Q8AYM0 (Q8AYM0_THUTH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Hemoglobin alpha chain 1 EMBL BAC21256.1
Organism	Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus) EMBL BAC21256.1
Taxonomic identifier	8237 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Perciformes › Scombroidei › Scombridae › Thunnus

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the globin family. RuleBase RU000356

Ontologies

Keywords
Biological process	Oxygen transport SAAS SAAS002338 RuleBase RU000356 Transport
Ligand	Heme SAAS SAAS002338 RuleBase RU000356 PDB 1V4U PDB 1V4W PDB 1V4X Iron Metal-binding
Technical term	3D-structure PDB 1V4U PDB 1V4W PDB 1V4X
Gene Ontology (GO)
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	90	1	Iron (heme axial ligand); via tele nitrogen PDB 1V4U PDB 1V4W PDB 1V4X

Sequences

	Sequence		Length	Mass (Da)
	Q8AYM0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5793FECA3ACB9DF6	FASTA	144	15,563
	10 20 30 40 50 60 MTTLSDKDKS TVKALWGKIS KSADAIGADA LGRMLAVYPQ TKTYFSHWPD MSPGSGPVKA 70 80 90 100 110 120 HGKKVMGGVA LAVSKIDDLT TGLGDLSELH AFKMRVDPSN FKILSHCILV VVAKMFPKEF 130 140 TPDAHVSLDK FLASVALALA ERYR

References

[1]	"Novel mechanisms of pH sensitivity in tuna hemoglobin: a structural explanation of the root effect." Yokoyama T., Chong K.T., Miyazaki G., Morimoto H., Shih D.T., Unzai S., Tame J.R., Park S.Y. J. Biol. Chem. 279:28632-28640(2004) [PubMed: 15117955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB093569 mRNA. Translation: BAC21256.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V4U	X-ray	2.00	A/C	2-144	[»]
1V4W	X-ray	1.70	A/C	2-144	[»]
1V4X	X-ray	1.60	A/C	2-144	[»]

ProteinModelPortal

Q8AYM0.

SMR

Q8AYM0. Positions 2-144.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG009709.

Family and domain databases

InterPro

IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR000971. Globin_subset.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]

Gene3D

G3DSA:1.10.490.10. Globin_related. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00612. ALPHAHAEM.
PR00815. PIHAEM.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8AYM0_THUTH

Accession

Primary (citable) accession number: Q8AYM0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	October 19, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)