Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptic vesicle 2-related protein

Gene

Svop

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.1.82.3 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle 2-related protein
Short name:
SV2-related protein
Gene namesi
Name:Svop
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915916 Svop

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 122VesicularSequence analysisAdd BLAST14
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 156CytoplasmicSequence analysisAdd BLAST13
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 180VesicularSequence analysis3
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 209CytoplasmicSequence analysis8
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 238VesicularSequence analysis8
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 316CytoplasmicSequence analysisAdd BLAST57
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 373VesicularSequence analysisAdd BLAST36
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 401CytoplasmicSequence analysis7
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 424VesicularSequence analysis2
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 457CytoplasmicSequence analysisAdd BLAST12
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 489VesicularSequence analysisAdd BLAST11
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 548CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794531 – 548Synaptic vesicle 2-related proteinAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BFT9
PaxDbiQ8BFT9
PRIDEiQ8BFT9

PTM databases

iPTMnetiQ8BFT9
PhosphoSitePlusiQ8BFT9
SwissPalmiQ8BFT9

Expressioni

Gene expression databases

BgeeiENSMUSG00000042078
CleanExiMM_SVOP
ExpressionAtlasiQ8BFT9 baseline and differential
GenevisibleiQ8BFT9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050730

Structurei

3D structure databases

ProteinModelPortaliQ8BFT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0253 Eukaryota
KOG0255 Eukaryota
ENOG410ZVDQ LUCA
GeneTreeiENSGT00550000074384
HOGENOMiHOG000114543
HOVERGENiHBG057057
InParanoidiQ8BFT9
OMAiKISVLWT
OrthoDBiEOG091G04VD
PhylomeDBiQ8BFT9
TreeFamiTF313465

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BFT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDIQIEG VRVGLEAIEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF IGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL LLLSAAPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK
410 420 430 440 450
KTMALCFIIF SLCSLLLFIC IGRNVLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AGVASCFLPI ETKGRALQES SHREWGQEMV GRGTNSAGVP RSDSGSQE
Length:548
Mass (Da):60,769
Last modified:March 1, 2003 - v1
Checksum:iED9779BD305DFB83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → F in AAH59878 (PubMed:15489334).Curated1
Sequence conflicti23A → T in BAC33150 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047764 mRNA Translation: BAC33150.1
AK053833 mRNA Translation: BAC35546.1
AK082744 mRNA Translation: BAC38595.1
BC059878 mRNA Translation: AAH59878.1
CCDSiCCDS39220.1
RefSeqiNP_081081.1, NM_026805.1
UniGeneiMm.63584

Genome annotation databases

EnsembliENSMUST00000058472; ENSMUSP00000050730; ENSMUSG00000042078
GeneIDi68666
KEGGimmu:68666
UCSCiuc008yzb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSVOP_MOUSE
AccessioniPrimary (citable) accession number: Q8BFT9
Secondary accession number(s): Q6PB56, Q8BKY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health