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Q8AWW5

- CRIM1_CHICK

UniProt

Q8AWW5 - CRIM1_CHICK

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Protein

Cysteine-rich motor neuron 1 protein

Gene

CRIM1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:CRIM1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646Sequence AnalysisAdd
BLAST
Chaini47 – 10481002Cysteine-rich motor neuron 1 proteinPRO_0000021000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi913 – 9131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8AWW5.
PRIDEiQ8AWW5.

Expressioni

Developmental stagei

Expressed at embryonic stage 20 in the notchcord and weakly in the foor plate and persist until stage 29. Expressed in the motor neuron pool at stage 23. At stage 26 and 29 highly expressed in the ventrolateral neural tube and also in the roof plate.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037171.

Structurei

3D structure databases

ProteinModelPortaliQ8AWW5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini47 – 952906ExtracellularSequence AnalysisAdd
BLAST
Topological domaini974 – 104875CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei953 – 97321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 12478IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini346 – 40358VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini413 – 46957VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini481 – 51030Antistasin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini517 – 54428Antistasin-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini551 – 57626Antistasin-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini579 – 60426Antistasin-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini618 – 67558VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini689 – 74759VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini763 – 82159VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini829 – 88658VWFC 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi326 – 3283Cell attachment siteSequence Analysis
Motifi904 – 9063Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 4 antistasin-like domains.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283828.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ8AWW5.
PhylomeDBiQ8AWW5.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8AWW5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYLAAVSAGR RRPGGDGGGG GGGWHLAAAG WLLLLALLLG QPGTRALVCL
60 70 80 90 100
PCDESKCEEP KSCPGIIVLG ICGCCFMCAR QRNESCGGVY GLHGACDRGL
110 120 130 140 150
RCVIRPPLNG DSITEYEVGV CEDENWDDDQ LLGFEPCNEN LITGCNIING
160 170 180 190 200
KCDCDTIRTC NNPFEFPSRD TCLSALKRIE EEKPDCSKAR CEVQFSPRCP
210 220 230 240 250
EDSILIEGYA PPGECCPLPS RCVCNPAGCL RKVCQPGYLN ILVSKASGKP
260 270 280 290 300
GECCDLYECK PVFSVDCSTV ECPPVQQVVC PLDSYETQVR LTADGCCTLP
310 320 330 340 350
TRCECLSGLC GFPMCEAGSV PQIVSRGDGT PGKCCDVFEC VNEVKPTCIF
360 370 380 390 400
NSMEYYDGDM FRMDACRFCR CQGGVSICFS AQCGELHCDR YYVPEGECCP
410 420 430 440 450
VCEDPVYPVN NPAGCYANGQ IQAHGDRWRE DDCTFCQCIN GNPHCVATAC
460 470 480 490 500
GQSCLNPVKV PGECCPVCEE PTYITIGPPT CELLVNCTLT EKDCIYSFKL
510 520 530 540 550
DQNGCRICQC KTREELCTGL ISGCSLDCSF GFQTDAHNCE ICQCRPRPKK
560 570 580 590 600
CKPIVCDKYC PFGYLKNKHG CEICRCKKCP EMPCGKICPM GFQQNSHGCV
610 620 630 640 650
ICKCREATAS LMPPVKTGSC LSMDGRRHEN EESWHDGCRE CYCHNGREMC
660 670 680 690 700
ALITCPVPNC GNPTIHPGQC CPSCPDEIIV QKPELTSPSI CHAPGGEYFV
710 720 730 740 750
EGETWNIDSC TQCTCHSGRV LCETEVCPPL LCQNPTRTQD SCCPQCPDEP
760 770 780 790 800
LQPSLSSNVS MPSYCKNDEG DIFLTAESWK PNVCTSCICM DGVIRCYSES
810 820 830 840 850
CPPVSCERPV LRKGQCCPYC IEDTVPKKVV CHFNGKTYAD EERWDIDSCT
860 870 880 890 900
HCYCLQGQTL CSTVSCPPLP CAEPINVEGS CCPMCPEMYV PEPTNIPIEK
910 920 930 940 950
TNHRGDVELE VPNWSTPSEN DIIHIHRDMN HLQGEYRSGN GPHPSEDASV
960 970 980 990 1000
SSVALVTVPI TIALLVIIVF LLINQKKQWI PVSCYKAPTK PSCLNNQLVY
1010 1020 1030 1040
VDCKKGTMVQ VDSSQRMLRI ADPDSRYSGF YSMQKQNNLQ ADNFYQTV
Length:1,048
Mass (Da):114,943
Last modified:March 1, 2003 - v1
Checksum:i25E4D82C40B08231
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098584 mRNA. Translation: AAM28339.1.
RefSeqiNP_989756.1. NM_204425.1.
UniGeneiGga.5001.

Genome annotation databases

GeneIDi395067.
KEGGigga:395067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098584 mRNA. Translation: AAM28339.1 .
RefSeqi NP_989756.1. NM_204425.1.
UniGenei Gga.5001.

3D structure databases

ProteinModelPortali Q8AWW5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000037171.

Proteomic databases

PaxDbi Q8AWW5.
PRIDEi Q8AWW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395067.
KEGGi gga:395067.

Organism-specific databases

CTDi 51232.

Phylogenomic databases

eggNOGi NOG283828.
HOGENOMi HOG000063671.
HOVERGENi HBG081345.
InParanoidi Q8AWW5.
PhylomeDBi Q8AWW5.

Miscellaneous databases

NextBioi 20815161.
PROi Q8AWW5.

Family and domain databases

Gene3Di 2.10.22.10. 3 hits.
InterProi IPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEi PS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "In ovo electroporation of Crim1 in the developing chick spinal cord."
    Kolle G.V., Jansen A., Yamada T., Little M.H.
    Dev. Dyn. 226:107-111(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCRIM1_CHICK
AccessioniPrimary (citable) accession number: Q8AWW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3