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Protein

Disrupted in renal carcinoma protein 2 homolog

Gene

Dirc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Electrogenic metabolite transporter.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Disrupted in renal carcinoma protein 2 homolog
Gene namesi
Name:Dirc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2387188. Dirc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 89LumenalSequence analysisAdd BLAST17
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 117CytoplasmicSequence analysis7
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 152LumenalSequence analysisAdd BLAST14
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 184CytoplasmicSequence analysisAdd BLAST11
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 229LumenalSequence analysisAdd BLAST24
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 281CytoplasmicSequence analysisAdd BLAST31
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 314LumenalSequence analysisAdd BLAST12
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 347CytoplasmicSequence analysisAdd BLAST12
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 384LumenalSequence analysisAdd BLAST16
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 414CytoplasmicSequence analysis9
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 442LumenalSequence analysis7
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 478CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713391 – 478Disrupted in renal carcinoma protein 2 homologAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated N-terminal and a non-glycosylated C-terminal fragment.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BFQ6.
PaxDbiQ8BFQ6.
PRIDEiQ8BFQ6.

PTM databases

PhosphoSitePlusiQ8BFQ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022848.
CleanExiMM_DIRC2.
ExpressionAtlasiQ8BFQ6. baseline and differential.
GenevisibleiQ8BFQ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023554.

Structurei

3D structure databases

ProteinModelPortaliQ8BFQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 15Mediates lysosomal localizationBy similarity2

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
GeneTreeiENSGT00530000062892.
HOGENOMiHOG000294083.
HOVERGENiHBG060348.
InParanoidiQ8BFQ6.
KOiK15381.
OMAiLRCIPVS.
OrthoDBiEOG091G0LKL.
PhylomeDBiQ8BFQ6.
TreeFamiTF314292.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BFQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGWSSEEE ERQPLLGPGL GPAPGAARRG REATAVLPAA GPNPGRVYGR
60 70 80 90 100
RWLVLLLFSL LAFAQGLVWN TWGPIQNSAR QAYGFSGWDI ALLVLWGPIG
110 120 130 140 150
FLPCFAFMWL LDKRGLRVTV LLTSFLMVLG TGLRCIPVSD LALKKRLIHG
160 170 180 190 200
GQILNGLAGP TVMNAAPFLS TTWFSADERA TATAIASMLS YLGGACAFLV
210 220 230 240 250
GPLVVPAPNG TAPLLAAESS RAHIKDRIET VLYAEFGVVC LIFSATLAYF
260 270 280 290 300
PPRPPLPPSV AAASQRLSYR RSFCRLLSNL RFLMIALAYA IPLGVFAGWS
310 320 330 340 350
GVLDLILTPV HVSQVDAGWI GFWSIVGGCV VGIAMARFAD FIRGMLKLIL
360 370 380 390 400
LLLFSGATLS STWFTLTCLN SITHLPLTTV TLYASCILLG VFLNSSVPIF
410 420 430 440 450
FELFVETVYP VPEGITCGVV TFLSNMFMGV LLFFVTFYHT ELSWFNWCLP
460 470
GSCLLSLLLI LCFRESYDRL YLDVVVSV
Length:478
Mass (Da):51,909
Last modified:March 1, 2003 - v1
Checksum:iFC87956C43885471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034214 mRNA. Translation: BAC28634.1.
AK172331 mRNA. Translation: BAE42949.1.
BC037460 mRNA. Translation: AAH37460.1.
CCDSiCCDS28141.1.
RefSeqiNP_705778.1. NM_153550.3.
UniGeneiMm.24094.

Genome annotation databases

EnsembliENSMUST00000023554; ENSMUSP00000023554; ENSMUSG00000022848.
GeneIDi224132.
KEGGimmu:224132.
UCSCiuc007zbo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034214 mRNA. Translation: BAC28634.1.
AK172331 mRNA. Translation: BAE42949.1.
BC037460 mRNA. Translation: AAH37460.1.
CCDSiCCDS28141.1.
RefSeqiNP_705778.1. NM_153550.3.
UniGeneiMm.24094.

3D structure databases

ProteinModelPortaliQ8BFQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023554.

PTM databases

PhosphoSitePlusiQ8BFQ6.

Proteomic databases

MaxQBiQ8BFQ6.
PaxDbiQ8BFQ6.
PRIDEiQ8BFQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023554; ENSMUSP00000023554; ENSMUSG00000022848.
GeneIDi224132.
KEGGimmu:224132.
UCSCiuc007zbo.1. mouse.

Organism-specific databases

CTDi84925.
MGIiMGI:2387188. Dirc2.

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
GeneTreeiENSGT00530000062892.
HOGENOMiHOG000294083.
HOVERGENiHBG060348.
InParanoidiQ8BFQ6.
KOiK15381.
OMAiLRCIPVS.
OrthoDBiEOG091G0LKL.
PhylomeDBiQ8BFQ6.
TreeFamiTF314292.

Miscellaneous databases

ChiTaRSiDirc2. mouse.
PROiQ8BFQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022848.
CleanExiMM_DIRC2.
ExpressionAtlasiQ8BFQ6. baseline and differential.
GenevisibleiQ8BFQ6. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDIRC2_MOUSE
AccessioniPrimary (citable) accession number: Q8BFQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.