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Protein

Epstein-Barr nuclear antigen leader protein

Gene

EBNA-LP

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the establishment of B-cell immortalization by acting as an EBNA2 coactivator. This transcriptional activation preferentially enhances the expression of the major viral protein LMP1. The interaction between EBNA-LP and host SP100 correlates with coactivation of EBNA2 and the relocalization of SP100 from PML nuclear bodies into nucleoplasm.

GO - Molecular functioni

  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  • disruption by symbiont of host cell PML body Source: BHF-UCL
  • DNA-templated viral transcription Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Epstein-Barr nuclear antigen leader protein
Short name:
EBNA-LP
Short name:
EBV nuclear antigen leader protein
Alternative name(s):
Epstein-Barr nuclear antigen 5
Short name:
EBNA-5
Short name:
EBV nuclear antigen 5
Gene namesi
Name:EBNA-LP
Synonyms:EBNA5
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

Subcellular locationi

  • Host nucleus 1 Publication

GO - Cellular componenti

  • host cell nucleus Source: UniProtKB
  • host cell PML body Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi35 – 351S → A: 95% loss of phosphorylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Epstein-Barr nuclear antigen leader proteinPRO_0000376060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351Phosphoserine; by host1 Publication

Post-translational modificationi

Phosphorylated by the cellular protein kinase cdc2.1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiQ8AZK7.

Interactioni

Subunit structurei

Homooligomer. Interacts with host SP100; this interaction is important for EBNA-LP coactivator activity. Interacts with host HAX1, ERR1 and HSPA2. Interacts with host PRKDC and AKAP8L; these interactions modulate the coactivator function of EBNA-LP.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BAG2O958163EBI-1185167,EBI-355275From a different organism.
Bag3Q9JLV12EBI-1185167,EBI-309231From a different organism.
CDKN2AQ8N7265EBI-1185167,EBI-625922From a different organism.
DDX5P178442EBI-1185167,EBI-351962From a different organism.
DNAJB5O759533EBI-1185167,EBI-5655937From a different organism.
HNRNPKP619782EBI-1185167,EBI-304185From a different organism.
HNRNPMP522722EBI-1185167,EBI-486809From a different organism.
HSPA1BP081073EBI-1185167,EBI-629985From a different organism.
HSPA8P111423EBI-1185167,EBI-351896From a different organism.
NCLP193382EBI-1185167,EBI-346967From a different organism.
NONOQ152332EBI-1185167,EBI-350527From a different organism.
PSMD2Q132002EBI-1185167,EBI-357648From a different organism.
SFPQP232462EBI-1185167,EBI-355453From a different organism.
TUBA1BP683633EBI-1185167,EBI-487083From a different organism.
TUBBP074373EBI-1185167,EBI-350864From a different organism.

Protein-protein interaction databases

BioGridi971788. 153 interactions.
DIPiDIP-39599N.
IntActiQ8AZK7. 190 interactions.
MINTiMINT-6732913.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 482454Arg-richAdd
BLAST
Compositional biasi500 – 5056Poly-Glu

Sequence similaritiesi

Belongs to the lymphocryptovirus EBNA-LP family.Curated

Phylogenomic databases

KOiK19456.

Family and domain databases

InterProiIPR005030. Herpes_LP.
[Graphical view]
PfamiPF03363. Herpes_LP. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AZK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRSEGPGP TRPGPPGIGP EGPLGQLLRR HRSPSPTRGG QEPRRVRRRV
60 70 80 90 100
LVQQEEEVVS GSPSGPRGDR SEGPGPTRPG PPGIGPEGPL GQLLRRHRSP
110 120 130 140 150
SPTRGGQEPR RVRRRVLVQQ EEEVVSGSPS GPRGDRSEGP GPTRPGPPGI
160 170 180 190 200
GPEGPLGQLL RRHRSPSPTR GGQEPRRVRR RVLVQQEEEV VSGSPSGPRG
210 220 230 240 250
DRSEGPGPTR PGPPGIGPEG PLGQLLRRHR SPSPTRGGQE PRRVRRRVLV
260 270 280 290 300
QQEEEVVSGS PSGPRGDRSE GPGPTRPGPP GIGPEGPLGQ LLRRHRSPSP
310 320 330 340 350
TRGGQEPRRV RRRVLVQQEE EVVSGSPSGP RGDRSEGPGP TRPGPPGIGP
360 370 380 390 400
EGPLGQLLRR HRSPSPTRGG QEPRRVRRRV LVQQEEEVVS GSPSGPRGDR
410 420 430 440 450
SEGPGPTRPG PPGIGPEGPL GQLLRRHRSP SPTRGGQEPR RVRRRVLVQQ
460 470 480 490 500
EEEVVSGSPS GPLRPRPRPP ARSLREWLLR IRDHFEPPTV TTQRQSVYIE

EEEDED
Length:506
Mass (Da):54,739
Last modified:March 1, 2003 - v1
Checksum:iCD2C6C3B737AC1E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. No translation available.
AJ507799 Genomic DNA. Translation: CAD53387.1.
RefSeqiYP_401636.1. NC_007605.1.

Genome annotation databases

GeneIDi3783746.
KEGGivg:3783746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. No translation available.
AJ507799 Genomic DNA. Translation: CAD53387.1.
RefSeqiYP_401636.1. NC_007605.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971788. 153 interactions.
DIPiDIP-39599N.
IntActiQ8AZK7. 190 interactions.
MINTiMINT-6732913.

PTM databases

iPTMnetiQ8AZK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783746.
KEGGivg:3783746.

Phylogenomic databases

KOiK19456.

Family and domain databases

InterProiIPR005030. Herpes_LP.
[Graphical view]
PfamiPF03363. Herpes_LP. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEBNA5_EBVB9
AccessioniPrimary (citable) accession number: Q8AZK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.