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Q8BG89

- ZN365_MOUSE

UniProt

Q8BG89 - ZN365_MOUSE

Protein

Protein ZNF365

Gene

Znf365

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ZNF365
    Alternative name(s):
    Su48
    Gene namesi
    Name:Znf365
    Synonyms:Kiaa0844, Zfp365
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2143676. Zfp365.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. microtubule organizing center Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Protein ZNF365PRO_0000076375Add
    BLAST

    Proteomic databases

    PRIDEiQ8BG89.

    PTM databases

    PhosphoSiteiQ8BG89.

    Expressioni

    Tissue specificityi

    Detected in several tissues, with highest levels in brain. Also expressed during embryonic development.2 Publications

    Gene expression databases

    BgeeiQ8BG89.
    CleanExiMM_ZFP365.
    GenevestigatoriQ8BG89.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with NDE1 and NDEL1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BG89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili170 – 298129Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG41382.
    GeneTreeiENSGT00530000063713.
    HOGENOMiHOG000155791.
    HOVERGENiHBG094181.
    InParanoidiQ8BG89.
    KOiK16737.
    OMAiKSIHEQA.
    OrthoDBiEOG7NSB28.
    PhylomeDBiQ8BG89.
    TreeFamiTF329439.

    Family and domain databases

    InterProiIPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BG89-1) [UniParc]FASTAAdd to Basket

    Also known as: ZNF365a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQQTTFEESR YHWQDSLENV AVCLPFRCPR CGDHTRFRSL SSLRAHLEFS    50
    HSYEERTLLT KCSLLPSLKD TELLRSSELP KQGKVLRGHA KVTKQKSSYV 100
    NLYSISHGHS KDTKPFEMVA ERPVSYVQTY TAVDIRADSL DAPCASPGLP 150
    TQDTKAAFEA HVREKFNRMV EAVDRTIEKR IDKLTKELAQ KTAELLEVRA 200
    AFAQLTQKKQ EVQRRERALN KQVDVAVEMI AVLKQRLTES EEELLRKEEE 250
    VVTFNHFLEA AAEKEVQGKA RLQDFIENLL QRVELAEKQL EYYQSQQASG 300
    FSCDTSEHML TDIPSNRKPR CLSRGHQHSV CNHPEMRAHF HLKGRSYLKK 350
    AKDERAGMQP AKAIHEPAES PREFFRPAKK GEHLGLSRKG NFRPKMAKKK 400
    PTAIVNII 408
    Length:408
    Mass (Da):46,860
    Last modified:March 1, 2003 - v1
    Checksum:iB4E18F21EC340E26
    GO
    Isoform 2 (identifier: Q8BG89-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         310-332: LTDIPSNRKPRCLSRGHQHSVCN → VSPLPVSHPMAPPEYSQNEPRQS
         333-408: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:332
    Mass (Da):38,109
    Checksum:iCBF39480F0AB2C78
    GO

    Sequence cautioni

    The sequence BAC65669.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971S → P in AAQ11828. (PubMed:16617106)Curated
    Sequence conflicti97 – 971S → P in BAC65669. (PubMed:12693553)Curated
    Sequence conflicti97 – 971S → P in BAC31866. (PubMed:16141072)Curated
    Sequence conflicti309 – 3091Missing in BAC65669. (PubMed:12693553)Curated
    Sequence conflicti336 – 3361M → L in AAQ11828. (PubMed:16617106)Curated
    Sequence conflicti336 – 3361M → L in BAC65669. (PubMed:12693553)Curated
    Sequence conflicti336 – 3361M → L in BAC31866. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei310 – 33223LTDIP…HSVCN → VSPLPVSHPMAPPEYSQNEP RQS in isoform 2. 1 PublicationVSP_016601Add
    BLAST
    Alternative sequencei333 – 40876Missing in isoform 2. 1 PublicationVSP_016602Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ516033 mRNA. Translation: CAD56774.1.
    AF543761 mRNA. Translation: AAQ11828.1.
    AK122387 mRNA. Translation: BAC65669.1. Different initiation.
    AK031846 mRNA. Translation: BAC27578.1.
    AK033892 mRNA. Translation: BAC28505.1.
    AK044322 mRNA. Translation: BAC31866.1.
    AK077316 mRNA. Translation: BAC36745.1.
    BC080272 mRNA. Translation: AAH80272.1.
    CCDSiCCDS23903.1. [Q8BG89-1]
    RefSeqiNP_848794.1. NM_178679.2. [Q8BG89-1]
    UniGeneiMm.268346.

    Genome annotation databases

    EnsembliENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855. [Q8BG89-1]
    GeneIDi216049.
    KEGGimmu:216049.
    UCSCiuc007fmb.1. mouse. [Q8BG89-1]
    uc007fmc.1. mouse. [Q8BG89-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ516033 mRNA. Translation: CAD56774.1 .
    AF543761 mRNA. Translation: AAQ11828.1 .
    AK122387 mRNA. Translation: BAC65669.1 . Different initiation.
    AK031846 mRNA. Translation: BAC27578.1 .
    AK033892 mRNA. Translation: BAC28505.1 .
    AK044322 mRNA. Translation: BAC31866.1 .
    AK077316 mRNA. Translation: BAC36745.1 .
    BC080272 mRNA. Translation: AAH80272.1 .
    CCDSi CCDS23903.1. [Q8BG89-1 ]
    RefSeqi NP_848794.1. NM_178679.2. [Q8BG89-1 ]
    UniGenei Mm.268346.

    3D structure databases

    ProteinModelPortali Q8BG89.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BG89.

    Proteomic databases

    PRIDEi Q8BG89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064656 ; ENSMUSP00000067197 ; ENSMUSG00000037855 . [Q8BG89-1 ]
    GeneIDi 216049.
    KEGGi mmu:216049.
    UCSCi uc007fmb.1. mouse. [Q8BG89-1 ]
    uc007fmc.1. mouse. [Q8BG89-2 ]

    Organism-specific databases

    CTDi 216049.
    MGIi MGI:2143676. Zfp365.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG41382.
    GeneTreei ENSGT00530000063713.
    HOGENOMi HOG000155791.
    HOVERGENi HBG094181.
    InParanoidi Q8BG89.
    KOi K16737.
    OMAi KSIHEQA.
    OrthoDBi EOG7NSB28.
    PhylomeDBi Q8BG89.
    TreeFami TF329439.

    Miscellaneous databases

    NextBioi 374968.
    PROi Q8BG89.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BG89.
    CleanExi MM_ZFP365.
    Genevestigatori Q8BG89.

    Family and domain databases

    InterProi IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage."
      Gianfrancesco F., Esposito T., Casu G., Maninchedda G., Roberto R., Parastu M.
      Gene 339:131-138(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Strain: C57BL/6J.
      Tissue: Retina.
    2. "Characterization of Su48, a centrosome protein essential for cell division."
      Wang Q., Du X., Meinkoth J., Hirohashi Y., Zhang H., Liu Q., Richter M., Greene M.I.
      Proc. Natl. Acad. Sci. U.S.A. 103:6512-6517(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Diencephalon and Medulla oblongata.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiZN365_MOUSE
    AccessioniPrimary (citable) accession number: Q8BG89
    Secondary accession number(s): Q80TQ4, Q8BK39, Q8BXT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3