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Protein

Relaxin-3

Gene

Rln3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: RGD
  2. hormone activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_325736. Relaxin receptors.
REACT_339234. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name:
Insulin-like peptide 7
Prorelaxin R3
Cleaved into the following 2 chains:
Gene namesi
Name:Rln3
Synonyms:Insl7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi628745. Rln3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Peptidei24 – 5027Relaxin-3 B chainBy similarityPRO_0000016094Add
BLAST
Propeptidei53 – 11664Connecting peptideBy similarityPRO_0000016095Add
BLAST
Peptidei117 – 14024Relaxin-3 A chainBy similarityPRO_0000016096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 127Interchain (between B and A chains)By similarity
Disulfide bondi45 ↔ 140Interchain (between B and A chains)By similarity
Disulfide bondi126 ↔ 131By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ8BFS3.

Expressioni

Tissue specificityi

Highly abundant expression is detected in neurons within the ventomedial dorsal tegmental nucleus and the laterally central gray alpha of the pons. Also detected at much lower levels within the hippocampus.1 Publication

Gene expression databases

GenevestigatoriQ8BFS3.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007775.

Structurei

3D structure databases

ProteinModelPortaliQ8BFS3.
SMRiQ8BFS3. Positions 24-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45013.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8BFS3.
KOiK05255.
OMAiPANSHTW.
OrthoDBiEOG7H1JNG.
PhylomeDBiQ8BFS3.
TreeFamiTF333404.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BFS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRGLLLAS WALLGALVLQ AEARPAPYGV KLCGREFIRA VIFTCGGSRW
60 70 80 90 100
RRADILAHDP LGEFFADGEA NTDHLASELD EAVGSSEWLA LTKSPQVFYG
110 120 130 140
GRSSWQGSPG VVRGSRDVLA GLSSSCCEWG CSKSQISSLC
Length:140
Mass (Da):14,922
Last modified:March 1, 2003 - v1
Checksum:iF4B6979756122EDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY112741 mRNA. Translation: AAM56033.1.
AB076564 mRNA. Translation: BAC53759.1.
RefSeqiNP_733767.1. NM_170667.2.
UniGeneiRn.45123.

Genome annotation databases

EnsembliENSRNOT00000007775; ENSRNOP00000007775; ENSRNOG00000005911.
GeneIDi266997.
KEGGirno:266997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY112741 mRNA. Translation: AAM56033.1.
AB076564 mRNA. Translation: BAC53759.1.
RefSeqiNP_733767.1. NM_170667.2.
UniGeneiRn.45123.

3D structure databases

ProteinModelPortaliQ8BFS3.
SMRiQ8BFS3. Positions 24-50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007775.

Proteomic databases

PRIDEiQ8BFS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007775; ENSRNOP00000007775; ENSRNOG00000005911.
GeneIDi266997.
KEGGirno:266997.

Organism-specific databases

CTDi117579.
RGDi628745. Rln3.

Phylogenomic databases

eggNOGiNOG45013.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8BFS3.
KOiK05255.
OMAiPANSHTW.
OrthoDBiEOG7H1JNG.
PhylomeDBiQ8BFS3.
TreeFamiTF333404.

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_325736. Relaxin receptors.
REACT_339234. G alpha (i) signalling events.

Miscellaneous databases

NextBioi624753.
PROiQ8BFS3.

Gene expression databases

GenevestigatoriQ8BFS3.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain."
    Burazin T.C.D., Bathgate R.A.D., Macris M., Layfield S., Gundlach A.L., Tregear G.W.
    J. Neurochem. 82:1553-1557(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiREL3_RAT
AccessioniPrimary (citable) accession number: Q8BFS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.