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Protein
Submitted name:

Capn8-a protein

Gene

capn8-like

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Capn8-a proteinImported
Gene namesi
Name:capn8-likeImported
Synonyms:capn8Imported, capn8-aImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251637. capn8-like.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ8AVE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 343Calpain catalyticInterPro annotationAdd BLAST299
Domaini573 – 599EF-handInterPro annotationAdd BLAST27
Domaini603 – 638EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili528 – 552Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOVERGENiHBG012645.
KOiK08577.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029543. CAPN8.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF52. PTHR10183:SF52. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8AVE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIASKVAK DRVLAQGLGT NDKPLKYLNQ DYEQLKARCL ESNTLFEDET
60 70 80 90 100
FPASQASMGV KELGPNSDKT KGIVWLRPLQ IHPKPEFIIS GATRSDVRQG
110 120 130 140 150
SLGDCWFLSS IASLTLNEEY LSRVVPGDQS FQTNYAGIFH FKFWQYGEWV
160 170 180 190 200
DVVVDDRLPT KKGKLVFVKS AEGNEFWSAL LEKAYAKLNG SYEALVGGSP
210 220 230 240 250
VDALEDFTGG IAELYYLQKP PADLFQRVQK ALRAKSLLTC TSKSDSTKVE
260 270 280 290 300
TVAKNNVVKN HAYTIIRAKE VIYRGEKVQL IRLRNPWGYK EWNGPWSDNA
310 320 330 340 350
CEWDEIDSEV KAALNTQCDD GEVWMSFSDF INEYYRLDIC NLSLDCVCSK
360 370 380 390 400
EERRWCLTQY SGSWKSGCTA GGCKKYPNTF WINPQFWIKL EEPDDDQNGA
410 420 430 440 450
GNAQCCTVIV GLIQKNRRKM KPMGEEEFPI GYYLYPIPKE FQGSHDVPLG
460 470 480 490 500
KDFFSKTKYV AWTDVYRKHR ETSCRHKLPI GEYIILPHTY YPCQDADFCL
510 520 530 540 550
RVFSKKKVGA LECGDVAVAD LYQLDPSNVQ VESEIEDILN ELEQKKMEMS
560 570 580 590 600
AEDLRINLSR ILSKKKDIKS DGFSLTTCKE MINLFDTDLT GKLNCKEFRP
610 620 630 640 650
LWIKLDTYMK IFKSVDNDRS DSIEAHEMRN ALQQAGFNLN NKIQEAIVQR
660 670 680 690 700
YISNELSINF DNFIACLIRL ENLFKIFEVL KTTESGVMSL SLSEWLCTAM

M
Length:701
Mass (Da):80,043
Last modified:March 1, 2003 - v1
Checksum:i8BF3FAF83E25D9CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042349 mRNA. Translation: AAH42349.1.
RefSeqiNP_001079452.1. NM_001085983.1.
UniGeneiXl.77282.

Genome annotation databases

GeneIDi379139.
KEGGixla:379139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042349 mRNA. Translation: AAH42349.1.
RefSeqiNP_001079452.1. NM_001085983.1.
UniGeneiXl.77282.

3D structure databases

ProteinModelPortaliQ8AVE8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379139.
KEGGixla:379139.

Organism-specific databases

CTDi379139.
XenbaseiXB-GENE-6251637. capn8-like.

Phylogenomic databases

HOVERGENiHBG012645.
KOiK08577.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029543. CAPN8.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF52. PTHR10183:SF52. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8AVE8_XENLA
AccessioniPrimary (citable) accession number: Q8AVE8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.