Q8AXS7 (Q8AXS7_XENLA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alpha-(1,6)-fucosyltransferase PIRNR PIRNR000472
EC=2.4.1.68 PIRNR PIRNR000472

Gene names

Name:

fut8 EMBL CAD55853.1 Xenbase XB-FEAT-6254427 Xenbase XB-GENE-6254427

Organism

Xenopus laevis (African clawed frog) EMBL CAD55853.1

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans By similarity. PIRNR PIRNR000472
Catalytic activity	GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine. PIRNR PIRNR000472
Pathway	Protein modification; protein glycosylation. PIRNR PIRNR000472
Subcellular location	Golgi apparatus › Golgi stack membrane By similarity PIRNR PIRNR000472.
Sequence similarities	Belongs to the glycosyltransferase 23 family. PIRNR PIRNR000472

Ontologies

Keywords
Cellular component	Golgi apparatus PIRNR PIRNR000472 Membrane PIRNR PIRNR000472
Molecular function	Glycosyltransferase PIRNR PIRNR000472 EMBL CAD55853.1 Transferase
Gene Ontology (GO)
Biological process	protein glycosylation in Golgi Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	glycoprotein 6-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8AXS7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2741A03BDB3C5265	FASTA	578	66,579
	10 20 30 40 50 60 MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNENPDHSS RELSKILAKL ERLKQQNEDL 70 80 90 100 110 120 RRMAESLRIP EGPIEQGAAA GRIRALEEQL LKAKEQIEMY KQQSSNAVSG LGKDHEILRR 130 140 150 160 170 180 AIENGAKEFW YLVQSEVKKL KHLDRNELQR HVDEILIDMG HQQRSVMTDL YYLSQTDGAG 190 200 210 220 230 240 DWREREAKDL TDLVQRRITY LQNPKDCSKA KKLVCNINKG CGYGCQLHHV VYCFMIAYGT 250 260 270 280 290 300 QRTLILESQS WRYATGGWET VFKPVSETCT DRSGSSTGHW AGEANDKNVQ VVELPIVDSL 310 320 330 340 350 360 HPRPPYLPLG VPEDLADQLI RLHGDPAVWW VSQFVKYLIR PQPWLEKEIE EATKKLAFKH 370 380 390 400 410 420 PVIGVHVRRT DKVGTEAAFH PIEEYMVHVE EHFQLLARRM QIDKKRVYLA TDDPTLLQEA 430 440 450 460 470 480 KAKYPQYEFI SDNSISWSAG LHNRYTENSL RGVILDIHFL SQANFLVCTF SSQVCRVAYE 490 500 510 520 530 540 IMQTLHPDAS AYFHSLDDIY YFGGQNANNQ VAIYPHQPRN ADEIPLEPGD IIGVAGNHWD 550 560 570 GYSKGINRKL GRTGLYPSYK VKEKIETVKY PTYQEAEK

References

[1]	Oriol R. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ514872 mRNA. Translation: CAD55853.1.
RefSeq	NP_001081102.1. NM_001087633.1.
UniGene	Xl.8653.
3D structure databases
ProteinModelPortal	Q8AXS7.
SMR	Q8AXS7. Positions 111-575.
ModBase	Search...
Protein family/group databases
CAZy	GT23. Glycosyltransferase Family 23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	394383.
KEGG	xla:394383.
Organism-specific databases
CTD	394383.
Xenbase	XB-GENE-6254427. fut8.
Phylogenomic databases
HOVERGEN	HBG028260.
Family and domain databases
InterPro	IPR015827. Alpha1_6FUT_euk. IPR001452. SH3_domain. [Graphical view]
KO	K00717.
PIRSF	PIRSF000472. Alpha1_6FUT_euk. 1 hit.
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8AXS7_XENLA

Accession

Primary (citable) accession number: Q8AXS7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)