Q8AYH0 (Q8AYH0_COTJA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Estrogen receptor alpha EMBL AAN63674.1
Organism	Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) EMBL AAN63674.1
Taxonomic identifier	93934 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Perdicinae › Coturnix

Protein attributes

Sequence length	589 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS000536
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS000536
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS000536
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL AAN63674.1
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	estrogen receptor activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8AYH0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 8271FDAA67552CA4	FASTA	589	66,767
	10 20 30 40 50 60 MTMTLHTKAS GVTLLHQIQG TELETLSRPQ LKIPLERSLS DMYVESNKTG VFNYPEGATY 70 80 90 100 110 120 DFGTTAPVYG STTLSYAPTS ESFGSSSLAG FHSLNNVPPS PVVFLQTAPQ LSPFIHHHSQ 130 140 150 160 170 180 QVPYYLENEQ GSFGMRETAP PAFYRPSSDN RRHSIRERMS SASEKGSLSM ESTKETRYCA 190 200 210 220 230 240 VCNDYASGYH YGVWSCEGCK AFFKRSIQGH NDYMCPATNQ CTIDKNRRKS CQACRLRKCY 250 260 270 280 290 300 EVGMMKGGIR KDRRGGRMMK QKRQREEQES RNGEASSTEL RAPTLWTSPL VVKHNKKNSP 310 320 330 340 350 360 ALSLTAEQMV SALLEAEPPI VYSEYDPNRP FNEASMMTLL TNLADRELVH MINWAKRVPG 370 380 390 400 410 420 FVDLTLHDQV HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD 430 440 450 460 470 480 MLLATAARFR MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEERDYIH RVLDKITDTL 490 500 510 520 530 540 IHFMAKSGLS LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA 550 560 570 580 HRLHAPAARS AAPMEEENRS QLTTAPASSH SLQSFYINSK EEESMQNTI

References

[1]	"cDNA cloning and mRNA expression of estrogen receptor alpha in Japanese quail." Ichikawa K., Yamamoto I., Tsukada A., Saito N., Shimada K. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAN63674.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF442965 mRNA. Translation: AAN63674.1.
3D structure databases
HSSP	HSSP built from PDB template 1HCP based on UniProtKB P03372.
ProteinModelPortal	Q8AYH0.
SMR	Q8AYH0. Positions 174-247, 295-544.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG108344.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR024178. Oest_rcpt/oest-rel_rcp. IPR001292. Oestr_rcpt. IPR024736. Oestrogen-typ_rcpt_final_C_dom. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF12743. ESR1_C. 1 hit. PF00104. Hormone_recep. 1 hit. PF02159. Oest_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PIRSF	PIRSF500101. ER-a. 1 hit. PIRSF002527. ER-like_NR. 1 hit.
PRINTS	PR00543. OESTROGENR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8AYH0_COTJA

Accession

Primary (citable) accession number: Q8AYH0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)