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Q8AVJ9

- FZD7B_XENLA

UniProt

Q8AVJ9 - FZD7B_XENLA

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Protein

Frizzled-7-B

Gene
fzd7-b, fz7-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension cell movements during gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation.By similarity3 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. syndecan binding Source: UniProtKB
  4. Wnt-activated receptor activity Source: InterPro
  5. Wnt-protein binding Source: UniProtKB

GO - Biological processi

  1. convergent extension involved in gastrulation Source: UniProtKB
  2. dorsal/ventral axis specification Source: UniProtKB
  3. mesoderm formation Source: UniProtKB
  4. protein localization Source: UniProtKB
  5. tissue morphogenesis Source: UniProtKB
  6. Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-7-B
Short name:
Fz-7-B
Short name:
Xfz7-B
Gene namesi
Name:fzd7-b
Synonyms:fz7-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-483735. fzd7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 230212Extracellular Reviewed predictionAdd
BLAST
Transmembranei231 – 25121Helical; Reviewed predictionAdd
BLAST
Topological domaini252 – 26211Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei263 – 28321Helical; Reviewed predictionAdd
BLAST
Topological domaini284 – 31128Extracellular Reviewed predictionAdd
BLAST
Transmembranei312 – 33221Helical; Reviewed predictionAdd
BLAST
Topological domaini333 – 35321Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei354 – 37421Helical; Reviewed predictionAdd
BLAST
Topological domaini375 – 39723Extracellular Reviewed predictionAdd
BLAST
Transmembranei398 – 41821Helical; Reviewed predictionAdd
BLAST
Topological domaini419 – 44426Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei445 – 46521Helical; Reviewed predictionAdd
BLAST
Topological domaini466 – 50237Extracellular Reviewed predictionAdd
BLAST
Transmembranei503 – 52321Helical; Reviewed predictionAdd
BLAST
Topological domaini524 – 54825Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi526 – 5261K → M: Reduced binding to dvl1. 1 Publication
Mutagenesisi531 – 5311W → G: Reduced binding to dvl1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 548530Frizzled-7-BPRO_0000282949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 97 By similarity
Disulfide bondi44 ↔ 90 By similarity
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi81 ↔ 118 By similarity
Disulfide bondi107 ↔ 147 By similarity
Disulfide bondi111 ↔ 135 By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

During gastrulation, broadly expressed on the dorsal side of the embryo in deep mesodermal cells surrounding the blastopore lip and in presumptive anterior neuroectoderm. During neurulation, localized to the cranial neural crest and heart field where expression is retained at later stages in addition to new areas of expression in the neural tube, pronephros and tailbud. At tailbud stage, expressed in the pronephric duct, and broad head expression becomes more restricted to the hindbrain. In tadpoles, strongly expressed in the eye and the pericardium and myocardium of the developing heart.1 Publication

Interactioni

Subunit structurei

Interacts with wnt11 and sdc4. The extracellular domain interacts with the extracellular domain of pcdh8/papc By similarity. Interacts (via C-terminus) with dvl1 (via PDZ domain).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dvl1P511413EBI-3870271,EBI-1538407From a different organism.

Protein-protein interaction databases

IntActiQ8AVJ9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8AVJ9.
SMRiQ8AVJ9. Positions 34-151.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 150120FZAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi526 – 5316Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Motifi546 – 5483PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
The FZ domain is involved in binding with Wnt ligands By similarity.By similarity
The extracellular domain interacts with Wnt proteins and the intracellular C-terminus transmits the Wnt signal.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006977.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8AVJ9-1 [UniParc]FASTAAdd to Basket

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MLAPVSLLFC LFLQLCPSAQ QYHGEKGISV PDHGFCQPIS IPLCTDIAYN    50
QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSPELRFFLC SMYAPVCTVL 100
EQAIPPCRSL CERARQGCEA LMNKFGFQWP ERLRCENFPV HGAGEICVGQ 150
NTSDNSPSGP TARPTLNLPD SITFQPHPHR DFTCPRQLKV PPYLGYRFLG 200
EKDCGAPCEP GKANGLMYFK EEEVRFARLW VGIWAILCGI STLFTVLTYL 250
VDMRRFSYPE RPIIFLSGCY FMVAVAYTAG FLLEERAVCV ERFSEDSYRT 300
VAQGTKKEGC TILFMILYFF GMASSIWWVI LALTWFLSAG MKWGHEAIEA 350
NSQYFHLAAW AVPAVKTITI LAMGQVDGDV LSGVCYVGIN SVDSLRGFVL 400
APLFVYLFLG TSFLLAGFVS LFRIRTIMKH DGTKTEKLEK LMVRIGVFSV 450
MYTVPATIVL ACYFYEQAFR DTWEKTWLVH TCKGYAVPCP NYNFAPMSPD 500
FTVFMIKYLM TMIVGITSSF WIWSGKTLQS WRRFYHRLGN GSKGETAV 548
Length:548
Mass (Da):61,906
Last modified:March 1, 2003 - v1
Checksum:i97B3408B3C0EA273
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681L → P in AAD44331. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159106 mRNA. Translation: AAD44331.1.
BC042228 mRNA. Translation: AAH42228.1.
UniGeneiXl.633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159106 mRNA. Translation: AAD44331.1 .
BC042228 mRNA. Translation: AAH42228.1 .
UniGenei Xl.633.

3D structure databases

ProteinModelPortali Q8AVJ9.
SMRi Q8AVJ9. Positions 34-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8AVJ9. 1 interaction.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-483735. fzd7.

Phylogenomic databases

HOVERGENi HBG006977.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel Xenopus frizzled genes expressed in developing heart and brain."
    Wheeler G.N., Hoppler S.
    Mech. Dev. 86:203-207(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "Inducible gene expression in transgenic Xenopus embryos."
    Wheeler G.N., Hamilton F.S., Hoppler S.
    Curr. Biol. 10:849-852(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Xenopus frizzled-7 morphant displays defects in dorsoventral patterning and convergent extension movements during gastrulation."
    Sumanas S., Ekker S.C.
    Genesis 30:119-122(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled."
    Wong H.C., Bourdelas A., Krauss A., Lee H.J., Shao Y., Wu D., Mlodzik M., Shi D.L., Zheng J.
    Mol. Cell 12:1251-1260(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DVL1, MUTAGENESIS OF LYS-526 AND TRP-531.

Entry informationi

Entry nameiFZD7B_XENLA
AccessioniPrimary (citable) accession number: Q8AVJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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