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Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene

Slc2a12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • glucose import Source: GO_Central
  • glucose transport Source: MGI
  • hexose transmembrane transport Source: GO_Central

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200. Cellular hexose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 12
Alternative name(s):
Glucose transporter type 12
Short name:
GLUT-12
Gene namesi
Name:Slc2a12
Synonyms:Glut12, Glut8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3052471. Slc2a12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 84ExtracellularSequence analysisAdd BLAST19
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 111CytoplasmicSequence analysis6
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 141ExtracellularSequence analysis9
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 168CytoplasmicSequence analysis6
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 201ExtracellularSequence analysisAdd BLAST12
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 282CytoplasmicSequence analysisAdd BLAST60
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 321ExtracellularSequence analysisAdd BLAST18
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 349CytoplasmicSequence analysis7
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 471ExtracellularSequence analysisAdd BLAST101
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 503CytoplasmicSequence analysisAdd BLAST11
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21
Topological domaini525 – 533ExtracellularSequence analysis9
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Topological domaini555 – 622CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920161 – 622Solute carrier family 2, facilitated glucose transporter member 12Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BFW9.
PaxDbiQ8BFW9.
PRIDEiQ8BFW9.

PTM databases

PhosphoSitePlusiQ8BFW9.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, brain, kidney, spleen, adipose tissues and to a lesser extent in small intestine and lung.1 Publication

Developmental stagei

Expression is clearly detected in ovulated oocytes and 2-cells embryos but decline day 3 morulae. Remains at very low levels between E2 and E11.1 Publication

Gene expression databases

BgeeiENSMUSG00000037490.
ExpressionAtlasiQ8BFW9. baseline and differential.
GenevisibleiQ8BFW9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043962.

Structurei

3D structure databases

ProteinModelPortaliQ8BFW9.
SMRiQ8BFW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00890000139365.
HOGENOMiHOG000202868.
HOVERGENiHBG051858.
InParanoidiQ8BFW9.
KOiK08149.
OMAiGSKTFLC.
OrthoDBiEOG091G085H.
PhylomeDBiQ8BFW9.
TreeFamiTF332408.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR036259. MFS_trans_sf.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 2 hits.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BFW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVENTEGP NLLNQKGREA ETEGSCGASG GGHPACAGGP SMFTFLTSVT
60 70 80 90 100
AAISGLLVGY ELGLISGALL QIRTLLALTC HEQEMVVSSL LIGAFLASLT
110 120 130 140 150
GGVLIDRYGR RLAIILSSCL LGLGSLVLIM SLSYTLLIMG RVAIGVSISL
160 170 180 190 200
SSIATCVYIA EIAPQHRRGL LVSLNELMIV TGILFAYISN YAFANISNGW
210 220 230 240 250
KYMFGLVIPL GVLQAIAMYF LPPSPRFLVM KGQEESAGKV LRKLRVISDT
260 270 280 290 300
TEELTLIKSS LKDEYQYSFW DLFRSKDNMR TRILIGLTLV FFVQTTGQPN
310 320 330 340 350
ILFYASTVLK SVGFQSNEAA SLASTGVGVV KVVSTIPATL LVDHIGSKTF
360 370 380 390 400
LCIGSSVMSA SLLTMGIVNL NINMNFTNIC RSHSLLNQSL EEFVFYATGN
410 420 430 440 450
LSISNSSLRE HFKRITPYSK GSFMPMGNGM EPKGEMTFTS SLPNAGLSRT
460 470 480 490 500
EHQGVTDTAV VPAAYKWLSL ASLLVYVAAF SIGLGPMPWL VLSEIFPGGI
510 520 530 540 550
RGRAMALTSS MNWGVNLLIS LTFLTVTDLI GLSWVCFIYT IMSLASLAFV
560 570 580 590 600
VLFIPETKGC SLEQISVELA KANYVKNNIC FMSHHQEELV PTQLQKRKPQ
610 620
EQLPECNHLC GRGQSQRPSP DT
Length:622
Mass (Da):67,336
Last modified:March 1, 2003 - v1
Checksum:iE308C83C3EA8267D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159I → L in BAE25329 (PubMed:16141072).Curated1
Sequence conflicti160A → S in AAI16316 (PubMed:15489334).Curated1
Sequence conflicti290V → I in BAC29262 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ549317 mRNA. Translation: CAD70577.1.
AY230881 mRNA. Translation: AAP45844.1.
AK028970 mRNA. Translation: BAC26220.1.
AK031659 mRNA. Translation: BAC27497.1.
AK035972 mRNA. Translation: BAC29262.1.
AK143263 mRNA. Translation: BAE25329.1.
BC096454 mRNA. Translation: AAH96454.1.
BC116314 mRNA. Translation: AAI16315.1.
BC116315 mRNA. Translation: AAI16316.1.
CCDSiCCDS23729.1.
RefSeqiNP_849265.2. NM_178934.4.
UniGeneiMm.473705.

Genome annotation databases

EnsembliENSMUST00000042261; ENSMUSP00000043962; ENSMUSG00000037490.
GeneIDi353169.
KEGGimmu:353169.
UCSCiuc007epo.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiGTR12_MOUSE
AccessioniPrimary (citable) accession number: Q8BFW9
Secondary accession number(s): Q14B60, Q3UPR6, Q8BZB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families