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Protein

Protein atonal homolog 7

Gene

atoh7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in the differentiation of retinal ganglion cells.2 Publications

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: ZFIN
  • cell fate commitment Source: ZFIN
  • eye development Source: ZFIN
  • positive regulation of neurogenesis Source: ZFIN
  • regulation of cell cycle Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • retina development in camera-type eye Source: ZFIN
  • retina layer formation Source: ZFIN
  • swimming behavior Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 7
Alternative name(s):
Helix-loop-helix protein zATH-5
Short name:
zATH5
Protein atonal homolog 5
Protein lakritz
Gene namesi
Name:atoh7
Synonyms:ath5, lak
ORF Names:si:packtrz.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-000926-1. atoh7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi44 – 441L → P in th241; no retinal ganglion cells. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Protein atonal homolog 7PRO_0000292408Add
BLAST

Proteomic databases

PaxDbiQ8AW52.

Expressioni

Developmental stagei

Expressed in the developing retina.1 Publication

Gene expression databases

BgeeiQ8AW52.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092102.

Structurei

3D structure databases

ProteinModelPortaliQ8AW52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 8053bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000034180.
HOVERGENiHBG096161.
InParanoidiQ8AW52.
KOiK09083.
OMAiPHRQWLD.
OrthoDBiEOG7PGDSD.
PhylomeDBiQ8AW52.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032663. Atoh7.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF99. PTHR19290:SF99. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AW52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPRRPSCAD SGSDSDSRDP EKFESAMRRR MAANARERKR MQGLNTAFDR
60 70 80 90 100
LRKVVPQWGQ DKKLSKYETL QMALSYIMAL NRILSDAGRH VDPQKDWLNL
110 120 130
QFDGLQTEGY FMHYDSPVES DCMLSSFSYH YESL
Length:134
Mass (Da):15,622
Last modified:March 1, 2003 - v1
Checksum:i3207DBD0E5972496
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231M → T in BAB15953 (PubMed:10985346).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049457 mRNA. Translation: BAB15953.1.
AL627094 Genomic DNA. Translation: CAD52125.1.
BC071520 mRNA. Translation: AAH71520.1.
RefSeqiNP_571707.1. NM_131632.1.
UniGeneiDr.82507.

Genome annotation databases

EnsembliENSDART00000101328; ENSDARP00000092102; ENSDARG00000069552.
GeneIDi58216.
KEGGidre:58216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049457 mRNA. Translation: BAB15953.1.
AL627094 Genomic DNA. Translation: CAD52125.1.
BC071520 mRNA. Translation: AAH71520.1.
RefSeqiNP_571707.1. NM_131632.1.
UniGeneiDr.82507.

3D structure databases

ProteinModelPortaliQ8AW52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092102.

Proteomic databases

PaxDbiQ8AW52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000101328; ENSDARP00000092102; ENSDARG00000069552.
GeneIDi58216.
KEGGidre:58216.

Organism-specific databases

CTDi220202.
ZFINiZDB-GENE-000926-1. atoh7.

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000034180.
HOVERGENiHBG096161.
InParanoidiQ8AW52.
KOiK09083.
OMAiPHRQWLD.
OrthoDBiEOG7PGDSD.
PhylomeDBiQ8AW52.
TreeFamiTF315153.

Miscellaneous databases

NextBioi20892405.
PROiQ8AW52.

Gene expression databases

BgeeiQ8AW52.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032663. Atoh7.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF99. PTHR19290:SF99. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Midline signals regulate retinal neurogenesis in zebrafish."
    Masai I., Stemple D.L., Okamoto H., Wilson S.W.
    Neuron 27:251-263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. "Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog."
    Kay J.N., Finger-Baier K.C., Roeser T., Staub W., Baier H.
    Neuron 30:725-736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LEU-44.

Entry informationi

Entry nameiATOH7_DANRE
AccessioniPrimary (citable) accession number: Q8AW52
Secondary accession number(s): Q9DGA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.