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Q8BG54

- SPTC3_MOUSE

UniProt

Q8BG54 - SPTC3_MOUSE

Protein

Serine palmitoyltransferase 3

Gene

Sptlc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference By similarity.By similarity

    Catalytic activityi

    Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sphingoid biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid metabolism, Sphingolipid metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_198151. Sphingolipid de novo biosynthesis.
    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine palmitoyltransferase 3 (EC:2.3.1.50)
    Alternative name(s):
    Long chain base biosynthesis protein 2b
    Short name:
    LCB2b
    Long chain base biosynthesis protein 3
    Short name:
    LCB 3
    Serine-palmitoyl-CoA transferase 3
    Short name:
    SPT 3
    Gene namesi
    Name:Sptlc3
    Synonyms:Sptlc2l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2444678. Sptlc3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. serine C-palmitoyltransferase complex Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Serine palmitoyltransferase 3PRO_0000304978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei371 – 3711N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiQ8BG54.

    PTM databases

    PhosphoSiteiQ8BG54.

    Expressioni

    Gene expression databases

    BgeeiQ8BG54.
    GenevestigatoriQ8BG54.

    Interactioni

    Subunit structurei

    Heterodimer with SPTLC1. Component of the serine palmitoyltransferase (SPT) complex, composed of LCB1/SPTLC1, LCB2 (SPTLC2 or SPTLC3) and ssPT (SPTSSA or SPTSSB) By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8BG54. 2 interactions.
    MINTiMINT-7985027.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BG54.
    SMRiQ8BG54. Positions 160-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0156.
    GeneTreeiENSGT00550000074678.
    HOGENOMiHOG000206826.
    HOVERGENiHBG002230.
    InParanoidiQ8BG54.
    KOiK00654.
    OMAiSTRNEMG.
    OrthoDBiEOG73RBB0.
    PhylomeDBiQ8BG54.
    TreeFamiTF300452.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BG54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANLNDSAVT NGTLHNPKTQ QGKRQSTGCV KNGISKEAQQ NRKAYAEDKP    50
    VFEPYQEAPL YVYVLTYMGY GIGILFGYLR DFMRNWGIEK CNAAVEREEQ 100
    KDFVPLYQDF ENFYKRNLYM RIRDSWSHTV CSAPEPYMNV MEKVTDDYNW 150
    TFRHTGKVIE NIINMASYNY LGLAGKYDDS MVRVKDTLEK YGVGVASTRN 200
    EMGTLDIHKE LEDLMAEFLN VEAVMSFGMG FATNAMNIPV FVGKGCLILS 250
    DEFNHTSVIL GSRLSGAVIR PFKHNNAENL EKLLREAIIR GQPGTGRAWK 300
    KILIVVEGVY SMEGSIVNLA QIVALKKKYK AYLYIDEAHS IGCTGPTGRG 350
    VRELFGLDPE DIDVYMGTFT KSFSGSGGYI GGKKEIVDYL RMQSHSTTYA 400
    TSMSPVVAAQ LIRSLKITMG YEGNIGGMER IQQLKENIKY FRRRLKEMGF 450
    IIYGNDFSPV IPVLLYMPAK VSAFSRFLLK KKISVVVVGF PATSLPEGRA 500
    RFSMSSAHTR EMLDTVLEVV DELGDLLNVK YFPLKKSGRA ILYNKEGFDN 550
    EASFEEMHSE PEA 563
    Length:563
    Mass (Da):63,486
    Last modified:March 1, 2003 - v1
    Checksum:iC373554525D2E980
    GO

    Sequence cautioni

    The sequence AAH94496.1 differs from that shown. Reason: Frameshift at position 420.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048374 mRNA. Translation: BAC33316.1.
    AK054240 mRNA. Translation: BAC35701.1.
    AK078679 mRNA. Translation: BAC37356.1.
    AK078686 mRNA. Translation: BAC37359.1.
    AL928899 Genomic DNA. Translation: CAM21721.1.
    BC094496 mRNA. Translation: AAH94496.1. Frameshift.
    CCDSiCCDS16800.1.
    RefSeqiNP_780676.1. NM_175467.3.
    XP_006499358.1. XM_006499295.1.
    UniGeneiMm.100450.

    Genome annotation databases

    EnsembliENSMUST00000047370; ENSMUSP00000048313; ENSMUSG00000039092.
    ENSMUST00000110083; ENSMUSP00000105710; ENSMUSG00000039092.
    GeneIDi228677.
    KEGGimmu:228677.
    UCSCiuc008mpd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048374 mRNA. Translation: BAC33316.1 .
    AK054240 mRNA. Translation: BAC35701.1 .
    AK078679 mRNA. Translation: BAC37356.1 .
    AK078686 mRNA. Translation: BAC37359.1 .
    AL928899 Genomic DNA. Translation: CAM21721.1 .
    BC094496 mRNA. Translation: AAH94496.1 . Frameshift.
    CCDSi CCDS16800.1.
    RefSeqi NP_780676.1. NM_175467.3.
    XP_006499358.1. XM_006499295.1.
    UniGenei Mm.100450.

    3D structure databases

    ProteinModelPortali Q8BG54.
    SMRi Q8BG54. Positions 160-527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BG54. 2 interactions.
    MINTi MINT-7985027.

    PTM databases

    PhosphoSitei Q8BG54.

    Proteomic databases

    PRIDEi Q8BG54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047370 ; ENSMUSP00000048313 ; ENSMUSG00000039092 .
    ENSMUST00000110083 ; ENSMUSP00000105710 ; ENSMUSG00000039092 .
    GeneIDi 228677.
    KEGGi mmu:228677.
    UCSCi uc008mpd.1. mouse.

    Organism-specific databases

    CTDi 55304.
    MGIi MGI:2444678. Sptlc3.

    Phylogenomic databases

    eggNOGi COG0156.
    GeneTreei ENSGT00550000074678.
    HOGENOMi HOG000206826.
    HOVERGENi HBG002230.
    InParanoidi Q8BG54.
    KOi K00654.
    OMAi STRNEMG.
    OrthoDBi EOG73RBB0.
    PhylomeDBi Q8BG54.
    TreeFami TF300452.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .
    Reactomei REACT_198151. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    NextBioi 379074.
    PROi Q8BG54.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BG54.
    Genevestigatori Q8BG54.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head, Eye and Oviduct.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiSPTC3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BG54
    Secondary accession number(s): Q505L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3