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Q8AW93 (DTX1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase DTX1

EC=6.3.2.-
Alternative name(s):
Protein deltex-1
Short name=xDtx1
Gene names
Name:dtx1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

May form a homo- or heterodimer with other members of the Deltex family. Probably interacts with Notch1 By similarity.

Tissue specificity

Specifically expressed in regions undergoing neuronal differentiation. Mainly colocalizes with Notch1.

Developmental stage

In the tailbud stage, it is expressed in the olfactory bulbs, pineal complex and along the neural tube according to an antero-posterior gradient showing a gap at the midbrain-hindbrain boundary. At tadpole stage, it is expressed in the differentiating retina, in the neuronal fibers of the outer and inner plexiform layers, while its expression in the pineal complex becomes restricted to the photosensitive frontal organ. Ref.1

Domain

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases By similarity.

Sequence similarities

Belongs to the Deltex family.

Contains 1 RING-type zinc finger.

Contains 2 WWE domains.

Ontologies

Keywords
   Biological processNotch signaling pathway
Ubl conjugation pathway
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 623623E3 ubiquitin-protein ligase DTX1
PRO_0000219082

Regions

Domain13 – 9381WWE 1
Domain94 – 17077WWE 2
Zinc finger413 – 47462RING-type
Compositional bias226 – 24318Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q8AW93 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0BBE3411882F8F36

FASTA62368,333
        10         20         30         40         50         60 
MSRPGVLLPV NGHNFGSQGG PPRVVVWEWL NEHGRWRPYT ATVCHHIENA LREDGRGRVA 

        70         80         90        100        110        120 
LGQVDAQLTP YVIDLQTMHQ YRQDTGTIRP VRRNFFEPSS APGKGIVWEW ENDAGSWTPY 

       130        140        150        160        170        180 
DTEICIAIQN AYEKHHPYLD LTTLGFCYLV HFHSMCQVNR QTHRKRRLRR RMDLAYPLTM 

       190        200        210        220        230        240 
GSIPKSQSWP VGSGSGLPCS CPQCLLVNST RAASNAILAS QRIKVPSGPP PALPPPPPPP 

       250        260        270        280        290        300 
IHPSGLRQSN TYSGGAAGWG RTGEGMRSTG GIRNGSGFSR SQSVPGAAPY PGQNNLNRPG 

       310        320        330        340        350        360 
EQRTSGSSSR ASIPPGVPAL PVKNLNGSGP VHPALAGMTG ILMCAAGLPV CLTRAPKPIL 

       370        380        390        400        410        420 
HPPPVSKEDI KPVSGVSGIC RKTKKKHLKK SKNPEEVVRR YIQKVKSPPD EDCTICMERL 

       430        440        450        460        470        480 
VTASGYDGVL SHRGIRAELV GKLGKCNHMY HVLCPVAMYN NGNKDGSLQC PTCKAIYGEK 

       490        500        510        520        530        540 
TGTQPPGKME FHVIPHSLPG FSDCKTIRIV YDIPSGMQGP EHPNPGKKFT ARGFPRHCYL 

       550        560        570        580        590        600 
PDNDKGRKVL RLLLAAWERR LIFAIGTSST TGESNTVVWN EIHHKTEFGS NLTGHGYPDP 

       610        620 
NYLDNVLTEL HRQGVMEERS LPY 

« Hide

References

[1]"Xdtx1, a Xenopus Deltex homologue expressed in differentiating neurons and in photoreceptive organs."
Andreazzoli M., Marracci S., Panattoni M., Nardi I.
Gene Expr. Patterns 2:283-287(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ431211 mRNA. Translation: CAD26517.1.
RefSeqNP_001082450.1. NM_001088981.1.
UniGeneXl.26491.

3D structure databases

ProteinModelPortalQ8AW93.
SMRQ8AW93. Positions 391-497.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398477.
KEGGxla:398477.

Organism-specific databases

CTD1840.
XenbaseXB-GENE-865444. dtx1.

Phylogenomic databases

HOVERGENHBG007213.
KOK06058.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF02825. WWE. 2 hits.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view]
PROSITEPS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDTX1_XENLA
AccessionPrimary (citable) accession number: Q8AW93
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways