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Protein

Protein ZNF365

Gene

Znf365

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF365
Alternative name(s):
Su48
Gene namesi
Name:Znf365
Synonyms:Kiaa0844, Zfp365
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2143676. Zfp365.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763751 – 408Protein ZNF365Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei176PhosphothreonineCombined sources1
Modified residuei370PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BG89.
PRIDEiQ8BG89.

PTM databases

iPTMnetiQ8BG89.
PhosphoSitePlusiQ8BG89.

Expressioni

Tissue specificityi

Detected in several tissues, with highest levels in brain. Also expressed during embryonic development.2 Publications

Gene expression databases

BgeeiENSMUSG00000037855.
CleanExiMM_ZFP365.
GenevisibleiQ8BG89. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with NDE1 and NDEL1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067197.

Structurei

3D structure databases

ProteinModelPortaliQ8BG89.
SMRiQ8BG89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili170 – 298Sequence analysisAdd BLAST129

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1N. Eukaryota.
ENOG4111IHT. LUCA.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000155791.
HOVERGENiHBG094181.
InParanoidiQ8BG89.
KOiK16737.
OMAiTHFHPKG.
OrthoDBiEOG091G0BHK.
PhylomeDBiQ8BG89.
TreeFamiTF329439.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BG89-1) [UniParc]FASTAAdd to basket
Also known as: ZNF365a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQTTFEESR YHWQDSLENV AVCLPFRCPR CGDHTRFRSL SSLRAHLEFS
60 70 80 90 100
HSYEERTLLT KCSLLPSLKD TELLRSSELP KQGKVLRGHA KVTKQKSSYV
110 120 130 140 150
NLYSISHGHS KDTKPFEMVA ERPVSYVQTY TAVDIRADSL DAPCASPGLP
160 170 180 190 200
TQDTKAAFEA HVREKFNRMV EAVDRTIEKR IDKLTKELAQ KTAELLEVRA
210 220 230 240 250
AFAQLTQKKQ EVQRRERALN KQVDVAVEMI AVLKQRLTES EEELLRKEEE
260 270 280 290 300
VVTFNHFLEA AAEKEVQGKA RLQDFIENLL QRVELAEKQL EYYQSQQASG
310 320 330 340 350
FSCDTSEHML TDIPSNRKPR CLSRGHQHSV CNHPEMRAHF HLKGRSYLKK
360 370 380 390 400
AKDERAGMQP AKAIHEPAES PREFFRPAKK GEHLGLSRKG NFRPKMAKKK

PTAIVNII
Length:408
Mass (Da):46,860
Last modified:March 1, 2003 - v1
Checksum:iB4E18F21EC340E26
GO
Isoform 2 (identifier: Q8BG89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-332: LTDIPSNRKPRCLSRGHQHSVCN → VSPLPVSHPMAPPEYSQNEPRQS
     333-408: Missing.

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):38,109
Checksum:iCBF39480F0AB2C78
GO

Sequence cautioni

The sequence BAC65669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → P in AAQ11828 (PubMed:16617106).Curated1
Sequence conflicti97S → P in BAC65669 (PubMed:12693553).Curated1
Sequence conflicti97S → P in BAC31866 (PubMed:16141072).Curated1
Sequence conflicti309Missing in BAC65669 (PubMed:12693553).Curated1
Sequence conflicti336M → L in AAQ11828 (PubMed:16617106).Curated1
Sequence conflicti336M → L in BAC65669 (PubMed:12693553).Curated1
Sequence conflicti336M → L in BAC31866 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016601310 – 332LTDIP…HSVCN → VSPLPVSHPMAPPEYSQNEP RQS in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_016602333 – 408Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516033 mRNA. Translation: CAD56774.1.
AF543761 mRNA. Translation: AAQ11828.1.
AK122387 mRNA. Translation: BAC65669.1. Different initiation.
AK031846 mRNA. Translation: BAC27578.1.
AK033892 mRNA. Translation: BAC28505.1.
AK044322 mRNA. Translation: BAC31866.1.
AK077316 mRNA. Translation: BAC36745.1.
BC080272 mRNA. Translation: AAH80272.1.
CCDSiCCDS23903.1. [Q8BG89-1]
RefSeqiNP_848794.1. NM_178679.2. [Q8BG89-1]
UniGeneiMm.268346.

Genome annotation databases

EnsembliENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855. [Q8BG89-1]
GeneIDi216049.
KEGGimmu:216049.
UCSCiuc007fmb.1. mouse. [Q8BG89-1]
uc007fmc.1. mouse. [Q8BG89-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516033 mRNA. Translation: CAD56774.1.
AF543761 mRNA. Translation: AAQ11828.1.
AK122387 mRNA. Translation: BAC65669.1. Different initiation.
AK031846 mRNA. Translation: BAC27578.1.
AK033892 mRNA. Translation: BAC28505.1.
AK044322 mRNA. Translation: BAC31866.1.
AK077316 mRNA. Translation: BAC36745.1.
BC080272 mRNA. Translation: AAH80272.1.
CCDSiCCDS23903.1. [Q8BG89-1]
RefSeqiNP_848794.1. NM_178679.2. [Q8BG89-1]
UniGeneiMm.268346.

3D structure databases

ProteinModelPortaliQ8BG89.
SMRiQ8BG89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067197.

PTM databases

iPTMnetiQ8BG89.
PhosphoSitePlusiQ8BG89.

Proteomic databases

PaxDbiQ8BG89.
PRIDEiQ8BG89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855. [Q8BG89-1]
GeneIDi216049.
KEGGimmu:216049.
UCSCiuc007fmb.1. mouse. [Q8BG89-1]
uc007fmc.1. mouse. [Q8BG89-2]

Organism-specific databases

CTDi216049.
MGIiMGI:2143676. Zfp365.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IH1N. Eukaryota.
ENOG4111IHT. LUCA.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000155791.
HOVERGENiHBG094181.
InParanoidiQ8BG89.
KOiK16737.
OMAiTHFHPKG.
OrthoDBiEOG091G0BHK.
PhylomeDBiQ8BG89.
TreeFamiTF329439.

Miscellaneous databases

PROiQ8BG89.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037855.
CleanExiMM_ZFP365.
GenevisibleiQ8BG89. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiZN365_MOUSE
AccessioniPrimary (citable) accession number: Q8BG89
Secondary accession number(s): Q80TQ4, Q8BK39, Q8BXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.