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Protein

Solute carrier family 2, facilitated glucose transporter member 12

Gene

Slc2a12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 12
Alternative name(s):
Glucose transporter type 12
Short name:
GLUT-12
Gene namesi
Name:Slc2a12
Synonyms:Glut12, Glut8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3052471 Slc2a12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 84ExtracellularSequence analysisAdd BLAST19
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 111CytoplasmicSequence analysis6
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 141ExtracellularSequence analysis9
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 168CytoplasmicSequence analysis6
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 201ExtracellularSequence analysisAdd BLAST12
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 282CytoplasmicSequence analysisAdd BLAST60
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 321ExtracellularSequence analysisAdd BLAST18
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 349CytoplasmicSequence analysis7
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 471ExtracellularSequence analysisAdd BLAST101
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 503CytoplasmicSequence analysisAdd BLAST11
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21
Topological domaini525 – 533ExtracellularSequence analysis9
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Topological domaini555 – 622CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920161 – 622Solute carrier family 2, facilitated glucose transporter member 12Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BFW9
PaxDbiQ8BFW9
PRIDEiQ8BFW9

PTM databases

PhosphoSitePlusiQ8BFW9

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, brain, kidney, spleen, adipose tissues and to a lesser extent in small intestine and lung.1 Publication

Developmental stagei

Expression is clearly detected in ovulated oocytes and 2-cells embryos but decline day 3 morulae. Remains at very low levels between E2 and E11.1 Publication

Gene expression databases

BgeeiENSMUSG00000037490
ExpressionAtlasiQ8BFW9 baseline and differential
GenevisibleiQ8BFW9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043962

Structurei

3D structure databases

ProteinModelPortaliQ8BFW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00910000144116
HOGENOMiHOG000202868
HOVERGENiHBG051858
InParanoidiQ8BFW9
KOiK08149
OMAiGSKTFLC
OrthoDBiEOG091G085H
PhylomeDBiQ8BFW9
TreeFamiTF332408

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BFW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVENTEGP NLLNQKGREA ETEGSCGASG GGHPACAGGP SMFTFLTSVT
60 70 80 90 100
AAISGLLVGY ELGLISGALL QIRTLLALTC HEQEMVVSSL LIGAFLASLT
110 120 130 140 150
GGVLIDRYGR RLAIILSSCL LGLGSLVLIM SLSYTLLIMG RVAIGVSISL
160 170 180 190 200
SSIATCVYIA EIAPQHRRGL LVSLNELMIV TGILFAYISN YAFANISNGW
210 220 230 240 250
KYMFGLVIPL GVLQAIAMYF LPPSPRFLVM KGQEESAGKV LRKLRVISDT
260 270 280 290 300
TEELTLIKSS LKDEYQYSFW DLFRSKDNMR TRILIGLTLV FFVQTTGQPN
310 320 330 340 350
ILFYASTVLK SVGFQSNEAA SLASTGVGVV KVVSTIPATL LVDHIGSKTF
360 370 380 390 400
LCIGSSVMSA SLLTMGIVNL NINMNFTNIC RSHSLLNQSL EEFVFYATGN
410 420 430 440 450
LSISNSSLRE HFKRITPYSK GSFMPMGNGM EPKGEMTFTS SLPNAGLSRT
460 470 480 490 500
EHQGVTDTAV VPAAYKWLSL ASLLVYVAAF SIGLGPMPWL VLSEIFPGGI
510 520 530 540 550
RGRAMALTSS MNWGVNLLIS LTFLTVTDLI GLSWVCFIYT IMSLASLAFV
560 570 580 590 600
VLFIPETKGC SLEQISVELA KANYVKNNIC FMSHHQEELV PTQLQKRKPQ
610 620
EQLPECNHLC GRGQSQRPSP DT
Length:622
Mass (Da):67,336
Last modified:March 1, 2003 - v1
Checksum:iE308C83C3EA8267D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159I → L in BAE25329 (PubMed:16141072).Curated1
Sequence conflicti160A → S in AAI16316 (PubMed:15489334).Curated1
Sequence conflicti290V → I in BAC29262 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ549317 mRNA Translation: CAD70577.1
AY230881 mRNA Translation: AAP45844.1
AK028970 mRNA Translation: BAC26220.1
AK031659 mRNA Translation: BAC27497.1
AK035972 mRNA Translation: BAC29262.1
AK143263 mRNA Translation: BAE25329.1
BC096454 mRNA Translation: AAH96454.1
BC116314 mRNA Translation: AAI16315.1
BC116315 mRNA Translation: AAI16316.1
CCDSiCCDS23729.1
RefSeqiNP_849265.2, NM_178934.4
UniGeneiMm.473705

Genome annotation databases

EnsembliENSMUST00000042261; ENSMUSP00000043962; ENSMUSG00000037490
GeneIDi353169
KEGGimmu:353169
UCSCiuc007epo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGTR12_MOUSE
AccessioniPrimary (citable) accession number: Q8BFW9
Secondary accession number(s): Q14B60, Q3UPR6, Q8BZB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health