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Q8BGA3 (LRRT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat transmembrane neuronal protein 2
Gene names
Name:Lrrtm2
Synonyms:Kiaa0416
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B By similarity.

Subunit structure

Interacts with DLG4 and NRXN1 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapsepostsynaptic cell membrane; Single-pass type I membrane protein By similarity. Note: Localized to excitatory synapses By similarity.

Tissue specificity

Expressed in neuronal tissues. Ref.1

Domain

Synaptogenic effects are mediated by the extracellular LRR region By similarity.

Sequence similarities

Belongs to the LRRTM family.

Contains 10 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence caution

The sequence BAC65560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 515482Leucine-rich repeat transmembrane neuronal protein 2
PRO_0000018354

Regions

Topological domain34 – 421388Extracellular Potential
Transmembrane422 – 44221Helical; Potential
Topological domain443 – 51573Cytoplasmic Potential
Domain34 – 6128LRRNT
Repeat63 – 8321LRR 1
Repeat86 – 10722LRR 2
Repeat110 – 13122LRR 3
Repeat134 – 15522LRR 4
Repeat158 – 17922LRR 5
Repeat182 – 20322LRR 6
Repeat206 – 22722LRR 7
Repeat230 – 25122LRR 8
Repeat254 – 27522LRR 9
Repeat278 – 29922LRR 10
Domain311 – 36252LRRCT
Motif512 – 5154Involved in DLG4-binding By similarity

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation3621N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8BGA3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B0EE6888A99F31C9

FASTA51558,816
        10         20         30         40         50         60 
MGLHFKWPLG APMLAAIYAM SVVLKMLPAL GMACPPKCRC EKLLFYCDSQ GFHSVPNATD 

        70         80         90        100        110        120 
KGSLGLSLRH NHITALERDQ FASFSQLTWL HLDHNQISTV KEDAFQGLYK LKELILSSNK 

       130        140        150        160        170        180 
IFYLPNTTFT QLINLQNLDL SFNQLSSLHP ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC 

       190        200        210        220        230        240 
RSLEFLDLST NRLRSLARNG FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK 

       250        260        270        280        290        300 
ISNLTCGMDW TWSTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL 

       310        320        330        340        350        360 
KSLTTVGLSG NLWECSPRVC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI LDAVHGFQLC 

       370        380        390        400        410        420 
WNLSTTVTAM ATTYRDPTTE YTKISSSSYH VGDKEIPTTA GIAVTTEEHF PEPDNAIFTQ 

       430        440        450        460        470        480 
RVITGTMALL FSFFFIIFIV FISRKCCPPT LRRIRQCSMI QNHRQLRSQT RLHMSNMSDQ 

       490        500        510 
GPYNEYEPTH EGPFIIINGY GQCKCQQLPY KECEV 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain cortex, Cerebellum, Hippocampus, Medulla oblongata and Retina.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY182027 mRNA. Translation: AAO67548.1.
AK043173 mRNA. Translation: BAC31484.1.
AK043784 mRNA. Translation: BAC31653.1.
AK044705 mRNA. Translation: BAC32042.1.
AK046818 mRNA. Translation: BAC32883.1.
AK049920 mRNA. Translation: BAC33985.1.
AK122278 mRNA. Translation: BAC65560.1. Different initiation.
RefSeqNP_821072.1. NM_178005.4.
UniGeneMm.39900.

3D structure databases

ProteinModelPortalQ8BGA3.
SMRQ8BGA3. Positions 4-355.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BGA3.

Proteomic databases

PaxDbQ8BGA3.
PRIDEQ8BGA3.

Protocols and materials databases

DNASU107065.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862.
GeneID107065.
KEGGmmu:107065.
UCSCuc008ema.2. mouse.

Organism-specific databases

CTD26045.
MGIMGI:2389174. Lrrtm2.
RougeSearch...

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00750000117232.
HOGENOMHOG000290681.
HOVERGENHBG052362.
InParanoidQ8BGA3.
OMAIRQCSMI.
OrthoDBEOG7S4X5J.
PhylomeDBQ8BGA3.
TreeFamTF332659.

Gene expression databases

BgeeQ8BGA3.
CleanExMM_LRRTM2.
GenevestigatorQ8BGA3.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF12799. LRR_4. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 4 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio358560.
PROQ8BGA3.
SOURCESearch...

Entry information

Entry nameLRRT2_MOUSE
AccessionPrimary (citable) accession number: Q8BGA3
Secondary accession number(s): Q80U08
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot