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Protein

Polymerase delta-interacting protein 3

Gene

Poldip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: UniProtKB
  • positive regulation of translation Source: MGI
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Translation regulation, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase delta-interacting protein 3
Alternative name(s):
S6K1 Aly/REF-like target
Short name:
SKAR
Gene namesi
Name:Poldip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1921076. Poldip3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000817232 – 420Polymerase delta-interacting protein 3Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei33Omega-N-methylarginineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei140PhosphothreonineBy similarity1
Modified residuei215PhosphoserineBy similarity1
Modified residuei217PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei385PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BG81.
MaxQBiQ8BG81.
PaxDbiQ8BG81.
PeptideAtlasiQ8BG81.
PRIDEiQ8BG81.

PTM databases

iPTMnetiQ8BG81.
PhosphoSitePlusiQ8BG81.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041815.
ExpressionAtlasiQ8BG81. baseline and differential.
GenevisibleiQ8BG81. MM.

Interactioni

Subunit structurei

Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. Interacts with THOC2, DDX39B and ZC3H11A; the interactions are ATP-dependent and indicative for an association with the TREX complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi216286. 2 interactors.
IntActiQ8BG81. 3 interactors.
MINTiMINT-4106914.
STRINGi10090.ENSMUSP00000054548.

Structurei

3D structure databases

ProteinModelPortaliQ8BG81.
SMRiQ8BG81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 351RRMPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0533. Eukaryota.
ENOG4111JAW. LUCA.
GeneTreeiENSGT00390000018868.
HOVERGENiHBG053550.
InParanoidiQ8BG81.
OMAiFLHHMAG.
OrthoDBiEOG091G0R8J.
TreeFamiTF313312.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BG81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLSLDELI RKRGTAAKGR LSVRPGIGGV RSRVGIQHSL VNQPARTATF
60 70 80 90 100
QQRFDARQKI GLSDARLKLG VKDAREKLLQ KDARFRIKGK VQDAREMLNS
110 120 130 140 150
RKQQGTVPQK PRQVADAREK ISLKRRSPAA FTSPPIGTVT PALKLTKTIQ
160 170 180 190 200
VPQQKAMVPL HAHPAGMRIN VVNNHQAKQN LYDLDEDDDI VVPVPPKQMK
210 220 230 240 250
FAATGSLVHH MTGLSSSKLS MSKALPLTKV VQNDAYTAPV LPSSVRTKAL
260 270 280 290 300
TSMSRTLVNK EEPPKELPPA EPVLSPLEGT KMTVNNLHPR VTEEDIVELF
310 320 330 340 350
CVCGALKRAR LVHPGVAEVV FVKKDDAITA YKKYNNRCLD GQPMKCNLHM
360 370 380 390 400
NGNVITSDQP ILLRLSDSPS VKKESELPRR GNPASSNPPA EVDPDTVLRA
410 420
LFKSSGASVT TQPTEFKIKL
Length:420
Mass (Da):46,132
Last modified:March 1, 2003 - v1
Checksum:iB898C54D485CF5FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081139 mRNA. Translation: BAC38144.1.
AK083924 mRNA. Translation: BAC39068.1.
AK087446 mRNA. Translation: BAC39877.1.
AL591952 Genomic DNA. Translation: CAQ51827.1.
BC037652 mRNA. Translation: AAH37652.2.
BC046505 mRNA. Translation: AAH46505.2.
BC058225 mRNA. Translation: AAH58225.2.
CCDSiCCDS27697.1.
RefSeqiNP_848742.1. NM_178627.3.
UniGeneiMm.23758.

Genome annotation databases

EnsembliENSMUST00000058793; ENSMUSP00000054548; ENSMUSG00000041815.
GeneIDi73826.
KEGGimmu:73826.
UCSCiuc007wzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081139 mRNA. Translation: BAC38144.1.
AK083924 mRNA. Translation: BAC39068.1.
AK087446 mRNA. Translation: BAC39877.1.
AL591952 Genomic DNA. Translation: CAQ51827.1.
BC037652 mRNA. Translation: AAH37652.2.
BC046505 mRNA. Translation: AAH46505.2.
BC058225 mRNA. Translation: AAH58225.2.
CCDSiCCDS27697.1.
RefSeqiNP_848742.1. NM_178627.3.
UniGeneiMm.23758.

3D structure databases

ProteinModelPortaliQ8BG81.
SMRiQ8BG81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216286. 2 interactors.
IntActiQ8BG81. 3 interactors.
MINTiMINT-4106914.
STRINGi10090.ENSMUSP00000054548.

PTM databases

iPTMnetiQ8BG81.
PhosphoSitePlusiQ8BG81.

Proteomic databases

EPDiQ8BG81.
MaxQBiQ8BG81.
PaxDbiQ8BG81.
PeptideAtlasiQ8BG81.
PRIDEiQ8BG81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058793; ENSMUSP00000054548; ENSMUSG00000041815.
GeneIDi73826.
KEGGimmu:73826.
UCSCiuc007wzz.1. mouse.

Organism-specific databases

CTDi84271.
MGIiMGI:1921076. Poldip3.

Phylogenomic databases

eggNOGiKOG0533. Eukaryota.
ENOG4111JAW. LUCA.
GeneTreeiENSGT00390000018868.
HOVERGENiHBG053550.
InParanoidiQ8BG81.
OMAiFLHHMAG.
OrthoDBiEOG091G0R8J.
TreeFamiTF313312.

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiPoldip3. mouse.
PROiQ8BG81.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041815.
ExpressionAtlasiQ8BG81. baseline and differential.
GenevisibleiQ8BG81. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDIP3_MOUSE
AccessioniPrimary (citable) accession number: Q8BG81
Secondary accession number(s): B2FDB4
, Q6PE83, Q80X99, Q8CI28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.