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Q8AXY5

- C356_FUNHE

UniProt

Q8AXY5 - C356_FUNHE

Protein

Cytochrome P450 3A56

Gene

cyp3a56

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Putative steroid 6-beta-hydroxylase.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi441 – 4411Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A56 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA56
    Gene namesi
    Name:cyp3a56
    OrganismiFundulus heteroclitus (Killifish) (Mummichog)Imported
    Taxonomic identifieri8078 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Cytochrome P450 3A56PRO_0000051810Add
    BLAST

    Expressioni

    Tissue specificityi

    Highly expressed in liver and intestine. Moderate expression in gill and spleen. Low expression in kidney, brain and heart.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8AXY5.
    SMRiQ8AXY5. Positions 29-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG108567.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8AXY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYFYLTAET WTLLVAFVTL LLIYAYWPYG TFKRLGISGP KPVPFFGTML    50
    HYRRGFFTFD EECKKKYGKV WGIYDGRQPV LCVTDPEIIK AVLVKECLSF 100
    FTNRRNFHLN GPLYDALSVA EDDQWKRIRS VLSPSFTSGR LKEMFEIMKN 150
    HSANLIRSMK KKADKDEPLD LKEFFGSYSM DVVTSTAFSV DIDSLNNPSD 200
    PFVTNIKKML KFDFLNPLFL AVAFFPFLGP ILEKFELSFF PKSVTDFFYA 250
    SLEKIKSNRE ASQQKSRVDF LQLMIDSQKN SGAQQDKSLT DHEILSQSMI 300
    FIFAGYETSS SSLTFLAYNL ATNPEVMKKL QEEIDATFPN KAPVHYQPLM 350
    EMEYLDCVIN ESLRLFPIAA RLERVAKAAV EINGIVIPKD MVVMIPTWPL 400
    HRDPEIWPEP EAFKPERFSK KNKDNIDPYI YMPFGSGPRN CIGMRFALVL 450
    IKLAVVEILQ QYSFSVCKET EVPFEMDIQG LLAPKRPIQL KLVPRS 496
    Length:496
    Mass (Da):57,054
    Last modified:March 1, 2003 - v1
    Checksum:iBAF945B260CA0220
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY143428 mRNA. Translation: AAN38837.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY143428 mRNA. Translation: AAN38837.1 .

    3D structure databases

    ProteinModelPortali Q8AXY5.
    SMRi Q8AXY5. Positions 29-495.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108567.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus)."
      Hegelund T., Celander M.C.
      Aquat. Toxicol. 64:277-291(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A genes."
      Celander M.C., Stegeman J.J.
      Biochem. Biophys. Res. Commun. 236:306-312(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 312-435.
      Tissue: Liver.

    Entry informationi

    Entry nameiC356_FUNHE
    AccessioniPrimary (citable) accession number: Q8AXY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Due to a recent gene duplication event, CYP3A30 and CYP3A56 are very similar. Because of this it was not possible to distinguish between the two genes when measuring the tissue expression.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3