Reviewed, UniProtKB/Swiss-Prot Q8AVI9 (S5A3_XENLA)

Names and origin

Protein names

Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 3
    EC=1.3.99.5
Alternative name(s):
    Steroid 5-alpha-reductase 3
    SR type 3

Gene names

Name:

srd5a3

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) By similarity.
Catalytic activity	A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.
Subcellular location	Microsome membrane; Multi-pass membrane proteinBy similarity. Endoplasmic reticulum membrane; Multi-pass membrane proteinPotential.
Sequence similarities	Belongs to the steroid 5-alpha reductase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	lipid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxo-5-alpha-steroid 4-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	3-oxo-5-alpha-steroid 4-dehydrogenase 3		PRO_0000317705
Regions
	Transmembrane	13 – 33	21	Potential
	Transmembrane	80 – 100	21	Potential
	Transmembrane	123 – 143	21	Potential
	Transmembrane	159 – 179	21	Potential
	Transmembrane	196 – 216	21	Potential
	Transmembrane	267 – 287	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8AVI9-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5163DCD07643B1DB	FASTA	319	36,591
	10 20 30 40 50 60 MQLVQLLPPG VSLLALVWLA VDAAFLTALL LYLQRGCDSG RSLLCSVFQD LIRYGKTKSG 70 80 90 100 110 120 LRRPSWLQWF DIPKRCFWHF YFVSLVWNGF LLWILLHLLL QSVPVPEWLQ AVLQFLCAGS 130 140 150 160 170 180 EPQVLGGELS VVLAFSLLWL HSLRRLLECL FVSIFSNGVI HFVQYCFGLG YYILIGFTIL 190 200 210 220 230 240 GYCPLDRRTA VSLDDLLMQG NWYHILGLTL YVWASLHQYT CHCILADLRK SASGAIINLK 250 260 270 280 290 300 HAVPTGDWFE KVSCPHYFAE LLIYLSIAVV FGLLNTIWWL VVLYVLLSQA LAAVLCHEFY 310 HEKFDSYPIH RKAFIPLIF

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC042255 mRNA. Translation: AAH42255.1.
RefSeq	NP_001079436.1.
UniGene	Xl.15326
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	379123.
KEGG	xla:379123.
Organism-specific databases
Xenbase	XB-FEAT-985510. srd5a3.
Phylogenomic databases
HOVERGEN	Q8AVI9.
Family and domain databases
InterPro	IPR001104. 3-oxo-5_a-steroid_4-DHase_C. [Graphical view]
Pfam	PF02544. Steroid_dh. 1 hit. [Graphical view]
PROSITE	PS50244. S5A_REDUCTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

S5A3_XENLA

Accession

Primary (citable) accession number: Q8AVI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2003
Last modified:	November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project