Q8AWY2 (HXAAB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A10b
Short name=Hox-A10

Gene names

Name:	hoxa10b
Synonyms:	hoxa10

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Developmental stage	At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit posterior to the last somite. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the somite 10/11 boundary. Ref.3
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Homeobox protein Hox-A10b		PRO_0000200092
Regions
	DNA binding	256 – 315	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	Q8AWY2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 0236BAE98AAC37AC	FASTA	330	36,947
	10 20 30 40 50 60 MSCSDSPSGN SFLVDSLIHG RSEGSGHYYQ NSGVYLQPTS EYSYGLSNCG YFSGLKRNES 70 80 90 100 110 120 NSQNVVPTCG PYQGMETWLE TSRSCRIEQP NSQITPRSFS PTIKEENSYC LYESEKCPKE 130 140 150 160 170 180 TITEDISYSR LTPNSCPSSN NNGCVPVPGY FRLSQTCTTS KGFTDNQTIP THVVAQRSTR 190 200 210 220 230 240 FDSSLSAIAA EASRDESDEP PTCAPCAPGR NKELRGSTGT ASSPEPPDSP EKAVTVTKAG 250 260 270 280 290 300 DSKSESTANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS RSVHLTDRQV 310 320 330 KIWFQNRRMK LKKMSRENRI RELSANFSFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB.
[2]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed: 16174031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-242. Strain: Tuebingen.
[3]	"Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk." Prince V.E., Joly L., Ekker M., Ho R.K. Development 125:407-420(1998) [PubMed: 9425136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-330, DEVELOPMENTAL STAGE. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL645795 Genomic DNA. Translation: CAD59110.1. DQ060538 mRNA. Translation: AAY67916.1. Y14527 mRNA. Translation: CAA74862.1.
IPI	IPI00510523.
RefSeq	NP_571230.1. NM_131155.1.
UniGene	Dr.75784.
3D structure databases
ProteinModelPortal	Q8AWY2.
SMR	Q8AWY2. Positions 248-317.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	30391.
KEGG	dre:30391.
Organism-specific databases
CTD	30391.
ZFIN	ZDB-GENE-990415-97. hoxa10b.
Phylogenomic databases
eggNOG	fiNOG06863.
GeneTree	ENSGT00560000076560.
HOGENOM	HBG445572.
HOVERGEN	HBG052934.
InParanoid	Q8AWY2.
OrthoDB	EOG4VX26S.
Gene expression databases
Bgee	Q8AWY2.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09295.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXAAB_DANRE

Accession

Primary (citable) accession number: Q8AWY2
Secondary accession number(s): O57357, Q4PRA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program