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Protein

Serine/threonine-protein kinase 17B

Gene

Stk17b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621ATPPROSITE-ProRule annotation
Active sitei158 – 1581Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 479ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 17B (EC:2.7.11.1)
Alternative name(s):
DAP kinase-related apoptosis-inducing protein kinase 2
Gene namesi
Name:Stk17b
Synonyms:Drak2
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138162. Stk17b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Serine/threonine-protein kinase 17BPRO_0000086707Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BG48.
MaxQBiQ8BG48.
PaxDbiQ8BG48.
PeptideAtlasiQ8BG48.
PRIDEiQ8BG48.

PTM databases

iPTMnetiQ8BG48.
PhosphoSiteiQ8BG48.

Expressioni

Gene expression databases

BgeeiQ8BG48.
CleanExiMM_STK17B.
ExpressionAtlasiQ8BG48. baseline and differential.
GenevisibleiQ8BG48. MM.

Interactioni

Subunit structurei

Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027263.

Structurei

3D structure databases

ProteinModelPortaliQ8BG48.
SMRiQ8BG48. Positions 26-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 293261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG106718.
InParanoidiQ8BG48.
KOiK08804.
OMAiCPHVINL.
OrthoDBiEOG7QZGBH.
PhylomeDBiQ8BG48.
TreeFamiTF314166.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BG48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRRFDCRS VSGLLTTTPQ TPIKTENFNN FYTLTPKELG RGKFAVVRQC
60 70 80 90 100
ISKSTGQEYA AKSLKKRRRG QDCRAEILHE IAVLELARSC PHVINLHEVY
110 120 130 140 150
ENATEIILVL EYAAGGEIFN LCLPELAEMV SENDVIRLIK QILEGVHYLH
160 170 180 190 200
QNNIVHLDLK PQNILLSSIY PLGDIKIVDF GMSRKIGNAS ELREIMGTPE
210 220 230 240 250
YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN QETYLNISQV
260 270 280 290 300
NVDYSEEMFS SVSQLATDFI QSLLVKNPEK RPTAESCLSH SWLQQWDFGS
310 320 330 340 350
LFHPEETSGS SQIQDLTLRS SEEKTSKSSC NGSCGAREDK ENIPEDGSLV
360 370
SKRFRFDDSL PSPHELVPDL FC
Length:372
Mass (Da):41,983
Last modified:March 1, 2003 - v1
Checksum:iC858E175196E7A32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231I → M in AAH06579 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY092028 mRNA. Translation: AAM18182.1.
AK035693 mRNA. Translation: BAC29154.1.
AK041139 mRNA. Translation: BAC30835.1.
AK076932 mRNA. Translation: BAC36531.1.
AK083332 mRNA. Translation: BAC38870.1.
AK153108 mRNA. Translation: BAE31726.1.
AK165291 mRNA. Translation: BAE38122.1.
BC006579 mRNA. Translation: AAH06579.1.
CCDSiCCDS14955.1.
RefSeqiNP_598571.2. NM_133810.3.
UniGeneiMm.25559.

Genome annotation databases

EnsembliENSMUST00000027263; ENSMUSP00000027263; ENSMUSG00000026094.
GeneIDi98267.
KEGGimmu:98267.
UCSCiuc007azj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY092028 mRNA. Translation: AAM18182.1.
AK035693 mRNA. Translation: BAC29154.1.
AK041139 mRNA. Translation: BAC30835.1.
AK076932 mRNA. Translation: BAC36531.1.
AK083332 mRNA. Translation: BAC38870.1.
AK153108 mRNA. Translation: BAE31726.1.
AK165291 mRNA. Translation: BAE38122.1.
BC006579 mRNA. Translation: AAH06579.1.
CCDSiCCDS14955.1.
RefSeqiNP_598571.2. NM_133810.3.
UniGeneiMm.25559.

3D structure databases

ProteinModelPortaliQ8BG48.
SMRiQ8BG48. Positions 26-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027263.

PTM databases

iPTMnetiQ8BG48.
PhosphoSiteiQ8BG48.

Proteomic databases

EPDiQ8BG48.
MaxQBiQ8BG48.
PaxDbiQ8BG48.
PeptideAtlasiQ8BG48.
PRIDEiQ8BG48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027263; ENSMUSP00000027263; ENSMUSG00000026094.
GeneIDi98267.
KEGGimmu:98267.
UCSCiuc007azj.2. mouse.

Organism-specific databases

CTDi9262.
MGIiMGI:2138162. Stk17b.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG106718.
InParanoidiQ8BG48.
KOiK08804.
OMAiCPHVINL.
OrthoDBiEOG7QZGBH.
PhylomeDBiQ8BG48.
TreeFamiTF314166.

Miscellaneous databases

ChiTaRSiStk17b. mouse.
PROiQ8BG48.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BG48.
CleanExiMM_STK17B.
ExpressionAtlasiQ8BG48. baseline and differential.
GenevisibleiQ8BG48. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "mDRAK2, a lymphoid-enriched apoptotic nuclear kinase, is activated during thymocyte selection."
    Walsh C.M., Wen B., Bain G., Kee B., Katayama C., Murre C., Hedrick S.M.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6JImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta, Bone marrow, Spleen, Testis, Thymus, Urinary bladder and Vein.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiST17B_MOUSE
AccessioniPrimary (citable) accession number: Q8BG48
Secondary accession number(s): Q3TNG7, Q8BLV9, Q923E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.