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Protein

CTD small phosphatase-like protein 2

Gene

Ctdspl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable phosphatase.By similarity

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: MGI

GO - Biological processi

  • negative regulation of BMP signaling pathway Source: MGI
  • positive regulation of protein export from nucleus Source: MGI
  • protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
CTD small phosphatase-like protein 2 (EC:3.1.3.-)
Short name:
CTDSP-like 2
Gene namesi
Name:Ctdspl2
Synonyms:D2Ertd485e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1196405. Ctdspl2.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465CTD small phosphatase-like protein 2PRO_0000331465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261N6-acetyllysineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei51 – 511PhosphoserineBy similarity
Modified residuei57 – 571N6-acetyllysineBy similarity
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei86 – 861PhosphothreonineBy similarity
Modified residuei104 – 1041PhosphoserineCombined sources
Modified residuei134 – 1341PhosphoserineBy similarity
Modified residuei165 – 1651PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BG15.
MaxQBiQ8BG15.
PaxDbiQ8BG15.
PeptideAtlasiQ8BG15.
PRIDEiQ8BG15.

PTM databases

iPTMnetiQ8BG15.
PhosphoSiteiQ8BG15.

Expressioni

Gene expression databases

BgeeiQ8BG15.
GenevisibleiQ8BG15. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047543.

Structurei

3D structure databases

ProteinModelPortaliQ8BG15.
SMRiQ8BG15. Positions 289-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 441160FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CTDSPL2 family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000017194.
HOVERGENiHBG107781.
InParanoidiQ8BG15.
KOiK17616.
OMAiFAYQNED.
OrthoDBiEOG7Q8CP4.
PhylomeDBiQ8BG15.
TreeFamiTF354278.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BG15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLRTRKASQ QSSPIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS
60 70 80 90 100
SIKKFIKGST PKEERENPSK RSRIERDIDN NLITSTPRTG EKPDKQLSRV
110 120 130 140 150
RRKSPVNGEA GSYEMTNQHI KQNGKLEDNP CSGSPPRTTL LGTIFSPVFN
160 170 180 190 200
FFSPANKNGT SGSDSPGQAV EAEEIVKQLD MEQVDEITTS TTSANGAAYS
210 220 230 240 250
NQAVQVRPSL NNGLEEAEET VTRDIPPLTA PVTPESGYSS AHAEATYEED
260 270 280 290 300
WEVFDPYYFI KHVPPLTEEQ LNRKPALPLK TRSTPEFSLV LDLDETLVHC
310 320 330 340 350
SLNELEDAAL TFPVLFQDVI YQVYVRLRPF FREFLERMSQ MYEIILFTAS
360 370 380 390 400
KKVYADKLLN ILDPKKQLVR HRLFREHCVC VQGNYIKDLN ILGRDLSKTI
410 420 430 440 450
IIDNSPQAFA YQLSNGIPIE SWFMDKNDNE LLKLIPFLEK LVELNEDVRP
460
HIRDRFRLHD LLPPD
Length:465
Mass (Da):52,813
Last modified:March 1, 2003 - v1
Checksum:iD3498BFA68B2DE15
GO
Isoform 2 (identifier: Q8BG15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):52,684
Checksum:iE794680F52A34DFE
GO
Isoform 3 (identifier: Q8BG15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-465: VYVRLRPFFR...FRLHDLLPPD → QVEARNTDTDPQEQLATLRQGFCLYFSP

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):38,926
Checksum:i40AD95596293B454
GO
Isoform 4 (identifier: Q8BG15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-158: Missing.
     324-465: YVRLRPFFRE...FRLHDLLPPD → ILSLIFKPLGNILSEENFFCDVQCVFL

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,431
Checksum:iEBACA0173A39DAB3
GO
Isoform 5 (identifier: Q8BG15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-465: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,073
Checksum:i2743834BA5C6D0DF
GO
Isoform 6 (identifier: Q8BG15-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-229: Missing.

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):45,382
Checksum:i01503C03A6165984
GO

