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Protein

Zinc finger protein 346

Gene

znf346

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds preferentially to dsRNA, but also to RNA-DNA hybrids.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Zinc 11 Publication1
Metal bindingi39Zinc 11 Publication1
Metal bindingi52Zinc 1; via tele nitrogen1 Publication1
Metal bindingi58Zinc 1; via pros nitrogen1 Publication1
Metal bindingi97Zinc 21 Publication1
Metal bindingi100Zinc 21 Publication1
Metal bindingi113Zinc 2; via tele nitrogen1 Publication1
Metal bindingi119Zinc 2; via pros nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 64Matrin-type 1Sequence analysisAdd BLAST31
Zinc fingeri92 – 126Matrin-type 2Sequence analysisAdd BLAST35
Zinc fingeri162 – 192Matrin-type 3Sequence analysisAdd BLAST31
Zinc fingeri226 – 260Matrin-type 4Sequence analysisAdd BLAST35
Zinc fingeri286 – 316Matrin-type 5Sequence analysisAdd BLAST31
Zinc fingeri343 – 373Matrin-type 6Sequence analysisAdd BLAST31
Zinc fingeri400 – 430Matrin-type 7Sequence analysisAdd BLAST31

GO - Molecular functioni

  • double-stranded RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346By similarity
Alternative name(s):
Double-stranded RNA-binding protein ZFa
Short name:
DsRBP-ZFaImported
Short name:
ZFa1 Publication
Just another zinc finger proteinBy similarity
Short name:
Protein jaz
Gene namesi
Name:znf346By similarity
Synonyms:jazImported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-967548. znf346.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Primarily nuclear.1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003489341 – 524Zinc finger protein 346Add BLAST524

Structurei

Secondary structure

1524
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 26Combined sources10
Turni27 – 30Combined sources4
Beta strandi33 – 36Combined sources4
Turni37 – 40Combined sources4
Helixi46 – 54Combined sources9
Helixi56 – 68Combined sources13
Turni93 – 95Combined sources3
Turni98 – 101Combined sources4
Helixi107 – 114Combined sources8
Helixi117 – 127Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZU1NMR-A2-128[»]
ProteinModelPortaliQ8AVN9.
SMRiQ8AVN9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8AVN9.

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.By similarity

Sequence similaritiesi

Contains 7 matrin-type zinc fingers.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 64Matrin-type 1Sequence analysisAdd BLAST31
Zinc fingeri92 – 126Matrin-type 2Sequence analysisAdd BLAST35
Zinc fingeri162 – 192Matrin-type 3Sequence analysisAdd BLAST31
Zinc fingeri226 – 260Matrin-type 4Sequence analysisAdd BLAST35
Zinc fingeri286 – 316Matrin-type 5Sequence analysisAdd BLAST31
Zinc fingeri343 – 373Matrin-type 6Sequence analysisAdd BLAST31
Zinc fingeri400 – 430Matrin-type 7Sequence analysisAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG061007.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AVN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEFGNGDA LDLPVGKDAV NSLIRENSHI FSDTQCKVCS AVLISESQKL
60 70 80 90 100
AHYQSRKHAN KVRRYMAINQ GEDSVPAKKF KAAPAEISDG EDRSKCCPVC
110 120 130 140 150
NMTFSSPVVA ESHYIGKTHI KNLRLREQGG VKEGMVNQAK KTRTPTVATK
160 170 180 190 200
SDNKMDHSDR AKFCKLCHST FNNPLMAEQH YAGKKHKKQE TKTQIMTIYT
210 220 230 240 250
SSGQTPAQAP IPLNLNSPMP GSGSAGKGFS CDKCNIVLNS IEQYQAHVSG
260 270 280 290 300
AKHKNQLMSM TPLSEEGHQA VVAPSAIASG SAGKGFSCDT CNIVLNSIEQ
310 320 330 340 350
YQAHISGAKH KNHLKSMTPL SEEGHTAAVA PSAFASGSAG KGFSCDTCNI
360 370 380 390 400
VLNSIEQYQA HISGAKHKNH LMSMTPLSEE GHTAAVAPSA FASGSAGKGF
410 420 430 440 450
SCDTCNIVLN SIEQYQAHVS GAKHKNQLMS MTPSSEEGLP SAVGPSAFAS
460 470 480 490 500
PLSAGGALSS GGPSGRGFCP SGDLTPKGPS SFGSLPPLGS LLPPLYPPAH
510 520
SSQPYVHDDT MSPDGYNYFN EDFE
Length:524
Mass (Da):55,546
Last modified:March 1, 2003 - v1
Checksum:iE55736038AC13D5C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397G → V in AAC60260 (PubMed:9268652).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005083 mRNA. Translation: AAC60260.1.
BC041713 mRNA. Translation: AAH41713.1.
RefSeqiNP_001080778.1. NM_001087309.1.
UniGeneiXl.386.

Genome annotation databases

GeneIDi380471.
KEGGixla:380471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005083 mRNA. Translation: AAC60260.1.
BC041713 mRNA. Translation: AAH41713.1.
RefSeqiNP_001080778.1. NM_001087309.1.
UniGeneiXl.386.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZU1NMR-A2-128[»]
ProteinModelPortaliQ8AVN9.
SMRiQ8AVN9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi380471.
KEGGixla:380471.

Organism-specific databases

CTDi23567.
XenbaseiXB-GENE-967548. znf346.

Phylogenomic databases

HOVERGENiHBG061007.

Miscellaneous databases

EvolutionaryTraceiQ8AVN9.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN346_XENLA
AccessioniPrimary (citable) accession number: Q8AVN9
Secondary accession number(s): O42147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.