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Q8BG89 (ZN365_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ZNF365
Alternative name(s):
Su48
Gene names
Name:Znf365
Synonyms:Kiaa0844, Zfp365
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homodimer. Interacts with NDE1 and NDEL1 By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity.

Tissue specificity

Detected in several tissues, with highest levels in brain. Also expressed during embryonic development. Ref.1 Ref.2

Sequence caution

The sequence BAC65669.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BG89-1)

Also known as: ZNF365a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BG89-2)

The sequence of this isoform differs from the canonical sequence as follows:
     310-332: LTDIPSNRKPRCLSRGHQHSVCN → VSPLPVSHPMAPPEYSQNEPRQS
     333-408: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Protein ZNF365
PRO_0000076375

Regions

Coiled coil170 – 298129 Potential

Natural variations

Alternative sequence310 – 33223LTDIP…HSVCN → VSPLPVSHPMAPPEYSQNEP RQS in isoform 2.
VSP_016601
Alternative sequence333 – 40876Missing in isoform 2.
VSP_016602

Experimental info

Sequence conflict971S → P in AAQ11828. Ref.2
Sequence conflict971S → P in BAC65669. Ref.3
Sequence conflict971S → P in BAC31866. Ref.4
Sequence conflict3091Missing in BAC65669. Ref.3
Sequence conflict3361M → L in AAQ11828. Ref.2
Sequence conflict3361M → L in BAC65669. Ref.3
Sequence conflict3361M → L in BAC31866. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ZNF365a) [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B4E18F21EC340E26

FASTA40846,860
        10         20         30         40         50         60 
MQQTTFEESR YHWQDSLENV AVCLPFRCPR CGDHTRFRSL SSLRAHLEFS HSYEERTLLT 

        70         80         90        100        110        120 
KCSLLPSLKD TELLRSSELP KQGKVLRGHA KVTKQKSSYV NLYSISHGHS KDTKPFEMVA 

       130        140        150        160        170        180 
ERPVSYVQTY TAVDIRADSL DAPCASPGLP TQDTKAAFEA HVREKFNRMV EAVDRTIEKR 

       190        200        210        220        230        240 
IDKLTKELAQ KTAELLEVRA AFAQLTQKKQ EVQRRERALN KQVDVAVEMI AVLKQRLTES 

       250        260        270        280        290        300 
EEELLRKEEE VVTFNHFLEA AAEKEVQGKA RLQDFIENLL QRVELAEKQL EYYQSQQASG 

       310        320        330        340        350        360 
FSCDTSEHML TDIPSNRKPR CLSRGHQHSV CNHPEMRAHF HLKGRSYLKK AKDERAGMQP 

       370        380        390        400 
AKAIHEPAES PREFFRPAKK GEHLGLSRKG NFRPKMAKKK PTAIVNII 

« Hide

Isoform 2 [UniParc].

Checksum: CBF39480F0AB2C78
Show »

FASTA33238,109

References

« Hide 'large scale' references
[1]"Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage."
Gianfrancesco F., Esposito T., Casu G., Maninchedda G., Roberto R., Parastu M.
Gene 339:131-138(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Strain: C57BL/6J.
Tissue: Retina.
[2]"Characterization of Su48, a centrosome protein essential for cell division."
Wang Q., Du X., Meinkoth J., Hirohashi Y., Zhang H., Liu Q., Richter M., Greene M.I.
Proc. Natl. Acad. Sci. U.S.A. 103:6512-6517(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Diencephalon and Medulla oblongata.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ516033 mRNA. Translation: CAD56774.1.
AF543761 mRNA. Translation: AAQ11828.1.
AK122387 mRNA. Translation: BAC65669.1. Different initiation.
AK031846 mRNA. Translation: BAC27578.1.
AK033892 mRNA. Translation: BAC28505.1.
AK044322 mRNA. Translation: BAC31866.1.
AK077316 mRNA. Translation: BAC36745.1.
BC080272 mRNA. Translation: AAH80272.1.
CCDSCCDS23903.1. [Q8BG89-1]
RefSeqNP_848794.1. NM_178679.2. [Q8BG89-1]
UniGeneMm.268346.

3D structure databases

ProteinModelPortalQ8BG89.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BG89.

Proteomic databases

PRIDEQ8BG89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855. [Q8BG89-1]
GeneID216049.
KEGGmmu:216049.
UCSCuc007fmb.1. mouse. [Q8BG89-1]
uc007fmc.1. mouse. [Q8BG89-2]

Organism-specific databases

CTD216049.
MGIMGI:2143676. Zfp365.
RougeSearch...

Phylogenomic databases

eggNOGNOG41382.
GeneTreeENSGT00530000063713.
HOGENOMHOG000155791.
HOVERGENHBG094181.
InParanoidQ8BG89.
KOK16737.
OMAKSIHEQA.
OrthoDBEOG7NSB28.
PhylomeDBQ8BG89.
TreeFamTF329439.

Gene expression databases

BgeeQ8BG89.
CleanExMM_ZFP365.
GenevestigatorQ8BG89.

Family and domain databases

InterProIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374968.
PROQ8BG89.
SOURCESearch...

Entry information

Entry nameZN365_MOUSE
AccessionPrimary (citable) accession number: Q8BG89
Secondary accession number(s): Q80TQ4, Q8BK39, Q8BXT2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot