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Q8AVU2 (UB2SB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S-B

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S-B
Ubiquitin-protein ligase S-B
Gene names
Name:ube2s-b
Synonyms:ube2s.1-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme ube2c/ubch10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Ubiquitin-conjugating enzyme E2 S-B
PRO_0000390432

Sites

Active site951Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8AVU2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EA930D5B61E9D251

FASTA21123,359
        10         20         30         40         50         60 
MNSNVENLPP HIIRRVYKEV STLTSDPPEG IKIIPNEEDI TDVQVNIEGP EGTPYAGGMF 

        70         80         90        100        110        120 
RMKLILGKDF PAAPPKGYFL TKIFHPNVSN NGEICVNVLK KDWKAELGIR HVLLTIKCLL 

       130        140        150        160        170        180 
IHPNPESALN EEAGRLLLEN YEEYASRARL MTDIHAQGTS LRGKDPTDPC SSASTPVVSG 

       190        200        210 
DGPMAKKHAG DRDKKLAAKK KTDKKRALRR L 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC041263 mRNA. Translation: AAH41263.1.
BC106317 mRNA. Translation: AAI06318.1.
RefSeqNP_001079388.1. NM_001085919.1.
UniGeneXl.32557.

3D structure databases

ProteinModelPortalQ8AVU2.
SMRQ8AVU2. Positions 6-156.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID379075.
KEGGxla:379075.

Organism-specific databases

CTD379075.
XenbaseXB-GENE-1008024. ube2s.

Phylogenomic databases

HOVERGENHBG063308.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUB2SB_XENLA
AccessionPrimary (citable) accession number: Q8AVU2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways