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Q8BGA3

- LRRT2_MOUSE

UniProt

Q8BGA3 - LRRT2_MOUSE

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Protein

Leucine-rich repeat transmembrane neuronal protein 2

Gene

Lrrtm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).By similarity

GO - Biological processi

  1. long-term synaptic potentiation Source: MGI
  2. negative regulation of receptor internalization Source: MGI
  3. synapse organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 2
Gene namesi
Name:Lrrtm2
Synonyms:Kiaa0416
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2389174. Lrrtm2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapsepostsynaptic cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Localized to excitatory synapses.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. excitatory synapse Source: Ensembl
  3. integral component of membrane Source: MGI
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 515482Leucine-rich repeat transmembrane neuronal protein 2PRO_0000018354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BGA3.
PRIDEiQ8BGA3.

PTM databases

PhosphoSiteiQ8BGA3.

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiQ8BGA3.
CleanExiMM_LRRTM2.
GenevestigatoriQ8BGA3.

Interactioni

Subunit structurei

Interacts with DLG4 and NRXN1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BGA3.
SMRiQ8BGA3. Positions 4-355.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 421388ExtracellularSequence AnalysisAdd
BLAST
Topological domaini443 – 51573CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei422 – 44221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNTAdd
BLAST
Repeati63 – 8321LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Repeati206 – 22722LRR 7Add
BLAST
Repeati230 – 25122LRR 8Add
BLAST
Repeati254 – 27522LRR 9Add
BLAST
Repeati278 – 29922LRR 10Add
BLAST
Domaini311 – 36252LRRCTAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi512 – 5154Involved in DLG4-bindingBy similarity

Domaini

Synaptogenic effects are mediated by the extracellular LRR region.By similarity

Sequence similaritiesi

Belongs to the LRRTM family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiQ8BGA3.
KOiK16665.
OMAiIRQCSMI.
OrthoDBiEOG7S4X5J.
PhylomeDBiQ8BGA3.
TreeFamiTF332659.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BGA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLHFKWPLG APMLAAIYAM SVVLKMLPAL GMACPPKCRC EKLLFYCDSQ
60 70 80 90 100
GFHSVPNATD KGSLGLSLRH NHITALERDQ FASFSQLTWL HLDHNQISTV
110 120 130 140 150
KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP
160 170 180 190 200
ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG
210 220 230 240 250
FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMDW
260 270 280 290 300
TWSTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL
310 320 330 340 350
KSLTTVGLSG NLWECSPRVC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI
360 370 380 390 400
LDAVHGFQLC WNLSTTVTAM ATTYRDPTTE YTKISSSSYH VGDKEIPTTA
410 420 430 440 450
GIAVTTEEHF PEPDNAIFTQ RVITGTMALL FSFFFIIFIV FISRKCCPPT
460 470 480 490 500
LRRIRQCSMI QNHRQLRSQT RLHMSNMSDQ GPYNEYEPTH EGPFIIINGY
510
GQCKCQQLPY KECEV
Length:515
Mass (Da):58,816
Last modified:March 1, 2003 - v1
Checksum:iB0EE6888A99F31C9
GO

Sequence cautioni

The sequence BAC65560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182027 mRNA. Translation: AAO67548.1.
AK043173 mRNA. Translation: BAC31484.1.
AK043784 mRNA. Translation: BAC31653.1.
AK044705 mRNA. Translation: BAC32042.1.
AK046818 mRNA. Translation: BAC32883.1.
AK049920 mRNA. Translation: BAC33985.1.
AK122278 mRNA. Translation: BAC65560.1. Different initiation.
CCDSiCCDS50251.1.
RefSeqiNP_821072.1. NM_178005.4.
UniGeneiMm.39900.

Genome annotation databases

EnsembliENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862.
GeneIDi107065.
KEGGimmu:107065.
UCSCiuc008ema.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY182027 mRNA. Translation: AAO67548.1 .
AK043173 mRNA. Translation: BAC31484.1 .
AK043784 mRNA. Translation: BAC31653.1 .
AK044705 mRNA. Translation: BAC32042.1 .
AK046818 mRNA. Translation: BAC32883.1 .
AK049920 mRNA. Translation: BAC33985.1 .
AK122278 mRNA. Translation: BAC65560.1 . Different initiation.
CCDSi CCDS50251.1.
RefSeqi NP_821072.1. NM_178005.4.
UniGenei Mm.39900.

3D structure databases

ProteinModelPortali Q8BGA3.
SMRi Q8BGA3. Positions 4-355.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BGA3.

Proteomic databases

PaxDbi Q8BGA3.
PRIDEi Q8BGA3.

Protocols and materials databases

DNASUi 107065.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000091636 ; ENSMUSP00000089225 ; ENSMUSG00000071862 .
GeneIDi 107065.
KEGGi mmu:107065.
UCSCi uc008ema.2. mouse.

Organism-specific databases

CTDi 26045.
MGIi MGI:2389174. Lrrtm2.
Rougei Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000290681.
HOVERGENi HBG052362.
InParanoidi Q8BGA3.
KOi K16665.
OMAi IRQCSMI.
OrthoDBi EOG7S4X5J.
PhylomeDBi Q8BGA3.
TreeFami TF332659.

Miscellaneous databases

NextBioi 358560.
PROi Q8BGA3.
SOURCEi Search...

Gene expression databases

Bgeei Q8BGA3.
CleanExi MM_LRRTM2.
Genevestigatori Q8BGA3.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF12799. LRR_4. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 4 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system."
    Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.
    Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex, Cerebellum, Hippocampus, Medulla oblongata and Retina.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLRRT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA3
Secondary accession number(s): Q80U08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3