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Protein

Putative P2Y purinoceptor 10

Gene

P2ry10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-417957 P2Y receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Putative P2Y purinoceptor 10
Short name:
P2Y10
Gene namesi
Name:P2ry10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1926076 P2ry10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 91ExtracellularSequence analysisAdd BLAST14
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 137CytoplasmicSequence analysisAdd BLAST25
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 182ExtracellularSequence analysisAdd BLAST24
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 233CytoplasmicSequence analysisAdd BLAST30
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 277ExtracellularSequence analysisAdd BLAST23
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 328CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3562168

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003038851 – 328Putative P2Y purinoceptor 10Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BFU7
PRIDEiQ8BFU7

PTM databases

iPTMnetiQ8BFU7
PhosphoSitePlusiQ8BFU7

Expressioni

Gene expression databases

BgeeiENSMUSG00000050921
CleanExiMM_P2RY10
ExpressionAtlasiQ8BFU7 baseline and differential
GenevisibleiQ8BFU7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061296

Structurei

3D structure databases

ProteinModelPortaliQ8BFU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMZ Eukaryota
ENOG410ZZCA LUCA
GeneTreeiENSGT00910000143980
HOGENOMiHOG000231258
HOVERGENiHBG099867
InParanoidiQ8BFU7
PhylomeDBiQ8BFU7
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027676 P2Y10_rcpt
PANTHERiPTHR24232:SF47 PTHR24232:SF47, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BFU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNSTSSAE SNCNATYLPF QYSLYATTYI FIFIPGLLAN SAALWVLCRF
60 70 80 90 100
ISKKNKAIIF MINLSVADLA HILSLPLRIY YYINRHWPFQ RALCLLCFYL
110 120 130 140 150
KYLNMYASIF FLTCISLQRC LFLLKPFRAR NWKRRYDVGI SAVIWIVVGT
160 170 180 190 200
ACLPFPILRN AGLANSTDSC FADLGYKQMD AVVLVTMVVI AELAGFVIPV
210 220 230 240 250
ITIACCTWKT TVSLKHPPIA FQGISERKKA LRMVFMCAAV FVICFTPYHI
260 270 280 290 300
NFIFYTMVKE SIITSCPTVK STLYFHPFSL CLASLCCLLD PILYYFMASE
310 320
FRDQLSRHGS SVTRSRLMSR ESGSSMVN
Length:328
Mass (Da):37,244
Last modified:March 1, 2003 - v1
Checksum:iEC1CE4CF9A97943E
GO

Sequence cautioni

The sequence CAM22200 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55N → Y in AAH53707 (PubMed:15489334).Curated1
Sequence conflicti170C → R in AAH53707 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041351 mRNA Translation: BAC30914.1
AK088234 mRNA Translation: BAC40227.1
AL928594 Genomic DNA Translation: CAM22201.1
AL928594 Genomic DNA Translation: CAM22200.1 Sequence problems.
BC053707 mRNA Translation: AAH53707.1
CCDSiCCDS30346.1
RefSeqiNP_766023.1, NM_172435.3
UniGeneiMm.74639

Genome annotation databases

EnsembliENSMUST00000053375; ENSMUSP00000061296; ENSMUSG00000050921
ENSMUST00000118666; ENSMUSP00000113507; ENSMUSG00000050921
GeneIDi78826
UCSCiuc009uby.1 mouse

Similar proteinsi

Entry informationi

Entry nameiP2Y10_MOUSE
AccessioniPrimary (citable) accession number: Q8BFU7
Secondary accession number(s): A2ASC0, Q7TMT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health