Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein atonal homolog 7

Gene

atoh7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in the differentiation of retinal ganglion cells.2 Publications

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: ZFIN
  • cell fate commitment Source: ZFIN
  • eye development Source: ZFIN
  • positive regulation of neurogenesis Source: ZFIN
  • regulation of cell cycle Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • retina development in camera-type eye Source: ZFIN
  • retina layer formation Source: ZFIN
  • swimming behavior Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 7
Alternative name(s):
Helix-loop-helix protein zATH-5
Short name:
zATH5
Protein atonal homolog 5
Protein lakritz
Gene namesi
Name:atoh7
Synonyms:ath5, lak
ORF Names:si:packtrz.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-000926-1. atoh7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi44 – 441L → P in th241; no retinal ganglion cells. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Protein atonal homolog 7PRO_0000292408Add
BLAST

Proteomic databases

PaxDbiQ8AW52.

Expressioni

Developmental stagei

Expressed in the developing retina.1 Publication

Gene expression databases

BgeeiENSDARG00000069552.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092102.

Structurei

3D structure databases

ProteinModelPortaliQ8AW52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 8053bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000034180.
HOVERGENiHBG096161.
InParanoidiQ8AW52.
KOiK09083.
OMAiPHRQWLD.
OrthoDBiEOG091G0R1N.
PhylomeDBiQ8AW52.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032663. Atoh7.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF99. PTHR19290:SF99. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AW52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPRRPSCAD SGSDSDSRDP EKFESAMRRR MAANARERKR MQGLNTAFDR
60 70 80 90 100
LRKVVPQWGQ DKKLSKYETL QMALSYIMAL NRILSDAGRH VDPQKDWLNL
110 120 130
QFDGLQTEGY FMHYDSPVES DCMLSSFSYH YESL
Length:134
Mass (Da):15,622
Last modified:March 1, 2003 - v1
Checksum:i3207DBD0E5972496
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231M → T in BAB15953 (PubMed:10985346).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049457 mRNA. Translation: BAB15953.1.
AL627094 Genomic DNA. Translation: CAD52125.1.
BC071520 mRNA. Translation: AAH71520.1.
RefSeqiNP_571707.1. NM_131632.1.
UniGeneiDr.82507.

Genome annotation databases

EnsembliENSDART00000101328; ENSDARP00000092102; ENSDARG00000069552.
GeneIDi58216.
KEGGidre:58216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049457 mRNA. Translation: BAB15953.1.
AL627094 Genomic DNA. Translation: CAD52125.1.
BC071520 mRNA. Translation: AAH71520.1.
RefSeqiNP_571707.1. NM_131632.1.
UniGeneiDr.82507.

3D structure databases

ProteinModelPortaliQ8AW52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092102.

Proteomic databases

PaxDbiQ8AW52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000101328; ENSDARP00000092102; ENSDARG00000069552.
GeneIDi58216.
KEGGidre:58216.

Organism-specific databases

CTDi220202.
ZFINiZDB-GENE-000926-1. atoh7.

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000034180.
HOVERGENiHBG096161.
InParanoidiQ8AW52.
KOiK09083.
OMAiPHRQWLD.
OrthoDBiEOG091G0R1N.
PhylomeDBiQ8AW52.
TreeFamiTF315153.

Miscellaneous databases

PROiQ8AW52.

Gene expression databases

BgeeiENSDARG00000069552.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032663. Atoh7.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF99. PTHR19290:SF99. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOH7_DANRE
AccessioniPrimary (citable) accession number: Q8AW52
Secondary accession number(s): Q9DGA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.