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Protein

Polymerase delta-interacting protein 3

Gene

Poldip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: UniProtKB
  • positive regulation of translation Source: MGI

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Translation regulation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase delta-interacting protein 3
Alternative name(s):
S6K1 Aly/REF-like target
Short name:
SKAR
Gene namesi
Name:Poldip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1921076 Poldip3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000817232 – 420Polymerase delta-interacting protein 3Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei33Omega-N-methylarginineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei140PhosphothreonineBy similarity1
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei215PhosphoserineBy similarity1
Modified residuei217PhosphoserineBy similarity1
Cross-linki223Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei244PhosphoserineBy similarity1
Cross-linki248Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei275PhosphoserineBy similarity1
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei385PhosphoserineBy similarity1
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BG81
MaxQBiQ8BG81
PaxDbiQ8BG81
PeptideAtlasiQ8BG81
PRIDEiQ8BG81

PTM databases

iPTMnetiQ8BG81
PhosphoSitePlusiQ8BG81

Expressioni

Gene expression databases

BgeeiENSMUSG00000041815
ExpressionAtlasiQ8BG81 baseline and differential
GenevisibleiQ8BG81 MM

Interactioni

Subunit structurei

Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. Interacts with THOC2, DDX39B and ZC3H11A; the interactions are ATP-dependent and indicative for an association with the TREX complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi216286, 2 interactors
IntActiQ8BG81, 3 interactors
MINTiQ8BG81
STRINGi10090.ENSMUSP00000054548

Structurei

3D structure databases

ProteinModelPortaliQ8BG81
SMRiQ8BG81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 351RRMPROSITE-ProRule annotationAdd BLAST72

Phylogenomic databases

eggNOGiKOG0533 Eukaryota
ENOG4111JAW LUCA
GeneTreeiENSGT00390000018868
HOVERGENiHBG053550
InParanoidiQ8BG81
KOiK22414
OMAiQQKAMAP
OrthoDBiEOG091G0R8J
TreeFamiTF313312

Family and domain databases

CDDicd12681 RRM_SKAR, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034785 PDIP3
IPR034784 PDIP3_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR19965:SF34 PTHR19965:SF34, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BG81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLSLDELI RKRGTAAKGR LSVRPGIGGV RSRVGIQHSL VNQPARTATF
60 70 80 90 100
QQRFDARQKI GLSDARLKLG VKDAREKLLQ KDARFRIKGK VQDAREMLNS
110 120 130 140 150
RKQQGTVPQK PRQVADAREK ISLKRRSPAA FTSPPIGTVT PALKLTKTIQ
160 170 180 190 200
VPQQKAMVPL HAHPAGMRIN VVNNHQAKQN LYDLDEDDDI VVPVPPKQMK
210 220 230 240 250
FAATGSLVHH MTGLSSSKLS MSKALPLTKV VQNDAYTAPV LPSSVRTKAL
260 270 280 290 300
TSMSRTLVNK EEPPKELPPA EPVLSPLEGT KMTVNNLHPR VTEEDIVELF
310 320 330 340 350
CVCGALKRAR LVHPGVAEVV FVKKDDAITA YKKYNNRCLD GQPMKCNLHM
360 370 380 390 400
NGNVITSDQP ILLRLSDSPS VKKESELPRR GNPASSNPPA EVDPDTVLRA
410 420
LFKSSGASVT TQPTEFKIKL
Length:420
Mass (Da):46,132
Last modified:March 1, 2003 - v1
Checksum:iB898C54D485CF5FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081139 mRNA Translation: BAC38144.1
AK083924 mRNA Translation: BAC39068.1
AK087446 mRNA Translation: BAC39877.1
AL591952 Genomic DNA No translation available.
BC037652 mRNA Translation: AAH37652.2
BC046505 mRNA Translation: AAH46505.2
BC058225 mRNA Translation: AAH58225.2
CCDSiCCDS27697.1
RefSeqiNP_001334011.1, NM_001347082.1
NP_848742.1, NM_178627.3
UniGeneiMm.23758

Genome annotation databases

EnsembliENSMUST00000058793; ENSMUSP00000054548; ENSMUSG00000041815
GeneIDi73826
KEGGimmu:73826
UCSCiuc007wzz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPDIP3_MOUSE
AccessioniPrimary (citable) accession number: Q8BG81
Secondary accession number(s): B2FDB4
, Q6PE83, Q80X99, Q8CI28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health