Reviewed, UniProtKB/Swiss-Prot Q8AWG2 (MTA_CARCW)

Names and origin

Protein names

Recommended name:
    Metallothionein A
      Short name=MT-A

Gene names

Name:

mta

Organism

Carassius cuvieri (Crucian carp)

Taxonomic identifier

52617 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Carassius

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 60	60	Metallothionein A		PRO_0000197271
Regions
	Region	1 – 28	28	Beta
	Region	29 – 60	32	Alpha
Sites
	Metal binding	4	1	Cluster B
	Metal binding	6	1	Cluster B
	Metal binding	12	1	Cluster B
	Metal binding	14	1	Cluster B
	Metal binding	18	1	Cluster B
	Metal binding	20	1	Cluster B
	Metal binding	23	1	Cluster B
	Metal binding	25	1	Cluster B
	Metal binding	28	1	Cluster B
	Metal binding	32	1	Cluster A
	Metal binding	33	1	Cluster A
	Metal binding	35	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	40	1	Cluster A
	Metal binding	43	1	Cluster A
	Metal binding	47	1	Cluster A
	Metal binding	49	1	Cluster A
	Metal binding	54	1	Cluster A
	Metal binding	58	1	Cluster A
	Metal binding	59	1	Cluster A

Sequences

	Sequence		Length	Mass (Da)
	Q8AWG2-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 543F9410864BB701	FASTA	60	5,958
	10 20 30 40 50 60 MDPCDCAKTG PCNCGATCKC TNCQCTTCKK SCCSCCPSGC SKCASGCVCK GNSCGSSCCQ

References

[1]

"Two metallothioneins in the fresh-water fish, crucian carp (Carassius cuvieri): cDNA cloning and assignment of their expression isoforms." Ren H.W., Itoh N., Kanekiyo M., Tominaga S., Kohroki J., Hwang G.S., Nakanishi T., Muto N., Tanaka K. Biol. Pharm. Bull. 23:145-148(2000) [PubMed: 10706375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY165047 mRNA. Translation: AAN85819.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q8AWG2.
Family and domain databases
InterPro	IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTA_CARCW

Accession

Primary (citable) accession number: Q8AWG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)