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Q8BFZ9

- ERLN2_MOUSE

UniProt

Q8BFZ9 - ERLN2_MOUSE

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Protein
Erlin-2
Gene
Erlin2, Spfh2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Erlin-2
Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Short name:
SPFH domain-containing protein 2
Gene namesi
Name:Erlin2
Synonyms:Spfh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2387215. Erlin2.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity
Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33Cytoplasmic Reviewed prediction
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Topological domaini25 – 340316Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
  4. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Erlin-2
PRO_0000002788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BFZ9.
PaxDbiQ8BFZ9.
PRIDEiQ8BFZ9.

PTM databases

PhosphoSiteiQ8BFZ9.

Expressioni

Gene expression databases

BgeeiQ8BFZ9.
CleanExiMM_ERLIN2.
GenevestigatoriQ8BFZ9.

Interactioni

Subunit structurei

Forms a heteromeric complex ERLIN1. In complex with ERLIN1, interacts with RNF170. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination By similarity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Psen1P497692EBI-1635049,EBI-990067

Protein-protein interaction databases

BioGridi232642. 3 interactions.
IntActiQ8BFZ9. 7 interactions.
MINTiMINT-1846748.
STRINGi10090.ENSMUSP00000033873.

Structurei

3D structure databases

ProteinModelPortaliQ8BFZ9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni177 – 309133Interaction with ERLIN1 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the band 7/mec-2 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307809.
GeneTreeiENSGT00390000014666.
HOGENOMiHOG000251613.
HOVERGENiHBG050934.
InParanoidiQ8BFZ9.
OMAiNMFVDSA.
OrthoDBiEOG7Z69D1.
PhylomeDBiQ8BFZ9.
TreeFamiTF313059.

Family and domain databases

InterProiIPR001107. Band_7.
[Graphical view]
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BFZ9-1 [UniParc]FASTAAdd to Basket

« Hide

MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH    50
LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPNAV 100
YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL 150
ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ 200
KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK KISEIEDAAF 250
LAREKAKADA ECYTALKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD 300
IPNMFMDSAG GLGKQFEGLS DDKLGFGLED EPLEAPTKEN 340
Length:340
Mass (Da):37,873
Last modified:March 1, 2003 - v1
Checksum:iDA76718E5DCB7664
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2811L → Q in BAC27019. 1 Publication
Sequence conflicti304 – 3041M → I in BAC27019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030557 mRNA. Translation: BAC27019.1.
BC036333 mRNA. Translation: AAH36333.1.
BC038374 mRNA. Translation: AAH38374.1.
CCDSiCCDS22209.1.
RefSeqiNP_705820.1. NM_153592.2.
XP_006509179.1. XM_006509116.1.
XP_006509180.1. XM_006509117.1.
UniGeneiMm.277699.

Genome annotation databases

EnsembliENSMUST00000033873; ENSMUSP00000033873; ENSMUSG00000031483.
GeneIDi244373.
KEGGimmu:244373.
UCSCiuc009lhr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK030557 mRNA. Translation: BAC27019.1 .
BC036333 mRNA. Translation: AAH36333.1 .
BC038374 mRNA. Translation: AAH38374.1 .
CCDSi CCDS22209.1.
RefSeqi NP_705820.1. NM_153592.2.
XP_006509179.1. XM_006509116.1.
XP_006509180.1. XM_006509117.1.
UniGenei Mm.277699.

3D structure databases

ProteinModelPortali Q8BFZ9.
ModBasei Search...

Protein-protein interaction databases

BioGridi 232642. 3 interactions.
IntActi Q8BFZ9. 7 interactions.
MINTi MINT-1846748.
STRINGi 10090.ENSMUSP00000033873.

PTM databases

PhosphoSitei Q8BFZ9.

Proteomic databases

MaxQBi Q8BFZ9.
PaxDbi Q8BFZ9.
PRIDEi Q8BFZ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033873 ; ENSMUSP00000033873 ; ENSMUSG00000031483 .
GeneIDi 244373.
KEGGi mmu:244373.
UCSCi uc009lhr.2. mouse.

Organism-specific databases

CTDi 11160.
MGIi MGI:2387215. Erlin2.

Phylogenomic databases

eggNOGi NOG307809.
GeneTreei ENSGT00390000014666.
HOGENOMi HOG000251613.
HOVERGENi HBG050934.
InParanoidi Q8BFZ9.
OMAi NMFVDSA.
OrthoDBi EOG7Z69D1.
PhylomeDBi Q8BFZ9.
TreeFami TF313059.

Miscellaneous databases

NextBioi 386244.
PROi Q8BFZ9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BFZ9.
CleanExi MM_ERLIN2.
Genevestigatori Q8BFZ9.

Family and domain databases

InterProi IPR001107. Band_7.
[Graphical view ]
Pfami PF01145. Band_7. 1 hit.
[Graphical view ]
SMARTi SM00244. PHB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. "SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells."
    Pearce M.M., Wang Y., Kelley G.G., Wojcikiewicz R.J.H.
    J. Biol. Chem. 282:20104-20115(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITPR1.
  4. "RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation."
    Lu J.P., Wang Y., Sliter D.A., Pearce M.M., Wojcikiewicz R.J.
    J. Biol. Chem. 286:24426-24433(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF170.

Entry informationi

Entry nameiERLN2_MOUSE
AccessioniPrimary (citable) accession number: Q8BFZ9
Secondary accession number(s): Q8BML8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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