Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8AW93

- DTX1_XENLA

UniProt

Q8AW93 - DTX1_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

E3 ubiquitin-protein ligase DTX1

Gene

dtx1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri413 – 47462RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. Notch signaling pathway Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase DTX1 (EC:6.3.2.-)
Alternative name(s):
Protein deltex-1
Short name:
xDtx1
Gene namesi
Name:dtx1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865444. dtx1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623E3 ubiquitin-protein ligase DTX1PRO_0000219082Add
BLAST

Expressioni

Tissue specificityi

Specifically expressed in regions undergoing neuronal differentiation. Mainly colocalizes with Notch1.

Developmental stagei

In the tailbud stage, it is expressed in the olfactory bulbs, pineal complex and along the neural tube according to an antero-posterior gradient showing a gap at the midbrain-hindbrain boundary. At tadpole stage, it is expressed in the differentiating retina, in the neuronal fibers of the outer and inner plexiform layers, while its expression in the pineal complex becomes restricted to the photosensitive frontal organ.1 Publication

Interactioni

Subunit structurei

May form a homo- or heterodimer with other members of the Deltex family. Probably interacts with Notch1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8AW93.
SMRiQ8AW93. Positions 391-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9381WWE 1PROSITE-ProRule annotationAdd
BLAST
Domaini94 – 17077WWE 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi226 – 24318Pro-richAdd
BLAST

Domaini

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

Sequence similaritiesi

Belongs to the Deltex family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 2 WWE domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri413 – 47462RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG007213.
KOiK06058.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02825. WWE. 2 hits.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view]
PROSITEiPS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AW93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRPGVLLPV NGHNFGSQGG PPRVVVWEWL NEHGRWRPYT ATVCHHIENA
60 70 80 90 100
LREDGRGRVA LGQVDAQLTP YVIDLQTMHQ YRQDTGTIRP VRRNFFEPSS
110 120 130 140 150
APGKGIVWEW ENDAGSWTPY DTEICIAIQN AYEKHHPYLD LTTLGFCYLV
160 170 180 190 200
HFHSMCQVNR QTHRKRRLRR RMDLAYPLTM GSIPKSQSWP VGSGSGLPCS
210 220 230 240 250
CPQCLLVNST RAASNAILAS QRIKVPSGPP PALPPPPPPP IHPSGLRQSN
260 270 280 290 300
TYSGGAAGWG RTGEGMRSTG GIRNGSGFSR SQSVPGAAPY PGQNNLNRPG
310 320 330 340 350
EQRTSGSSSR ASIPPGVPAL PVKNLNGSGP VHPALAGMTG ILMCAAGLPV
360 370 380 390 400
CLTRAPKPIL HPPPVSKEDI KPVSGVSGIC RKTKKKHLKK SKNPEEVVRR
410 420 430 440 450
YIQKVKSPPD EDCTICMERL VTASGYDGVL SHRGIRAELV GKLGKCNHMY
460 470 480 490 500
HVLCPVAMYN NGNKDGSLQC PTCKAIYGEK TGTQPPGKME FHVIPHSLPG
510 520 530 540 550
FSDCKTIRIV YDIPSGMQGP EHPNPGKKFT ARGFPRHCYL PDNDKGRKVL
560 570 580 590 600
RLLLAAWERR LIFAIGTSST TGESNTVVWN EIHHKTEFGS NLTGHGYPDP
610 620
NYLDNVLTEL HRQGVMEERS LPY
Length:623
Mass (Da):68,333
Last modified:March 1, 2003 - v1
Checksum:i0BBE3411882F8F36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ431211 mRNA. Translation: CAD26517.1.
RefSeqiNP_001082450.1. NM_001088981.1.
UniGeneiXl.26491.

Genome annotation databases

GeneIDi398477.
KEGGixla:398477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ431211 mRNA. Translation: CAD26517.1 .
RefSeqi NP_001082450.1. NM_001088981.1.
UniGenei Xl.26491.

3D structure databases

ProteinModelPortali Q8AW93.
SMRi Q8AW93. Positions 391-497.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398477.
KEGGi xla:398477.

Organism-specific databases

CTDi 1840.
Xenbasei XB-GENE-865444. dtx1.

Phylogenomic databases

HOVERGENi HBG007213.
KOi K06058.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02825. WWE. 2 hits.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view ]
PROSITEi PS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xdtx1, a Xenopus Deltex homologue expressed in differentiating neurons and in photoreceptive organs."
    Andreazzoli M., Marracci S., Panattoni M., Nardi I.
    Gene Expr. Patterns 2:283-287(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDTX1_XENLA
AccessioniPrimary (citable) accession number: Q8AW93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3