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Protein

Probable G-protein coupled receptor 171

Gene

Gpr171

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of myeloid cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 171
Gene namesi
Name:Gpr171
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2442043. Gpr171.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 486CytoplasmicSequence analysis
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini70 – 8920ExtracellularSequence analysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini111 – 13222CytoplasmicSequence analysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini154 – 18128ExtracellularSequence analysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini203 – 22422CytoplasmicSequence analysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini246 – 26823ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 31930CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Probable G-protein coupled receptor 171PRO_0000303237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8BG55.
PaxDbiQ8BG55.
PRIDEiQ8BG55.

PTM databases

iPTMnetiQ8BG55.
PhosphoSiteiQ8BG55.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050075.
CleanExiMM_GPR171.
GenevisibleiQ8BG55. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082115.

Structurei

3D structure databases

ProteinModelPortaliQ8BG55.
SMRiQ8BG55. Positions 17-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IICW. Eukaryota.
ENOG410YCG6. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG095159.
InParanoidiQ8BG55.
KOiK08441.
OMAiIMVPNMV.
OrthoDBiEOG091G0B1Z.
PhylomeDBiQ8BG55.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BG55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSTFCPV YRDLEPFTYF FYLVFLIGII GSCFATWAFI QKTTNHRCVS
60 70 80 90 100
IYLINLLTAD FLLTLALPVK IIVDLGVAPW KLRIFHCQVT ACLIYINMYL
110 120 130 140 150
SIIFLAFVSI DRCLQLIHSC KIYRIQEPGF AKMISAVVWL MVLLIMVPNM
160 170 180 190 200
VIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSVIILISNF
210 220 230 240 250
LAIRQLYRNR DNTNYPSVKS ALLHILLVTA SYIICFVPYH AVRIPYTLSQ
260 270 280 290 300
TEVISDCSTR IALFKAKEAT LLLAVSNLCF DPILYYHLSK AFRLKVTETF
310
ASPKKSKPLE ERLRSENDV
Length:319
Mass (Da):36,720
Last modified:March 1, 2003 - v1
Checksum:iC2E0D658FB694364
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 412Missing in BAC40815 (PubMed:16141072).Curated
Sequence conflicti72 – 721I → V in AAH24054 (PubMed:15489334).Curated
Sequence conflicti151 – 1511V → A in BAC40815 (PubMed:16141072).Curated
Sequence conflicti258 – 2581S → T in BAC30993 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041381 mRNA. Translation: BAC30925.1.
AK041582 mRNA. Translation: BAC30993.1.
AK089252 mRNA. Translation: BAC40815.1.
AK089287 mRNA. Translation: BAC40829.1.
AK154725 mRNA. Translation: BAE32789.1.
BC024054 mRNA. Translation: AAH24054.1.
CCDSiCCDS17370.1.
RefSeqiNP_775574.1. NM_173398.3.
UniGeneiMm.123648.

Genome annotation databases

EnsembliENSMUST00000085040; ENSMUSP00000082115; ENSMUSG00000050075.
GeneIDi229323.
KEGGimmu:229323.
UCSCiuc008pij.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041381 mRNA. Translation: BAC30925.1.
AK041582 mRNA. Translation: BAC30993.1.
AK089252 mRNA. Translation: BAC40815.1.
AK089287 mRNA. Translation: BAC40829.1.
AK154725 mRNA. Translation: BAE32789.1.
BC024054 mRNA. Translation: AAH24054.1.
CCDSiCCDS17370.1.
RefSeqiNP_775574.1. NM_173398.3.
UniGeneiMm.123648.

3D structure databases

ProteinModelPortaliQ8BG55.
SMRiQ8BG55. Positions 17-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082115.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8BG55.
PhosphoSiteiQ8BG55.

Proteomic databases

EPDiQ8BG55.
PaxDbiQ8BG55.
PRIDEiQ8BG55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085040; ENSMUSP00000082115; ENSMUSG00000050075.
GeneIDi229323.
KEGGimmu:229323.
UCSCiuc008pij.2. mouse.

Organism-specific databases

CTDi29909.
MGIiMGI:2442043. Gpr171.

Phylogenomic databases

eggNOGiENOG410IICW. Eukaryota.
ENOG410YCG6. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG095159.
InParanoidiQ8BG55.
KOiK08441.
OMAiIMVPNMV.
OrthoDBiEOG091G0B1Z.
PhylomeDBiQ8BG55.
TreeFamiTF330969.

Miscellaneous databases

PROiQ8BG55.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050075.
CleanExiMM_GPR171.
GenevisibleiQ8BG55. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP171_MOUSE
AccessioniPrimary (citable) accession number: Q8BG55
Secondary accession number(s): Q8BTN1, Q8BY85, Q8CIF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.