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Protein

Protein ZNF365

Gene

Znf365

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF365
Alternative name(s):
Su48
Gene namesi
Name:Znf365
Synonyms:Kiaa0844, Zfp365
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2143676. Zfp365.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule organizing center Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Protein ZNF365PRO_0000076375Add
BLAST

Proteomic databases

PRIDEiQ8BG89.

PTM databases

PhosphoSiteiQ8BG89.

Expressioni

Tissue specificityi

Detected in several tissues, with highest levels in brain. Also expressed during embryonic development.2 Publications

Gene expression databases

BgeeiQ8BG89.
CleanExiMM_ZFP365.
GenevestigatoriQ8BG89.

Interactioni

Subunit structurei

Homodimer. Interacts with NDE1 and NDEL1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BG89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili170 – 298129Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG41382.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000155791.
HOVERGENiHBG094181.
InParanoidiQ8BG89.
KOiK16737.
OMAiCRDISEH.
OrthoDBiEOG7NSB28.
PhylomeDBiQ8BG89.
TreeFamiTF329439.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BG89-1) [UniParc]FASTAAdd to basket

Also known as: ZNF365a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQTTFEESR YHWQDSLENV AVCLPFRCPR CGDHTRFRSL SSLRAHLEFS
60 70 80 90 100
HSYEERTLLT KCSLLPSLKD TELLRSSELP KQGKVLRGHA KVTKQKSSYV
110 120 130 140 150
NLYSISHGHS KDTKPFEMVA ERPVSYVQTY TAVDIRADSL DAPCASPGLP
160 170 180 190 200
TQDTKAAFEA HVREKFNRMV EAVDRTIEKR IDKLTKELAQ KTAELLEVRA
210 220 230 240 250
AFAQLTQKKQ EVQRRERALN KQVDVAVEMI AVLKQRLTES EEELLRKEEE
260 270 280 290 300
VVTFNHFLEA AAEKEVQGKA RLQDFIENLL QRVELAEKQL EYYQSQQASG
310 320 330 340 350
FSCDTSEHML TDIPSNRKPR CLSRGHQHSV CNHPEMRAHF HLKGRSYLKK
360 370 380 390 400
AKDERAGMQP AKAIHEPAES PREFFRPAKK GEHLGLSRKG NFRPKMAKKK

PTAIVNII
Length:408
Mass (Da):46,860
Last modified:March 1, 2003 - v1
Checksum:iB4E18F21EC340E26
GO
Isoform 2 (identifier: Q8BG89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-332: LTDIPSNRKPRCLSRGHQHSVCN → VSPLPVSHPMAPPEYSQNEPRQS
     333-408: Missing.

Note: No experimental confirmation available.

Show »
Length:332
Mass (Da):38,109
Checksum:iCBF39480F0AB2C78
GO

Sequence cautioni

The sequence BAC65669.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971S → P in AAQ11828 (PubMed:16617106).Curated
Sequence conflicti97 – 971S → P in BAC65669 (PubMed:12693553).Curated
Sequence conflicti97 – 971S → P in BAC31866 (PubMed:16141072).Curated
Sequence conflicti309 – 3091Missing in BAC65669 (PubMed:12693553).Curated
Sequence conflicti336 – 3361M → L in AAQ11828 (PubMed:16617106).Curated
Sequence conflicti336 – 3361M → L in BAC65669 (PubMed:12693553).Curated
Sequence conflicti336 – 3361M → L in BAC31866 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei310 – 33223LTDIP…HSVCN → VSPLPVSHPMAPPEYSQNEP RQS in isoform 2. 1 PublicationVSP_016601Add
BLAST
Alternative sequencei333 – 40876Missing in isoform 2. 1 PublicationVSP_016602Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516033 mRNA. Translation: CAD56774.1.
AF543761 mRNA. Translation: AAQ11828.1.
AK122387 mRNA. Translation: BAC65669.1. Different initiation.
AK031846 mRNA. Translation: BAC27578.1.
AK033892 mRNA. Translation: BAC28505.1.
AK044322 mRNA. Translation: BAC31866.1.
AK077316 mRNA. Translation: BAC36745.1.
BC080272 mRNA. Translation: AAH80272.1.
CCDSiCCDS23903.1. [Q8BG89-1]
RefSeqiNP_848794.1. NM_178679.2. [Q8BG89-1]
UniGeneiMm.268346.

Genome annotation databases

EnsembliENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855. [Q8BG89-1]
GeneIDi216049.
KEGGimmu:216049.
UCSCiuc007fmb.1. mouse. [Q8BG89-1]
uc007fmc.1. mouse. [Q8BG89-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516033 mRNA. Translation: CAD56774.1.
AF543761 mRNA. Translation: AAQ11828.1.
AK122387 mRNA. Translation: BAC65669.1. Different initiation.
AK031846 mRNA. Translation: BAC27578.1.
AK033892 mRNA. Translation: BAC28505.1.
AK044322 mRNA. Translation: BAC31866.1.
AK077316 mRNA. Translation: BAC36745.1.
BC080272 mRNA. Translation: AAH80272.1.
CCDSiCCDS23903.1. [Q8BG89-1]
RefSeqiNP_848794.1. NM_178679.2. [Q8BG89-1]
UniGeneiMm.268346.

3D structure databases

ProteinModelPortaliQ8BG89.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BG89.

Proteomic databases

PRIDEiQ8BG89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064656; ENSMUSP00000067197; ENSMUSG00000037855. [Q8BG89-1]
GeneIDi216049.
KEGGimmu:216049.
UCSCiuc007fmb.1. mouse. [Q8BG89-1]
uc007fmc.1. mouse. [Q8BG89-2]

Organism-specific databases

CTDi216049.
MGIiMGI:2143676. Zfp365.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG41382.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000155791.
HOVERGENiHBG094181.
InParanoidiQ8BG89.
KOiK16737.
OMAiCRDISEH.
OrthoDBiEOG7NSB28.
PhylomeDBiQ8BG89.
TreeFamiTF329439.

Miscellaneous databases

NextBioi374968.
PROiQ8BG89.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BG89.
CleanExiMM_ZFP365.
GenevestigatoriQ8BG89.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage."
    Gianfrancesco F., Esposito T., Casu G., Maninchedda G., Roberto R., Parastu M.
    Gene 339:131-138(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Retina.
  2. "Characterization of Su48, a centrosome protein essential for cell division."
    Wang Q., Du X., Meinkoth J., Hirohashi Y., Zhang H., Liu Q., Richter M., Greene M.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:6512-6517(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Diencephalon and Medulla oblongata.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiZN365_MOUSE
AccessioniPrimary (citable) accession number: Q8BG89
Secondary accession number(s): Q80TQ4, Q8BK39, Q8BXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.