC EKLLFYCDSQ
60 70 80 90 100
GFHSVPNATD KGSLGLSLRH NHITALERDQ FASFSQLTWL HLDHNQISTV
110 120 130 140 150
KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP
160 170 180 190 200
ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG
210 220 230 240 250
FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMDW
260 270 280 290 300
TWSTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL
310 320 330 340 350
KSLTTVGLSG NLWECSPRVC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI
360 370 380 390 400
LDAVHGFQLC WNLSTTVTAM ATTYRDPTTE YTKISSSSYH VGDKEIPTTA
410 420 430 440 450
GIAVTTEEHF PEPDNAIFTQ RVITGTMALL FSFFFIIFIV FISRKCCPPT
460 470 480 490 500
LRRIRQCSMI QNHRQLRSQT RLHMSNMSDQ GPYNEYEPTH EGPFIIINGY
510
GQCKCQQLPY KECEV
Length:515
Mass (Da):58,816
Last modified:March 1, 2003 - v1
Checksum:iB0EE6888A99F31C9
GO

Sequence cautioni

The sequence BAC65560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182027 mRNA. Translation: AAO67548.1.
AK043173 mRNA. Translation: BAC31484.1.
AK043784 mRNA. Translation: BAC31653.1.
AK044705 mRNA. Translation: BAC32042.1.
AK046818 mRNA. Translation: BAC32883.1.
AK049920 mRNA. Translation: BAC33985.1.
AK122278 mRNA. Translation: BAC65560.1. Different initiation.
CCDSiCCDS50251.1.
RefSeqiNP_821072.1. NM_178005.4.
UniGeneiMm.39900.

Genome annotation databases

EnsembliENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862.
GeneIDi107065.
KEGGimmu:107065.
UCSCiuc008ema.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182027 mRNA. Translation: AAO67548.1.
AK043173 mRNA. Translation: BAC31484.1.
AK043784 mRNA. Translation: BAC31653.1.
AK044705 mRNA. Translation: BAC32042.1.
AK046818 mRNA. Translation: BAC32883.1.
AK049920 mRNA. Translation: BAC33985.1.
AK122278 mRNA. Translation: BAC65560.1. Different initiation.
CCDSiCCDS50251.1.
RefSeqiNP_821072.1. NM_178005.4.
UniGeneiMm.39900.

3D structure databases

ProteinModelPortaliQ8BGA3.
SMRiQ8BGA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089225.

PTM databases

iPTMnetiQ8BGA3.
PhosphoSitePlusiQ8BGA3.

Proteomic databases

PaxDbiQ8BGA3.
PeptideAtlasiQ8BGA3.
PRIDEiQ8BGA3.

Protocols and materials databases

DNASUi107065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862.
GeneIDi107065.
KEGGimmu:107065.
UCSCiuc008ema.2. mouse.

Organism-specific databases

CTDi26045.
MGIiMGI:2389174. Lrrtm2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8BGA3.
KOiK16665.
OMAiAMATTYR.
OrthoDBiEOG091G03BI.
PhylomeDBiQ8BGA3.
TreeFamiTF332659.

Enzyme and pathway databases

ReactomeiR-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

PROiQ8BGA3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071862.
CleanExiMM_LRRTM2.
GenevisibleiQ8BGA3. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA3
Secondary accession number(s): Q80U08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.