Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HAUS augmin-like complex subunit 4

Gene

Haus4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 4
Gene namesi
Name:Haus4
Synonyms:D14Ertd500e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1261794. Haus4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363HAUS augmin-like complex subunit 4PRO_0000089902Add
BLAST

Proteomic databases

EPDiQ8BFT2.
MaxQBiQ8BFT2.
PaxDbiQ8BFT2.
PRIDEiQ8BFT2.

PTM databases

PhosphoSiteiQ8BFT2.

Expressioni

Gene expression databases

BgeeiQ8BFT2.
CleanExiMM_D14ERTD500E.
GenevisibleiQ8BFT2. MM.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity).By similarity

Protein-protein interaction databases

BioGridi230105. 30 interactions.
IntActiQ8BFT2. 30 interactions.
STRINGi10090.ENSMUSP00000022784.

Structurei

3D structure databases

ProteinModelPortaliQ8BFT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAUS4 family.Curated

Phylogenomic databases

eggNOGiENOG410IFF7. Eukaryota.
ENOG4111KUB. LUCA.
GeneTreeiENSGT00390000014634.
HOGENOMiHOG000081781.
InParanoidiQ8BFT2.
KOiK16587.
OMAiWENESEG.
OrthoDBiEOG78M029.
PhylomeDBiQ8BFT2.
TreeFamiTF330353.

Family and domain databases

InterProiIPR029327. HAUS4.
IPR026214. HAUS4_met.
[Graphical view]
PfamiPF14735. HAUS4. 1 hit.
[Graphical view]
PRINTSiPR02090. HAUSAUGMINL4.

Sequencei

Sequence statusi: Complete.

Q8BFT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGDFCAPG EGVEMLLQVC GKQFPPCALT EEDLIQNPRF SKLLLSLSQH
60 70 80 90 100
VDESGLSLTL AKEQAQAWSE VRHRKTAWLR YEILQRVIQE LLVDYYVKAQ
110 120 130 140 150
DTNLTSEDKK FHETLEQRLL VTELTQLSGP GQETELPPLL GLERTDLLEL
160 170 180 190 200
MPPSQDFVWM KARLQLEVEE QLKRKCFTLL CYHDPSSDTD GDTLKAAKVW
210 220 230 240 250
TLTEVLVREK QQCLEAKSQQ KEQLVLLEKK RTTYSQVLLR CLALLQRLLQ
260 270 280 290 300
EHRLQTKSEL DRINAQYLEL KCSAMILRLR MEELKVLSDT YSAEKVEMHR
310 320 330 340 350
LIRDRLEGAI RLQEQDLEKS RLVLHTYEAL GEDFESLVRE YTQLRLAADN
360
KRWALQELSK AQR
Length:363
Mass (Da):42,197
Last modified:March 1, 2003 - v1
Checksum:iF10ABB1163E16EE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211G → V in AAH04644 (PubMed:15489334).Curated
Sequence conflicti21 – 211G → V in AAH11095 (PubMed:15489334).Curated
Sequence conflicti212 – 2121Q → H in AAH04644 (PubMed:15489334).Curated
Sequence conflicti212 – 2121Q → H in AAH11095 (PubMed:15489334).Curated
Sequence conflicti292 – 2921S → N in AAH04644 (PubMed:15489334).Curated
Sequence conflicti292 – 2921S → N in AAH11095 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079161 mRNA. Translation: BAC37564.1.
AK079852 mRNA. Translation: BAC37767.1.
BC004644 mRNA. Translation: AAH04644.1.
BC011095 mRNA. Translation: AAH11095.1.
CCDSiCCDS27092.1.
RefSeqiNP_663437.2. NM_145462.2.
XP_006518908.1. XM_006518845.2.
UniGeneiMm.202152.

Genome annotation databases

EnsembliENSMUST00000022784; ENSMUSP00000022784; ENSMUSG00000022177.
GeneIDi219072.
KEGGimmu:219072.
UCSCiuc007twh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079161 mRNA. Translation: BAC37564.1.
AK079852 mRNA. Translation: BAC37767.1.
BC004644 mRNA. Translation: AAH04644.1.
BC011095 mRNA. Translation: AAH11095.1.
CCDSiCCDS27092.1.
RefSeqiNP_663437.2. NM_145462.2.
XP_006518908.1. XM_006518845.2.
UniGeneiMm.202152.

3D structure databases

ProteinModelPortaliQ8BFT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230105. 30 interactions.
IntActiQ8BFT2. 30 interactions.
STRINGi10090.ENSMUSP00000022784.

PTM databases

PhosphoSiteiQ8BFT2.

Proteomic databases

EPDiQ8BFT2.
MaxQBiQ8BFT2.
PaxDbiQ8BFT2.
PRIDEiQ8BFT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022784; ENSMUSP00000022784; ENSMUSG00000022177.
GeneIDi219072.
KEGGimmu:219072.
UCSCiuc007twh.2. mouse.

Organism-specific databases

CTDi54930.
MGIiMGI:1261794. Haus4.

Phylogenomic databases

eggNOGiENOG410IFF7. Eukaryota.
ENOG4111KUB. LUCA.
GeneTreeiENSGT00390000014634.
HOGENOMiHOG000081781.
InParanoidiQ8BFT2.
KOiK16587.
OMAiWENESEG.
OrthoDBiEOG78M029.
PhylomeDBiQ8BFT2.
TreeFamiTF330353.

Miscellaneous databases

ChiTaRSiHaus4. mouse.
NextBioi376559.
PROiQ8BFT2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BFT2.
CleanExiMM_D14ERTD500E.
GenevisibleiQ8BFT2. MM.

Family and domain databases

InterProiIPR029327. HAUS4.
IPR026214. HAUS4_met.
[Graphical view]
PfamiPF14735. HAUS4. 1 hit.
[Graphical view]
PRINTSiPR02090. HAUSAUGMINL4.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiHAUS4_MOUSE
AccessioniPrimary (citable) accession number: Q8BFT2
Secondary accession number(s): Q99KI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: April 13, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.