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Q8BFW9

- GTR12_MOUSE

UniProt

Q8BFW9 - GTR12_MOUSE

Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene

Slc2a12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Facilitative glucose transporter.By similarity

    GO - Molecular functioni

    1. substrate-specific transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. glucose transport Source: MGI

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_206357. Facilitative Na+-independent glucose transporters.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 12
    Alternative name(s):
    Glucose transporter type 12
    Short name:
    GLUT-12
    Gene namesi
    Name:Slc2a12
    Synonyms:Glut12, Glut8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:3052471. Slc2a12.

    Subcellular locationi

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Solute carrier family 2, facilitated glucose transporter member 12PRO_0000292016Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi400 – 4001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8BFW9.

    PTM databases

    PhosphoSiteiQ8BFW9.

    Expressioni

    Tissue specificityi

    Expressed in skeletal muscle, heart, brain, kidney, spleen, adipose tissues and to a lesser extend in small intestine and lung.1 Publication

    Developmental stagei

    Expression is clearly detected in ovulated oocytes and 2-cells embryos but decline day 3 morulae. Remains at very low levels betwen E2 and E11.1 Publication

    Gene expression databases

    ArrayExpressiQ8BFW9.
    BgeeiQ8BFW9.
    GenevestigatoriQ8BFW9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BFW9.
    SMRiQ8BFW9. Positions 63-368, 458-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini66 – 8419ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini106 – 1116CytoplasmicSequence Analysis
    Topological domaini133 – 1419ExtracellularSequence Analysis
    Topological domaini163 – 1686CytoplasmicSequence Analysis
    Topological domaini190 – 20112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 28260CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini304 – 32118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini343 – 3497CytoplasmicSequence Analysis
    Topological domaini371 – 471101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini493 – 50311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini525 – 5339ExtracellularSequence Analysis
    Topological domaini555 – 62268CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei504 – 52421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei534 – 55421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00590000083062.
    HOGENOMiHOG000202868.
    HOVERGENiHBG051858.
    InParanoidiQ8BFW9.
    KOiK08149.
    OMAiANISNGW.
    OrthoDBiEOG75B852.
    PhylomeDBiQ8BFW9.
    TreeFamiTF332408.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 2 hits.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BFW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPVENTEGP NLLNQKGREA ETEGSCGASG GGHPACAGGP SMFTFLTSVT    50
    AAISGLLVGY ELGLISGALL QIRTLLALTC HEQEMVVSSL LIGAFLASLT 100
    GGVLIDRYGR RLAIILSSCL LGLGSLVLIM SLSYTLLIMG RVAIGVSISL 150
    SSIATCVYIA EIAPQHRRGL LVSLNELMIV TGILFAYISN YAFANISNGW 200
    KYMFGLVIPL GVLQAIAMYF LPPSPRFLVM KGQEESAGKV LRKLRVISDT 250
    TEELTLIKSS LKDEYQYSFW DLFRSKDNMR TRILIGLTLV FFVQTTGQPN 300
    ILFYASTVLK SVGFQSNEAA SLASTGVGVV KVVSTIPATL LVDHIGSKTF 350
    LCIGSSVMSA SLLTMGIVNL NINMNFTNIC RSHSLLNQSL EEFVFYATGN 400
    LSISNSSLRE HFKRITPYSK GSFMPMGNGM EPKGEMTFTS SLPNAGLSRT 450
    EHQGVTDTAV VPAAYKWLSL ASLLVYVAAF SIGLGPMPWL VLSEIFPGGI 500
    RGRAMALTSS MNWGVNLLIS LTFLTVTDLI GLSWVCFIYT IMSLASLAFV 550
    VLFIPETKGC SLEQISVELA KANYVKNNIC FMSHHQEELV PTQLQKRKPQ 600
    EQLPECNHLC GRGQSQRPSP DT 622
    Length:622
    Mass (Da):67,336
    Last modified:March 1, 2003 - v1
    Checksum:iE308C83C3EA8267D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591I → L in BAE25329. (PubMed:16141072)Curated
    Sequence conflicti160 – 1601A → S in AAI16316. (PubMed:15489334)Curated
    Sequence conflicti290 – 2901V → I in BAC29262. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ549317 mRNA. Translation: CAD70577.1.
    AY230881 mRNA. Translation: AAP45844.1.
    AK028970 mRNA. Translation: BAC26220.1.
    AK031659 mRNA. Translation: BAC27497.1.
    AK035972 mRNA. Translation: BAC29262.1.
    AK143263 mRNA. Translation: BAE25329.1.
    BC096454 mRNA. Translation: AAH96454.1.
    BC116314 mRNA. Translation: AAI16315.1.
    BC116315 mRNA. Translation: AAI16316.1.
    CCDSiCCDS23729.1.
    RefSeqiNP_849265.2. NM_178934.4.
    UniGeneiMm.473705.

    Genome annotation databases

    EnsembliENSMUST00000042261; ENSMUSP00000043962; ENSMUSG00000037490.
    GeneIDi353169.
    KEGGimmu:353169.
    UCSCiuc007epo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ549317 mRNA. Translation: CAD70577.1 .
    AY230881 mRNA. Translation: AAP45844.1 .
    AK028970 mRNA. Translation: BAC26220.1 .
    AK031659 mRNA. Translation: BAC27497.1 .
    AK035972 mRNA. Translation: BAC29262.1 .
    AK143263 mRNA. Translation: BAE25329.1 .
    BC096454 mRNA. Translation: AAH96454.1 .
    BC116314 mRNA. Translation: AAI16315.1 .
    BC116315 mRNA. Translation: AAI16316.1 .
    CCDSi CCDS23729.1.
    RefSeqi NP_849265.2. NM_178934.4.
    UniGenei Mm.473705.

    3D structure databases

    ProteinModelPortali Q8BFW9.
    SMRi Q8BFW9. Positions 63-368, 458-565.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BFW9.

    Proteomic databases

    PRIDEi Q8BFW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042261 ; ENSMUSP00000043962 ; ENSMUSG00000037490 .
    GeneIDi 353169.
    KEGGi mmu:353169.
    UCSCi uc007epo.2. mouse.

    Organism-specific databases

    CTDi 154091.
    MGIi MGI:3052471. Slc2a12.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00590000083062.
    HOGENOMi HOG000202868.
    HOVERGENi HBG051858.
    InParanoidi Q8BFW9.
    KOi K08149.
    OMAi ANISNGW.
    OrthoDBi EOG75B852.
    PhylomeDBi Q8BFW9.
    TreeFami TF332408.

    Enzyme and pathway databases

    Reactomei REACT_206357. Facilitative Na+-independent glucose transporters.

    Miscellaneous databases

    NextBioi 400315.
    PROi Q8BFW9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BFW9.
    Bgeei Q8BFW9.
    Genevestigatori Q8BFW9.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 2 hits.
    [Graphical view ]
    PRINTSi PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues."
      Wood I.S., Hunter L., Trayhurn P.
      Biochem. Biophys. Res. Commun. 308:43-49(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: CD-1.
      Tissue: White adipose tissue.
    2. "Identification of the facilitative glucose transporter 12 gene Glut12 in mouse preimplantation embryos."
      Zhou Y., Kaye P.L., Pantaleon M.
      Gene Expr. Patterns 4:621-631(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Oviduct, Skin and Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiGTR12_MOUSE
    AccessioniPrimary (citable) accession number: Q8BFW9
    Secondary accession number(s): Q14B60, Q3UPR6, Q8BZB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3