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Protein

Hexokinase

Gene

HK1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_115616. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:HK1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006708.

Structurei

3D structure databases

ProteinModelPortaliQ8AYP8.
SMRiQ8AYP8. Positions 16-912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000162671.
HOVERGENiHBG005020.
PhylomeDBiQ8AYP8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AYP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAAQLLAYY FTELKEDQVK KIDKYLYAMR LSDETLIDIM ARFRREMKNG
60 70 80 90 100
LSRDFNPTAT VKMLPTFVRS IPDGSEKGDF IALDLGGSYF RILRVKVSHE
110 120 130 140 150
KKQTVQMESE IYNTPEDIIH GSGTRLFDHV AECLGDFMEK QQIKDKKLPV
160 170 180 190 200
GFTFSFPCRQ SKLDEGILIT WTKRFKASGV EGADVVKLLN KAIKKRGDYD
210 220 230 240 250
ADIMAVVNDT VGTMMTCGFD DQRCEVGLII GTGTNACYME EMRHIDLVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGSL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM
310 320 330 340 350
YMGELVRLIL VKMAKEGLLF EGRITPELPT KGKFETKHVS AIEKSKEGLN
360 370 380 390 400
KAKEILTRLG VEPSHEDCIA VQHVCTIVSF RSANLAASTL GAILNQLRDN
410 420 430 440 450
KGVGRLRTTV GVDGSLYKMH PQYARRLHKT TRRLVPDSDV RFLLSESGSG
460 470 480 490 500
KGAAMVTAVA YRLSEQHRLI DETLAEFKLT HEQLLQVKKR MRTEMEAGLK
510 520 530 540 550
KKSHETAKVK MLPTFVRSTP DGTENGDFLA LDLGGTNFRV LLVKIRSGKR
560 570 580 590 600
RTVEMHNKIY AIPIEVMQGT GEELFDHIVT CISDFLDYMG IRGARLPLGF
610 620 630 640 650
TFSFPCKQTS LDAGILLNWT KGFKATDCEG EDVVYLLREG IKRREEFDLD
660 670 680 690 700
VVAVVNDTVG TMMTCAYEDP NCEIGLIVGT GSNACYMEEM RNIEMVDGEQ
710 720 730 740 750
GRMCVNMEWG AFGDNGCLDD IRTIYDKAVD DYSLNAGKQR YEKMISGMYL
760 770 780 790 800
GEIVRNILID FTKRGFLFRG QISETLKTRH IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RTILQQLGLN STCDDSIIVK TVCGGVSKRA AQLCGAGMAA VVDKIRENRG
860 870 880 890 900
LEHLEITVGV DGTLYKLHPH FSRIMHQTVK DLAPKCDVTF LLSEDGSGKG
910
AALITAVGCR VRDAEQN
Length:917
Mass (Da):102,715
Last modified:March 1, 2003 - v1
Checksum:iFD6B22E0B93DEF18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083369 mRNA. Translation: BAC20932.1.
RefSeqiNP_989432.1. NM_204101.1.
UniGeneiGga.2197.

Genome annotation databases

GeneIDi373889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083369 mRNA. Translation: BAC20932.1.
RefSeqiNP_989432.1. NM_204101.1.
UniGeneiGga.2197.

3D structure databases

ProteinModelPortaliQ8AYP8.
SMRiQ8AYP8. Positions 16-912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373889.

Organism-specific databases

CTDi3098.

Phylogenomic databases

HOGENOMiHOG000162671.
HOVERGENiHBG005020.
PhylomeDBiQ8AYP8.

Enzyme and pathway databases

ReactomeiREACT_115616. Glucose transport.

Miscellaneous databases

NextBioi20813421.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and gene expression of hexokinase I and II in the chicken skeletal muscle."
    Seki Y., Sato K., Kono T., Akiba Y.
    Anim. Sci. J. 76:491-497(2005)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8AYP8_CHICK
AccessioniPrimary (citable) accession number: Q8AYP8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.