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Protein

Putative P2Y purinoceptor 10

Gene

P2ry10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative P2Y purinoceptor 10
Short name:
P2Y10
Gene namesi
Name:P2ry10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1926076. P2ry10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 91ExtracellularSequence analysisAdd BLAST14
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 137CytoplasmicSequence analysisAdd BLAST25
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 182ExtracellularSequence analysisAdd BLAST24
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 233CytoplasmicSequence analysisAdd BLAST30
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 277ExtracellularSequence analysisAdd BLAST23
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 328CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3562168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003038851 – 328Putative P2Y purinoceptor 10Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BFU7.
PRIDEiQ8BFU7.

PTM databases

iPTMnetiQ8BFU7.
PhosphoSitePlusiQ8BFU7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050921.
CleanExiMM_P2RY10.
ExpressionAtlasiQ8BFU7. baseline and differential.
GenevisibleiQ8BFU7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061296.

Structurei

3D structure databases

ProteinModelPortaliQ8BFU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMZ. Eukaryota.
ENOG410ZZCA. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ8BFU7.
KOiK04274.
PhylomeDBiQ8BFU7.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027676. P2Y10_rcpt.
[Graphical view]
PANTHERiPTHR24232:SF47. PTHR24232:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BFU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNSTSSAE SNCNATYLPF QYSLYATTYI FIFIPGLLAN SAALWVLCRF
60 70 80 90 100
ISKKNKAIIF MINLSVADLA HILSLPLRIY YYINRHWPFQ RALCLLCFYL
110 120 130 140 150
KYLNMYASIF FLTCISLQRC LFLLKPFRAR NWKRRYDVGI SAVIWIVVGT
160 170 180 190 200
ACLPFPILRN AGLANSTDSC FADLGYKQMD AVVLVTMVVI AELAGFVIPV
210 220 230 240 250
ITIACCTWKT TVSLKHPPIA FQGISERKKA LRMVFMCAAV FVICFTPYHI
260 270 280 290 300
NFIFYTMVKE SIITSCPTVK STLYFHPFSL CLASLCCLLD PILYYFMASE
310 320
FRDQLSRHGS SVTRSRLMSR ESGSSMVN
Length:328
Mass (Da):37,244
Last modified:March 1, 2003 - v1
Checksum:iEC1CE4CF9A97943E
GO

Sequence cautioni

The sequence CAM22200 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55N → Y in AAH53707 (PubMed:15489334).Curated1
Sequence conflicti170C → R in AAH53707 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041351 mRNA. Translation: BAC30914.1.
AK088234 mRNA. Translation: BAC40227.1.
AL928594 Genomic DNA. Translation: CAM22201.1.
AL928594 Genomic DNA. Translation: CAM22200.1. Sequence problems.
BC053707 mRNA. Translation: AAH53707.1.
CCDSiCCDS30346.1.
RefSeqiNP_766023.1. NM_172435.3.
UniGeneiMm.74639.

Genome annotation databases

EnsembliENSMUST00000053375; ENSMUSP00000061296; ENSMUSG00000050921.
ENSMUST00000118666; ENSMUSP00000113507; ENSMUSG00000050921.
GeneIDi78826.
KEGGimmu:78826.
UCSCiuc009uby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041351 mRNA. Translation: BAC30914.1.
AK088234 mRNA. Translation: BAC40227.1.
AL928594 Genomic DNA. Translation: CAM22201.1.
AL928594 Genomic DNA. Translation: CAM22200.1. Sequence problems.
BC053707 mRNA. Translation: AAH53707.1.
CCDSiCCDS30346.1.
RefSeqiNP_766023.1. NM_172435.3.
UniGeneiMm.74639.

3D structure databases

ProteinModelPortaliQ8BFU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061296.

Chemistry databases

ChEMBLiCHEMBL3562168.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8BFU7.
PhosphoSitePlusiQ8BFU7.

Proteomic databases

PaxDbiQ8BFU7.
PRIDEiQ8BFU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053375; ENSMUSP00000061296; ENSMUSG00000050921.
ENSMUST00000118666; ENSMUSP00000113507; ENSMUSG00000050921.
GeneIDi78826.
KEGGimmu:78826.
UCSCiuc009uby.1. mouse.

Organism-specific databases

CTDi27334.
MGIiMGI:1926076. P2ry10.

Phylogenomic databases

eggNOGiENOG410IHMZ. Eukaryota.
ENOG410ZZCA. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ8BFU7.
KOiK04274.
PhylomeDBiQ8BFU7.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-417957. P2Y receptors.

Miscellaneous databases

PROiQ8BFU7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050921.
CleanExiMM_P2RY10.
ExpressionAtlasiQ8BFU7. baseline and differential.
GenevisibleiQ8BFU7. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027676. P2Y10_rcpt.
[Graphical view]
PANTHERiPTHR24232:SF47. PTHR24232:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2Y10_MOUSE
AccessioniPrimary (citable) accession number: Q8BFU7
Secondary accession number(s): A2ASC0, Q7TMT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.