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Protein

Synaptic vesicle 2-related protein

Gene

Svop

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.82.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle 2-related protein
Short name:
SV2-related protein
Gene namesi
Name:Svop
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915916. Svop.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 122VesicularSequence analysisAdd BLAST14
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 156CytoplasmicSequence analysisAdd BLAST13
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 180VesicularSequence analysis3
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 209CytoplasmicSequence analysis8
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 238VesicularSequence analysis8
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 316CytoplasmicSequence analysisAdd BLAST57
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 373VesicularSequence analysisAdd BLAST36
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 401CytoplasmicSequence analysis7
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 424VesicularSequence analysis2
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 457CytoplasmicSequence analysisAdd BLAST12
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 489VesicularSequence analysisAdd BLAST11
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 548CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794531 – 548Synaptic vesicle 2-related proteinAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BFT9.
PaxDbiQ8BFT9.
PRIDEiQ8BFT9.

PTM databases

iPTMnetiQ8BFT9.
PhosphoSitePlusiQ8BFT9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042078.
CleanExiMM_SVOP.
ExpressionAtlasiQ8BFT9. baseline and differential.
GenevisibleiQ8BFT9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050730.

Structurei

3D structure databases

ProteinModelPortaliQ8BFT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
KOG0255. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ8BFT9.
OMAiKEDYMDL.
OrthoDBiEOG091G04VD.
PhylomeDBiQ8BFT9.
TreeFamiTF313465.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BFT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDIQIEG VRVGLEAIEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF IGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL LLLSAAPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK
410 420 430 440 450
KTMALCFIIF SLCSLLLFIC IGRNVLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AGVASCFLPI ETKGRALQES SHREWGQEMV GRGTNSAGVP RSDSGSQE
Length:548
Mass (Da):60,769
Last modified:March 1, 2003 - v1
Checksum:iED9779BD305DFB83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → F in AAH59878 (PubMed:15489334).Curated1
Sequence conflicti23A → T in BAC33150 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047764 mRNA. Translation: BAC33150.1.
AK053833 mRNA. Translation: BAC35546.1.
AK082744 mRNA. Translation: BAC38595.1.
BC059878 mRNA. Translation: AAH59878.1.
CCDSiCCDS39220.1.
RefSeqiNP_081081.1. NM_026805.1.
UniGeneiMm.63584.

Genome annotation databases

EnsembliENSMUST00000058472; ENSMUSP00000050730; ENSMUSG00000042078.
GeneIDi68666.
KEGGimmu:68666.
UCSCiuc008yzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047764 mRNA. Translation: BAC33150.1.
AK053833 mRNA. Translation: BAC35546.1.
AK082744 mRNA. Translation: BAC38595.1.
BC059878 mRNA. Translation: AAH59878.1.
CCDSiCCDS39220.1.
RefSeqiNP_081081.1. NM_026805.1.
UniGeneiMm.63584.

3D structure databases

ProteinModelPortaliQ8BFT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050730.

Protein family/group databases

TCDBi2.A.1.82.3. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8BFT9.
PhosphoSitePlusiQ8BFT9.

Proteomic databases

MaxQBiQ8BFT9.
PaxDbiQ8BFT9.
PRIDEiQ8BFT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058472; ENSMUSP00000050730; ENSMUSG00000042078.
GeneIDi68666.
KEGGimmu:68666.
UCSCiuc008yzb.1. mouse.

Organism-specific databases

CTDi55530.
MGIiMGI:1915916. Svop.

Phylogenomic databases

eggNOGiKOG0253. Eukaryota.
KOG0255. Eukaryota.
ENOG410ZVDQ. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ8BFT9.
OMAiKEDYMDL.
OrthoDBiEOG091G04VD.
PhylomeDBiQ8BFT9.
TreeFamiTF313465.

Miscellaneous databases

PROiQ8BFT9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042078.
CleanExiMM_SVOP.
ExpressionAtlasiQ8BFT9. baseline and differential.
GenevisibleiQ8BFT9. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSVOP_MOUSE
AccessioniPrimary (citable) accession number: Q8BFT9
Secondary accession number(s): Q6PB56, Q8BKY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.