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Protein

Zinc finger protein 346

Gene

znf346

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds preferentially to dsRNA, but also to RNA-DNA hybrids.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Zinc 11 Publication
Metal bindingi39 – 391Zinc 11 Publication
Metal bindingi52 – 521Zinc 1; via tele nitrogen1 Publication
Metal bindingi58 – 581Zinc 1; via pros nitrogen1 Publication
Metal bindingi97 – 971Zinc 21 Publication
Metal bindingi100 – 1001Zinc 21 Publication
Metal bindingi113 – 1131Zinc 2; via tele nitrogen1 Publication
Metal bindingi119 – 1191Zinc 2; via pros nitrogen1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6431Matrin-type 1Sequence analysisAdd
BLAST
Zinc fingeri92 – 12635Matrin-type 2Sequence analysisAdd
BLAST
Zinc fingeri162 – 19231Matrin-type 3Sequence analysisAdd
BLAST
Zinc fingeri226 – 26035Matrin-type 4Sequence analysisAdd
BLAST
Zinc fingeri286 – 31631Matrin-type 5Sequence analysisAdd
BLAST
Zinc fingeri343 – 37331Matrin-type 6Sequence analysisAdd
BLAST
Zinc fingeri400 – 43031Matrin-type 7Sequence analysisAdd
BLAST

GO - Molecular functioni

  • double-stranded RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346By similarity
Alternative name(s):
Double-stranded RNA-binding protein ZFa
Short name:
DsRBP-ZFaImported
Short name:
ZFa1 Publication
Just another zinc finger proteinBy similarity
Short name:
Protein jaz
Gene namesi
Name:znf346By similarity
Synonyms:jazImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-967548. znf346.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Primarily nuclear.1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Zinc finger protein 346PRO_0000348934Add
BLAST

Structurei

Secondary structure

1
524
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 2610Combined sources
Turni27 – 304Combined sources
Beta strandi33 – 364Combined sources
Turni37 – 404Combined sources
Helixi46 – 549Combined sources
Helixi56 – 6813Combined sources
Turni93 – 953Combined sources
Turni98 – 1014Combined sources
Helixi107 – 1148Combined sources
Helixi117 – 12711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZU1NMR-A2-128[»]
ProteinModelPortaliQ8AVN9.
SMRiQ8AVN9. Positions 2-128.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8AVN9.

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.By similarity

Sequence similaritiesi

Contains 7 matrin-type zinc fingers.Sequence analysis

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6431Matrin-type 1Sequence analysisAdd
BLAST
Zinc fingeri92 – 12635Matrin-type 2Sequence analysisAdd
BLAST
Zinc fingeri162 – 19231Matrin-type 3Sequence analysisAdd
BLAST
Zinc fingeri226 – 26035Matrin-type 4Sequence analysisAdd
BLAST
Zinc fingeri286 – 31631Matrin-type 5Sequence analysisAdd
BLAST
Zinc fingeri343 – 37331Matrin-type 6Sequence analysisAdd
BLAST
Zinc fingeri400 – 43031Matrin-type 7Sequence analysisAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG061007.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AVN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEFGNGDA LDLPVGKDAV NSLIRENSHI FSDTQCKVCS AVLISESQKL
60 70 80 90 100
AHYQSRKHAN KVRRYMAINQ GEDSVPAKKF KAAPAEISDG EDRSKCCPVC
110 120 130 140 150
NMTFSSPVVA ESHYIGKTHI KNLRLREQGG VKEGMVNQAK KTRTPTVATK
160 170 180 190 200
SDNKMDHSDR AKFCKLCHST FNNPLMAEQH YAGKKHKKQE TKTQIMTIYT
210 220 230 240 250
SSGQTPAQAP IPLNLNSPMP GSGSAGKGFS CDKCNIVLNS IEQYQAHVSG
260 270 280 290 300
AKHKNQLMSM TPLSEEGHQA VVAPSAIASG SAGKGFSCDT CNIVLNSIEQ
310 320 330 340 350
YQAHISGAKH KNHLKSMTPL SEEGHTAAVA PSAFASGSAG KGFSCDTCNI
360 370 380 390 400
VLNSIEQYQA HISGAKHKNH LMSMTPLSEE GHTAAVAPSA FASGSAGKGF
410 420 430 440 450
SCDTCNIVLN SIEQYQAHVS GAKHKNQLMS MTPSSEEGLP SAVGPSAFAS
460 470 480 490 500
PLSAGGALSS GGPSGRGFCP SGDLTPKGPS SFGSLPPLGS LLPPLYPPAH
510 520
SSQPYVHDDT MSPDGYNYFN EDFE
Length:524
Mass (Da):55,546
Last modified:March 1, 2003 - v1
Checksum:iE55736038AC13D5C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti397 – 3971G → V in AAC60260 (PubMed:9268652).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005083 mRNA. Translation: AAC60260.1.
BC041713 mRNA. Translation: AAH41713.1.
RefSeqiNP_001080778.1. NM_001087309.1.
UniGeneiXl.386.

Genome annotation databases

GeneIDi380471.
KEGGixla:380471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005083 mRNA. Translation: AAC60260.1.
BC041713 mRNA. Translation: AAH41713.1.
RefSeqiNP_001080778.1. NM_001087309.1.
UniGeneiXl.386.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZU1NMR-A2-128[»]
ProteinModelPortaliQ8AVN9.
SMRiQ8AVN9. Positions 2-128.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi380471.
KEGGixla:380471.

Organism-specific databases

CTDi23567.
XenbaseiXB-GENE-967548. znf346.

Phylogenomic databases

HOVERGENiHBG061007.

Miscellaneous databases

EvolutionaryTraceiQ8AVN9.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN346_XENLA
AccessioniPrimary (citable) accession number: Q8AVN9
Secondary accession number(s): O42147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: December 9, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.