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Q8BFS3

- REL3_RAT

UniProt

Q8BFS3 - REL3_RAT

Protein

Relaxin-3

Gene

Rln3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor binding Source: RGD
    2. hormone activity Source: RGD

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_196378. Relaxin receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Relaxin-3
    Alternative name(s):
    Insulin-like peptide INSL7
    Short name:
    Insulin-like peptide 7
    Prorelaxin R3
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Rln3
    Synonyms:Insl7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi628745. Rln3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Peptidei24 – 5027Relaxin-3 B chainBy similarityPRO_0000016094Add
    BLAST
    Propeptidei53 – 11664Connecting peptideBy similarityPRO_0000016095Add
    BLAST
    Peptidei117 – 14024Relaxin-3 A chainBy similarityPRO_0000016096Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 127Interchain (between B and A chains)By similarity
    Disulfide bondi45 ↔ 140Interchain (between B and A chains)By similarity
    Disulfide bondi126 ↔ 131By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ8BFS3.

    Expressioni

    Tissue specificityi

    Highly abundant expression is detected in neurons within the ventomedial dorsal tegmental nucleus and the laterally central gray alpha of the pons. Also detected at much lower levels within the hippocampus.1 Publication

    Gene expression databases

    GenevestigatoriQ8BFS3.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007775.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BFS3.
    SMRiQ8BFS3. Positions 24-50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45013.
    GeneTreeiENSGT00510000048203.
    HOGENOMiHOG000111888.
    HOVERGENiHBG045048.
    InParanoidiQ8BFS3.
    KOiK05255.
    OMAiYGGRSSW.
    OrthoDBiEOG7H1JNG.
    PhylomeDBiQ8BFS3.
    TreeFamiTF333404.

    Family and domain databases

    InterProiIPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 2 hits.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BFS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATRGLLLAS WALLGALVLQ AEARPAPYGV KLCGREFIRA VIFTCGGSRW    50
    RRADILAHDP LGEFFADGEA NTDHLASELD EAVGSSEWLA LTKSPQVFYG 100
    GRSSWQGSPG VVRGSRDVLA GLSSSCCEWG CSKSQISSLC 140
    Length:140
    Mass (Da):14,922
    Last modified:March 1, 2003 - v1
    Checksum:iF4B6979756122EDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112741 mRNA. Translation: AAM56033.1.
    AB076564 mRNA. Translation: BAC53759.1.
    RefSeqiNP_733767.1. NM_170667.2.
    UniGeneiRn.45123.

    Genome annotation databases

    EnsembliENSRNOT00000007775; ENSRNOP00000007775; ENSRNOG00000005911.
    GeneIDi266997.
    KEGGirno:266997.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112741 mRNA. Translation: AAM56033.1 .
    AB076564 mRNA. Translation: BAC53759.1 .
    RefSeqi NP_733767.1. NM_170667.2.
    UniGenei Rn.45123.

    3D structure databases

    ProteinModelPortali Q8BFS3.
    SMRi Q8BFS3. Positions 24-50.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007775.

    Proteomic databases

    PRIDEi Q8BFS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007775 ; ENSRNOP00000007775 ; ENSRNOG00000005911 .
    GeneIDi 266997.
    KEGGi rno:266997.

    Organism-specific databases

    CTDi 117579.
    RGDi 628745. Rln3.

    Phylogenomic databases

    eggNOGi NOG45013.
    GeneTreei ENSGT00510000048203.
    HOGENOMi HOG000111888.
    HOVERGENi HBG045048.
    InParanoidi Q8BFS3.
    KOi K05255.
    OMAi YGGRSSW.
    OrthoDBi EOG7H1JNG.
    PhylomeDBi Q8BFS3.
    TreeFami TF333404.

    Enzyme and pathway databases

    Reactomei REACT_196378. Relaxin receptors.

    Miscellaneous databases

    NextBioi 624753.
    PROi Q8BFS3.

    Gene expression databases

    Genevestigatori Q8BFS3.

    Family and domain databases

    InterProi IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 2 hits.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain."
      Burazin T.C.D., Bathgate R.A.D., Macris M., Layfield S., Gundlach A.L., Tregear G.W.
      J. Neurochem. 82:1553-1557(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiREL3_RAT
    AccessioniPrimary (citable) accession number: Q8BFS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3