Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LHFPL tetraspan subfamily member 2 protein

Gene

Lhfpl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in female and male fertility. Involved in distal reproductive tract development (PubMed:26964900).1 Publication

GO - Biological processi

  • development of primary female sexual characteristics Source: UniProtKB
  • development of primary male sexual characteristics Source: UniProtKB
  • positive regulation of fertilization Source: UniProtKB
  • single fertilization Source: UniProtKB-KW

Keywordsi

Biological processFertilization

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Protein family/group databases

TCDBi1.A.82.1.2. the lhfpl tetraspan protein (ltsp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
LHFPL tetraspan subfamily member 2 proteinBy similarity
Alternative name(s):
Lipoma HMGIC fusion partner-like 2 proteinImported
Gene namesi
Name:Lhfpl2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145236. Lhfpl2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002447641 – 222LHFPL tetraspan subfamily member 2 proteinAdd BLAST222

Proteomic databases

MaxQBiQ8BGA2.
PaxDbiQ8BGA2.
PRIDEiQ8BGA2.

PTM databases

PhosphoSitePlusiQ8BGA2.

Expressioni

Tissue specificityi

Expressed in the epithelium of the vas deferens (at protein level). Widely expressed (PubMed:26964900). Strongly expressed in heart, spleen, liver, kidney, thymus, testis, brain, lung, intestine, vagina, ovary and uterus (PubMed:26964900). Expressed in follicle cells of the ovary, epithelial cells of the oviduct, both luminal and glandular epithelial cells of the uterus, and epithelial cells of the vagina (PubMed:26964900).1 Publication

Gene expression databases

BgeeiENSMUSG00000045312.
CleanExiMM_LHFPL2.
ExpressionAtlasiQ8BGA2. baseline and differential.
GenevisibleiQ8BGA2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062239.

Structurei

3D structure databases

ProteinModelPortaliQ8BGA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000285972.
HOVERGENiHBG054430.
InParanoidiQ8BGA2.
OMAiYPGEWKA.
OrthoDBiEOG091G0J9C.
PhylomeDBiQ8BGA2.
TreeFamiTF321143.

Family and domain databases

InterProiView protein in InterPro
IPR019372. Lipome_HGMIC_fus_partner-like.
PfamiView protein in Pfam
PF10242. L_HMGIC_fpl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BGA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHVIVTCRS MLWTLLSIVV AFAELVAFMS ADWLIGKAKT RSGSGDEQAG
60 70 80 90 100
MNSEPHYLGI LCIRTPAMQQ VSRDTLCGTY AKSFGEIASG FWQATAIFLA
110 120 130 140 150
VGIFILCVVA LVSVFTMCVQ SIMRKSIFNV CGLLQGIAGL FLILGLILYP
160 170 180 190 200
AGWGCQKAID CGRYASPYKP GDCSLGWAFY TATGGTVLTF ICAVFSAQAE
210 220
IATSSDKVQE EIEEGKNLVC LL
Length:222
Mass (Da):23,873
Last modified:March 1, 2003 - v1
Checksum:iB105BF041868F1A9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti102G → E Causes malformations in the distal reproductive tract development in both female and male. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040389 mRNA. Translation: AAH40389.1.
AK030103 mRNA. Translation: BAC26786.1.
AK052969 mRNA. Translation: BAC35225.1.
AK087506 mRNA. Translation: BAC39903.1.
CCDSiCCDS26692.1.
RefSeqiNP_766177.1. NM_172589.2.
XP_011242941.1. XM_011244639.2.
XP_011242942.1. XM_011244640.1.
XP_011242943.1. XM_011244641.2.
XP_011242944.1. XM_011244642.2.
XP_011242945.1. XM_011244643.2.
XP_011242946.1. XM_011244644.2.
UniGeneiMm.316553.

Genome annotation databases

EnsembliENSMUST00000054274; ENSMUSP00000062239; ENSMUSG00000045312.
ENSMUST00000118195; ENSMUSP00000112655; ENSMUSG00000045312.
ENSMUST00000121618; ENSMUSP00000113468; ENSMUSG00000045312.
GeneIDi218454.
KEGGimmu:218454.
UCSCiuc007rlp.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLHPL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BGA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families