Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

17-beta-hydroxysteroid dehydrogenase type 4

Gene

hsd17b4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-DRE-2046106. alpha-linolenic acid (ALA) metabolism.
R-DRE-389887. Beta-oxidation of pristanoyl-CoA.
R-DRE-390247. Beta-oxidation of very long chain fatty acids.

Names & Taxonomyi

Protein namesi
Submitted name:
17-beta-hydroxysteroid dehydrogenase type 4Imported
Submitted name:
Hsd17b4 proteinImported
Submitted name:
Hydroxysteroid (17-beta) dehydrogenase 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:hsd17b4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-040421-1. hsd17b4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000046430.

Structurei

3D structure databases

SMRiQ8AYH1. Positions 4-303, 320-598, 613-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini477 – 585109MaoC-likeInterPro annotationAdd
BLAST
Domaini620 – 720101SCP2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1206. Eukaryota.
COG2030. LUCA.
GeneTreeiENSGT00530000062928.
HOVERGENiHBG002174.
KOiK12405.
OrthoDBiEOG7RBZ7V.
TreeFamiTF105656.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR029069. HotDog_dom.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF54637. SSF54637. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AYH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPLRFDGK VVLVTGAGGG LGREYALAFG QRGAAVIVND LGGDIKGGGK
60 70 80 90 100
SSAAADKVVE EIRAAGGKAV ANYDSVEDGE KLIQTALDAF GRIDVVVNNA
110 120 130 140 150
GILRDRSFAR TSDVDWDLIQ RVHLRGSFLV TRAAWNHMKQ QKFGRIIMTS
160 170 180 190 200
SAAGIYGNFG QANYSAAKLG LLGLANTLAI EGQKYNIHCN TIAPTAGSRL
210 220 230 240 250
TETVMPPDLV QSLKAEYVAP LVLWLCHESC QENSGLFEVG AGWIGKLRWE
260 270 280 290 300
RSLGRIVRQK SECVTPEAVR DAWRDICDFT NATKPASIQE SLQTLVEVLS
310 320 330 340 350
RVEDERKIGA NPTAVATNPA QAIGHVLPDM TFTHTHMNCI LYALGVGVSS
360 370 380 390 400
RDPQQLQFLY EGHTHFSCLP TFGVIPAQGA LLGLGSIPGL DIDFTRLLHG
410 420 430 440 450
EQYLELYKPL PTSGTLTSRA TVADVLDKGS GMLILLDVHT YSEQELLCYN
460 470 480 490 500
QFSVFIVGSG GFGGKRVSQK AVAPAAPPDR PADAVVVEET SRDQAALYRL
510 520 530 540 550
SGDWNPLHID PNFAAMGGFQ SPILHGLCSF GFAARHVLKQ FAGNDVSRFK
560 570 580 590 600
AMKVRFVKPV YPGQSLQTEM WKENSRVHIQ CTVKESGAVV LSGAYIDLHP
610 620 630 640 650
AASVNTGPPQ TELQSDLVFA EIERRIKDSG EELVKKVNAV FGWEITTDGE
660 670 680 690 700
TRRHWTVDLK TGRGSVQRAA AKADVTFTVS DQDFMEVVMG KLNPQKAFFA
710 720
GKLKVKGNIM LSQKLEAVLK DQARL
Length:725
Mass (Da):78,625
Last modified:March 1, 2003 - v1
Checksum:iE6566A078130AE8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929368 Genomic DNA. No translation available.
BC044422 mRNA. Translation: AAH44422.1.
BC165653 mRNA. Translation: AAI65653.1.
AF439319
, AF439315, AF439316, AF439317, AF439318 Genomic DNA. Translation: AAN62014.1.
RefSeqiNP_956430.1. NM_200136.1.
UniGeneiDr.4883.

Genome annotation databases

EnsembliENSDART00000162032; ENSDARP00000137710; ENSDARG00000101239.
GeneIDi393105.
KEGGidre:393105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929368 Genomic DNA. No translation available.
BC044422 mRNA. Translation: AAH44422.1.
BC165653 mRNA. Translation: AAI65653.1.
AF439319
, AF439315, AF439316, AF439317, AF439318 Genomic DNA. Translation: AAN62014.1.
RefSeqiNP_956430.1. NM_200136.1.
UniGeneiDr.4883.

3D structure databases

SMRiQ8AYH1. Positions 4-303, 320-598, 613-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000046430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000162032; ENSDARP00000137710; ENSDARG00000101239.
GeneIDi393105.
KEGGidre:393105.

Organism-specific databases

CTDi3295.
ZFINiZDB-GENE-040421-1. hsd17b4.

Phylogenomic databases

eggNOGiKOG1206. Eukaryota.
COG2030. LUCA.
GeneTreeiENSGT00530000062928.
HOVERGENiHBG002174.
KOiK12405.
OrthoDBiEOG7RBZ7V.
TreeFamiTF105656.

Enzyme and pathway databases

ReactomeiR-DRE-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-DRE-2046106. alpha-linolenic acid (ALA) metabolism.
R-DRE-389887. Beta-oxidation of pristanoyl-CoA.
R-DRE-390247. Beta-oxidation of very long chain fatty acids.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
3.30.1050.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR029069. HotDog_dom.
IPR002539. MaoC_dom.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR003033. SCP2_sterol-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF01575. MaoC_dehydratas. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF54637. SSF54637. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of hsd17b4 gene in zebrafish."
    Mindnich R., Adamski J.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
    Tissue: Whole bodyImported.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  5. Ensembl
    Submitted (NOV-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ8AYH1_DANRE
AccessioniPrimary (citable) accession number: Q8AYH1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.