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Q8BGA3

- LRRT2_MOUSE

UniProt

Q8BGA3 - LRRT2_MOUSE

Protein

Leucine-rich repeat transmembrane neuronal protein 2

Gene

Lrrtm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B By similarity.By similarity

    GO - Biological processi

    1. long-term synaptic potentiation Source: MGI
    2. negative regulation of receptor internalization Source: MGI
    3. synapse organization Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat transmembrane neuronal protein 2
    Gene namesi
    Name:Lrrtm2
    Synonyms:Kiaa0416
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2389174. Lrrtm2.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Cell junctionsynapsepostsynaptic cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Localized to excitatory synapses.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. excitatory synapse Source: Ensembl
    3. integral component of membrane Source: MGI
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 515482Leucine-rich repeat transmembrane neuronal protein 2PRO_0000018354Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8BGA3.
    PRIDEiQ8BGA3.

    PTM databases

    PhosphoSiteiQ8BGA3.

    Expressioni

    Tissue specificityi

    Expressed in neuronal tissues.1 Publication

    Gene expression databases

    BgeeiQ8BGA3.
    CleanExiMM_LRRTM2.
    GenevestigatoriQ8BGA3.

    Interactioni

    Subunit structurei

    Interacts with DLG4 and NRXN1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BGA3.
    SMRiQ8BGA3. Positions 4-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 421388ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini443 – 51573CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 6128LRRNTAdd
    BLAST
    Repeati63 – 8321LRR 1Add
    BLAST
    Repeati86 – 10722LRR 2Add
    BLAST
    Repeati110 – 13122LRR 3Add
    BLAST
    Repeati134 – 15522LRR 4Add
    BLAST
    Repeati158 – 17922LRR 5Add
    BLAST
    Repeati182 – 20322LRR 6Add
    BLAST
    Repeati206 – 22722LRR 7Add
    BLAST
    Repeati230 – 25122LRR 8Add
    BLAST
    Repeati254 – 27522LRR 9Add
    BLAST
    Repeati278 – 29922LRR 10Add
    BLAST
    Domaini311 – 36252LRRCTAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi512 – 5154Involved in DLG4-bindingBy similarity

    Domaini

    Synaptogenic effects are mediated by the extracellular LRR region.By similarity

    Sequence similaritiesi

    Belongs to the LRRTM family.Curated
    Contains 10 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00750000117232.
    HOGENOMiHOG000290681.
    HOVERGENiHBG052362.
    InParanoidiQ8BGA3.
    OMAiIRQCSMI.
    OrthoDBiEOG7S4X5J.
    PhylomeDBiQ8BGA3.
    TreeFamiTF332659.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 4 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BGA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLHFKWPLG APMLAAIYAM SVVLKMLPAL GMACPPKCRC EKLLFYCDSQ    50
    GFHSVPNATD KGSLGLSLRH NHITALERDQ FASFSQLTWL HLDHNQISTV 100
    KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP 150
    ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG 200
    FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMDW 250
    TWSTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL 300
    KSLTTVGLSG NLWECSPRVC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI 350
    LDAVHGFQLC WNLSTTVTAM ATTYRDPTTE YTKISSSSYH VGDKEIPTTA 400
    GIAVTTEEHF PEPDNAIFTQ RVITGTMALL FSFFFIIFIV FISRKCCPPT 450
    LRRIRQCSMI QNHRQLRSQT RLHMSNMSDQ GPYNEYEPTH EGPFIIINGY 500
    GQCKCQQLPY KECEV 515
    Length:515
    Mass (Da):58,816
    Last modified:March 1, 2003 - v1
    Checksum:iB0EE6888A99F31C9
    GO

    Sequence cautioni

    The sequence BAC65560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY182027 mRNA. Translation: AAO67548.1.
    AK043173 mRNA. Translation: BAC31484.1.
    AK043784 mRNA. Translation: BAC31653.1.
    AK044705 mRNA. Translation: BAC32042.1.
    AK046818 mRNA. Translation: BAC32883.1.
    AK049920 mRNA. Translation: BAC33985.1.
    AK122278 mRNA. Translation: BAC65560.1. Different initiation.
    CCDSiCCDS50251.1.
    RefSeqiNP_821072.1. NM_178005.4.
    UniGeneiMm.39900.

    Genome annotation databases

    EnsembliENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862.
    GeneIDi107065.
    KEGGimmu:107065.
    UCSCiuc008ema.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY182027 mRNA. Translation: AAO67548.1 .
    AK043173 mRNA. Translation: BAC31484.1 .
    AK043784 mRNA. Translation: BAC31653.1 .
    AK044705 mRNA. Translation: BAC32042.1 .
    AK046818 mRNA. Translation: BAC32883.1 .
    AK049920 mRNA. Translation: BAC33985.1 .
    AK122278 mRNA. Translation: BAC65560.1 . Different initiation.
    CCDSi CCDS50251.1.
    RefSeqi NP_821072.1. NM_178005.4.
    UniGenei Mm.39900.

    3D structure databases

    ProteinModelPortali Q8BGA3.
    SMRi Q8BGA3. Positions 4-355.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BGA3.

    Proteomic databases

    PaxDbi Q8BGA3.
    PRIDEi Q8BGA3.

    Protocols and materials databases

    DNASUi 107065.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000091636 ; ENSMUSP00000089225 ; ENSMUSG00000071862 .
    GeneIDi 107065.
    KEGGi mmu:107065.
    UCSCi uc008ema.2. mouse.

    Organism-specific databases

    CTDi 26045.
    MGIi MGI:2389174. Lrrtm2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00750000117232.
    HOGENOMi HOG000290681.
    HOVERGENi HBG052362.
    InParanoidi Q8BGA3.
    OMAi IRQCSMI.
    OrthoDBi EOG7S4X5J.
    PhylomeDBi Q8BGA3.
    TreeFami TF332659.

    Miscellaneous databases

    NextBioi 358560.
    PROi Q8BGA3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BGA3.
    CleanExi MM_LRRTM2.
    Genevestigatori Q8BGA3.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 4 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
      Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
      Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex, Cerebellum, Hippocampus, Medulla oblongata and Retina.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiLRRT2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BGA3
    Secondary accession number(s): Q80U08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3