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Protein

Cytochrome P450 3A56

Gene

cyp3a56

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative steroid 6-beta-hydroxylase.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A56 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA56
Gene namesi
Name:cyp3a56
OrganismiFundulus heteroclitus (Killifish) (Mummichog)Imported
Taxonomic identifieri8078 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Cytochrome P450 3A56PRO_0000051810Add
BLAST

Expressioni

Tissue specificityi

Highly expressed in liver and intestine. Moderate expression in gill and spleen. Low expression in kidney, brain and heart.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8AXY5.
SMRiQ8AXY5. Positions 29-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AXY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYFYLTAET WTLLVAFVTL LLIYAYWPYG TFKRLGISGP KPVPFFGTML
60 70 80 90 100
HYRRGFFTFD EECKKKYGKV WGIYDGRQPV LCVTDPEIIK AVLVKECLSF
110 120 130 140 150
FTNRRNFHLN GPLYDALSVA EDDQWKRIRS VLSPSFTSGR LKEMFEIMKN
160 170 180 190 200
HSANLIRSMK KKADKDEPLD LKEFFGSYSM DVVTSTAFSV DIDSLNNPSD
210 220 230 240 250
PFVTNIKKML KFDFLNPLFL AVAFFPFLGP ILEKFELSFF PKSVTDFFYA
260 270 280 290 300
SLEKIKSNRE ASQQKSRVDF LQLMIDSQKN SGAQQDKSLT DHEILSQSMI
310 320 330 340 350
FIFAGYETSS SSLTFLAYNL ATNPEVMKKL QEEIDATFPN KAPVHYQPLM
360 370 380 390 400
EMEYLDCVIN ESLRLFPIAA RLERVAKAAV EINGIVIPKD MVVMIPTWPL
410 420 430 440 450
HRDPEIWPEP EAFKPERFSK KNKDNIDPYI YMPFGSGPRN CIGMRFALVL
460 470 480 490
IKLAVVEILQ QYSFSVCKET EVPFEMDIQG LLAPKRPIQL KLVPRS
Length:496
Mass (Da):57,054
Last modified:March 1, 2003 - v1
Checksum:iBAF945B260CA0220
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY143428 mRNA. Translation: AAN38837.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY143428 mRNA. Translation: AAN38837.1.

3D structure databases

ProteinModelPortaliQ8AXY5.
SMRiQ8AXY5. Positions 29-495.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG108567.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus)."
    Hegelund T., Celander M.C.
    Aquat. Toxicol. 64:277-291(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A genes."
    Celander M.C., Stegeman J.J.
    Biochem. Biophys. Res. Commun. 236:306-312(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 312-435.
    Tissue: Liver.

Entry informationi

Entry nameiC356_FUNHE
AccessioniPrimary (citable) accession number: Q8AXY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Due to a recent gene duplication event, CYP3A30 and CYP3A56 are very similar. Because of this it was not possible to distinguish between the two genes when measuring the tissue expression.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.