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Protein

BTB/POZ domain-containing protein KCTD3

Gene

Kctd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD3
Gene namesi
Name:Kctd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2444629. Kctd3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478401 – 815BTB/POZ domain-containing protein KCTD3Add BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei605PhosphoserineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1
Modified residuei793PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BFX3.
PeptideAtlasiQ8BFX3.
PRIDEiQ8BFX3.

PTM databases

iPTMnetiQ8BFX3.
PhosphoSitePlusiQ8BFX3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026608.
ExpressionAtlasiQ8BFX3. baseline and differential.
GenevisibleiQ8BFX3. MM.

Interactioni

Protein-protein interaction databases

BioGridi230557. 1 interactor.
STRINGi10090.ENSMUSP00000082821.

Structurei

3D structure databases

ProteinModelPortaliQ8BFX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 87BTBPROSITE-ProRule annotationAdd BLAST70
Repeati225 – 272WD 1Add BLAST48
Repeati277 – 314WD 2Add BLAST38
Repeati316 – 351WD 3Add BLAST36
Repeati420 – 458WD 4Add BLAST39
Repeati538 – 578WD 5Add BLAST41

Sequence similaritiesi

Belongs to the KCTD3 family.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2714. Eukaryota.
ENOG410XSWI. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000006656.
HOVERGENiHBG061001.
InParanoidiQ8BFX3.
OMAiIILWSIQ.
OrthoDBiEOG091G0391.
PhylomeDBiQ8BFX3.
TreeFamiTF313754.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BFX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGHCGSFA ASAASSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG
60 70 80 90 100
RISTLRDETG AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY
110 120 130 140 150
GITPLVRRLL LCEELERSSC GSVLFHGYLP PPGIPSRKVT NTARSSVDAR
160 170 180 190 200
NGLNSMEGEA RGNGTQPVLA GNGEDTIRLG VPVDPRKVLI VAGHHNWIVA
210 220 230 240 250
AYAHFAVCYR IKESSGWQQV FTSPYLDWTI ERVALNAKVV GGPHGDKDKM
260 270 280 290 300
VAVASESSII LWSVQDGGSG SEIGVFSLGV PVDALFFIGN QLVATSHTGK
310 320 330 340 350
VGVWNAVTQH WQVQDVVPIT SYDTAGSFLL LGCNNGSIYY IDMQKFPLRM
360 370 380 390 400
KDNDLLVTEL YHDPSNDAVT ALSVYLTPKT SVSGNWIEIA YGTSSGAVRV
410 420 430 440 450
IVQHPETVGS GPQLFQTFTV HRSPVTKIML SEKHLVSVCA DNNHVRTWTV
460 470 480 490 500
TRFRGMISTQ PGSTPLASFK ILSLEETESH GSYSSGNDIG PFGERDDQQV
510 520 530 540 550
FIQKVVPITN KLFVRLSSTG KRICEIQAVD CTTISSFTVR ECEGSSRMGS
560 570 580 590 600
RPRRYLFTGH TNGSIQMWDL TTAMDMVNKT EDKDAGGPTE EELLKLLDQC
610 620 630 640 650
DLSTSRCATP NISPATSVLQ HSRLRESSSS LQLQHHETIH EAATYGATRP
660 670 680 690 700
YRESPLLARA RRTESFHSYR DFQTLNLNRS IERPVPENGH MGPAQTEVKG
710 720 730 740 750
AAGECAMSER RSPGTEVRCG RESDGGLEVH RTAEGLSEPK KRSAEDENEH
760 770 780 790 800
KVEFRKKGFE AGGFLGRKKV PYLASSPSTS DGGTDSPGTA SPSPTKTTPS
810
PRHKKSDSSG QEYSL
Length:815
Mass (Da):88,862
Last modified:March 1, 2003 - v1
Checksum:iE2A45B4169A6E40C
GO
Isoform 2 (identifier: Q8BFX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     382-403: VSGNWIEIAYGTSSGAVRVIVQ → QYTVSAETGLRSPMVRALEPCE
     404-815: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):43,681
Checksum:i11D3E28D9B606F7A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020070382 – 403VSGNW…RVIVQ → QYTVSAETGLRSPMVRALEP CE in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_020071404 – 815Missing in isoform 2. 1 PublicationAdd BLAST412

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049362 mRNA. Translation: BAC33709.1.
AK087865 mRNA. Translation: BAC40028.1.
BC061458 mRNA. Translation: AAH61458.1.
BC079581 mRNA. Translation: AAH79581.1.
CCDSiCCDS15608.1. [Q8BFX3-1]
RefSeqiNP_766238.1. NM_172650.2. [Q8BFX3-1]
UniGeneiMm.209880.
Mm.471891.

Genome annotation databases

EnsembliENSMUST00000085678; ENSMUSP00000082821; ENSMUSG00000026608. [Q8BFX3-1]
GeneIDi226823.
KEGGimmu:226823.
UCSCiuc007eai.1. mouse. [Q8BFX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049362 mRNA. Translation: BAC33709.1.
AK087865 mRNA. Translation: BAC40028.1.
BC061458 mRNA. Translation: AAH61458.1.
BC079581 mRNA. Translation: AAH79581.1.
CCDSiCCDS15608.1. [Q8BFX3-1]
RefSeqiNP_766238.1. NM_172650.2. [Q8BFX3-1]
UniGeneiMm.209880.
Mm.471891.

3D structure databases

ProteinModelPortaliQ8BFX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230557. 1 interactor.
STRINGi10090.ENSMUSP00000082821.

PTM databases

iPTMnetiQ8BFX3.
PhosphoSitePlusiQ8BFX3.

Proteomic databases

PaxDbiQ8BFX3.
PeptideAtlasiQ8BFX3.
PRIDEiQ8BFX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085678; ENSMUSP00000082821; ENSMUSG00000026608. [Q8BFX3-1]
GeneIDi226823.
KEGGimmu:226823.
UCSCiuc007eai.1. mouse. [Q8BFX3-1]

Organism-specific databases

CTDi51133.
MGIiMGI:2444629. Kctd3.

Phylogenomic databases

eggNOGiKOG2714. Eukaryota.
ENOG410XSWI. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000006656.
HOVERGENiHBG061001.
InParanoidiQ8BFX3.
OMAiIILWSIQ.
OrthoDBiEOG091G0391.
PhylomeDBiQ8BFX3.
TreeFamiTF313754.

Miscellaneous databases

ChiTaRSiKctd3. mouse.
PROiQ8BFX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026608.
ExpressionAtlasiQ8BFX3. baseline and differential.
GenevisibleiQ8BFX3. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD3_MOUSE
AccessioniPrimary (citable) accession number: Q8BFX3
Secondary accession number(s): Q6P7X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.