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Protein
Submitted name:

Hexokinase2

Gene

HK2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. glucose transport Source: Reactome
  3. glycolytic process Source: UniProtKB-KW
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_115616. Glucose transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Hexokinase2Imported
Gene namesi
Name:HK2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ8AYP7.
PRIDEiQ8AYP7.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035324.

Structurei

3D structure databases

ProteinModelPortaliQ8AYP7.
SMRiQ8AYP7. Positions 17-913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
KOiK00844.
PhylomeDBiQ8AYP7.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AYP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIASHLLAYF FTELNHDQAQ KVDKYLYHMR LSEDTLQEVS ERFRKEMEKG
60 70 80 90 100
LGADTNPTAS VKMLPSFVRS TPDGTEDGDF LALDLGGTNF RVLRVKVSDN
110 120 130 140 150
GLQKVEMESQ IYEIHEDLMR GSGMQLFDHI AECLGNFMEK LKIKDKKLPL
160 170 180 190 200
GFTFSFPCHQ TKLDESILVN WTKGFKCSSV EGKDVVSLLR RAIKKRGDFD
210 220 230 240 250
IDIVAVVNDT VGTMMSCGYD DQNCEVGLIV GTGTNACYME EMRHIDLVEG
260 270 280 290 300
DEGRMCINME WGAFGDDGAL NDIRTEFDHE IDMGSLNPGK QLFEKMISGM
310 320 330 340 350
YMGELVRLIL VKMAKEGLLF QGKLSSDLRT TGHFETRFVS AIEKEKEGLQ
360 370 380 390 400
KAHEILTKLG LEPSHEDCLA THRICQIVST RSANLCGATL AARLRRIKEY
410 420 430 440 450
KGVDPLRSTV GVDGSVYKKY PHFARRLHKT VRKLLPDCEI RFVRSEDGSG
460 470 480 490 500
KGAAMVTAVA YRLAAQHKAR QKILEALKLS HEQLLEVKRR MRVEMEKGLG
510 520 530 540 550
KETHAEATVK MLPTYVCSTP DGTEKGDFLA LDLGGTNFRV LLVRVRNGMR
560 570 580 590 600
RGVEMHNKIY SIPLEVMQGT GEELFDHIVH CISDFLEYMG MKGVSLPLGF
610 620 630 640 650
TFSFPCKQTN LDEGILLKWT KGFKATGCEG EDVVSLLKEA IHRREEFDLD
660 670 680 690 700
VVAVVNDTVG TMMTCGYEDP YCEVGLIVGT GSNACYMEEM RNVELVEGDE
710 720 730 740 750
GRMCVNMEWG AFGDNGCLDD IQTEFDLAVD ELSLNPGKQR FEKMISGMYL
760 770 780 790 800
GEIVRNILMD FTKRGLLFRG RISERLKTRG IFETKFLSQI ESDCLALLQV
810 820 830 840 850
RSILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA VVDKIRENRG
860 870 880 890 900
LDFLKVTVGV DGTLYKLHPH FSAIMQDTVR QLSPCCEVTF LQSEDGSGKG
910
AALITAVACR IREAGQ
Length:916
Mass (Da):102,417
Last modified:March 1, 2003 - v1
Checksum:i81E4A1E7D76FF550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083370 mRNA. Translation: BAC20933.1.
RefSeqiNP_989543.1. NM_204212.1.
UniGeneiGga.1055.

Genome annotation databases

GeneIDi374044.
KEGGigga:374044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083370 mRNA. Translation: BAC20933.1.
RefSeqiNP_989543.1. NM_204212.1.
UniGeneiGga.1055.

3D structure databases

ProteinModelPortaliQ8AYP7.
SMRiQ8AYP7. Positions 17-913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035324.

Proteomic databases

PaxDbiQ8AYP7.
PRIDEiQ8AYP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374044.
KEGGigga:374044.

Organism-specific databases

CTDi3099.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
KOiK00844.
PhylomeDBiQ8AYP7.

Enzyme and pathway databases

ReactomeiREACT_115616. Glucose transport.

Miscellaneous databases

NextBioi20813567.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and gene expression of hexokinase I and II in the chicken skeletal muscle."
    Seki Y., Sato K., Kono T., Akiba Y.
    Anim. Sci. J. 76:491-497(2005)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8AYP7_CHICK
AccessioniPrimary (citable) accession number: Q8AYP7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.