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Q8AWW5 (CRIM1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cysteine-rich motor neuron 1 protein

Short name=CRIM-1
Gene names
Name:CRIM1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1048 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Developmental stage

Expressed at embryonic stage 20 in the notchcord and weakly in the foor plate and persist until stage 29. Expressed in the motor neuron pool at stage 23. At stage 26 and 29 highly expressed in the ventrolateral neural tube and also in the roof plate.

Sequence similarities

Contains 4 antistasin-like domains.

Contains 1 IGFBP N-terminal domain.

Contains 6 VWFC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4646 Potential
Chain47 – 10481002Cysteine-rich motor neuron 1 protein
PRO_0000021000

Regions

Topological domain47 – 952906Extracellular Potential
Transmembrane953 – 97321Helical; Potential
Topological domain974 – 104875Cytoplasmic Potential
Domain47 – 12478IGFBP N-terminal
Domain346 – 40358VWFC 1
Domain413 – 46957VWFC 2
Domain481 – 51030Antistasin-like 1
Domain517 – 54428Antistasin-like 2
Domain551 – 57626Antistasin-like 3
Domain579 – 60426Antistasin-like 4
Domain618 – 67558VWFC 3
Domain689 – 74759VWFC 4
Domain763 – 82159VWFC 5
Domain829 – 88658VWFC 6
Motif326 – 3283Cell attachment site Potential
Motif904 – 9063Cell attachment site Potential

Amino acid modifications

Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation4861N-linked (GlcNAc...) Potential
Glycosylation7581N-linked (GlcNAc...) Potential
Glycosylation9131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8AWW5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 25E4D82C40B08231

FASTA1,048114,943
        10         20         30         40         50         60 
MYLAAVSAGR RRPGGDGGGG GGGWHLAAAG WLLLLALLLG QPGTRALVCL PCDESKCEEP 

        70         80         90        100        110        120 
KSCPGIIVLG ICGCCFMCAR QRNESCGGVY GLHGACDRGL RCVIRPPLNG DSITEYEVGV 

       130        140        150        160        170        180 
CEDENWDDDQ LLGFEPCNEN LITGCNIING KCDCDTIRTC NNPFEFPSRD TCLSALKRIE 

       190        200        210        220        230        240 
EEKPDCSKAR CEVQFSPRCP EDSILIEGYA PPGECCPLPS RCVCNPAGCL RKVCQPGYLN 

       250        260        270        280        290        300 
ILVSKASGKP GECCDLYECK PVFSVDCSTV ECPPVQQVVC PLDSYETQVR LTADGCCTLP 

       310        320        330        340        350        360 
TRCECLSGLC GFPMCEAGSV PQIVSRGDGT PGKCCDVFEC VNEVKPTCIF NSMEYYDGDM 

       370        380        390        400        410        420 
FRMDACRFCR CQGGVSICFS AQCGELHCDR YYVPEGECCP VCEDPVYPVN NPAGCYANGQ 

       430        440        450        460        470        480 
IQAHGDRWRE DDCTFCQCIN GNPHCVATAC GQSCLNPVKV PGECCPVCEE PTYITIGPPT 

       490        500        510        520        530        540 
CELLVNCTLT EKDCIYSFKL DQNGCRICQC KTREELCTGL ISGCSLDCSF GFQTDAHNCE 

       550        560        570        580        590        600 
ICQCRPRPKK CKPIVCDKYC PFGYLKNKHG CEICRCKKCP EMPCGKICPM GFQQNSHGCV 

       610        620        630        640        650        660 
ICKCREATAS LMPPVKTGSC LSMDGRRHEN EESWHDGCRE CYCHNGREMC ALITCPVPNC 

       670        680        690        700        710        720 
GNPTIHPGQC CPSCPDEIIV QKPELTSPSI CHAPGGEYFV EGETWNIDSC TQCTCHSGRV 

       730        740        750        760        770        780 
LCETEVCPPL LCQNPTRTQD SCCPQCPDEP LQPSLSSNVS MPSYCKNDEG DIFLTAESWK 

       790        800        810        820        830        840 
PNVCTSCICM DGVIRCYSES CPPVSCERPV LRKGQCCPYC IEDTVPKKVV CHFNGKTYAD 

       850        860        870        880        890        900 
EERWDIDSCT HCYCLQGQTL CSTVSCPPLP CAEPINVEGS CCPMCPEMYV PEPTNIPIEK 

       910        920        930        940        950        960 
TNHRGDVELE VPNWSTPSEN DIIHIHRDMN HLQGEYRSGN GPHPSEDASV SSVALVTVPI 

       970        980        990       1000       1010       1020 
TIALLVIIVF LLINQKKQWI PVSCYKAPTK PSCLNNQLVY VDCKKGTMVQ VDSSQRMLRI 

      1030       1040 
ADPDSRYSGF YSMQKQNNLQ ADNFYQTV 

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References

[1]"In ovo electroporation of Crim1 in the developing chick spinal cord."
Kolle G.V., Jansen A., Yamada T., Little M.H.
Dev. Dyn. 226:107-111(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY098584 mRNA. Translation: AAM28339.1.
RefSeqNP_989756.1. NM_204425.1.
UniGeneGga.5001.

3D structure databases

ProteinModelPortalQ8AWW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000037171.

Proteomic databases

PaxDbQ8AWW5.
PRIDEQ8AWW5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395067.
KEGGgga:395067.

Organism-specific databases

CTD51232.

Phylogenomic databases

eggNOGNOG283828.
HOGENOMHOG000063671.
HOVERGENHBG081345.
PhylomeDBQ8AWW5.

Family and domain databases

Gene3D2.10.22.10. 3 hits.
InterProIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815161.
PROQ8AWW5.

Entry information

Entry nameCRIM1_CHICK
AccessionPrimary (citable) accession number: Q8AWW5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families