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Protein

Homeobox protein PKNOX2

Gene

Pknox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi291 – 350HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • actin filament binding Source: MGI
  • actin monomer binding Source: MGI
  • DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI

GO - Biological processi

  • regulation of transcription from RNA polymerase II promoter Source: MGI

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein PKNOX2
Alternative name(s):
Homeobox protein PREP-2
PBX/knotted homeobox 2
Gene namesi
Name:Pknox2
Synonyms:Prep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2445415. Pknox2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498801 – 474Homeobox protein PKNOX2Add BLAST474

Proteomic databases

MaxQBiQ8BG99.
PaxDbiQ8BG99.
PeptideAtlasiQ8BG99.
PRIDEiQ8BG99.

PTM databases

PhosphoSitePlusiQ8BG99.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035934.
CleanExiMM_PKNOX2.
ExpressionAtlasiQ8BG99. baseline and differential.
GenevisibleiQ8BG99. MM.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: MGI
  • actin monomer binding Source: MGI

Protein-protein interaction databases

BioGridi228942. 6 interactors.
IntActiQ8BG99. 1 interactor.
MINTiMINT-4110211.
STRINGi10090.ENSMUSP00000035806.

Structurei

3D structure databases

ProteinModelPortaliQ8BG99.
SMRiQ8BG99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 23Poly-Pro4
Compositional biasi426 – 456Asp/Glu-rich (acidic)Add BLAST31

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253922.
HOVERGENiHBG055193.
InParanoidiQ8BG99.
OMAiTMMATQS.
OrthoDBiEOG091G09WJ.
PhylomeDBiQ8BG99.
TreeFamiTF318093.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR032453. PKNOX/Meis_N.
PfamiView protein in Pfam
PF05920. Homeobox_KN. 1 hit.
PF16493. Meis_PKNOX_N. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BG99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQHASPAPA LTMMATQNVP PPPYQDSPQM TATAQPPSKA QAVHISAPSA
60 70 80 90 100
TASTPVPSAP IDPQAQLEAD KRAVYRHPLF PLLTLLFEKC EQATQGSECI
110 120 130 140 150
TSASFDVDIE NFVHQQEQEH KPFFSDDPEL DNLMVKAIQV LRIHLLELEK
160 170 180 190 200
VNELCKDFCN RYITCLKTKM HSDNLLRNDL GGPYSPNQPS INLHSQDLLQ
210 220 230 240 250
NSPNSMSGVS NNPQGIVVPA SALQQGNIAM TTVNSQVVSG GALYQPVTMV
260 270 280 290 300
TSQGQVVTQA IPQGAIQIQN TQVNLDLTSL LDNEDKKSKN KRGVLPKHAT
310 320 330 340 350
NIMRSWLFQH LMHPYPTEDE KRQIAAQTNL TLLQVNNWFI NARRRILQPM
360 370 380 390 400
LDASNPDPAP KAKKIKSQHR PTQRFWPNSI AAGVLQQQGG TPGTNPDGSI
410 420 430 440 450
NLDNLQSLSS DNATMAMQQA MMAAHDDSLD GTEEEDEDDM EEEEEEEEEL
460 470
EEEADELQTT NVSDLGLEHS DSLE
Length:474
Mass (Da):52,331
Last modified:March 1, 2003 - v1
Checksum:iB2B160A7D13E7579
GO

Sequence cautioni

The sequence AAM18702 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487460 mRNA. Translation: AAM18702.1. Different initiation.
AB086817 mRNA. Translation: BAC20215.1.
AK082952 mRNA. Translation: BAC38705.1.
BC050865 mRNA. Translation: AAH50865.2.
CCDSiCCDS22974.1.
RefSeqiNP_001025009.1. NM_001029838.2.
NP_683752.2. NM_148950.3.
XP_006510187.1. XM_006510124.3.
XP_006510188.1. XM_006510125.3.
XP_006510189.1. XM_006510126.3.
XP_006510190.1. XM_006510127.3.
XP_017168744.1. XM_017313255.1.
UniGeneiMm.260335.

Genome annotation databases

EnsembliENSMUST00000039674; ENSMUSP00000035806; ENSMUSG00000035934.
ENSMUST00000080754; ENSMUSP00000079578; ENSMUSG00000035934.
ENSMUST00000177218; ENSMUSP00000135581; ENSMUSG00000035934.
GeneIDi208076.
KEGGimmu:208076.
UCSCiuc009oue.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiPKNX2_MOUSE
AccessioniPrimary (citable) accession number: Q8BG99
Secondary accession number(s): Q8R4B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families