Q8AYM1 (Q8AYM1_THUTH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Hemoglobin beta chain EMBL BAC21255.1
Organism	Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus) EMBL BAC21255.1
Taxonomic identifier	8237 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Scombroidei › Scombridae › Thunnus

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the globin family. RuleBase RU000356

Ontologies

Keywords
Biological process	Oxygen transport RuleBase RU000356 SAAS SAAS002337 Transport
Ligand	Heme RuleBase RU000356 SAAS SAAS002337 PDB 1V4U PDB 1V4W PDB 1V4X Iron Metal-binding
Technical term	3D-structure PDB 1V4U PDB 1V4W PDB 1V4X
Gene Ontology (GO)
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	93	1	Iron (heme axial ligand); via tele nitrogen PDB 1V4U PDB 1V4W PDB 1V4X

Sequences

	Sequence		Length	Mass (Da)
	Q8AYM1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: D22C5A98EC4A2F4A	FASTA	147	16,313
	10 20 30 40 50 60 MVEWTQQERS IIAGIFANLN YEDIGPKALA RCLIVYPWTQ RYFGAYGDLS TPDAIKGNAK 70 80 90 100 110 120 IAAHGVKVLH GLDRAVKNMD NINEAYSELS VLHSDKLHVD PDNFRILGDC LTVVIAANLG 130 140 DAFTVETQCA FQKFLAVVVF ALGRKYH

References

[1]	"Novel mechanisms of pH sensitivity in tuna hemoglobin: a structural explanation of the root effect." Yokoyama T., Chong K.T., Miyazaki G., Morimoto H., Shih D.T., Unzai S., Tame J.R., Park S.Y. J. Biol. Chem. 279:28632-28640(2004) [PubMed: 15117955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB093568 mRNA. Translation: BAC21255.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V4U	X-ray	2.00	B/D	2-147	[»]
1V4W	X-ray	1.70	B/D	2-147	[»]
1V4X	X-ray	1.60	B/D	2-147	[»]

ProteinModelPortal

Q8AYM1.

SMR

Q8AYM1. Positions 2-147.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG009709.

Family and domain databases

InterPro

IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR000971. Globin_subset.
IPR002337. Haemoglobin_b.
[Graphical view]

Gene3D

G3DSA:1.10.490.10. Globin_related. 1 hit.

PANTHER

PTHR11442:SF7. Beta_haem. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00814. BETAHAEM.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8AYM1_THUTH

Accession

Primary (citable) accession number: Q8AYM1

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	October 19, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)