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Protein

CTD small phosphatase-like protein 2

Gene

Ctdspl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable phosphatase.By similarity

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: MGI

GO - Biological processi

  • negative regulation of BMP signaling pathway Source: MGI
  • positive regulation of protein export from nucleus Source: MGI
  • protein dephosphorylation Source: MGI

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
CTD small phosphatase-like protein 2 (EC:3.1.3.-)
Short name:
CTDSP-like 2
Gene namesi
Name:Ctdspl2
Synonyms:D2Ertd485e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1196405 Ctdspl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314651 – 465CTD small phosphatase-like protein 2Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26N6-acetyllysineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1
Modified residuei85PhosphoserineBy similarity1
Modified residuei86PhosphothreonineBy similarity1
Modified residuei104PhosphoserineCombined sources1
Modified residuei134PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8BG15
PeptideAtlasiQ8BG15
PRIDEiQ8BG15

PTM databases

iPTMnetiQ8BG15
PhosphoSitePlusiQ8BG15

Expressioni

Gene expression databases

BgeeiENSMUSG00000033411
GenevisibleiQ8BG15 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047543

Structurei

3D structure databases

ProteinModelPortaliQ8BG15
SMRiQ8BG15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini282 – 441FCP1 homologyPROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Belongs to the CTDSPL2 family.Curated

Phylogenomic databases

eggNOGiKOG1605 Eukaryota
COG5190 LUCA
GeneTreeiENSGT00910000144223
HOVERGENiHBG107781
InParanoidiQ8BG15
KOiK17616
OMAiYTSQAVQ
OrthoDBiEOG091G0GO9
PhylomeDBiQ8BG15
TreeFamiTF354278

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BG15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLRTRKASQ QSSPIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS
60 70 80 90 100
SIKKFIKGST PKEERENPSK RSRIERDIDN NLITSTPRTG EKPDKQLSRV
110 120 130 140 150
RRKSPVNGEA GSYEMTNQHI KQNGKLEDNP CSGSPPRTTL LGTIFSPVFN
160 170 180 190 200
FFSPANKNGT SGSDSPGQAV EAEEIVKQLD MEQVDEITTS TTSANGAAYS
210 220 230 240 250
NQAVQVRPSL NNGLEEAEET VTRDIPPLTA PVTPESGYSS AHAEATYEED
260 270 280 290 300
WEVFDPYYFI KHVPPLTEEQ LNRKPALPLK TRSTPEFSLV LDLDETLVHC
310 320 330 340 350
SLNELEDAAL TFPVLFQDVI YQVYVRLRPF FREFLERMSQ MYEIILFTAS
360 370 380 390 400
KKVYADKLLN ILDPKKQLVR HRLFREHCVC VQGNYIKDLN ILGRDLSKTI
410 420 430 440 450
IIDNSPQAFA YQLSNGIPIE SWFMDKNDNE LLKLIPFLEK LVELNEDVRP
460
HIRDRFRLHD LLPPD
Length:465
Mass (Da):52,813
Last modified:March 1, 2003 - v1
Checksum:iD3498BFA68B2DE15
GO
Isoform 2 (identifier: Q8BG15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):52,684
Checksum:iE794680F52A34DFE
GO
Isoform 3 (identifier: Q8BG15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-465: VYVRLRPFFR...FRLHDLLPPD → QVEARNTDTDPQEQLATLRQGFCLYFSP

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):38,926
Checksum:i40AD95596293B454
GO
Isoform 4 (identifier: Q8BG15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-158: Missing.
     324-465: YVRLRPFFRE...FRLHDLLPPD → ILSLIFKPLGNILSEENFFCDVQCVFL

Note: No experimental confirmation available.
Show »
Length:300
Mass (Da):33,431
Checksum:iEBACA0173A39DAB3
GO
Isoform 5 (identifier: Q8BG15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-465: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,073
Checksum:i2743834BA5C6D0DF
GO
Isoform 6 (identifier: Q8BG15-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-229: Missing.

Note: No experimental confirmation available.
Show »
Length:394
Mass (Da):45,382
Checksum:i01503C03A6165984
GO

Sequence cautioni

The sequence BAC25842 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104S → N in AAH52660 (PubMed:15489334).Curated1
Sequence conflicti187I → V in BAE37265 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033219109 – 158Missing in isoform 4. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_033220109Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_033221159 – 229Missing in isoform 6. CuratedAdd BLAST71
Alternative sequenceiVSP_033222257 – 465Missing in isoform 5. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_033223323 – 465VYVRL…LLPPD → QVEARNTDTDPQEQLATLRQ GFCLYFSP in isoform 3. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_033224324 – 465YVRLR…LLPPD → ILSLIFKPLGNILSEENFFC DVQCVFL in isoform 4. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028251 mRNA Translation: BAC25842.1 Different initiation.
AK030085 mRNA Translation: BAC26775.1
AK033382 mRNA Translation: BAC28257.1
AK041422 mRNA Translation: BAC30939.1
AK049463 mRNA Translation: BAC33759.1
AK053513 mRNA Translation: BAC35412.1
AK082646 mRNA Translation: BAC38557.1
AK160431 mRNA Translation: BAE35784.1
AK163262 mRNA Translation: BAE37265.1
AK169248 mRNA Translation: BAE41012.1
AL845457 Genomic DNA No translation available.
BC052660 mRNA Translation: AAH52660.1
CCDSiCCDS16652.1 [Q8BG15-1]
CCDS71130.1 [Q8BG15-2]
RefSeqiNP_001277920.1, NM_001290991.1 [Q8BG15-2]
NP_001277921.1, NM_001290992.1
NP_997615.1, NM_212450.4 [Q8BG15-1]
UniGeneiMm.249405
Mm.404014

Genome annotation databases

EnsembliENSMUST00000036647; ENSMUSP00000047543; ENSMUSG00000033411 [Q8BG15-1]
ENSMUST00000110572; ENSMUSP00000106201; ENSMUSG00000033411 [Q8BG15-6]
ENSMUST00000110574; ENSMUSP00000106203; ENSMUSG00000033411 [Q8BG15-1]
ENSMUST00000110578; ENSMUSP00000106207; ENSMUSG00000033411 [Q8BG15-2]
GeneIDi329506
KEGGimmu:329506
UCSCiuc008lzw.2 mouse [Q8BG15-1]
uc008lzx.2 mouse [Q8BG15-4]
uc008maa.2 mouse [Q8BG15-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCTSL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BG15
Secondary accession number(s): A2ARL6
, Q3TF86, Q3TQW7, Q3TV36, Q7TPZ9, Q8BPR3, Q8C9S0, Q8CEG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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