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Protein

F-box only protein 46

Gene

Fbxo46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 46
Alternative name(s):
F-box only protein 34-like
Gene namesi
Name:Fbxo46
Synonyms:Fbx46, Fbxo34l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2444918. Fbxo46.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603F-box only protein 46PRO_0000119951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei347 – 3471PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BG80.
PaxDbiQ8BG80.
PeptideAtlasiQ8BG80.
PRIDEiQ8BG80.

PTM databases

iPTMnetiQ8BG80.
PhosphoSiteiQ8BG80.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050428.
CleanExiMM_FBXO46.
GenevisibleiQ8BG80. MM.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi232572. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8BG80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini470 – 52253F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJQD. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000112549.
HOVERGENiHBG051583.
InParanoidiQ8BG80.
KOiK10320.
OMAiYSQNQPR.
OrthoDBiEOG091G04LZ.
PhylomeDBiQ8BG80.
TreeFamiTF331673.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BG80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGSLLPFQ LWCPRPFSKY SQNQPRPPST ALKPPVCPDT SSGTEPDHRP
60 70 80 90 100
AHLESTPPAV AAEAPTSQPA PLLSTAASGD EGRVLLDTWY VIKPGNTKEK
110 120 130 140 150
VAFFVAHQCG GSSRASSMKV KGHWGSDSSK AKRRRRCLEP TKAPPDQGGR
160 170 180 190 200
EGTPATEVTP TSSGDDVDLV SVAEMVALVE QRAALALQSY PRPSTPAPVV
210 220 230 240 250
FVSADQGGPA KGLGSERRSG GGDCSRVAEA VAHFEAQRDS PPTKGLRKEE
260 270 280 290 300
RPGPGPGEVR IAFRISNVRE PHSPDGNLPN GGGGRPGCAY PGSPGPGTRA
310 320 330 340 350
KDKITCDLYQ LISPSRDALP SNVEFLLARA DEASEGETPA PTRPEDTPPA
360 370 380 390 400
PPPPPARDCG ASGFHVDVVV TGVVDACIFF GKDGTKNVKE ETVCLTVSPE
410 420 430 440 450
EPPPPGQLFF LQSRGPEGPP EPPPADIPST VPGPDDSEGT TDTSLCRLYR
460 470 480 490 500
HVSHDFLEIR FKIQRLLEPR QYMLLLPEHV LVKIFSFLPT RALAALKCTC
510 520 530 540 550
HHFKGIIEAF GVRATDSRWS RDPLYRDDPC KQCRKRYEKG DVSLCRWHPK
560 570 580 590 600
PYHHDLPYGR SYWMCCRRAD RETPGCRLGL HDNNWVLPCN GVGGGRAGRE

EGR
Length:603
Mass (Da):65,294
Last modified:March 1, 2003 - v1
Checksum:iB8B6AF154D1BAD5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030147 mRNA. Translation: BAC26809.1.
AK030220 mRNA. Translation: BAC26851.1.
BC049813 mRNA. Translation: AAH49813.1.
CCDSiCCDS20890.1.
RefSeqiNP_780739.1. NM_175530.3.
XP_006539998.1. XM_006539935.2.
XP_006539999.1. XM_006539936.2.
XP_006540000.1. XM_006539937.2.
UniGeneiMm.230830.

Genome annotation databases

EnsembliENSMUST00000053109; ENSMUSP00000055692; ENSMUSG00000050428.
ENSMUST00000165913; ENSMUSP00000129427; ENSMUSG00000050428.
GeneIDi243867.
KEGGimmu:243867.
UCSCiuc009fkt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030147 mRNA. Translation: BAC26809.1.
AK030220 mRNA. Translation: BAC26851.1.
BC049813 mRNA. Translation: AAH49813.1.
CCDSiCCDS20890.1.
RefSeqiNP_780739.1. NM_175530.3.
XP_006539998.1. XM_006539935.2.
XP_006539999.1. XM_006539936.2.
XP_006540000.1. XM_006539937.2.
UniGeneiMm.230830.

3D structure databases

ProteinModelPortaliQ8BG80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232572. 1 interaction.

PTM databases

iPTMnetiQ8BG80.
PhosphoSiteiQ8BG80.

Proteomic databases

MaxQBiQ8BG80.
PaxDbiQ8BG80.
PeptideAtlasiQ8BG80.
PRIDEiQ8BG80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053109; ENSMUSP00000055692; ENSMUSG00000050428.
ENSMUST00000165913; ENSMUSP00000129427; ENSMUSG00000050428.
GeneIDi243867.
KEGGimmu:243867.
UCSCiuc009fkt.2. mouse.

Organism-specific databases

CTDi23403.
MGIiMGI:2444918. Fbxo46.

Phylogenomic databases

eggNOGiENOG410IJQD. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000112549.
HOVERGENiHBG051583.
InParanoidiQ8BG80.
KOiK10320.
OMAiYSQNQPR.
OrthoDBiEOG091G04LZ.
PhylomeDBiQ8BG80.
TreeFamiTF331673.

Miscellaneous databases

PROiQ8BG80.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050428.
CleanExiMM_FBXO46.
GenevisibleiQ8BG80. MM.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX46_MOUSE
AccessioniPrimary (citable) accession number: Q8BG80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.