Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat transmembrane neuronal protein 2

Gene

Lrrtm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • long-term synaptic potentiation Source: MGI
  • negative regulation of receptor internalization Source: MGI
  • positive regulation of synapse assembly Source: MGI
  • synapse organization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 2
Gene namesi
Name:Lrrtm2
Synonyms:Kiaa0416
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2389174 Lrrtm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 421ExtracellularSequence analysisAdd BLAST388
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 515CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000001835434 – 515Leucine-rich repeat transmembrane neuronal protein 2Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BGA3
PeptideAtlasiQ8BGA3
PRIDEiQ8BGA3

PTM databases

iPTMnetiQ8BGA3
PhosphoSitePlusiQ8BGA3
SwissPalmiQ8BGA3

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000071862
CleanExiMM_LRRTM2
GenevisibleiQ8BGA3 MM

Interactioni

Subunit structurei

Interacts with DLG4 and NRXN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089225

Structurei

3D structure databases

ProteinModelPortaliQ8BGA3
SMRiQ8BGA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 61LRRNTAdd BLAST28
Repeati63 – 83LRR 1Add BLAST21
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Repeati206 – 227LRR 7Add BLAST22
Repeati230 – 251LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati278 – 299LRR 10Add BLAST22
Domaini311 – 362LRRCTAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi512 – 515Involved in DLG4-bindingBy similarity4

Domaini

Synaptogenic effects are mediated by the extracellular LRR region.By similarity

Sequence similaritiesi

Belongs to the LRRTM family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118777
HOGENOMiHOG000290681
HOVERGENiHBG052362
InParanoidiQ8BGA3
KOiK16665
OMAiAMATTYR
OrthoDBiEOG091G03BI
PhylomeDBiQ8BGA3
TreeFamiTF332659

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLHFKWPLG APMLAAIYAM SVVLKMLPAL GMACPPKCRC EKLLFYCDSQ
60 70 80 90 100
GFHSVPNATD KGSLGLSLRH NHITALERDQ FASFSQLTWL HLDHNQISTV
110 120 130 140 150
KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP
160 170 180 190 200
ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG
210 220 230 240 250
FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMDW
260 270 280 290 300
TWSTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL
310 320 330 340 350
KSLTTVGLSG NLWECSPRVC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI
360 370 380 390 400
LDAVHGFQLC WNLSTTVTAM ATTYRDPTTE YTKISSSSYH VGDKEIPTTA
410 420 430 440 450
GIAVTTEEHF PEPDNAIFTQ RVITGTMALL FSFFFIIFIV FISRKCCPPT
460 470 480 490 500
LRRIRQCSMI QNHRQLRSQT RLHMSNMSDQ GPYNEYEPTH EGPFIIINGY
510
GQCKCQQLPY KECEV
Length:515
Mass (Da):58,816
Last modified:March 1, 2003 - v1
Checksum:iB0EE6888A99F31C9
GO

Sequence cautioni

The sequence BAC65560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182027 mRNA Translation: AAO67548.1
AK043173 mRNA Translation: BAC31484.1
AK043784 mRNA Translation: BAC31653.1
AK044705 mRNA Translation: BAC32042.1
AK046818 mRNA Translation: BAC32883.1
AK049920 mRNA Translation: BAC33985.1
AK122278 mRNA Translation: BAC65560.1 Different initiation.
CCDSiCCDS50251.1
RefSeqiNP_821072.1, NM_178005.4
UniGeneiMm.39900

Genome annotation databases

EnsembliENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862
GeneIDi107065
KEGGimmu:107065
UCSCiuc008ema.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLRRT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA3
Secondary accession number(s): Q80U08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health