Reviewed, UniProtKB/Swiss-Prot Q8AWZ2 (HXA3A_DANRE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A3a

Gene names

Name:	hoxa3a
Synonyms:	hoxa1a

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Homeobox protein Hox-A3a		PRO_0000200046
Regions
	DNA binding	163 – 222	60	Homeobox
	Motif	127 – 132	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	154	1	D → RQ in AAD15938. Ref.1
	Sequence conflict	273 – 274	2	AS → HL in AAD15938. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8AWZ2-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 61AEBA565A10F2DC	FASTA	410	44,107
	10 20 30 40 50 60 MQKATYCDGS AIYSGLPYQS ANGLGYDASQ QQYLQALHAE SEYHRPACSL QSPGISAGLH 70 80 90 100 110 120 TSNEMSEVCQ QINGTQATVT DTSDNKQPPT APSGPSSPSS LNQIPNIDSA AKNPVHVSPT 130 140 150 160 170 180 PSTRKHIFPW MKESRQNTKQ KSCSIISVES CAGDKSPPGS AASKRARTAY TSAQLVELEK 190 200 210 220 230 240 EFHFNRYLCR PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGLGMMPS PGAQSPHSPV 250 260 270 280 290 300 SLSSGGGGGG GSAYLSSMHS LVNSVTYDSP SPASYNKPQS NTYSLPTSYP PLNNCPPPQK 310 320 330 340 350 360 RYQGTGTATP EYDTHHIQGN NNYGTQVQGS PVYVSGGGGY SDSLVGMGAS VFGLTHLPHP 370 380 390 400 410 SQGNIDYNGA ITMGNSHQQG ACDSNPCTFT DLTPHYSQGR IQEAPKLTHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zebrafish hox clusters and vertebrate genome evolution." Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K., Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M., Postlethwait J.H. Science 282:1711-1714(1998) [PubMed: 9831563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB and Tuebingen.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed: 16174031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 65-154. Strain: Tuebingen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF071245 mRNA. Translation: AAD15938.1. AL645756 Genomic DNA. Translation: CAD52134.1. CR382300 Genomic DNA. Translation: CAK10851.1. BC076469 mRNA. Translation: AAH76469.1. DQ060532 mRNA. Translation: AAY67910.1.
IPI	IPI00487095.
RefSeq	NP_571609.1.
UniGene	Dr.32618
3D structure databases
SMR	Q8AWZ2. Positions 165-222.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8AWZ2.
Genome annotation databases
Ensembl	ENSDART00000052633; ENSDARP00000052632; ENSDARG00000036231; Danio rerio. [Genome view]
GeneID	58049.
KEGG	dre:58049.
Organism-specific databases
CTD	58049.
ZFIN	ZDB-GENE-000823-3. hoxa3a.
Phylogenomic databases
HOGENOM	Q8AWZ2.
HOVERGEN	Q8AWZ2.
OMA	YDSSAIY
OrthoDB	EOG9HHRMP
Gene expression databases
ArrayExpress	Q8AWZ2.
Bgee	Q8AWZ2.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA3A_DANRE

Accession

Primary (citable) accession number: Q8AWZ2
Secondary accession number(s): Q1L969, Q4PRB1, Q9YGT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project