Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8AWW5

- CRIM1_CHICK

UniProt

Q8AWW5 - CRIM1_CHICK

Protein

Cysteine-rich motor neuron 1 protein

Gene

CRIM1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: InterPro

    GO - Biological processi

    1. regulation of cell growth Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich motor neuron 1 protein
    Short name:
    CRIM-1
    Gene namesi
    Name:CRIM1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4646Sequence AnalysisAdd
    BLAST
    Chaini47 – 10481002Cysteine-rich motor neuron 1 proteinPRO_0000021000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi913 – 9131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8AWW5.
    PRIDEiQ8AWW5.

    Expressioni

    Developmental stagei

    Expressed at embryonic stage 20 in the notchcord and weakly in the foor plate and persist until stage 29. Expressed in the motor neuron pool at stage 23. At stage 26 and 29 highly expressed in the ventrolateral neural tube and also in the roof plate.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000037171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8AWW5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini47 – 952906ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini974 – 104875CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei953 – 97321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 12478IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini346 – 40358VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini413 – 46957VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini481 – 51030Antistasin-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 54428Antistasin-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini551 – 57626Antistasin-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini579 – 60426Antistasin-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini618 – 67558VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini689 – 74759VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini763 – 82159VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini829 – 88658VWFC 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi326 – 3283Cell attachment siteSequence Analysis
    Motifi904 – 9063Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 4 antistasin-like domains.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 6 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283828.
    HOGENOMiHOG000063671.
    HOVERGENiHBG081345.
    PhylomeDBiQ8AWW5.

    Family and domain databases

    Gene3Di2.10.22.10. 3 hits.
    InterProiIPR004094. Antistasin-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011061. Hirudin/antistatin.
    IPR000867. IGFBP-like.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF02822. Antistasin. 4 hits.
    PF00093. VWC. 6 hits.
    [Graphical view]
    SMARTiSM00121. IB. 1 hit.
    SM00214. VWC. 6 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57262. SSF57262. 3 hits.
    PROSITEiPS51252. ANTISTASIN. 4 hits.
    PS51323. IGFBP_N_2. 1 hit.
    PS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8AWW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLAAVSAGR RRPGGDGGGG GGGWHLAAAG WLLLLALLLG QPGTRALVCL     50
    PCDESKCEEP KSCPGIIVLG ICGCCFMCAR QRNESCGGVY GLHGACDRGL 100
    RCVIRPPLNG DSITEYEVGV CEDENWDDDQ LLGFEPCNEN LITGCNIING 150
    KCDCDTIRTC NNPFEFPSRD TCLSALKRIE EEKPDCSKAR CEVQFSPRCP 200
    EDSILIEGYA PPGECCPLPS RCVCNPAGCL RKVCQPGYLN ILVSKASGKP 250
    GECCDLYECK PVFSVDCSTV ECPPVQQVVC PLDSYETQVR LTADGCCTLP 300
    TRCECLSGLC GFPMCEAGSV PQIVSRGDGT PGKCCDVFEC VNEVKPTCIF 350
    NSMEYYDGDM FRMDACRFCR CQGGVSICFS AQCGELHCDR YYVPEGECCP 400
    VCEDPVYPVN NPAGCYANGQ IQAHGDRWRE DDCTFCQCIN GNPHCVATAC 450
    GQSCLNPVKV PGECCPVCEE PTYITIGPPT CELLVNCTLT EKDCIYSFKL 500
    DQNGCRICQC KTREELCTGL ISGCSLDCSF GFQTDAHNCE ICQCRPRPKK 550
    CKPIVCDKYC PFGYLKNKHG CEICRCKKCP EMPCGKICPM GFQQNSHGCV 600
    ICKCREATAS LMPPVKTGSC LSMDGRRHEN EESWHDGCRE CYCHNGREMC 650
    ALITCPVPNC GNPTIHPGQC CPSCPDEIIV QKPELTSPSI CHAPGGEYFV 700
    EGETWNIDSC TQCTCHSGRV LCETEVCPPL LCQNPTRTQD SCCPQCPDEP 750
    LQPSLSSNVS MPSYCKNDEG DIFLTAESWK PNVCTSCICM DGVIRCYSES 800
    CPPVSCERPV LRKGQCCPYC IEDTVPKKVV CHFNGKTYAD EERWDIDSCT 850
    HCYCLQGQTL CSTVSCPPLP CAEPINVEGS CCPMCPEMYV PEPTNIPIEK 900
    TNHRGDVELE VPNWSTPSEN DIIHIHRDMN HLQGEYRSGN GPHPSEDASV 950
    SSVALVTVPI TIALLVIIVF LLINQKKQWI PVSCYKAPTK PSCLNNQLVY 1000
    VDCKKGTMVQ VDSSQRMLRI ADPDSRYSGF YSMQKQNNLQ ADNFYQTV 1048
    Length:1,048
    Mass (Da):114,943
    Last modified:March 1, 2003 - v1
    Checksum:i25E4D82C40B08231
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098584 mRNA. Translation: AAM28339.1.
    RefSeqiNP_989756.1. NM_204425.1.
    UniGeneiGga.5001.

    Genome annotation databases

    GeneIDi395067.
    KEGGigga:395067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098584 mRNA. Translation: AAM28339.1 .
    RefSeqi NP_989756.1. NM_204425.1.
    UniGenei Gga.5001.

    3D structure databases

    ProteinModelPortali Q8AWW5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000037171.

    Proteomic databases

    PaxDbi Q8AWW5.
    PRIDEi Q8AWW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395067.
    KEGGi gga:395067.

    Organism-specific databases

    CTDi 51232.

    Phylogenomic databases

    eggNOGi NOG283828.
    HOGENOMi HOG000063671.
    HOVERGENi HBG081345.
    PhylomeDBi Q8AWW5.

    Miscellaneous databases

    NextBioi 20815161.
    PROi Q8AWW5.

    Family and domain databases

    Gene3Di 2.10.22.10. 3 hits.
    InterProi IPR004094. Antistasin-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011061. Hirudin/antistatin.
    IPR000867. IGFBP-like.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF02822. Antistasin. 4 hits.
    PF00093. VWC. 6 hits.
    [Graphical view ]
    SMARTi SM00121. IB. 1 hit.
    SM00214. VWC. 6 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57262. SSF57262. 3 hits.
    PROSITEi PS51252. ANTISTASIN. 4 hits.
    PS51323. IGFBP_N_2. 1 hit.
    PS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In ovo electroporation of Crim1 in the developing chick spinal cord."
      Kolle G.V., Jansen A., Yamada T., Little M.H.
      Dev. Dyn. 226:107-111(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCRIM1_CHICK
    AccessioniPrimary (citable) accession number: Q8AWW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3