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Protein

Synaptic vesicle glycoprotein 2B

Gene

Sv2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in the control of regulated secretion in neural and endocrine cells.By similarity
Receptor for the botulinium neurotoxin type A/BOTA.2 Publications

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • neurotransmitter transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2B
Short name:
Synaptic vesicle protein 2B
Gene namesi
Name:Sv2b
Synonyms:Kiaa0735
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1927338. Sv2b.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasmic vesiclesecretory vesicleacrosome By similarity

  • Note: Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 110110CytoplasmicSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Topological domaini132 – 14817ExtracellularSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Topological domaini170 – 18213CytoplasmicSequence analysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST
Topological domaini204 – 2052ExtracellularSequence analysis
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 23711CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Topological domaini259 – 27719ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST
Topological domaini299 – 39092CytoplasmicSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Topological domaini412 – 535124ExtracellularSequence analysisAdd
BLAST
Transmembranei536 – 55621HelicalSequence analysisAdd
BLAST
Topological domaini557 – 5659CytoplasmicSequence analysis
Transmembranei566 – 58621HelicalSequence analysisAdd
BLAST
Topological domaini587 – 5926ExtracellularSequence analysis
Transmembranei593 – 61321HelicalSequence analysisAdd
BLAST
Topological domaini614 – 62613CytoplasmicSequence analysisAdd
BLAST
Transmembranei627 – 64923HelicalSequence analysisAdd
BLAST
Topological domaini650 – 6534ExtracellularSequence analysis
Transmembranei654 – 67219HelicalSequence analysisAdd
BLAST
Topological domaini673 – 68311CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mice display no particular phenotype. Mice lacking both Sv2a and Sv2b experience severe epileptic seizures and die immediately or shortly after birth similarly to mice lacking only Sv2a.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683Synaptic vesicle glycoprotein 2BPRO_0000239769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphoserineCombined sources
Modified residuei36 – 361PhosphothreonineCombined sources
Modified residuei423 – 4231PhosphotyrosineCombined sources
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity
The N-terminal cytoplasmic domain is phosphorylated by CK1.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BG39.
PaxDbiQ8BG39.
PeptideAtlasiQ8BG39.
PRIDEiQ8BG39.

PTM databases

iPTMnetiQ8BG39.
PhosphoSiteiQ8BG39.

Expressioni

Tissue specificityi

Expressed in ribbon synapses of the retina (at protein level).1 Publication

Developmental stagei

Expressed during synaptogenesis in the retina (at protein level).1 Publication

Inductioni

Up-regulated upon Sv2a depletion.1 Publication

Gene expression databases

BgeeiENSMUSG00000053025.
CleanExiMM_SV2B.
GenevisibleiQ8BG39. MM.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082254.

Structurei

3D structure databases

ProteinModelPortaliQ8BG39.
SMRiQ8BG39. Positions 128-402, 439-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni486 – 52338BOTA-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ8BG39.
KOiK06258.
OMAiKMYFKHV.
OrthoDBiEOG091G02NC.
PhylomeDBiQ8BG39.
TreeFamiTF324824.

Family and domain databases

CDDicd06174. MFS. 2 hits.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BG39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDYRYRDNY EGYAPSDGYY RSNEQNQEED AQSDVTEGHD EEDEIYEGEY
60 70 80 90 100
QGIPHPDDVK SKQTKMAPSR ADGLGGQADL MAERMEDEEE LAHQYETIID
110 120 130 140 150
ECGHGRFQWT LFFVLGLALM ADGVEIFVVS FALPSAEKDM CLSSSKKGML
160 170 180 190 200
GLIVYLGMMA GAFILGGLAD KLGRKKVLSM SLAINASFAS LSSFVQGYGA
210 220 230 240 250
FLFCRLISGI GIGGSLPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGIYA
260 270 280 290 300
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPATVS MVALKFMPES
310 320 330 340 350
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSHI KTPKQMDEFI
360 370 380 390 400
EIQSSTGTWY QRWLVRFMTI FKQVWDNALY CVMGPYRMNT LILAVVWFTM
410 420 430 440 450
ALSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVHGATI NFTMENQIHQ
460 470 480 490 500
HGKLVNDKFI KMYFKHVLFE DTFFDKCYFE DVTSTDTYFK NCTIESTTFY
510 520 530 540 550
NTDLYKHKFI NCRFINSTFL EQKEGCHMDF EEDNDFLIYL VSFLGSLSVL
560 570 580 590 600
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC
610 620 630 640 650
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG
660 670 680
ITKVVPILLA AASLVGGGLI ALRLPETREQ VLM
Length:683
Mass (Da):77,457
Last modified:March 1, 2003 - v1
Checksum:iCBDC19B281B9E4F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181G → D in AAG28491 (PubMed:10624962).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029736 mRNA. Translation: BAC26590.1.
AK043830 mRNA. Translation: BAC31669.1.
AK139478 mRNA. Translation: BAE24029.1.
AK140104 mRNA. Translation: BAE24238.1.
AK147261 mRNA. Translation: BAE27804.1.
BC060224 mRNA. Translation: AAH60224.1.
AF196782 Genomic DNA. Translation: AAG28491.1.
AK122359 mRNA. Translation: BAC65641.1.
CCDSiCCDS21368.1.
RefSeqiNP_001103223.1. NM_001109753.1.
NP_705807.2. NM_153579.4.
XP_006541121.1. XM_006541058.2.
XP_006541122.1. XM_006541059.2.
XP_006541123.1. XM_006541060.2.
XP_006541124.1. XM_006541061.1.
UniGeneiMm.273082.

Genome annotation databases

EnsembliENSMUST00000085164; ENSMUSP00000082254; ENSMUSG00000053025.
ENSMUST00000165175; ENSMUSP00000127245; ENSMUSG00000053025.
ENSMUST00000206344; ENSMUSP00000146049; ENSMUSG00000053025.
GeneIDi64176.
KEGGimmu:64176.
UCSCiuc009hwk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029736 mRNA. Translation: BAC26590.1.
AK043830 mRNA. Translation: BAC31669.1.
AK139478 mRNA. Translation: BAE24029.1.
AK140104 mRNA. Translation: BAE24238.1.
AK147261 mRNA. Translation: BAE27804.1.
BC060224 mRNA. Translation: AAH60224.1.
AF196782 Genomic DNA. Translation: AAG28491.1.
AK122359 mRNA. Translation: BAC65641.1.
CCDSiCCDS21368.1.
RefSeqiNP_001103223.1. NM_001109753.1.
NP_705807.2. NM_153579.4.
XP_006541121.1. XM_006541058.2.
XP_006541122.1. XM_006541059.2.
XP_006541123.1. XM_006541060.2.
XP_006541124.1. XM_006541061.1.
UniGeneiMm.273082.

3D structure databases

ProteinModelPortaliQ8BG39.
SMRiQ8BG39. Positions 128-402, 439-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082254.

PTM databases

iPTMnetiQ8BG39.
PhosphoSiteiQ8BG39.

Proteomic databases

MaxQBiQ8BG39.
PaxDbiQ8BG39.
PeptideAtlasiQ8BG39.
PRIDEiQ8BG39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085164; ENSMUSP00000082254; ENSMUSG00000053025.
ENSMUST00000165175; ENSMUSP00000127245; ENSMUSG00000053025.
ENSMUST00000206344; ENSMUSP00000146049; ENSMUSG00000053025.
GeneIDi64176.
KEGGimmu:64176.
UCSCiuc009hwk.2. mouse.

Organism-specific databases

CTDi9899.
MGIiMGI:1927338. Sv2b.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ8BG39.
KOiK06258.
OMAiKMYFKHV.
OrthoDBiEOG091G02NC.
PhylomeDBiQ8BG39.
TreeFamiTF324824.

Miscellaneous databases

PROiQ8BG39.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053025.
CleanExiMM_SV2B.
GenevisibleiQ8BG39. MM.

Family and domain databases

CDDicd06174. MFS. 2 hits.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSV2B_MOUSE
AccessioniPrimary (citable) accession number: Q8BG39
Secondary accession number(s): Q80TT1, Q9ES95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.