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Protein

COMM domain-containing protein 7

Gene

Commd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 7
Gene namesi
Name:Commd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914197. Commd7.

Subcellular locationi

  • Cytoplasmic vesicle By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200COMM domain-containing protein 7PRO_0000077400Add
BLAST

Proteomic databases

EPDiQ8BG94.
MaxQBiQ8BG94.
PaxDbiQ8BG94.
PRIDEiQ8BG94.

PTM databases

PhosphoSiteiQ8BG94.

Expressioni

Gene expression databases

BgeeiENSMUSG00000056941.
CleanExiMM_COMMD7.
ExpressionAtlasiQ8BG94. baseline and differential.
GenevisibleiQ8BG94. MM.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071752.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 20068COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410INVK. Eukaryota.
ENOG4111ICZ. LUCA.
GeneTreeiENSGT00390000012419.
HOGENOMiHOG000031075.
HOVERGENiHBG051072.
InParanoidiQ8BG94.
OMAiGPLKNIV.
OrthoDBiEOG091G195X.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BG94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLHCTQDP VPEAVRGDMQ QLNQLGAQQF SDLTEVLFHF LTEPKEVERF
60 70 80 90 100
LAQLSEFATS NQISLGPLKS IMKSLLLVPN GALKKGLTAE QVRTDLQTLG
110 120 130 140 150
LSEEKATYFS EKWKQNASTL AQWAMGQTLM VNQLIDMEWR FGVTSGSSEL
160 170 180 190 200
EKVGSIFLQL KLVVKKGKQT ENLYMELTLP QFYSFLHEME RVRASMECLS
Length:200
Mass (Da):22,652
Last modified:March 1, 2003 - v1
Checksum:iB3A4B93DE045B78E
GO

Sequence cautioni

The sequence AAH03310 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009274 mRNA. Translation: BAC25249.1.
AK078774 mRNA. Translation: BAC37387.1.
BC003310 mRNA. Translation: AAH03310.1. Different initiation.
CCDSiCCDS16912.2.
RefSeqiNP_001182319.1. NM_001195390.1.
NP_598611.2. NM_133850.2.
UniGeneiMm.294478.

Genome annotation databases

EnsembliENSMUST00000071852; ENSMUSP00000071752; ENSMUSG00000056941.
GeneIDi99311.
KEGGimmu:99311.
UCSCiuc008nhx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009274 mRNA. Translation: BAC25249.1.
AK078774 mRNA. Translation: BAC37387.1.
BC003310 mRNA. Translation: AAH03310.1. Different initiation.
CCDSiCCDS16912.2.
RefSeqiNP_001182319.1. NM_001195390.1.
NP_598611.2. NM_133850.2.
UniGeneiMm.294478.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071752.

PTM databases

PhosphoSiteiQ8BG94.

Proteomic databases

EPDiQ8BG94.
MaxQBiQ8BG94.
PaxDbiQ8BG94.
PRIDEiQ8BG94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071852; ENSMUSP00000071752; ENSMUSG00000056941.
GeneIDi99311.
KEGGimmu:99311.
UCSCiuc008nhx.2. mouse.

Organism-specific databases

CTDi149951.
MGIiMGI:1914197. Commd7.

Phylogenomic databases

eggNOGiENOG410INVK. Eukaryota.
ENOG4111ICZ. LUCA.
GeneTreeiENSGT00390000012419.
HOGENOMiHOG000031075.
HOVERGENiHBG051072.
InParanoidiQ8BG94.
OMAiGPLKNIV.
OrthoDBiEOG091G195X.

Miscellaneous databases

ChiTaRSiCommd7. mouse.
PROiQ8BG94.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056941.
CleanExiMM_COMMD7.
ExpressionAtlasiQ8BG94. baseline and differential.
GenevisibleiQ8BG94. MM.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD7_MOUSE
AccessioniPrimary (citable) accession number: Q8BG94
Secondary accession number(s): Q99J75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.