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Q8BFW9

- GTR12_MOUSE

UniProt

Q8BFW9 - GTR12_MOUSE

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Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene

Slc2a12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.By similarity

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. glucose transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_206357. Facilitative Na+-independent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 12
Alternative name(s):
Glucose transporter type 12
Short name:
GLUT-12
Gene namesi
Name:Slc2a12
Synonyms:Glut12, Glut8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:3052471. Slc2a12.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Solute carrier family 2, facilitated glucose transporter member 12PRO_0000292016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BFW9.

PTM databases

PhosphoSiteiQ8BFW9.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, brain, kidney, spleen, adipose tissues and to a lesser extend in small intestine and lung.1 Publication

Developmental stagei

Expression is clearly detected in ovulated oocytes and 2-cells embryos but decline day 3 morulae. Remains at very low levels betwen E2 and E11.1 Publication

Gene expression databases

BgeeiQ8BFW9.
ExpressionAtlasiQ8BFW9. baseline and differential.
GenevestigatoriQ8BFW9.

Structurei

3D structure databases

ProteinModelPortaliQ8BFW9.
SMRiQ8BFW9. Positions 44-565.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini66 – 8419ExtracellularSequence AnalysisAdd
BLAST
Topological domaini106 – 1116CytoplasmicSequence Analysis
Topological domaini133 – 1419ExtracellularSequence Analysis
Topological domaini163 – 1686CytoplasmicSequence Analysis
Topological domaini190 – 20112ExtracellularSequence AnalysisAdd
BLAST
Topological domaini223 – 28260CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini304 – 32118ExtracellularSequence AnalysisAdd
BLAST
Topological domaini343 – 3497CytoplasmicSequence Analysis
Topological domaini371 – 471101ExtracellularSequence AnalysisAdd
BLAST
Topological domaini493 – 50311CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini525 – 5339ExtracellularSequence Analysis
Topological domaini555 – 62268CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence AnalysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Transmembranei472 – 49221HelicalSequence AnalysisAdd
BLAST
Transmembranei504 – 52421HelicalSequence AnalysisAdd
BLAST
Transmembranei534 – 55421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ8BFW9.
KOiK08149.
OMAiANISNGW.
OrthoDBiEOG75B852.
PhylomeDBiQ8BFW9.
TreeFamiTF332408.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BFW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPVENTEGP NLLNQKGREA ETEGSCGASG GGHPACAGGP SMFTFLTSVT
60 70 80 90 100
AAISGLLVGY ELGLISGALL QIRTLLALTC HEQEMVVSSL LIGAFLASLT
110 120 130 140 150
GGVLIDRYGR RLAIILSSCL LGLGSLVLIM SLSYTLLIMG RVAIGVSISL
160 170 180 190 200
SSIATCVYIA EIAPQHRRGL LVSLNELMIV TGILFAYISN YAFANISNGW
210 220 230 240 250
KYMFGLVIPL GVLQAIAMYF LPPSPRFLVM KGQEESAGKV LRKLRVISDT
260 270 280 290 300
TEELTLIKSS LKDEYQYSFW DLFRSKDNMR TRILIGLTLV FFVQTTGQPN
310 320 330 340 350
ILFYASTVLK SVGFQSNEAA SLASTGVGVV KVVSTIPATL LVDHIGSKTF
360 370 380 390 400
LCIGSSVMSA SLLTMGIVNL NINMNFTNIC RSHSLLNQSL EEFVFYATGN
410 420 430 440 450
LSISNSSLRE HFKRITPYSK GSFMPMGNGM EPKGEMTFTS SLPNAGLSRT
460 470 480 490 500
EHQGVTDTAV VPAAYKWLSL ASLLVYVAAF SIGLGPMPWL VLSEIFPGGI
510 520 530 540 550
RGRAMALTSS MNWGVNLLIS LTFLTVTDLI GLSWVCFIYT IMSLASLAFV
560 570 580 590 600
VLFIPETKGC SLEQISVELA KANYVKNNIC FMSHHQEELV PTQLQKRKPQ
610 620
EQLPECNHLC GRGQSQRPSP DT
Length:622
Mass (Da):67,336
Last modified:March 1, 2003 - v1
Checksum:iE308C83C3EA8267D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591I → L in BAE25329. (PubMed:16141072)Curated
Sequence conflicti160 – 1601A → S in AAI16316. (PubMed:15489334)Curated
Sequence conflicti290 – 2901V → I in BAC29262. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ549317 mRNA. Translation: CAD70577.1.
AY230881 mRNA. Translation: AAP45844.1.
AK028970 mRNA. Translation: BAC26220.1.
AK031659 mRNA. Translation: BAC27497.1.
AK035972 mRNA. Translation: BAC29262.1.
AK143263 mRNA. Translation: BAE25329.1.
BC096454 mRNA. Translation: AAH96454.1.
BC116314 mRNA. Translation: AAI16315.1.
BC116315 mRNA. Translation: AAI16316.1.
CCDSiCCDS23729.1.
RefSeqiNP_849265.2. NM_178934.4.
UniGeneiMm.473705.

Genome annotation databases

EnsembliENSMUST00000042261; ENSMUSP00000043962; ENSMUSG00000037490.
GeneIDi353169.
KEGGimmu:353169.
UCSCiuc007epo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ549317 mRNA. Translation: CAD70577.1 .
AY230881 mRNA. Translation: AAP45844.1 .
AK028970 mRNA. Translation: BAC26220.1 .
AK031659 mRNA. Translation: BAC27497.1 .
AK035972 mRNA. Translation: BAC29262.1 .
AK143263 mRNA. Translation: BAE25329.1 .
BC096454 mRNA. Translation: AAH96454.1 .
BC116314 mRNA. Translation: AAI16315.1 .
BC116315 mRNA. Translation: AAI16316.1 .
CCDSi CCDS23729.1.
RefSeqi NP_849265.2. NM_178934.4.
UniGenei Mm.473705.

3D structure databases

ProteinModelPortali Q8BFW9.
SMRi Q8BFW9. Positions 44-565.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BFW9.

Proteomic databases

PRIDEi Q8BFW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042261 ; ENSMUSP00000043962 ; ENSMUSG00000037490 .
GeneIDi 353169.
KEGGi mmu:353169.
UCSCi uc007epo.2. mouse.

Organism-specific databases

CTDi 154091.
MGIi MGI:3052471. Slc2a12.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00590000083062.
HOGENOMi HOG000202868.
HOVERGENi HBG051858.
InParanoidi Q8BFW9.
KOi K08149.
OMAi ANISNGW.
OrthoDBi EOG75B852.
PhylomeDBi Q8BFW9.
TreeFami TF332408.

Enzyme and pathway databases

Reactomei REACT_206357. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

NextBioi 400315.
PROi Q8BFW9.
SOURCEi Search...

Gene expression databases

Bgeei Q8BFW9.
ExpressionAtlasi Q8BFW9. baseline and differential.
Genevestigatori Q8BFW9.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 2 hits.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues."
    Wood I.S., Hunter L., Trayhurn P.
    Biochem. Biophys. Res. Commun. 308:43-49(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: CD-1.
    Tissue: White adipose tissue.
  2. "Identification of the facilitative glucose transporter 12 gene Glut12 in mouse preimplantation embryos."
    Zhou Y., Kaye P.L., Pantaleon M.
    Gene Expr. Patterns 4:621-631(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Oviduct, Skin and Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiGTR12_MOUSE
AccessioniPrimary (citable) accession number: Q8BFW9
Secondary accession number(s): Q14B60, Q3UPR6, Q8BZB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3