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Q8AY29

- CEGTA_XENLA

UniProt

Q8AY29 - CEGTA_XENLA

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Protein

Ceramide glucosyltransferase-A

Gene
ugcg-a, ugcg
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development.1 Publication

Catalytic activityi

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.1 Publication

Pathwayi

GO - Molecular functioni

  1. ceramide glucosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. glycosphingolipid catabolic process Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00222.

Protein family/group databases

CAZyiGT21. Glycosyltransferase Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide glucosyltransferase-A (EC:2.4.1.80)
Short name:
XLCGT
Alternative name(s):
UDP-glucose ceramide glucosyltransferase
Gene namesi
Name:ugcg-a
Synonyms:ugcg
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254211. ugcg.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein Reviewed prediction 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Lumenal Reviewed prediction
Transmembranei11 – 3222Helical; Reviewed predictionAdd
BLAST
Topological domaini33 – 195163Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei196 – 21520Helical; Reviewed predictionAdd
BLAST
Topological domaini216 – 28772Lumenal Reviewed predictionAdd
BLAST
Transmembranei288 – 30417Helical; Reviewed predictionAdd
BLAST
Topological domaini305 – 3095Cytoplasmic Reviewed prediction
Transmembranei310 – 32819Helical; Reviewed predictionAdd
BLAST
Topological domaini329 – 34820Lumenal Reviewed predictionAdd
BLAST
Transmembranei349 – 36921Helical; Reviewed predictionAdd
BLAST
Topological domaini370 – 39425Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Ceramide glucosyltransferase-APRO_0000376854Add
BLAST

Expressioni

Tissue specificityi

At the late gastrula stage, weakly expressed ubiquitously. As neurulation proceeds (stages 15-16), expression moves towards the dorsal structures: involuted paraxial mesoderm and neural folds. In the tailbud embryo (stage 28), expression is restricted to the notochord. At later stages (stage 35), expression remains in the notochord and also appears weakly in the cephalic region.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Expressed at all stages of oogenesis except in previtellogenic oocytes. During embryogenesis, weakly expressed as early as the one-cell stage shortly after fertilization, and remains at a relatively uniform level throughout embryogenesis, persisting at least until stage 35 (early tadpole).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8AY29.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK00720.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8AY29-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLDLALQG LAIFGCVLFF VLWFMHFLSI VYTRLHLNKK ISDKQPYSKL    50
PGVSLLKPLK GVDPNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK 100
LLGKYPSDDA KLFIGGKKVG INPKINNLMP GYEVAKYDLI WICDSGIKVK 150
PDTLTDMANQ MTEKVGLVHG LPYVADRQGF AATLEQVYFG TSHPRSYISA 200
NVTGFKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA KAIADRGWKF 250
SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS 300
LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA 350
VAWFIRESMT IYIFLSALWD PTISWRTGRF RLRCGGTAEE ILDV 394
Length:394
Mass (Da):44,651
Last modified:March 1, 2003 - v1
Checksum:iD25C6236C6A3388A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081D → V in AAH89245. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY112732 mRNA. Translation: AAM49061.1.
BC089245 mRNA. Translation: AAH89245.1.
RefSeqiNP_001083944.1. NM_001090475.1.
UniGeneiXl.21362.

Genome annotation databases

GeneIDi399204.
KEGGixla:399204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY112732 mRNA. Translation: AAM49061.1 .
BC089245 mRNA. Translation: AAH89245.1 .
RefSeqi NP_001083944.1. NM_001090475.1.
UniGenei Xl.21362.

3D structure databases

ProteinModelPortali Q8AY29.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT21. Glycosyltransferase Family 21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399204.
KEGGi xla:399204.

Organism-specific databases

CTDi 399204.
Xenbasei XB-GENE-6254211. ugcg.

Phylogenomic databases

KOi K00720.

Enzyme and pathway databases

UniPathwayi UPA00222 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF13506. Glyco_transf_21. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of two key enzymes of glycosphingolipid biosynthesis in the amphibian Xenopus laevis."
    Luque M.E., Crespo P.M., Monaco M.E., Aybar M.J., Daniotti J.L., Sanchez S.S.
    Dev. Dyn. 237:112-123(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, PATHWAY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.

Entry informationi

Entry nameiCEGTA_XENLA
AccessioniPrimary (citable) accession number: Q8AY29
Secondary accession number(s): Q5FWQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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