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Q8BGA3

- LRRT2_MOUSE

UniProt

Q8BGA3 - LRRT2_MOUSE

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Protein
Leucine-rich repeat transmembrane neuronal protein 2
Gene
Lrrtm2, Kiaa0416
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B By similarity.

GO - Biological processi

  1. long-term synaptic potentiation Source: MGI
  2. negative regulation of receptor internalization Source: MGI
  3. synapse organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 2
Gene namesi
Name:Lrrtm2
Synonyms:Kiaa0416
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2389174. Lrrtm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 421388Extracellular Reviewed prediction
Add
BLAST
Transmembranei422 – 44221Helical; Reviewed prediction
Add
BLAST
Topological domaini443 – 51573Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. excitatory synapse Source: Ensembl
  3. integral component of membrane Source: MGI
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 515482Leucine-rich repeat transmembrane neuronal protein 2
PRO_0000018354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi243 – 2431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi362 – 3621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BGA3.
PRIDEiQ8BGA3.

PTM databases

PhosphoSiteiQ8BGA3.

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiQ8BGA3.
CleanExiMM_LRRTM2.
GenevestigatoriQ8BGA3.

Interactioni

Subunit structurei

Interacts with DLG4 and NRXN1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BGA3.
SMRiQ8BGA3. Positions 4-355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNT
Add
BLAST
Repeati63 – 8321LRR 1
Add
BLAST
Repeati86 – 10722LRR 2
Add
BLAST
Repeati110 – 13122LRR 3
Add
BLAST
Repeati134 – 15522LRR 4
Add
BLAST
Repeati158 – 17922LRR 5
Add
BLAST
Repeati182 – 20322LRR 6
Add
BLAST
Repeati206 – 22722LRR 7
Add
BLAST
Repeati230 – 25122LRR 8
Add
BLAST
Repeati254 – 27522LRR 9
Add
BLAST
Repeati278 – 29922LRR 10
Add
BLAST
Domaini311 – 36252LRRCT
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi512 – 5154Involved in DLG4-binding By similarity

Domaini

Synaptogenic effects are mediated by the extracellular LRR region By similarity.

Sequence similaritiesi

Belongs to the LRRTM family.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00750000117232.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8BGA3.
OMAiIRQCSMI.
OrthoDBiEOG7S4X5J.
PhylomeDBiQ8BGA3.
TreeFamiTF332659.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGA3-1 [UniParc]FASTAAdd to Basket

« Hide

MGLHFKWPLG APMLAAIYAM SVVLKMLPAL GMACPPKCRC EKLLFYCDSQ    50
GFHSVPNATD KGSLGLSLRH NHITALERDQ FASFSQLTWL HLDHNQISTV 100
KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP 150
ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG 200
FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMDW 250
TWSTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL 300
KSLTTVGLSG NLWECSPRVC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI 350
LDAVHGFQLC WNLSTTVTAM ATTYRDPTTE YTKISSSSYH VGDKEIPTTA 400
GIAVTTEEHF PEPDNAIFTQ RVITGTMALL FSFFFIIFIV FISRKCCPPT 450
LRRIRQCSMI QNHRQLRSQT RLHMSNMSDQ GPYNEYEPTH EGPFIIINGY 500
GQCKCQQLPY KECEV 515
Length:515
Mass (Da):58,816
Last modified:March 1, 2003 - v1
Checksum:iB0EE6888A99F31C9
GO

Sequence cautioni

The sequence BAC65560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182027 mRNA. Translation: AAO67548.1.
AK043173 mRNA. Translation: BAC31484.1.
AK043784 mRNA. Translation: BAC31653.1.
AK044705 mRNA. Translation: BAC32042.1.
AK046818 mRNA. Translation: BAC32883.1.
AK049920 mRNA. Translation: BAC33985.1.
AK122278 mRNA. Translation: BAC65560.1. Different initiation.
CCDSiCCDS50251.1.
RefSeqiNP_821072.1. NM_178005.4.
UniGeneiMm.39900.

Genome annotation databases

EnsembliENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862.
GeneIDi107065.
KEGGimmu:107065.
UCSCiuc008ema.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182027 mRNA. Translation: AAO67548.1 .
AK043173 mRNA. Translation: BAC31484.1 .
AK043784 mRNA. Translation: BAC31653.1 .
AK044705 mRNA. Translation: BAC32042.1 .
AK046818 mRNA. Translation: BAC32883.1 .
AK049920 mRNA. Translation: BAC33985.1 .
AK122278 mRNA. Translation: BAC65560.1 . Different initiation.
CCDSi CCDS50251.1.
RefSeqi NP_821072.1. NM_178005.4.
UniGenei Mm.39900.

3D structure databases

ProteinModelPortali Q8BGA3.
SMRi Q8BGA3. Positions 4-355.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BGA3.

Proteomic databases

PaxDbi Q8BGA3.
PRIDEi Q8BGA3.

Protocols and materials databases

DNASUi 107065.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000091636 ; ENSMUSP00000089225 ; ENSMUSG00000071862 .
GeneIDi 107065.
KEGGi mmu:107065.
UCSCi uc008ema.2. mouse.

Organism-specific databases

CTDi 26045.
MGIi MGI:2389174. Lrrtm2.
Rougei Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00750000117232.
HOGENOMi HOG000290681.
HOVERGENi HBG052362.
InParanoidi Q8BGA3.
OMAi IRQCSMI.
OrthoDBi EOG7S4X5J.
PhylomeDBi Q8BGA3.
TreeFami TF332659.

Miscellaneous databases

NextBioi 358560.
PROi Q8BGA3.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGA3.
CleanExi MM_LRRTM2.
Genevestigatori Q8BGA3.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 4 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
    Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Cerebellum, Hippocampus, Medulla oblongata and Retina.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLRRT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA3
Secondary accession number(s): Q80U08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi