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Reviewed, UniProtKB/Swiss-Prot Q8BG02 (2ABG_MOUSE)

Last modified February 9, 2010. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Alternative name(s):
    PP2A subunit B isoform gamma
    PP2A subunit B isoform B55-gamma
    PP2A subunit B isoform PR55-gamma
    PP2A subunit B isoform R2-gamma
Gene names
Name: Ppp2r2c
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules By similarity.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 7 WD repeats.

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Ontologies

Keywords
   DomainRepeat
WD repeat
Gene Ontology (GO)
   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentprotein phosphatase type 2A complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein phosphatase type 2A regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
PRO_0000071430

Regions

Repeat22 – 6140WD 1
Repeat87 – 12842WD 2
Repeat171 – 20939WD 3
Repeat220 – 26041WD 4
Repeat279 – 31739WD 5
Repeat334 – 37542WD 6
Repeat410 – 44637WD 7

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Sequences

Sequence LengthMass (Da)Tools
Q8BG02-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D94D0156CB4A3035

FASTA44751,462
        10         20         30         40         50         60 
MGEDTDTRKI NHSFLRDHSY VTEADVISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 

        70         80         90        100        110        120 
PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 

       130        140        150        160        170        180 
TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRTFAN GHTYHINSIS 

       190        200        210        220        230        240 
VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY 

       250        260        270        280        290        300 
SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 

       310        320        330        340        350        360 
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYESDCIFD KFECAWNGSD SVIMTGAYNN 

       370        380        390        400        410        420 
FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW 

       430        440 
HPAENIIAIA ATNNLYIFQD KVNSDMH

« Hide

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References

« Hide 'large scale' references
[1]"Cloning of mouse protein phosphatase 2 (formerly 2A), regulatory subunit B."
Zhou G., Huang X., Yu L.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus and Medulla oblongata.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY348866 mRNA. Translation: AAQ55226.1.
AK032023 mRNA. Translation: BAC27654.1.
AK049830 mRNA. Translation: BAC33942.1.
BC059811 mRNA. Translation: AAH59811.1.
IPIIPI00221411.
RefSeqNP_766582.1.
UniGeneMm.41694

3D structure databases

SMRQ8BG02. Positions 24-369, 75-439.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8BG02.

PTM databases

PhosphoSiteQ8BG02.

Proteomic databases

PRIDEQ8BG02.

Genome annotation databases

EnsemblENSMUST00000031003; ENSMUSP00000031003; ENSMUSG00000029120; Mus musculus. [Genome view]
GeneID269643.
KEGGmmu:269643.
UCSCuc008xfe.1. mouse.

Organism-specific databases

CTD269643.
MGIMGI:2442660. Ppp2r2c.

Phylogenomic databases

eggNOGroNOG04944.
HOGENOMHBG443924.
HOVERGENQ8BG02.
InParanoidQ8BG02.
OMALPIQEGQ.
OrthoDBEOG9Q87GQ.
PhylomeDBQ8BG02.

Gene expression databases

ArrayExpressQ8BG02.
BgeeQ8BG02.
GenevestigatorQ8BG02.
GermOnlineENSMUSG00000029120. Mus musculus.

Family and domain databases

InterProIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019781. WD40_repeat_sg.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PANTHERPTHR11871. Pp2A_PR55. 1 hit.
PfamPF00400. WD40. 1 hit.
[Graphical view]
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 6 hits.
[Graphical view]
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
PS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio392963.
SOURCESearch...

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Entry information

Entry name2ABG_MOUSE
AccessionPrimary (citable) accession number: Q8BG02
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents