Q8AYS8 (KCMA1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-activated potassium channel subunit alpha-1

Alternative name(s):
BK channel
BKCA alpha
Calcium-activated potassium channel, subfamily M subunit alpha-1
K(VCA)alpha
KCa1.1
Maxi K channel
Short name=MaxiK
Slo-alpha
Slo1
Slowpoke homolog
Short name=Slo homolog
Short name=cSlo

Gene names

Name:	KCNMA1
Synonyms:	KCNMA

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	1137 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca2+, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Ref.6
Enzyme regulation	Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation By similarity.
Subunit structure	Homotetramer; which constitutes the calcium-activated potassium channel By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Domain	The S0 segment is essential for the modulation by the accessory beta subunits By similarity. The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor By similarity. The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium By similarity. The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca2+ and Mg2+ By similarity. The calcium bowl constitutes one of the Ca2+ sensors and probably acts as a Ca2+-binding site. There are however other Ca2+ sensors regions required for activation of the channel By similarity. The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation By similarity.
Miscellaneous	The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca2+ and Mg2+.
Sequence similarities	Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. [View classification] Contains 1 RCK N-terminal domain.
Caution	It is uncertain whether Met-1 is the initiator or if the sequence starts further upstream.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Calcium Magnesium Metal-binding Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from electronic annotation. Source: Compara auditory receptor cell differentiation Inferred from electronic annotation. Source: Compara cell maturation Inferred from electronic annotation. Source: Compara cellular potassium ion homeostasis Inferred from electronic annotation. Source: Compara eye blink reflex Inferred from electronic annotation. Source: Compara locomotor rhythm Inferred from electronic annotation. Source: Compara negative regulation of cell volume Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara regulation of action potential in neuron Inferred from electronic annotation. Source: Compara regulation of aldosterone metabolic process Inferred from electronic annotation. Source: Compara relaxation of vascular smooth muscle Inferred from electronic annotation. Source: Compara response to calcium ion Inferred from electronic annotation. Source: Compara response to carbon monoxide Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to osmotic stress Inferred from electronic annotation. Source: Compara saliva secretion Inferred from electronic annotation. Source: Compara sensory perception of sound Inferred from electronic annotation. Source: Compara smooth muscle contraction involved in micturition Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara caveola Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara voltage-gated potassium channel complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	large conductance calcium-activated potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P08106	3	EBI-1635766,EBI-1636307
akt1	O57513	2	EBI-1635766,EBI-4306384
ANXA5	P17153	3	EBI-1635766,EBI-1635947
CTTN1	Q01406	2	EBI-1635766,EBI-2530463
GSK3B	F1NPL8	2	EBI-1635766,EBI-4306413
HPCAL1	P42324	3	EBI-1635766,EBI-1636399
HSPA5	Q90593	3	EBI-1635766,EBI-1635886
HSPD1	Q5ZL72	3	EBI-1635766,EBI-1635874
LIN7C	Q5F425	3	EBI-1635766,EBI-1636456
LOC425178	F1NLP2	2	EBI-1635766,EBI-4306427
PHB	P84173	3	EBI-1635766,EBI-1636878
RAP1A	F1NSA8	2	EBI-1635766,EBI-4306330
SNAP25	P60878	3	EBI-1635766,EBI-1637031
SOD1	P80566	3	EBI-1635766,EBI-1637015
STMN1	P31395	3	EBI-1635766,EBI-1636998
vcp	Q5ZMU9	3	EBI-1635766,EBI-1637127
YWHAG	Q5F3W6	3	EBI-1635766,EBI-1635853

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q8AYS8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8AYS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     602-602: S → RSRKR

Isoform 3 (identifier: Q8AYS8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     657-657: L → PKMSIYKRMKLACCFDCGRSERDCSCMSGSVHSNMDTLERAFPLSSVSVNDCSTSLRAF

Isoform 4 (identifier: Q8AYS8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1130-1137: KYVQEDRL → NSTRMNRMGQEKKWFTDEPDNAYPRNIQIKPMSTHMANQINQYKSTSSLIPPIREVEDEC

Isoform 5 (identifier: Q8AYS8-5)

Also known as: IK;

The sequence of this isoform differs from the canonical sequence as follows:
     906-906: L → LAKPGKLLPLVSISQEKNSGTQILMITEL

Isoform 6 (identifier: Q8AYS8-6)

The sequence of this isoform differs from the canonical sequence as follows:
     657-657: L → IYF

Isoform 7 (identifier: Q8AYS8-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MSNNINANNLNTDSSSS → MKPFEVSLPPPPPS

Isoform 8 (identifier: Q8AYS8-8)

The sequence of this isoform differs from the canonical sequence as follows:
     160-160: N → KSRTADSLI

Isoform 9 (identifier: Q8AYS8-9)

The sequence of this isoform differs from the canonical sequence as follows:
     602-602: S → RSRKRYALFVTFPSNLNPTST

Isoform 10 (identifier: Q8AYS8-10)

The sequence of this isoform differs from the canonical sequence as follows:
     687-687: M → MRFSCPFLP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1137	1137	Calcium-activated potassium channel subunit alpha-1		PRO_0000054138
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 65	21	Helical; Name=Segment S0; Potential
	Topological domain	66 – 137	72	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=Segment S1; Potential
	Topological domain	159 – 173	15	Extracellular Potential
	Transmembrane	174 – 194	21	Helical; Name=Segment S2; Potential
	Topological domain	195 – 198	4	Cytoplasmic Potential
	Transmembrane	199 – 219	21	Helical; Name=Segment S3; Potential
	Topological domain	220 – 223	4	Extracellular Potential
	Transmembrane	224 – 244	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	245 – 259	15	Cytoplasmic Potential
	Transmembrane	260 – 280	21	Helical; Name=Segment S5; Potential
	Topological domain	281 – 294	14	Extracellular Potential
	Intramembrane	295 – 317	23	Pore-forming; Name=P region; Potential
	Topological domain	318 – 326	9	Extracellular Potential
	Transmembrane	327 – 347	21	Helical; Name=Segment S6; Potential
	Topological domain	348 – 1137	790	Cytoplasmic Potential
	Domain	374 – 517	144	RCK N-terminal
	Region	515 – 535	21	Segment S7
	Region	572 – 592	21	Segment S8
	Region	636 – 640	5	Heme-binding motif
	Region	738 – 758	21	Segment S9
	Region	933 – 953	21	Segment S10
	Motif	311 – 314	4	Selectivity for potassium
	Motif	904 – 926	23	Calcium bowl
Sites
	Metal binding	398	1	Magnesium By similarity
	Metal binding	421	1	Magnesium By similarity
	Metal binding	423	1	Magnesium By similarity
	Metal binding	913	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	916	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	919	1	Calcium By similarity
	Metal binding	921	1	Calcium By similarity
Natural variations
	Alternative sequence	1 – 17	17	MSNNI…DSSSS → MKPFEVSLPPPPPS in isoform 7.		VSP_009983
	Alternative sequence	160	1	N → KSRTADSLI in isoform 8.		VSP_009984
	Alternative sequence	602	1	S → RSRKR in isoform 2.		VSP_009985
	Alternative sequence	602	1	S → RSRKRYALFVTFPSNLNPTS T in isoform 9.		VSP_009986
	Alternative sequence	657	1	L → PKMSIYKRMKLACCFDCGRS ERDCSCMSGSVHSNMDTLER AFPLSSVSVNDCSTSLRAF in isoform 3.		VSP_009987
	Alternative sequence	657	1	L → IYF in isoform 6.		VSP_009988
	Alternative sequence	687	1	M → MRFSCPFLP in isoform 10.		VSP_009989
	Alternative sequence	906	1	L → LAKPGKLLPLVSISQEKNSG TQILMITEL in isoform 5.		VSP_009990
	Alternative sequence	1130 – 1137	8	KYVQEDRL → NSTRMNRMGQEKKWFTDEPD NAYPRNIQIKPMSTHMANQI NQYKSTSSLIPPIREVEDEC in isoform 4.		VSP_009991
Experimental info
	Sequence conflict	96	1	Q → R in AAC60378. Ref.1
	Sequence conflict	397	1	V → I in AAC60378. Ref.1
	Sequence conflict	409	1	L → P in AAC35370. Ref.4
	Sequence conflict	522	1	C → S in AAC60378. Ref.1
	Sequence conflict	712	1	S → W in BAC20639. Ref.5
	Sequence conflict	937	1	T → P in BAC20639. Ref.5
	Sequence conflict	941	1	V → D in BAC20639. Ref.5
	Sequence conflict	1034	1	L → F in AAC35370. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: 40A9735E586F0BD1	FASTA	1,137	127,647
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SSILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH DDITDPKRIK KCGCKRLEDE 670 680 690 700 710 720 QPSTLSPKKK QRNGGMRNSP NSSPKLMRHD PLLIPGNEQI DNMDANVKKY DSTGMFHWCP 730 740 750 760 770 780 AKDIEKVILT RSEAAMTVLS GHVVVCIFGD VKSALIGLRN LVMPLRASNF HYHELKHIVF 790 800 810 820 830 840 VGSLEYLRRE WETLHNFPKV SILPGTPLSR ADLRAVNINL CDMCVILSAN QNNIDDASLQ 850 860 870 880 890 900 DKECILASLN IKSMQFDDSI GVLQANSQGF TPPGMDRSSP DNSPVHGLLR QPSITTGANI 910 920 930 940 950 960 PIITELVNDS NVQFLDQDDD DDPDTELYLT QPFACGTAFA VSVLDSLMSA TYFNDNILTL 970 980 990 1000 1010 1020 IRTLVTGGAT PELEALIAEE NALRGGYSTP QTLANRDRCR VAQLALYDGP FADLGDGGCY 1030 1040 1050 1060 1070 1080 GDLFCKALKT YNMLCFGIYR LRDAHLSTPS QCTKRYVITN PPYEFELVPT DLIFCLMQFD 1090 1100 1110 1120 1130 HNAGQSRASL SHSSHSSYSS SKKSSSVHSI PSTANRPNRT KTRDSREKQK YVQEDRL
	Isoform 2 [UniParc]. Checksum: 60A2C0EAB0534269	FASTA	1,141	128,243
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SRSRKRILIN PGNHVKIQEG TLGFFIASDA KEVKRAFFYC KACHDDITDP KRIKKCGCKR 670 680 690 700 710 720 LEDEQPSTLS PKKKQRNGGM RNSPNSSPKL MRHDPLLIPG NEQIDNMDAN VKKYDSTGMF 730 740 750 760 770 780 HWCPAKDIEK VILTRSEAAM TVLSGHVVVC IFGDVKSALI GLRNLVMPLR ASNFHYHELK 790 800 810 820 830 840 HIVFVGSLEY LRREWETLHN FPKVSILPGT PLSRADLRAV NINLCDMCVI LSANQNNIDD 850 860 870 880 890 900 ASLQDKECIL ASLNIKSMQF DDSIGVLQAN SQGFTPPGMD RSSPDNSPVH GLLRQPSITT 910 920 930 940 950 960 GANIPIITEL VNDSNVQFLD QDDDDDPDTE LYLTQPFACG TAFAVSVLDS LMSATYFNDN 970 980 990 1000 1010 1020 ILTLIRTLVT GGATPELEAL IAEENALRGG YSTPQTLANR DRCRVAQLAL YDGPFADLGD 1030 1040 1050 1060 1070 1080 GGCYGDLFCK ALKTYNMLCF GIYRLRDAHL STPSQCTKRY VITNPPYEFE LVPTDLIFCL 1090 1100 1110 1120 1130 1140 MQFDHNAGQS RASLSHSSHS SYSSSKKSSS VHSIPSTANR PNRTKTRDSR EKQKYVQEDR L
	Isoform 3 [UniParc]. Checksum: 6AAD8F835A7A8177	FASTA	1,195	134,076
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SSILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH DDITDPKRIK KCGCKRPKMS 670 680 690 700 710 720 IYKRMKLACC FDCGRSERDC SCMSGSVHSN MDTLERAFPL SSVSVNDCST SLRAFEDEQP 730 740 750 760 770 780 STLSPKKKQR NGGMRNSPNS SPKLMRHDPL LIPGNEQIDN MDANVKKYDS TGMFHWCPAK 790 800 810 820 830 840 DIEKVILTRS EAAMTVLSGH VVVCIFGDVK SALIGLRNLV MPLRASNFHY HELKHIVFVG 850 860 870 880 890 900 SLEYLRREWE TLHNFPKVSI LPGTPLSRAD LRAVNINLCD MCVILSANQN NIDDASLQDK 910 920 930 940 950 960 ECILASLNIK SMQFDDSIGV LQANSQGFTP PGMDRSSPDN SPVHGLLRQP SITTGANIPI 970 980 990 1000 1010 1020 ITELVNDSNV QFLDQDDDDD PDTELYLTQP FACGTAFAVS VLDSLMSATY FNDNILTLIR 1030 1040 1050 1060 1070 1080 TLVTGGATPE LEALIAEENA LRGGYSTPQT LANRDRCRVA QLALYDGPFA DLGDGGCYGD 1090 1100 1110 1120 1130 1140 LFCKALKTYN MLCFGIYRLR DAHLSTPSQC TKRYVITNPP YEFELVPTDL IFCLMQFDHN 1150 1160 1170 1180 1190 AGQSRASLSH SSHSSYSSSK KSSSVHSIPS TANRPNRTKT RDSREKQKYV QEDRL
	Isoform 4 [UniParc]. Checksum: B334AAB3F4714EED	FASTA	1,189	133,667
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SSILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH DDITDPKRIK KCGCKRLEDE 670 680 690 700 710 720 QPSTLSPKKK QRNGGMRNSP NSSPKLMRHD PLLIPGNEQI DNMDANVKKY DSTGMFHWCP 730 740 750 760 770 780 AKDIEKVILT RSEAAMTVLS GHVVVCIFGD VKSALIGLRN LVMPLRASNF HYHELKHIVF 790 800 810 820 830 840 VGSLEYLRRE WETLHNFPKV SILPGTPLSR ADLRAVNINL CDMCVILSAN QNNIDDASLQ 850 860 870 880 890 900 DKECILASLN IKSMQFDDSI GVLQANSQGF TPPGMDRSSP DNSPVHGLLR QPSITTGANI 910 920 930 940 950 960 PIITELVNDS NVQFLDQDDD DDPDTELYLT QPFACGTAFA VSVLDSLMSA TYFNDNILTL 970 980 990 1000 1010 1020 IRTLVTGGAT PELEALIAEE NALRGGYSTP QTLANRDRCR VAQLALYDGP FADLGDGGCY 1030 1040 1050 1060 1070 1080 GDLFCKALKT YNMLCFGIYR LRDAHLSTPS QCTKRYVITN PPYEFELVPT DLIFCLMQFD 1090 1100 1110 1120 1130 1140 HNAGQSRASL SHSSHSSYSS SKKSSSVHSI PSTANRPNRT KTRDSREKQN STRMNRMGQE 1150 1160 1170 1180 KKWFTDEPDN AYPRNIQIKP MSTHMANQIN QYKSTSSLIP PIREVEDEC
	Isoform 5 (IK) [UniParc]. Checksum: 905BB9D1B2344E58	FASTA	1,165	130,638
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SSILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH DDITDPKRIK KCGCKRLEDE 670 680 690 700 710 720 QPSTLSPKKK QRNGGMRNSP NSSPKLMRHD PLLIPGNEQI DNMDANVKKY DSTGMFHWCP 730 740 750 760 770 780 AKDIEKVILT RSEAAMTVLS GHVVVCIFGD VKSALIGLRN LVMPLRASNF HYHELKHIVF 790 800 810 820 830 840 VGSLEYLRRE WETLHNFPKV SILPGTPLSR ADLRAVNINL CDMCVILSAN QNNIDDASLQ 850 860 870 880 890 900 DKECILASLN IKSMQFDDSI GVLQANSQGF TPPGMDRSSP DNSPVHGLLR QPSITTGANI 910 920 930 940 950 960 PIITELAKPG KLLPLVSISQ EKNSGTQILM ITELVNDSNV QFLDQDDDDD PDTELYLTQP 970 980 990 1000 1010 1020 FACGTAFAVS VLDSLMSATY FNDNILTLIR TLVTGGATPE LEALIAEENA LRGGYSTPQT 1030 1040 1050 1060 1070 1080 LANRDRCRVA QLALYDGPFA DLGDGGCYGD LFCKALKTYN MLCFGIYRLR DAHLSTPSQC 1090 1100 1110 1120 1130 1140 TKRYVITNPP YEFELVPTDL IFCLMQFDHN AGQSRASLSH SSHSSYSSSK KSSSVHSIPS 1150 1160 TANRPNRTKT RDSREKQKYV QEDRL
	Isoform 6 [UniParc]. Checksum: 45822D895211C704	FASTA	1,139	127,957
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SSILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH DDITDPKRIK KCGCKRIYFE 670 680 690 700 710 720 DEQPSTLSPK KKQRNGGMRN SPNSSPKLMR HDPLLIPGNE QIDNMDANVK KYDSTGMFHW 730 740 750 760 770 780 CPAKDIEKVI LTRSEAAMTV LSGHVVVCIF GDVKSALIGL RNLVMPLRAS NFHYHELKHI 790 800 810 820 830 840 VFVGSLEYLR REWETLHNFP KVSILPGTPL SRADLRAVNI NLCDMCVILS ANQNNIDDAS 850 860 870 880 890 900 LQDKECILAS LNIKSMQFDD SIGVLQANSQ GFTPPGMDRS SPDNSPVHGL LRQPSITTGA 910 920 930 940 950 960 NIPIITELVN DSNVQFLDQD DDDDPDTELY LTQPFACGTA FAVSVLDSLM SATYFNDNIL 970 980 990 1000 1010 1020 TLIRTLVTGG ATPELEALIA EENALRGGYS TPQTLANRDR CRVAQLALYD GPFADLGDGG 1030 1040 1050 1060 1070 1080 CYGDLFCKAL KTYNMLCFGI YRLRDAHLST PSQCTKRYVI TNPPYEFELV PTDLIFCLMQ 1090 1100 1110 1120 1130 FDHNAGQSRA SLSHSSHSSY SSSKKSSSVH SIPSTANRPN RTKTRDSREK QKYVQEDRL
	Isoform 7 [UniParc]. Checksum: 40B414AEFE0F1B55	FASTA	1,134	127,387
	10 20 30 40 50 60 MKPFEVSLPP PPPSPVNVPK MDALIIPVTM EVPCDSRGQR MWWAFLASSM VTFFGGLFII 70 80 90 100 110 120 LLWRTLKYLW TVCCHCGVKN KEAQKINGGG DTQADGACKP TDEKEENVAA EVGWMTSVKD 130 140 150 160 170 180 WAGVMISAQT LTGRVLVVLV FALSIGALVI YFIDSSNPIE SCQNFYKDFT LQIDMAFNVF 190 200 210 220 230 240 FLLYFGLRFI AANDKLWFWL EVNSVVDFFT VPPVFVSVYL NRSWLGLRFL RALRLIQFSE 250 260 270 280 290 300 ILQFLNILKT SNSIKLVNLC SIFISTWLTA AGFIHLVENS GDPWENFQNN QQLTYWECVY 310 320 330 340 350 360 LLMVTMSTVG YGDVYAKTTL GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV 370 380 390 400 410 420 SGRKHIVVCG HITLESVSNF LKDFLHKDRD DVNVEIVFLH NISPNLELEA LFKRHFTQVE 430 440 450 460 470 480 FYQGSVLNPH DLARVKIESA DACLILANKY CADPDAEDAS NIMRVISIKN YHPKIRIITQ 490 500 510 520 530 540 MLQYHNKAHL LNIPSWNWKE GDDAICLAEL KLGFIAQSCL APGLSTMLAN LFSMRSFIKI 550 560 570 580 590 600 EEDTWQKYYL EGVANEMYTE YLSSAFVGLS FPAVCELVFA KLKLLMIAIE YKSEKRESSI 610 620 630 640 650 660 LINPGNHVKI QEGTLGFFIA SDAKEVKRAF FYCKACHDDI TDPKRIKKCG CKRLEDEQPS 670 680 690 700 710 720 TLSPKKKQRN GGMRNSPNSS PKLMRHDPLL IPGNEQIDNM DANVKKYDST GMFHWCPAKD 730 740 750 760 770 780 IEKVILTRSE AAMTVLSGHV VVCIFGDVKS ALIGLRNLVM PLRASNFHYH ELKHIVFVGS 790 800 810 820 830 840 LEYLRREWET LHNFPKVSIL PGTPLSRADL RAVNINLCDM CVILSANQNN IDDASLQDKE 850 860 870 880 890 900 CILASLNIKS MQFDDSIGVL QANSQGFTPP GMDRSSPDNS PVHGLLRQPS ITTGANIPII 910 920 930 940 950 960 TELVNDSNVQ FLDQDDDDDP DTELYLTQPF ACGTAFAVSV LDSLMSATYF NDNILTLIRT 970 980 990 1000 1010 1020 LVTGGATPEL EALIAEENAL RGGYSTPQTL ANRDRCRVAQ LALYDGPFAD LGDGGCYGDL 1030 1040 1050 1060 1070 1080 FCKALKTYNM LCFGIYRLRD AHLSTPSQCT KRYVITNPPY EFELVPTDLI FCLMQFDHNA 1090 1100 1110 1120 1130 GQSRASLSHS SHSSYSSSKK SSSVHSIPST ANRPNRTKTR DSREKQKYVQ EDRL
	Isoform 8 [UniParc]. Checksum: C27FD559A611453C	FASTA	1,145	128,505
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSK SRTADSLIPI ESCQNFYKDF 190 200 210 220 230 240 TLQIDMAFNV FFLLYFGLRF IAANDKLWFW LEVNSVVDFF TVPPVFVSVY LNRSWLGLRF 250 260 270 280 290 300 LRALRLIQFS EILQFLNILK TSNSIKLVNL CSIFISTWLT AAGFIHLVEN SGDPWENFQN 310 320 330 340 350 360 NQQLTYWECV YLLMVTMSTV GYGDVYAKTT LGRLFMVFFI LGGLAMFASY VPEIIELIGN 370 380 390 400 410 420 RKKYGGSYSA VSGRKHIVVC GHITLESVSN FLKDFLHKDR DDVNVEIVFL HNISPNLELE 430 440 450 460 470 480 ALFKRHFTQV EFYQGSVLNP HDLARVKIES ADACLILANK YCADPDAEDA SNIMRVISIK 490 500 510 520 530 540 NYHPKIRIIT QMLQYHNKAH LLNIPSWNWK EGDDAICLAE LKLGFIAQSC LAPGLSTMLA 550 560 570 580 590 600 NLFSMRSFIK IEEDTWQKYY LEGVANEMYT EYLSSAFVGL SFPAVCELVF AKLKLLMIAI 610 620 630 640 650 660 EYKSEKRESS ILINPGNHVK IQEGTLGFFI ASDAKEVKRA FFYCKACHDD ITDPKRIKKC 670 680 690 700 710 720 GCKRLEDEQP STLSPKKKQR NGGMRNSPNS SPKLMRHDPL LIPGNEQIDN MDANVKKYDS 730 740 750 760 770 780 TGMFHWCPAK DIEKVILTRS EAAMTVLSGH VVVCIFGDVK SALIGLRNLV MPLRASNFHY 790 800 810 820 830 840 HELKHIVFVG SLEYLRREWE TLHNFPKVSI LPGTPLSRAD LRAVNINLCD MCVILSANQN 850 860 870 880 890 900 NIDDASLQDK ECILASLNIK SMQFDDSIGV LQANSQGFTP PGMDRSSPDN SPVHGLLRQP 910 920 930 940 950 960 SITTGANIPI ITELVNDSNV QFLDQDDDDD PDTELYLTQP FACGTAFAVS VLDSLMSATY 970 980 990 1000 1010 1020 FNDNILTLIR TLVTGGATPE LEALIAEENA LRGGYSTPQT LANRDRCRVA QLALYDGPFA 1030 1040 1050 1060 1070 1080 DLGDGGCYGD LFCKALKTYN MLCFGIYRLR DAHLSTPSQC TKRYVITNPP YEFELVPTDL 1090 1100 1110 1120 1130 1140 IFCLMQFDHN AGQSRASLSH SSHSSYSSSK KSSSVHSIPS TANRPNRTKT RDSREKQKYV QEDRL
	Isoform 9 [UniParc]. Checksum: 6284CAE9979B4A00	FASTA	1,157	129,997
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SRSRKRYALF VTFPSNLNPT STILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH 670 680 690 700 710 720 DDITDPKRIK KCGCKRLEDE QPSTLSPKKK QRNGGMRNSP NSSPKLMRHD PLLIPGNEQI 730 740 750 760 770 780 DNMDANVKKY DSTGMFHWCP AKDIEKVILT RSEAAMTVLS GHVVVCIFGD VKSALIGLRN 790 800 810 820 830 840 LVMPLRASNF HYHELKHIVF VGSLEYLRRE WETLHNFPKV SILPGTPLSR ADLRAVNINL 850 860 870 880 890 900 CDMCVILSAN QNNIDDASLQ DKECILASLN IKSMQFDDSI GVLQANSQGF TPPGMDRSSP 910 920 930 940 950 960 DNSPVHGLLR QPSITTGANI PIITELVNDS NVQFLDQDDD DDPDTELYLT QPFACGTAFA 970 980 990 1000 1010 1020 VSVLDSLMSA TYFNDNILTL IRTLVTGGAT PELEALIAEE NALRGGYSTP QTLANRDRCR 1030 1040 1050 1060 1070 1080 VAQLALYDGP FADLGDGGCY GDLFCKALKT YNMLCFGIYR LRDAHLSTPS QCTKRYVITN 1090 1100 1110 1120 1130 1140 PPYEFELVPT DLIFCLMQFD HNAGQSRASL SHSSHSSYSS SKKSSSVHSI PSTANRPNRT 1150 KTRDSREKQK YVQEDRL
	Isoform 10 [UniParc]. Checksum: 61A433CB6C95073E	FASTA	1,145	128,595
	10 20 30 40 50 60 MSNNINANNL NTDSSSSPVN VPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 70 80 90 100 110 120 FIILLWRTLK YLWTVCCHCG VKNKEAQKIN GGGDTQADGA CKPTDEKEEN VAAEVGWMTS 130 140 150 160 170 180 VKDWAGVMIS AQTLTGRVLV VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF 190 200 210 220 230 240 NVFFLLYFGL RFIAANDKLW FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ 250 260 270 280 290 300 FSEILQFLNI LKTSNSIKLV NLCSIFISTW LTAAGFIHLV ENSGDPWENF QNNQQLTYWE 310 320 330 340 350 360 CVYLLMVTMS TVGYGDVYAK TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY 370 380 390 400 410 420 SAVSGRKHIV VCGHITLESV SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT 430 440 450 460 470 480 QVEFYQGSVL NPHDLARVKI ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI 490 500 510 520 530 540 ITQMLQYHNK AHLLNIPSWN WKEGDDAICL AELKLGFIAQ SCLAPGLSTM LANLFSMRSF 550 560 570 580 590 600 IKIEEDTWQK YYLEGVANEM YTEYLSSAFV GLSFPAVCEL VFAKLKLLMI AIEYKSEKRE 610 620 630 640 650 660 SSILINPGNH VKIQEGTLGF FIASDAKEVK RAFFYCKACH DDITDPKRIK KCGCKRLEDE 670 680 690 700 710 720 QPSTLSPKKK QRNGGMRNSP NSSPKLMRFS CPFLPRHDPL LIPGNEQIDN MDANVKKYDS 730 740 750 760 770 780 TGMFHWCPAK DIEKVILTRS EAAMTVLSGH VVVCIFGDVK SALIGLRNLV MPLRASNFHY 790 800 810 820 830 840 HELKHIVFVG SLEYLRREWE TLHNFPKVSI LPGTPLSRAD LRAVNINLCD MCVILSANQN 850 860 870 880 890 900 NIDDASLQDK ECILASLNIK SMQFDDSIGV LQANSQGFTP PGMDRSSPDN SPVHGLLRQP 910 920 930 940 950 960 SITTGANIPI ITELVNDSNV QFLDQDDDDD PDTELYLTQP FACGTAFAVS VLDSLMSATY 970 980 990 1000 1010 1020 FNDNILTLIR TLVTGGATPE LEALIAEENA LRGGYSTPQT LANRDRCRVA QLALYDGPFA 1030 1040 1050 1060 1070 1080 DLGDGGCYGD LFCKALKTYN MLCFGIYRLR DAHLSTPSQC TKRYVITNPP YEFELVPTDL 1090 1100 1110 1120 1130 1140 IFCLMQFDHN AGQSRASLSH SSHSSYSSSK KSSSVHSIPS TANRPNRTKT RDSREKQKYV QEDRL

References

[1]	"CSlo encodes calcium-activated potassium channels in the chick's cochlea." Jiang G.J., Zidanic M., Michaels R.L., Michael T.H., Griguer C., Fuchs P.A. Proc. R. Soc. B 264:731-737(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE OF 398-1137 (ISOFORM 4). Strain: Leghorn. Tissue: Cochlear duct.
[2]	"Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea." Rosenblatt K.P., Sun Z.-P., Heller S., Hudspeth A.J. Neuron 19:1061-1075(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9 AND 10). Strain: White leghorn. Tissue: Brain.
[3]	"Molecular biology and electrophysiology of calcium-activated potassium channels from lens epithelium." Rae J.L., Shepard A.R. Curr. Eye Res. 17:264-275(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: White leghorn. Tissue: Lens epithelium.
[4]	"Characterization of a newly found stretch-activated KCa,ATP channel in cultured chick ventricular myocytes." Kawakubo T., Naruse K., Matsubara T., Hotta N., Sokabe M. Am. J. Physiol. 276:H1827-H1838(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-1137 (ISOFORM 3).
[5]	"Posttranslational regulation of Ca(2+)-activated K+ currents by a target-derived factor in developing parasympathetic neurons." Subramony P., Raucher S., Dryer L., Dryer S.E. Neuron 17:115-124(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 710-973 (ISOFORM 5).
[6]	"A molecular mechanism for electrical tuning of cochlear hair cells." Ramanathan K., Michael T.H., Jiang G.-J., Hiel H., Fuchs P.A. Science 283:215-217(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23821 mRNA. Translation: AAC60378.1. U23823 mRNA. Translation: AAC60125.1. U73189 mRNA. Translation: AAB17873.1. AF087663 mRNA. Translation: AAC35370.1. AB072618 mRNA. Translation: BAC20639.1.
IPI	IPI00572258. IPI00573276. IPI00577303. IPI00579525. IPI00581229. IPI00588093. IPI00589569. IPI00593457. IPI00601382. IPI00963770.
RefSeq	NP_989555.1. NM_204224.1.
UniGene	Gga.3260.
3D structure databases
ProteinModelPortal	Q8AYS8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8AYS8. 107 interactions.
MINT	MINT-7260456.
Proteomic databases
PaxDb	Q8AYS8.
PRIDE	Q8AYS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	374065.
KEGG	gga:374065.
Organism-specific databases
CTD	3778.
Phylogenomic databases
eggNOG	COG1226.
HOVERGEN	HBG052222.
InParanoid	Q8AYS8.
KO	K04936.
OrthoDB	EOG4QFWCD.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR024939. Ca-act_K_channel_Slo. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003929. K_chnl_Ca-activ_BK_asu. IPR016040. NAD(P)-bd_dom. IPR003148. RCK_N. [Graphical view]
PANTHER	PTHR10027:SF3. PTHR10027:SF3. 1 hit.
Pfam	PF03493. BK_channel_a. 1 hit. PF00520. Ion_trans. 1 hit. PF02254. TrkA_N. 1 hit. [Graphical view]
PRINTS	PR01449. BKCHANNELA. PR00169. KCHANNEL.
PROSITE	PS51201. RCK_N. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20813586.

Entry information

Entry name

KCMA1_CHICK

Accession

Primary (citable) accession number: Q8AYS8
Secondary accession number(s): O12942 , O13110, O93569, Q98951, Q9PS76

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	April 3, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program