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Protein

Ovarian cancer G-protein coupled receptor 1

Gene

Gpr68

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to pH Source: MGI
  • negative regulation of monocyte differentiation Source: MGI
  • positive regulation of insulin secretion Source: MGI
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  • positive regulation of osteoclast development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian cancer G-protein coupled receptor 1
Alternative name(s):
G-protein coupled receptor 68
Sphingosylphosphorylcholine receptor
Gene namesi
Name:Gpr68
Synonyms:Ogr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2441763. Gpr68.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 46Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini47 – 58CytoplasmicSequence analysisAdd BLAST12
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 95ExtracellularSequence analysisAdd BLAST15
Transmembranei96 – 117Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 158Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini159 – 183ExtracellularSequence analysisAdd BLAST25
Transmembranei184 – 205Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini206 – 228CytoplasmicSequence analysisAdd BLAST23
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 263ExtracellularSequence analysisAdd BLAST14
Transmembranei264 – 284Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini285 – 365CytoplasmicSequence analysisAdd BLAST81

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice have reduced osteoclasts derived from bone marrow cells, a pH-dependent osteoclast survival effect is also detected. However, the overall bone structures of the mice are not affected. In addition melanoma cell tumorigenesis is significantly inhibited.1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701141 – 365Ovarian cancer G-protein coupled receptor 1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8BFQ3.
PaxDbiQ8BFQ3.
PRIDEiQ8BFQ3.

PTM databases

iPTMnetiQ8BFQ3.
PhosphoSitePlusiQ8BFQ3.

Expressioni

Tissue specificityi

Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable.1 Publication

Gene expression databases

BgeeiENSMUSG00000047415.
CleanExiMM_GPR68.
GenevisibleiQ8BFQ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057510.

Structurei

3D structure databases

ProteinModelPortaliQ8BFQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ8BFQ3.
KOiK08408.
OMAiDRHRVCF.
OrthoDBiEOG091G06ZG.
PhylomeDBiQ8BFQ3.
TreeFamiTF331803.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005389. OGR1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01564. OGR1RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BFQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNITTENSS LSCPIDHTIH QTLAPVVYVT VLVVGFPANC LSLYFGYLQI
60 70 80 90 100
KARNELGVYL CNLTIADLFY ICSLPFWLQY VLQHDDWSHG DLSCQVCGIL
110 120 130 140 150
LYENIYISVG FLCCISIDRY LAVAHPFRFH QFRTLKAAVG VSVLIWAKEL
160 170 180 190 200
LTSIYFLNHK EVIEDEDQHR VCFEHYPIQA WQRSINYYRF LVGFLFPICL
210 220 230 240 250
LLASYQGILR AVRRSHGTQK SRKDQIQRLV LSTVVIFLAC FLPYHVLLLV
260 270 280 290 300
RSLWERNCEF AKSIFNVYHF SLLLTSFNCV ADPVLYCFVS ETTHRDLARL
310 320 330 340 350
RGACLAVLTC SRTSRAREAY PLGAPEASGK SGAQGEEPEL LTKLHSAFQT
360
PSSLGVGGPS TVGLA
Length:365
Mass (Da):41,209
Last modified:March 1, 2003 - v1
Checksum:iFD36FFB064D9E349
GO

Sequence cautioni

The sequence AAI18035 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI18045 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC29521 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC39863 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE33483 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036659 mRNA. Translation: BAC29521.1. Different initiation.
AK087410 mRNA. Translation: BAC39863.1. Different initiation.
AK155886 mRNA. Translation: BAE33483.1. Different initiation.
BC118034 mRNA. Translation: AAI18035.2. Different initiation.
BC118044 mRNA. Translation: AAI18045.2. Different initiation.
AY255616 mRNA. Translation: AAO85128.1.
CCDSiCCDS26109.1.
RefSeqiNP_001171144.1. NM_001177673.1.
NP_001171145.1. NM_001177674.1.
NP_780702.1. NM_175493.4.
UniGeneiMm.32160.

Genome annotation databases

EnsembliENSMUST00000053668; ENSMUSP00000057510; ENSMUSG00000047415.
ENSMUST00000110065; ENSMUSP00000105692; ENSMUSG00000047415.
ENSMUST00000110066; ENSMUSP00000105693; ENSMUSG00000047415.
GeneIDi238377.
KEGGimmu:238377.
UCSCiuc007ota.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036659 mRNA. Translation: BAC29521.1. Different initiation.
AK087410 mRNA. Translation: BAC39863.1. Different initiation.
AK155886 mRNA. Translation: BAE33483.1. Different initiation.
BC118034 mRNA. Translation: AAI18035.2. Different initiation.
BC118044 mRNA. Translation: AAI18045.2. Different initiation.
AY255616 mRNA. Translation: AAO85128.1.
CCDSiCCDS26109.1.
RefSeqiNP_001171144.1. NM_001177673.1.
NP_001171145.1. NM_001177674.1.
NP_780702.1. NM_175493.4.
UniGeneiMm.32160.

3D structure databases

ProteinModelPortaliQ8BFQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057510.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8BFQ3.
PhosphoSitePlusiQ8BFQ3.

Proteomic databases

EPDiQ8BFQ3.
PaxDbiQ8BFQ3.
PRIDEiQ8BFQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053668; ENSMUSP00000057510; ENSMUSG00000047415.
ENSMUST00000110065; ENSMUSP00000105692; ENSMUSG00000047415.
ENSMUST00000110066; ENSMUSP00000105693; ENSMUSG00000047415.
GeneIDi238377.
KEGGimmu:238377.
UCSCiuc007ota.2. mouse.

Organism-specific databases

CTDi8111.
MGIiMGI:2441763. Gpr68.

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ8BFQ3.
KOiK08408.
OMAiDRHRVCF.
OrthoDBiEOG091G06ZG.
PhylomeDBiQ8BFQ3.
TreeFamiTF331803.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ8BFQ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047415.
CleanExiMM_GPR68.
GenevisibleiQ8BFQ3. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005389. OGR1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01564. OGR1RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOGR1_MOUSE
AccessioniPrimary (citable) accession number: Q8BFQ3
Secondary accession number(s): Q148P7, Q3U1L3, Q80T34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.