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Q8AWW5

- CRIM1_CHICK

UniProt

Q8AWW5 - CRIM1_CHICK

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Protein

Cysteine-rich motor neuron 1 protein

Gene
CRIM1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival By similarity.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:CRIM1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini47 – 952906Extracellular Reviewed predictionAdd
BLAST
Transmembranei953 – 97321Helical; Reviewed predictionAdd
BLAST
Topological domaini974 – 104875Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646 Reviewed predictionAdd
BLAST
Chaini47 – 10481002Cysteine-rich motor neuron 1 proteinPRO_0000021000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi486 – 4861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi758 – 7581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi913 – 9131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8AWW5.
PRIDEiQ8AWW5.

Expressioni

Developmental stagei

Expressed at embryonic stage 20 in the notchcord and weakly in the foor plate and persist until stage 29. Expressed in the motor neuron pool at stage 23. At stage 26 and 29 highly expressed in the ventrolateral neural tube and also in the roof plate.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037171.

Structurei

3D structure databases

ProteinModelPortaliQ8AWW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 12478IGFBP N-terminalAdd
BLAST
Domaini346 – 40358VWFC 1Add
BLAST
Domaini413 – 46957VWFC 2Add
BLAST
Domaini481 – 51030Antistasin-like 1Add
BLAST
Domaini517 – 54428Antistasin-like 2Add
BLAST
Domaini551 – 57626Antistasin-like 3Add
BLAST
Domaini579 – 60426Antistasin-like 4Add
BLAST
Domaini618 – 67558VWFC 3Add
BLAST
Domaini689 – 74759VWFC 4Add
BLAST
Domaini763 – 82159VWFC 5Add
BLAST
Domaini829 – 88658VWFC 6Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi326 – 3283Cell attachment site Reviewed prediction
Motifi904 – 9063Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 6 VWFC domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283828.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
PhylomeDBiQ8AWW5.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8AWW5-1 [UniParc]FASTAAdd to Basket

« Hide

MYLAAVSAGR RRPGGDGGGG GGGWHLAAAG WLLLLALLLG QPGTRALVCL     50
PCDESKCEEP KSCPGIIVLG ICGCCFMCAR QRNESCGGVY GLHGACDRGL 100
RCVIRPPLNG DSITEYEVGV CEDENWDDDQ LLGFEPCNEN LITGCNIING 150
KCDCDTIRTC NNPFEFPSRD TCLSALKRIE EEKPDCSKAR CEVQFSPRCP 200
EDSILIEGYA PPGECCPLPS RCVCNPAGCL RKVCQPGYLN ILVSKASGKP 250
GECCDLYECK PVFSVDCSTV ECPPVQQVVC PLDSYETQVR LTADGCCTLP 300
TRCECLSGLC GFPMCEAGSV PQIVSRGDGT PGKCCDVFEC VNEVKPTCIF 350
NSMEYYDGDM FRMDACRFCR CQGGVSICFS AQCGELHCDR YYVPEGECCP 400
VCEDPVYPVN NPAGCYANGQ IQAHGDRWRE DDCTFCQCIN GNPHCVATAC 450
GQSCLNPVKV PGECCPVCEE PTYITIGPPT CELLVNCTLT EKDCIYSFKL 500
DQNGCRICQC KTREELCTGL ISGCSLDCSF GFQTDAHNCE ICQCRPRPKK 550
CKPIVCDKYC PFGYLKNKHG CEICRCKKCP EMPCGKICPM GFQQNSHGCV 600
ICKCREATAS LMPPVKTGSC LSMDGRRHEN EESWHDGCRE CYCHNGREMC 650
ALITCPVPNC GNPTIHPGQC CPSCPDEIIV QKPELTSPSI CHAPGGEYFV 700
EGETWNIDSC TQCTCHSGRV LCETEVCPPL LCQNPTRTQD SCCPQCPDEP 750
LQPSLSSNVS MPSYCKNDEG DIFLTAESWK PNVCTSCICM DGVIRCYSES 800
CPPVSCERPV LRKGQCCPYC IEDTVPKKVV CHFNGKTYAD EERWDIDSCT 850
HCYCLQGQTL CSTVSCPPLP CAEPINVEGS CCPMCPEMYV PEPTNIPIEK 900
TNHRGDVELE VPNWSTPSEN DIIHIHRDMN HLQGEYRSGN GPHPSEDASV 950
SSVALVTVPI TIALLVIIVF LLINQKKQWI PVSCYKAPTK PSCLNNQLVY 1000
VDCKKGTMVQ VDSSQRMLRI ADPDSRYSGF YSMQKQNNLQ ADNFYQTV 1048
Length:1,048
Mass (Da):114,943
Last modified:March 1, 2003 - v1
Checksum:i25E4D82C40B08231
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098584 mRNA. Translation: AAM28339.1.
RefSeqiNP_989756.1. NM_204425.1.
UniGeneiGga.5001.

Genome annotation databases

GeneIDi395067.
KEGGigga:395067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098584 mRNA. Translation: AAM28339.1 .
RefSeqi NP_989756.1. NM_204425.1.
UniGenei Gga.5001.

3D structure databases

ProteinModelPortali Q8AWW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000037171.

Proteomic databases

PaxDbi Q8AWW5.
PRIDEi Q8AWW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395067.
KEGGi gga:395067.

Organism-specific databases

CTDi 51232.

Phylogenomic databases

eggNOGi NOG283828.
HOGENOMi HOG000063671.
HOVERGENi HBG081345.
PhylomeDBi Q8AWW5.

Miscellaneous databases

NextBioi 20815161.
PROi Q8AWW5.

Family and domain databases

Gene3Di 2.10.22.10. 3 hits.
InterProi IPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEi PS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "In ovo electroporation of Crim1 in the developing chick spinal cord."
    Kolle G.V., Jansen A., Yamada T., Little M.H.
    Dev. Dyn. 226:107-111(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCRIM1_CHICK
AccessioniPrimary (citable) accession number: Q8AWW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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