ID   S5A3_XENLA              Reviewed;         319 AA.
AC   Q8AVI9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=3-oxo-5-alpha-steroid 4-dehydrogenase 3;
DE            EC=1.3.99.5;
DE   AltName: Full=Steroid 5-alpha-reductase 3;
DE   AltName: Full=SR type 3;
GN   Name=srd5a3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts testosterone (T) into 5-alpha-
CC       dihydrotestosterone (DHT) (By similarity).
CC   -!- CATALYTIC ACTIVITY: A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-
CC       Delta(4)-steroid + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane
CC       protein (By similarity). Endoplasmic reticulum membrane; Multi-
CC       pass membrane protein (Potential).
CC   -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
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DR   EMBL; BC042255; AAH42255.1; -; mRNA.
DR   RefSeq; NP_001079436.1; -.
DR   UniGene; Xl.15326; -.
DR   GeneID; 379123; -.
DR   KEGG; xla:379123; -.
DR   Xenbase; XB-FEAT-985510; srd5a3.
DR   HOVERGEN; Q8AVI9; -.
DR   BRENDA; 1.3.99.5; 648.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003865; F:3-oxo-5-alpha-steroid 4-dehydrogenase activity; IEA:EC.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   Pfam; PF02544; Steroid_dh; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Microsome; Oxidoreductase;
KW   Transmembrane.
FT   CHAIN         1    319       3-oxo-5-alpha-steroid 4-dehydrogenase 3.
FT                                /FTId=PRO_0000317705.
FT   TRANSMEM     13     33       Potential.
FT   TRANSMEM     80    100       Potential.
FT   TRANSMEM    123    143       Potential.
FT   TRANSMEM    159    179       Potential.
FT   TRANSMEM    196    216       Potential.
FT   TRANSMEM    267    287       Potential.
SQ   SEQUENCE   319 AA;  36591 MW;  5163DCD07643B1DB CRC64;
     MQLVQLLPPG VSLLALVWLA VDAAFLTALL LYLQRGCDSG RSLLCSVFQD LIRYGKTKSG
     LRRPSWLQWF DIPKRCFWHF YFVSLVWNGF LLWILLHLLL QSVPVPEWLQ AVLQFLCAGS
     EPQVLGGELS VVLAFSLLWL HSLRRLLECL FVSIFSNGVI HFVQYCFGLG YYILIGFTIL
     GYCPLDRRTA VSLDDLLMQG NWYHILGLTL YVWASLHQYT CHCILADLRK SASGAIINLK
     HAVPTGDWFE KVSCPHYFAE LLIYLSIAVV FGLLNTIWWL VVLYVLLSQA LAAVLCHEFY
     HEKFDSYPIH RKAFIPLIF
//