Sequence cautioni

The sequence BAC25842.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041S → N in AAH52660 (PubMed:15489334).Curated
Sequence conflicti187 – 1871I → V in BAE37265 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 15850Missing in isoform 4. 1 PublicationVSP_033219Add
BLAST
Alternative sequencei109 – 1091Missing in isoform 2. 1 PublicationVSP_033220
Alternative sequencei159 – 22971Missing in isoform 6. CuratedVSP_033221Add
BLAST
Alternative sequencei257 – 465209Missing in isoform 5. 1 PublicationVSP_033222Add
BLAST
Alternative sequencei323 – 465143VYVRL…LLPPD → QVEARNTDTDPQEQLATLRQ GFCLYFSP in isoform 3. 1 PublicationVSP_033223Add
BLAST
Alternative sequencei324 – 465142YVRLR…LLPPD → ILSLIFKPLGNILSEENFFC DVQCVFL in isoform 4. 1 PublicationVSP_033224Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028251 mRNA. Translation: BAC25842.1. Different initiation.
AK030085 mRNA. Translation: BAC26775.1.
AK033382 mRNA. Translation: BAC28257.1.
AK041422 mRNA. Translation: BAC30939.1.
AK049463 mRNA. Translation: BAC33759.1.
AK053513 mRNA. Translation: BAC35412.1.
AK082646 mRNA. Translation: BAC38557.1.
AK160431 mRNA. Translation: BAE35784.1.
AK163262 mRNA. Translation: BAE37265.1.
AK169248 mRNA. Translation: BAE41012.1.
AL845457 Genomic DNA. Translation: CAM21777.1.
AL845457 Genomic DNA. Translation: CAM21778.1.
AL845457 Genomic DNA. Translation: CAM21779.1.
BC052660 mRNA. Translation: AAH52660.1.
CCDSiCCDS16652.1. [Q8BG15-1]
CCDS71130.1. [Q8BG15-2]
RefSeqiNP_001277920.1. NM_001290991.1. [Q8BG15-2]
NP_001277921.1. NM_001290992.1.
NP_997615.1. NM_212450.4. [Q8BG15-1]
UniGeneiMm.249405.
Mm.404014.

Genome annotation databases

EnsembliENSMUST00000036647; ENSMUSP00000047543; ENSMUSG00000033411. [Q8BG15-1]
ENSMUST00000110572; ENSMUSP00000106201; ENSMUSG00000033411. [Q8BG15-6]
ENSMUST00000110574; ENSMUSP00000106203; ENSMUSG00000033411. [Q8BG15-1]
ENSMUST00000110578; ENSMUSP00000106207; ENSMUSG00000033411. [Q8BG15-2]
GeneIDi329506.
KEGGimmu:329506.
UCSCiuc008lzw.2. mouse. [Q8BG15-1]
uc008lzx.2. mouse. [Q8BG15-4]
uc008maa.2. mouse. [Q8BG15-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028251 mRNA. Translation: BAC25842.1. Different initiation.
AK030085 mRNA. Translation: BAC26775.1.
AK033382 mRNA. Translation: BAC28257.1.
AK041422 mRNA. Translation: BAC30939.1.
AK049463 mRNA. Translation: BAC33759.1.
AK053513 mRNA. Translation: BAC35412.1.
AK082646 mRNA. Translation: BAC38557.1.
AK160431 mRNA. Translation: BAE35784.1.
AK163262 mRNA. Translation: BAE37265.1.
AK169248 mRNA. Translation: BAE41012.1.
AL845457 Genomic DNA. Translation: CAM21777.1.
AL845457 Genomic DNA. Translation: CAM21778.1.
AL845457 Genomic DNA. Translation: CAM21779.1.
BC052660 mRNA. Translation: AAH52660.1.
CCDSiCCDS16652.1. [Q8BG15-1]
CCDS71130.1. [Q8BG15-2]
RefSeqiNP_001277920.1. NM_001290991.1. [Q8BG15-2]
NP_001277921.1. NM_001290992.1.
NP_997615.1. NM_212450.4. [Q8BG15-1]
UniGeneiMm.249405.
Mm.404014.

3D structure databases

ProteinModelPortaliQ8BG15.
SMRiQ8BG15. Positions 289-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047543.

PTM databases

iPTMnetiQ8BG15.
PhosphoSiteiQ8BG15.

Proteomic databases

EPDiQ8BG15.
MaxQBiQ8BG15.
PaxDbiQ8BG15.
PeptideAtlasiQ8BG15.
PRIDEiQ8BG15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036647; ENSMUSP00000047543; ENSMUSG00000033411. [Q8BG15-1]
ENSMUST00000110572; ENSMUSP00000106201; ENSMUSG00000033411. [Q8BG15-6]
ENSMUST00000110574; ENSMUSP00000106203; ENSMUSG00000033411. [Q8BG15-1]
ENSMUST00000110578; ENSMUSP00000106207; ENSMUSG00000033411. [Q8BG15-2]
GeneIDi329506.
KEGGimmu:329506.
UCSCiuc008lzw.2. mouse. [Q8BG15-1]
uc008lzx.2. mouse. [Q8BG15-4]
uc008maa.2. mouse. [Q8BG15-2]

Organism-specific databases

CTDi51496.
MGIiMGI:1196405. Ctdspl2.

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000017194.
HOVERGENiHBG107781.
InParanoidiQ8BG15.
KOiK17616.
OMAiFAYQNED.
OrthoDBiEOG7Q8CP4.
PhylomeDBiQ8BG15.
TreeFamiTF354278.

Miscellaneous databases

PROiQ8BG15.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BG15.
GenevisibleiQ8BG15. MM.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Egg, Eye, Head, Kidney, Lung, Testis and Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Egg.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiCTSL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BG15
Secondary accession number(s): A2ARL6
, Q3TF86, Q3TQW7, Q3TV36, Q7TPZ9, Q8BPR3, Q8C9S0, Q8CEG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.