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Protein
Submitted name:

17-beta-hydroxysteroid dehydrogenase type 4

Gene

hsd17b4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • embryonic organ development Source: ZFIN
  • neuron development Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-DRE-2046106 alpha-linolenic acid (ALA) metabolism
R-DRE-389887 Beta-oxidation of pristanoyl-CoA
R-DRE-390247 Beta-oxidation of very long chain fatty acids
R-DRE-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Submitted name:
17-beta-hydroxysteroid dehydrogenase type 4Imported
Submitted name:
Hsd17b4 proteinImported
Submitted name:
Hydroxysteroid (17-beta) dehydrogenase 4Imported
Gene namesi
Name:hsd17b4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-040421-1 hsd17b4

Expressioni

Gene expression databases

BgeeiENSDARG00000101239

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000046430

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini477 – 585MaoC-likeInterPro annotationAdd BLAST109
Domaini620 – 720SCP2InterPro annotationAdd BLAST101

Phylogenomic databases

eggNOGiKOG1206 Eukaryota
COG2030 LUCA
GeneTreeiENSGT00530000062928
HOVERGENiHBG002174
KOiK12405
OMAiSRMTQTV
OrthoDBiEOG091G02S9
TreeFamiTF105656

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
InterProiView protein in InterPro
IPR029069 HotDog_dom_sf
IPR002539 MaoC_dom
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF01575 MaoC_dehydratas, 1 hit
PF02036 SCP2, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
SSF54637 SSF54637, 2 hits
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8AYH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPLRFDGK VVLVTGAGGG LGREYALAFG QRGAAVIVND LGGDIKGGGK
60 70 80 90 100
SSAAADKVVE EIRAAGGKAV ANYDSVEDGE KLIQTALDAF GRIDVVVNNA
110 120 130 140 150
GILRDRSFAR TSDVDWDLIQ RVHLRGSFLV TRAAWNHMKQ QKFGRIIMTS
160 170 180 190 200
SAAGIYGNFG QANYSAAKLG LLGLANTLAI EGQKYNIHCN TIAPTAGSRL
210 220 230 240 250
TETVMPPDLV QSLKAEYVAP LVLWLCHESC QENSGLFEVG AGWIGKLRWE
260 270 280 290 300
RSLGRIVRQK SECVTPEAVR DAWRDICDFT NATKPASIQE SLQTLVEVLS
310 320 330 340 350
RVEDERKIGA NPTAVATNPA QAIGHVLPDM TFTHTHMNCI LYALGVGVSS
360 370 380 390 400
RDPQQLQFLY EGHTHFSCLP TFGVIPAQGA LLGLGSIPGL DIDFTRLLHG
410 420 430 440 450
EQYLELYKPL PTSGTLTSRA TVADVLDKGS GMLILLDVHT YSEQELLCYN
460 470 480 490 500
QFSVFIVGSG GFGGKRVSQK AVAPAAPPDR PADAVVVEET SRDQAALYRL
510 520 530 540 550
SGDWNPLHID PNFAAMGGFQ SPILHGLCSF GFAARHVLKQ FAGNDVSRFK
560 570 580 590 600
AMKVRFVKPV YPGQSLQTEM WKENSRVHIQ CTVKESGAVV LSGAYIDLHP
610 620 630 640 650
AASVNTGPPQ TELQSDLVFA EIERRIKDSG EELVKKVNAV FGWEITTDGE
660 670 680 690 700
TRRHWTVDLK TGRGSVQRAA AKADVTFTVS DQDFMEVVMG KLNPQKAFFA
710 720
GKLKVKGNIM LSQKLEAVLK DQARL
Length:725
Mass (Da):78,625
Last modified:March 1, 2003 - v1
Checksum:iE6566A078130AE8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929368 Genomic DNA No translation available.
BC044422 mRNA Translation: AAH44422.1
BC165653 mRNA Translation: AAI65653.1
AH012110
, AF439315, AF439316, AF439317 Genomic DNA Translation: AAN62014.1
RefSeqiNP_956430.1, NM_200136.1
UniGeneiDr.4883

Genome annotation databases

EnsembliENSDART00000162032; ENSDARP00000137710; ENSDARG00000101239
GeneIDi393105
KEGGidre:393105

Similar proteinsi

Entry informationi

Entry nameiQ8AYH1_DANRE
AccessioniPrimary (citable) accession number: Q8AYH1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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