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Protein

HAUS augmin-like complex subunit 4

Gene

Haus4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 4
Gene namesi
Name:Haus4
Synonyms:D14Ertd500e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1261794. Haus4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899021 – 363HAUS augmin-like complex subunit 4Add BLAST363

Proteomic databases

EPDiQ8BFT2.
MaxQBiQ8BFT2.
PaxDbiQ8BFT2.
PeptideAtlasiQ8BFT2.
PRIDEiQ8BFT2.

PTM databases

PhosphoSitePlusiQ8BFT2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022177.
CleanExiMM_D14ERTD500E.
GenevisibleiQ8BFT2. MM.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity).By similarity

Protein-protein interaction databases

BioGridi230105. 30 interactors.
CORUMiQ8BFT2.
IntActiQ8BFT2. 30 interactors.
STRINGi10090.ENSMUSP00000022784.

Structurei

3D structure databases

ProteinModelPortaliQ8BFT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAUS4 family.Curated

Phylogenomic databases

eggNOGiENOG410IFF7. Eukaryota.
ENOG4111KUB. LUCA.
GeneTreeiENSGT00390000014634.
HOGENOMiHOG000081781.
InParanoidiQ8BFT2.
KOiK16587.
OMAiVKAAKVW.
OrthoDBiEOG091G0GFJ.
PhylomeDBiQ8BFT2.
TreeFamiTF330353.

Family and domain databases

InterProiView protein in InterPro
IPR029327. HAUS4.
IPR026214. HAUS4_met.
PANTHERiPTHR16219. PTHR16219. 1 hit.
PfamiView protein in Pfam
PF14735. HAUS4. 1 hit.
PRINTSiPR02090. HAUSAUGMINL4.

Sequencei

Sequence statusi: Complete.

Q8BFT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGDFCAPG EGVEMLLQVC GKQFPPCALT EEDLIQNPRF SKLLLSLSQH
60 70 80 90 100
VDESGLSLTL AKEQAQAWSE VRHRKTAWLR YEILQRVIQE LLVDYYVKAQ
110 120 130 140 150
DTNLTSEDKK FHETLEQRLL VTELTQLSGP GQETELPPLL GLERTDLLEL
160 170 180 190 200
MPPSQDFVWM KARLQLEVEE QLKRKCFTLL CYHDPSSDTD GDTLKAAKVW
210 220 230 240 250
TLTEVLVREK QQCLEAKSQQ KEQLVLLEKK RTTYSQVLLR CLALLQRLLQ
260 270 280 290 300
EHRLQTKSEL DRINAQYLEL KCSAMILRLR MEELKVLSDT YSAEKVEMHR
310 320 330 340 350
LIRDRLEGAI RLQEQDLEKS RLVLHTYEAL GEDFESLVRE YTQLRLAADN
360
KRWALQELSK AQR
Length:363
Mass (Da):42,197
Last modified:March 1, 2003 - v1
Checksum:iF10ABB1163E16EE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21G → V in AAH04644 (PubMed:15489334).Curated1
Sequence conflicti21G → V in AAH11095 (PubMed:15489334).Curated1
Sequence conflicti212Q → H in AAH04644 (PubMed:15489334).Curated1
Sequence conflicti212Q → H in AAH11095 (PubMed:15489334).Curated1
Sequence conflicti292S → N in AAH04644 (PubMed:15489334).Curated1
Sequence conflicti292S → N in AAH11095 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079161 mRNA. Translation: BAC37564.1.
AK079852 mRNA. Translation: BAC37767.1.
BC004644 mRNA. Translation: AAH04644.1.
BC011095 mRNA. Translation: AAH11095.1.
CCDSiCCDS27092.1.
RefSeqiNP_663437.2. NM_145462.2.
XP_006518908.1. XM_006518845.3.
UniGeneiMm.202152.

Genome annotation databases

EnsembliENSMUST00000022784; ENSMUSP00000022784; ENSMUSG00000022177.
GeneIDi219072.
KEGGimmu:219072.
UCSCiuc007twh.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiHAUS4_MOUSE
AccessioniPrimary (citable) accession number: Q8BFT2
Secondary accession number(s): Q99KI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families